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Bromodomain and WD repeat domain containing 1

N143, WDR9, BRWD1, repro5, BRWDI
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: Phosphoglucomutase, BRG1, Actin, Histone, CAN
Papers on N143
Histone reader BRWD1 targets and restricts recombination to the Igk locus.
New
Impact
Clark et al., Chicago, United States. In Nat Immunol, Oct 2015
Here we show that developmental downregulation of interleukin 7 (IL-7)-receptor signaling in small pre-B cells induced expression of the bromodomain-family member BRWD1, which was recruited to a specific epigenetic landscape at Igk dictated by pre-B cell receptor (pre-BCR)-dependent Erk activation.
Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability.
New
De La Fuente et al., Athens, United States. In J Cell Biol, Feb 2015
We report that the dual bromodomain-containing protein BRWD1, which is essential for both male and female fertility, promotes haploid spermatid-specific transcription but has distinct roles in oocyte meiotic progression.
Excess of rare variants in genes that are key epigenetic regulators of spermatogenesis in the patients with non-obstructive azoospermia.
Gui et al., Shenzhen, China. In Sci Rep, 2014
We found a significant excess of rare, non-silent variants in genes that are key epigenetic regulators of spermatogenesis, such as BRWD1, DNMT1, DNMT3B, RNF17, UBR2, USP1 and USP26, in NOA patients (P = 5.5 × 10(-7)), corresponding to a carrier frequency of 22.5% of patients and 13.7% of controls (P = 1.4 × 10(-5)).
Association of variants in 21q22 with ankylosing spondylitis in the Chinese Guangxi Zhuang population.
Zhao et al., Nanning, China. In Rheumatol Int, 2014
The findings was consistent with previous genetic and functional studies that point at variants of the BRWD1 and/or PSMG1 loci as interesting genetic factors contributing to AS.
Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks.
Scott et al., Kuala Selangor, Malaysia. In Bmc Genomics, 2013
We validated 8 selected DEGs from the cerebral cortex (Brwd1, Donson, Erdr1, Ifnar1, Itgb8, Itsn1, Mrps6 and Tmem50b), 18 DEGs from the cerebellum (Atp5o, Brwd1, Donson, Dopey2, Erdr1, Hmgn1, Ifnar1, Ifnar2, Ifngr2, Itgb8, Itsn1, Mrps6, Paxbp1, Son, Stat1, Tbata, Tmem50b and Wrb) and 11 DEGs from the hippocampus (Atp5o, Brwd1, Cbr1, Donson, Erdr1, Itgb8, Itsn1, Morc3, Son, Tmem50b and Wrb).
Interactions between mecamylamine and alcohol in Long-Evans rats: flash-evoked potentials, body temperature, behavior, and blood alcohol concentration.
Bauer et al., Appleton, United States. In Prog Neuropsychopharmacol Biol Psychiatry, 2013
In the VC, alcohol significantly decreased the amplitudes of components P23, N29, N39, P89, N143, and P237, but increased P46.
Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.
Rotter et al., Los Angeles, United States. In Inflamm Bowel Dis, 2010
Only the 21q22.2/BRWDI
Quantification of isotopically overlapping deamidated and 18o-labeled peptides using isotopic envelope mixture modeling.
David et al., Portland, United States. In J Proteome Res, 2009
A series of normal (3 day, 2 year, 35 year, and 70 year) and cataractous (93 year) human lenses were analyzed using two-dimensional liquid chromatography tandem mass spectrometry, and deamidation quantities of several gammaS-crystallin peptides ([N14-Q16], N53, [Q63-Q70], and N143) were determined.
The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte-embryo transition.
GeneRIF
Schimenti et al., Ithaca, United States. In Dev Biol, 2008
Brwd1 represents one of a small number of genes whose elimination disrupts gametogenesis in both sexes after the major events of meiotic prophase I have been completed.
The Drosophila ramshackle gene encodes a chromatin-associated protein required for cell morphology in the developing eye.
Moses et al., Atlanta, United States. In Mech Dev, 2006
ram is a conserved gene: its vertebrate homolog (WDR9), which lies in Down's Syndrome Critical region 2 (DCR2) is also known to be associated with Brahma-Related-Gene 1 (BRG1).
Expression of the Wdr9 gene and protein products during mouse development.
GeneRIF
Featherstone et al., Montréal, Canada. In Dev Dyn, 2003
WDR9 is a transcriptional regulator involved in chromatin remodeling through the action of two bromodomains and contacts to the SWI/SNF complex
Engagement of the NG2 proteoglycan triggers cell spreading via rac and p130cas.
Stallcup et al., Los Angeles, United States. In Cell Signal, 2003
On surfaces coated with the N143 monoclonal antibody, this cell spreading occurs by extension of lamellipodia, suggesting that activation of the small GTPase rac is involved in the observed morphological change.
Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21.
GeneRIF
Oliva et al., Barcelona, Spain. In Biochim Biophys Acta, 2002
isolation and characterization of the gene located in the Down Syndrome critical region-2 of chromosome 21
Cytoskeletal reorganization induced by engagement of the NG2 proteoglycan leads to cell spreading and migration.
Stallcup et al., Los Angeles, United States. In Mol Biol Cell, 1999
On mAb D120, the cells contain radial actin spikes characteristic of filopodial extension, whereas on mAb N143, the cells contain cortical actin bundles characteristic of lamellipodia.
Expression of NG2/human melanoma proteoglycan in human adult articular chondrocytes.
Salter et al., Edinburgh, United Kingdom. In Osteoarthritis Cartilage, 1998
DESIGN: Cryostat sections of human fetal knee joints and normal and osteoarthritic articular cartilage were immunostained with antibodies against rat NG2 (N143.8)
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