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NGFI-A binding protein 1

transcriptional repressor and an immediate-early gene [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Egr-1, NAB2, Early Growth Response Protein 2, Egr3, CAN
Papers on NAB1
Solution structure of the RNA-binding cold-shock domain of the Chlamydomonas reinhardtii NAB1 protein and insights into RNA recognition.
Hankamer et al., Australia. In Biochem J, Aug 2015
The Chlamydomonas reinhardtii nucleic acid-binding protein 1 (NAB1) is a negative regulator of LHC protein translation.
Integration of carbon assimilation modes with photosynthetic light capture in the green alga Chlamydomonas reinhardtii.
Kruse et al., Bielefeld, Germany. In Mol Plant, 2014
In C. reinhardtii, synthesis of PSII-associated light-harvesting proteins (LHCBMs) is controlled by the cytosolic RNA-binding protein NAB1, which represses translation of particular LHCBM isoform transcripts.
Ovarian cancer stem cell-specific gene expression profiling and targeted drug prescreening.
Hao et al., Tianjin, China. In Oncol Rep, 2014
NAB1 and NPIPL1 were commonly upregulated whereas PROS1, GREB1, KLF9 and MTUS1 were commonly downregulated in all 3 groups.
Effective myofibroblast dedifferentiation by concomitant inhibition of TGF-β signaling and perturbation of MAPK signaling.
Cermak et al., Praha, Czech Republic. In Eur J Cell Biol, 2013
Detailed analysis of the possible molecular mechanisms employed by EGR4 revealed FOXG1, BAMBI, NAB1, NAB2 and DUSP5 genes forming an EGR4 regulated network counteracting autocrine TGF-β signaling.
Altered calcium regulation in isolated cardiomyocytes from Egr-1 knock-out mice.
Calogero et al., Latina, Italy. In Can J Physiol Pharmacol, 2013
Furthermore, genes involved in heart development (GATA-4, TGF-β) and in Egr-1 regulation (Nab1, Nab2) were down regulated in Egr-1(-/-) mice.
Type I IFNs downregulate myeloid cell IFN-γ receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription.
Lenz et al., Denver, United States. In J Immunol, 2013
Three Egr proteins and two Egr/NGFI-A binding (Nab) proteins were found to be expressed in bone macrophages, but only Egr3 and Nab1 were recruited to the ifngr1 promoter upon IFN-β stimulation.
A novel role for Pax6 in the segmental organization of the hindbrain.
Sela-Donenfeld et al., Jerusalem, Israel. In Development, 2013
A mutual negative cross-talk between Pax6 and Krox20 allows these genes to be co-expressed in the hindbrain through regulation of the Krox20-repressor gene Nab1 by Pax6.
Unbiased discovery of interactions at a control locus driving expression of the cancer-specific therapeutic and diagnostic target, mesothelin.
Kern et al., Baltimore, United States. In J Proteome Res, 2012
The screens agreed in confirming binding by TEAD proteins and by newly identified NAB1 and NFATc.
Pleiotropic effects of long-term monotherapy with rosuvastatin in dogs with moderate heart failure.
Sabbah et al., Detroit, United States. In Cardiology, 2011
mRNA and protein expression of prohypertrophic mediator NGFI-A binding protein 1 (Nab1), phosphatase and tensin homolog (PTEN), phosphoinositide-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) were measured, as well as that of proinflammatory cytokine interleukin-6 (IL-6), bone marrow-derived stem cell markers cKit and Sca1, vascular endothelial and fibroblast growth factors (VEGF and FGF) and nitric oxide synthase (NOS) isoforms.
Thiol-based redox switches and gene regulation.
Helmann et al., Greifswald, Germany. In Antioxid Redox Signal, 2011
In eukaryotes, thiol-based switches control the yeast Yap1p transcription factor, the Nrf2/Keap1 electrophile and oxidative stress response, and the Chlamydomonas NAB1 translational repressor.
Valproic acid suppresses interleukin-1ß-induced microsomal prostaglandin E2 synthase-1 expression in chondrocytes through upregulation of NAB1.
Fahmi et al., Montréal, Canada. In J Rheumatol, 2011
Data show that the suppressive effect of valproic acid on chondrocytes is not due to reduced expression or recruitment of Egr-1 to the mPGES-1 promoter and involves upregulation of NAB1.
Egr-1 regulates the transcriptional repression of mouse δ-aminolevulinic acid synthase 1 by heme.
Taketani et al., Kyoto, Japan. In Gene, 2011
Subsequently, EMSA and ChIP assays showed that a transcription factor, early growth response 1 (Egr-1) and its major corepressors, NAB1 and NAB2 were found to bind to the ALAS1-HRE, and these bindings increased dependent on the level of intracellular heme.
Protein arginine methylation modulates light-harvesting antenna translation in Chlamydomonas reinhardtii.
Kruse et al., Bielefeld, Germany. In Plant J, 2011
In this work, we successfully identified and characterized arginine methylation as a crucial type of post-translational modification in the activity regulation of the cytosolic translation repressor protein NAB1 in the plant model organism Chlamydomonas reinhardtii.
Hemizygous deletion of COL3A1, COL5A2, and MSTN causes a complex phenotype with aortic dissection: a lesson for and from true haploinsufficiency.
Mátyás et al., Zürich, Switzerland. In Eur J Hum Genet, 2010
This deletion affects not only COL3A1 but also 21 other known genes (GULP1, DIRC1, COL5A2, WDR75, SLC40A1, ASNSD1, ANKAR, OSGEPL1, ORMDL1, LOC100129592, PMS1, MSTN, C2orf88, HIBCH, INPP1, MFSD6, TMEM194B, NAB1, GLS, STAT1, and STAT4), mutations in three of which (COL5A2, SLC40A1, and MSTN) have also been associated with an autosomal dominant disorder (EDS classical type, hemochromatosis type 4, and muscle hypertrophy).
Cysteine modification of a specific repressor protein controls the translational status of nucleus-encoded LHCII mRNAs in Chlamydomonas.
Kruse et al., Bielefeld, Germany. In Proc Natl Acad Sci U S A, 2009
All examined cysteine single and double mutants exhibited a reduced antenna at photosystem II caused by a perturbed NAB1 deactivation mechanism.
Active gene repression by the Egr2.NAB complex during peripheral nerve myelination.
Svaren et al., Madison, United States. In J Biol Chem, 2008
Egr2 directly represses genes during myelination in conjunction with NAB corepressors
The glucocorticoid receptor gene exon 1-F promoter is not methylated at the NGFI-A binding site in human hippocampus.
Meyer et al., Trier, Germany. In World J Biol Psychiatry, 2006
Methylation pattern of the corresponding NGFI-A binding site in the human glucocorticoid receptor exon 1-F specific promoter in post mortem hippocampal tissue.
The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy.
Engelhardt et al., Würzburg, Germany. In Nat Med, 2005
Nab1 is a potent inhibitor of cardiac growth in response to pathological stimuli in vivo.
Nab proteins are essential for peripheral nervous system myelination.
Milbrandt et al., Saint Louis, United States. In Nat Neurosci, 2005
Nab1 and Nab2 proteins are necessary for Schwann cells to exit the cell cycle, downregulate suppressed cAMP-inducible protein (SCIP) expression and upregulate expression of critical myelination genes.
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