Kras Is Critical for B Cell Lymphopoiesis.
Beijing, China. In J Immunol, Feb 2016
UNASSIGNED: The three major Ras members, Kras, Hras, and Nras, are highly homologous and individual Ras genes can have distinct biological functions.
Myelodysplastic syndromes: Contemporary review and how we treat.
Rochester, United States. In Am J Hematol, Jan 2016
With the advent of next generation sequencing, recurrent somatic mutations in genes involved in epigenetic regulation (TET2, ASXL1, EZH2, DNMT3A, IDH1/2), RNA splicing (SF3B1, SRSF2, U2AF1, ZRSR2), DNA damage response (TP53), transcriptional regulation (RUNX1, BCOR, ETV6) and signal transduction (CBL, NRAS, JAK2) have been identified in MDS.
MicroRNAs as potential diagnostic and prognostic biomarkers in melanoma.
Mashhad, Iran. In Eur J Cancer, Jan 2016
let-7a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR-214, miR-221 and 222, has been recognised to be linked with melanoma-associated genes such as NRAS, microphthalmia-associated transcription factor, receptor tyrosine kinase c-KIT, AP-2 transcription factor, etc.
The genomic landscape of juvenile myelomonocytic leukemia.
San Francisco, United States. In Nat Genet, Nov 2015
Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in 85% of patients, yet there are currently no risk stratification algorithms capable of predicting which patients will be refractory to conventional treatment and could therefore be candidates for experimental therapies.
Colorectal Cancer: Personalized Therapy.
Bochum, Germany. In Gastrointest Tumors, 2014
The presence of wild-type KRAS and NRAS (all RAS) is a positive predictive factor for epidermal growth factor receptor antibody treatment.
A comprehensive survey of Ras mutations in cancer.
Liverpool, United Kingdom. In Cancer Res, 2012
study examined the mutational spectra of Ras isoforms curated from large-scale tumor profiling and found that each isoform exhibits surprisingly distinctive codon mutation and amino-acid substitution biases