MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.
Philadelphia, United States. In Cell Metab, Jan 2016
We report here that deregulated expression of MYC or N-MYC disrupts the molecular clock in vitro by directly inducing REV-ERBα to dampen expression and oscillation of BMAL1, and this could be rescued by knockdown of REV-ERB.
Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.
Boston, United States. In Cancer Cell, 2012
Coexpression of activated ALK with MYCN provides prosurvival signals that block this apoptotic response and allow continued expansion and oncogenic transformation of hyperplastic neuroblasts, thus promoting progression to neuroblastoma.