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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Neuroblastoma RAS viral

N-ras
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011] (from NCBI)
Papers using N-ras antibodies
CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.
Supplier
Najbauer Joseph, In PLoS ONE, 2008
... ERK2, p-ERK1/2 (Thr202/Tyr204), MEK1, MEK2 and p-MEK1/MEK2 (Ser217/221) (Cell Signaling Technology, Beverly, MA); BRAF and NRAS (F-7; Santa Cruz Biotechnology, Santa Cruz, CA); KRAS ...
Papers on N-ras
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
GeneRIF
Pao et al., Nashville, United States. In Proc Natl Acad Sci U S A, 2012
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma.
Impact
GeneRIF
Palmieri et al., Italy. In J Clin Oncol, 2012
BRAF/NRAS mutations were identified in 58% of primary melanomas
Marked genetic differences between BRAF and NRAS mutated primary melanomas as revealed by array comparative genomic hybridization.
GeneRIF
Bal√°zs et al., Debrecen, Hungary. In Melanoma Res, 2012
Report marked differences in the genetic pattern of the BRAF or NRAS mutated and wild-type melanoma subgroups.
A comprehensive survey of Ras mutations in cancer.
GeneRIF
Mattos et al., Liverpool, United Kingdom. In Cancer Res, 2012
study examined the mutational spectra of Ras isoforms curated from large-scale tumor profiling and found that each isoform exhibits surprisingly distinctive codon mutation and amino-acid substitution biases
Combined mutational analysis of KRAS, NRAS and BRAF genes in Indian patients with colorectal carcinoma.
GeneRIF
Das et al., Mumbai, India. In Int J Biol Markers, 2012
Investigation the prevalence of mutations in the NRAS gene and its correlation with demographic characteristics, tumor location and stage in 100 colorectal carcinoma patients from India.
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