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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Wiskott-Aldrich syndrome-like

N-WASP, neural Wiskott-Aldrich syndrome protein
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Wasp, Actin, Arp2, Cdc42, CAN
Papers using N-WASP antibodies
aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues.
Supplier
Appanna Vasu D., In PLoS ONE, 2008
... Antibody against neural Wiskott-Aldrich syndrome protein (N-WASp) was purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity
Supplier
Martín-Belmonte Fernando et al., In The Journal of Cell Biology, 2007
... Antibodies against ITSN2 (Novus Biologicals), N-WASP (Santa Cruz Biotechnology, Inc.), Cdc42 (BD), pericentrin ...
Local signaling by the EGF receptor
Supplier
Segall Jeffrey E. et al., In The Journal of Cell Biology, 1999
... The following antibodies for immunofluorescence were used: PY72, anti-phosphotyrosine (BabCO), goat anti–N-WASP (Santa Cruz Biotechnology, Inc.), anti-phosphoAkt (Ser473) antibody ...
Papers on N-WASP
Invadopodia proteins, cortactin, N-WASP and WIP differentially promote local invasiveness in ameloblastoma.
New
Ng et al., Kuala Lumpur, Malaysia. In J Oral Pathol Med, Feb 2016
Other invadopodia regulators, namely N-WASP, WIP and Src kinase remain unclarified.
Loss of CD73-mediated actin polymerization promotes endometrial tumor progression.
New
Broaddus et al., In J Clin Invest, Feb 2016
We determined that CD73-generated adenosine induces cortical actin polymerization via adenosine A1 receptor (A1R) induction of a Rho GTPase CDC42-dependent conformational change of the actin-related proteins 2 and 3 (ARP2/3) actin polymerization complex member N-WASP.
A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation.
New
Sherwood et al., Boston, United States. In Plos Genet, Jan 2016
CDC-42 is required for the invasive membrane localization of WSP-1 (N-WASP), a CDC-42 effector that promotes polymerization of F-actin.
Neuritic complexity of hippocampal neurons depends on WIP-mediated mTORC1 and Abl family kinases activities.
New
Antón et al., Madrid, Spain. In Brain Behav, Nov 2015
Although WIP controls activity of the actin-nucleation-promoting factor neural WASP (N-WASP) during neuritic differentiation, its implication in signal transduction remains unknown.
Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation.
New
Impact
Itoh et al., Kōbe, Japan. In Nat Cell Biol, Jun 2015
Here, we demonstrate that FBP17, a membrane-bending protein and an activator of WASP/N-WASP-dependent actin nucleation, is a PM tension sensor involved in leading edge formation.
microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements.
Götte et al., Münster, Germany. In Plos One, 2014
Supported by transcriptomic Affymetrix array analysis and confirmatory investigations at the mRNA and protein level, we demonstrate that overexpression of miR-142-3p in MDA-MB-231, MDA-MB-468 and MCF-7 breast cancer cells leads to downregulation of WASL (Wiskott-Aldrich syndrome-like, protein: N-WASP), Integrin-αV, RAC1, and CFL2, molecules implicated in cytoskeletal regulation and cell motility.
A role for the small GTPase Rac1 in vaccinia actin-based motility.
Review
Agaisse et al., Buenos Aires, Argentina. In Small Gtpases, 2014
Vaccinia virus dissemination relies on the recruitment of the nucleation promoting factor N-WASP underneath cell-associated extracellular virus (CEVs) and subsequent recruitment and activation of the ARP2/3 complex, a major actin nucleator of the host cell.
Role of host GTPases in infection by Listeria monocytogenes.
Review
Dowd et al., Dunedin, New Zealand. In Cell Microbiol, 2014
The human GTPase Cdc42, its activator Tuba, and its effector N-WASP form a complex with the potential to restrict Listeria protrusions.
Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.
Impact
Shaw et al., Los Angeles, United States. In Nat Med, 2014
We also found that T-tubule inner folds are rescued by expression of the BIN1 isoform BIN1+13+17, which promotes N-WASP-dependent actin polymerization to stabilize the T-tubule membrane at cardiac Z discs.
Lateral junction dynamics lead the way out.
Impact
Heisenberg et al., Klosterneuburg, Austria. In Nat Cell Biol, 2014
Cell integration into epithelial sheets is now shown to depend on the N-WASP-regulated stabilization of cortical F-actin, which generates distinct patterns of apical-lateral contractility at E-cadherin-based cell-cell junctions.
Cortical F-actin stabilization generates apical-lateral patterns of junctional contractility that integrate cells into epithelia.
Impact
Yap et al., Brisbane, Australia. In Nat Cell Biol, 2014
We demonstrate that N-WASP (also known as WASL) enhances apical junctional tension by stabilizing local F-actin networks, which otherwise undergo stress-induced turnover.
Dynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions.
Review
Schnittler et al., Münster, Germany. In Cell Adh Migr, 2013
The actin-related protein complex ARP2/3 and its activating molecules, such as N-WASP and WAVE, have been shown to regulate the lammellipodia-mediated formation of cell junctions in both epithelium and endothelium.
Molecular mechanism of protrusion formation during cell-to-cell spread of Listeria.
Review
Schubert et al., Dunedin, New Zealand. In Front Cell Infect Microbiol, 2013
Recent results indicate that formation of Listeria protrusions in polarized human cells involves bacterial antagonism of a host signaling pathway comprised of the scaffolding protein Tuba and its effectors N-WASP and Cdc42.
Syndapin--a membrane remodelling and endocytic F-BAR protein.
Review
Robinson et al., Sydney, Australia. In Febs J, 2013
The membrane remodelling activity of syndapin via its F-BAR domain and its interaction partners, such as dynamin and neural Wiskott-Aldrich syndrome protein binding to its Src-homology 3 domain, are important with respect to its function.
Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion.
Impact
Meyer et al., Stanford, United States. In Nat Cell Biol, 2012
Here we show that antigen activation of mast cells induces oscillations in Ca(2+) and PtdIns(4,5)P(2) lipid levels that in turn drive cyclic recruitment of N-WASP and cortical actin level oscillations.
Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.
GeneRIF
López-Larrea et al., Oviedo, Spain. In Eur J Immunol, 2012
study describes that both N-WASp and WASp participate in the inhibition of NK-cell chemotaxis in response to NKG2D WASp engagement, and that this effect is not dependent on the regulation of F-actin dynamics
The actin regulator N-WASp is required for muscle-cell fusion in mice.
GeneRIF
Schejter et al., Israel. In Proc Natl Acad Sci U S A, 2012
N-WASp is an actin regulator required for muscle-cell fusion in mice
N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors.
GeneRIF
Condeelis et al., United States. In J Cell Sci, 2012
tumor cells in vivo that have a decreased activity of N-WASP also have a reduced ability to form invadopodia, migrate, invade, intravasate and disseminate to lung compared with tumor cells with parental N-WASP levels
LPS induces phosphorylation of actin-regulatory proteins leading to actin reassembly and macrophage motility.
GeneRIF
Kwiatkowska et al., Warsaw, Poland. In J Cell Biochem, 2012
Paxillin and N-WASP are involved in the reorganization of actin cytoskeleton driving motility of LPS-stimulated cells.
N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway.
Impact
GeneRIF
Yap et al., Brisbane, Australia. In Nat Cell Biol, 2011
N-WASP-WIRE serves as an integrator that couples actin nucleation with the subsequent steps of filament stabilization and organization necessary for zonula adherens integrity.
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