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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cadherin 2, type 1, N-cadherin

N-cadherin
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: E-cadherin, vimentin, SNAIL, V1a, CAN
Papers using N-cadherin antibodies
Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells
Supplier
Hunter Tony et al., In The Journal of Cell Biology, 2006
... (Cell Signaling Technology); E- and N-cadherin (BD Biosciences); and phosphorylated ERK2(T183, Y185) ...
Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression
Supplier
Lee Ming-Ting et al., In Molecular Cancer, 2006
... Anti-Snail was obtained from Abcam (Cambridge, MA) and anti-N-cadherin was purchased from Abgent (San Diego, CA) ...
Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression.
Supplier
Dent Paul, In PLoS ONE, 2006
... Anti-E-cadherin, anti-N-cadherin, anti-Twist and Anti-phosphotyrosine monoclonal antibodies were purchased from Cell Signaling (Danvers, MA, USA) ...
FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma
Supplier
Pizzo Salvatore V., In PLoS ONE, 2004
... Rabbit monoclonal antibodies against MMP-2, MMP-9, E-cadherin, integrin β4, N-cadherin and TIMP-1 were purchased from Cell Signaling Techonolgies (USA) ...
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Papers on N-cadherin
Blood-testis barrier and Sertoli cell function: lessons from SCCx43KO mice.
Review
New
Brehm et al., Hannover, Germany. In Reproduction, Feb 2016
Although the SC specific KO of CX43 does not seem to have an adverse effect on BTB integrity, CX43 influences BTB composition as the expression pattern of different BTB proteins (like OCCLUDIN, β-CATENIN, N-CADHERIN, and CLAUDIN11) is altered in mutant males.
Substrate Stiffness Modulates Lung Cancer Cell Migration but not Epithelial to Mesenchymal Transition.
New
Ghadiali et al., Columbus, United States. In J Biomed Mater Res A, Feb 2016
E-cadherin and N-cadherin, and the phosphorylation of focal adhesion proteins.
Adenosine inhibits migration, invasion and induces apoptosis of human cervical cancer cells.
New
Zhang et al., In Neoplasma, Feb 2016
Moreover, by determining the expression of molecules which were involved in epithelial to mesenchymal transition (EMT) progress, we found that epithelial marker E-cadherin was significantly increased in response to adenosine treatment, while the mesenchymal markers including N-cadherin and fibronectin were decreased.
Taiwan cobra cardiotoxin III suppresses EGF/EGFR-mediated epithelial-to-mesenchymal transition and invasion of human breast cancer MDA-MB-231 cells.
New
Lin et al., Kao-hsiung, Taiwan. In Toxicon, Feb 2016
CTX III treatment resulted in morphological changes from elongated and spindle shape to rounded and epithelial-like shape, induced upregulation of E-cadherin and concurrent downregulation of N-cadherin and Vimentin protein levels, corresponding to observed decreases in cell migration and invasion.
WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells.
New
Zhang et al., Shanghai, China. In Int J Oncol, Feb 2016
Besides, the metastatic potential and expression of EMT markers (such as N-cadherin, vimentin, Snail) were also found suppressed by PP.
The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain.
Review
New
Lichtenthaler et al., Kiel, Germany. In Prog Neurobiol, Dec 2015
Mechanistically, ADAM10 controls these functions by utilizing unique postsynaptic substrates in the central nervous system, in particular synaptic cell adhesion molecules, such as neuroligin-1, N-cadherin, NCAM, Ephrin A2 and A5.
Anti-Alzheimer Therapeutic Drugs Targeting γ-Secretase.
Review
New
Hua et al., Beijing, China. In Curr Top Med Chem, Dec 2015
γ-secretase is a membrane-embedded aspartyl protease carrying out cleavage of more than 100 single transmembrane-spanning proteins, including APP, Notch, N-cadherin, etc.
Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc.
New
Delmar et al., New York City, United States. In Nat Commun, Dec 2015
Here we combine nanoscale-imaging (single-molecule localization microscopy; electron microscopy; and 'angle view' scanning patch clamp) with mathematical simulations to demonstrate distinct hubs at the cardiac intercalated disc, populated by clusters of the adhesion molecule N-cadherin and the VGSC NaV1.5.
Rab, Arf and Arl-Regulated Membrane Traffic in Cortical Neuron Migration.
Review
New
Tang, Singapore, Singapore. In J Cell Physiol, Dec 2015
Rab5 and Rab11, which are key modulators of endocytosis and endocytic recycling respectively, ensure proper surface expression and distribution of N-cadherin, a key adhesion protein that tethers migrating neurons to the radial glia fiber tracts during pia-directed migration.
The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells.
New
Impact
Zhang et al., Houston, United States. In Cancer Cell, Mar 2015
Niche interactions are mediated by heterotypic adherens junctions (hAJs) involving cancer-derived E-cadherin and osteogenic N-cadherin, the disruption of which abolishes niche-conferred advantages.
Cellullar insights into cerebral cortical development: focusing on the locomotion mode of neuronal migration.
Review
Kawauchi, Tokyo, Japan. In Front Cell Neurosci, 2014
The locomoting neurons exhibit unique features; a radial glial fiber-dependent migration requiring the endocytic recycling of N-cadherin and a neuron-specific migration mode with dilation/swelling formation that requires the actin and microtubule organization possibly regulated by cyclin-dependent kinase 5 (Cdk5), Dcx, p27(kip1), Rac1, and POSH.
Retrograde flow of cadherins in collective cell migration.
Impact
Sahai et al., London, United Kingdom. In Nat Cell Biol, 2014
The maintenance of N-cadherin-based junctions during collective migration is now shown to be facilitated by their treadmilling from the cell front to the rear, followed by N-cadherin endocytosis and recycling to the leading edge.
Neural stem cell quiescence comes to an un-sticky end.
Impact
Ffrench-Constant et al., Edinburgh, United Kingdom. In Nat Cell Biol, 2014
N-cadherin-mediated anchorage of neural stem cells within the adult neural niche maintains stem cell quiescence, and its release by the metalloproteinase MT5-MMP promotes neural stem cell activation.
Adherens junction treadmilling during collective migration.
Impact
Etienne-Manneville et al., Paris, France. In Nat Cell Biol, 2014
The treadmilling is driven by an actin-dependent rearward movement of AJs and is supported by the polarized recycling of N-cadherin.
MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin.
Impact
Fariñas et al., Madrid, Spain. In Nat Cell Biol, 2014
We show that N-cadherin-mediated anchorage of neural stem cells (NSCs) to ependymocytes in the adult murine subependymal zone modulates their quiescence.
Re-expression of N-cadherin in remyelinating lesions of experimental inflammatory demyelination.
GeneRIF
Storch et al., Graz, Austria. In Exp Neurol, 2012
A predominant expression of N-cadherin is found on oligodendrocytes in early remyelinating lesions, while in fully remyelinated shadow plaques there is no detectable immunoreactivity for N-cadherin.
Neuronal cadherin (NCAD) increases sensory neurite formation and outgrowth on astrocytes.
GeneRIF
Scherer et al., Philadelphia, United States. In Neurosci Lett, 2012
the loss of NCAD greatly impairs the formation and extension neurites on astrocytes.
Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells.
GeneRIF
Calvi et al., Rochester, United States. In Blood, 2012
Targeted deletion of N-cadherin resulted in an age-dependent bone phenotype, characterized by decreased mineralized bone, but no difference in steady-state HSC numbers or function at any time tested, and normal recovery from myeloablative injury.
C-terminal fragment of N-cadherin accelerates synapse destabilization by amyloid-β.
GeneRIF
Gottmann et al., Germany. In Brain, 2012
an inhibition of N-cadherin function by proteolytically generated N-cadherin C-terminal fragment 1 might play an important role in Alzheimer's disease progression by accelerating amyloid-b-triggered synapse damage.
Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases.
GeneRIF
Becker et al., London, United Kingdom. In Plos One, 2011
Cx43 and N-cadherin are potential therapeutic targets in the promotion of healing of venous leg ulcers, by acting at least in part through distinct contributions of cell adhesion, migration, proliferation and cytoskeletal dynamics.
More papers using N-cadherin antibodies
Ephrin-B2 overexpression enhances integrin-mediated ECM-attachment and migration of B16 melanoma cells.
Supplier
Callaerts Patrick, In PLoS ONE, 2004
... The following antibodies were used: anti-FN (1∶400; Sigma), anti-laminin (1∶100, Sigma), anti N-cadherin (clone 32, 1∶100, BD Biosciences), and the appropriate Alexa ...
Growth hormone and epidermal growth factor in salivary glands of giant and dwarf transgenic mice
Supplier
Sawa Yoshihiko et al., In Acta Histochemica et Cytochemica, 2003
... P-cadherin (R&D Systems Inc., Minneapolis, MN), monoclonal rat anti-mouse E-cadherin (R&D Systems), polyclonal rabbit anti-mouse N-cadherin (Abcam, Cambridge, UK), polyclonal rabbit ...
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
Supplier
Katoh Masaru, In PLoS ONE, 2002
... (M2), anti-actin, anti-nucleolin from Sigma-Aldrich (St Louis, MO), anti-E-cadherin from BD Biosciences (San Diego, CA), anti-N-cadherin from Epitomics (Burlingame, CA), anti-Snail (ab85931), ...
Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins
Supplier
Bredt David S. et al., In The Journal of Cell Biology, 2001
... Baekkeskov, Hormone Research Institute, University of California, San Francisco), and N-Cadherin (BD Biosciences).
Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via slug induction and actin remodeling
Supplier
Sobue Kenji et al., In The Journal of Cell Biology, 1997
... anti-SRF (G-20; Santa Cruz Biotechnology, Inc.), antivinculin (HVIN-1; Sigma-Aldrich), anti-talin (8d4; Sigma-Aldrich), anti–E-cadherin (BD Biosciences), anti–N-cadherin (BD Biosciences), antivimentin (Transformation Research), anti–β-catenin ...
Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix
Supplier
Slack Barbara E et al., In BMC Cell Biology, 1997
... to the C-terminus of ADAM10 from Chemicon International (Temecula CA), and mouse antibodies to the N-cadherin C-terminus from BD Biosciences (San Jose, CA) ...
p120 catenin associates with kinesin and facilitates the transport of cadherin–catenin complexes to intercellular junctions
Supplier
Green Kathleen J. et al., In The Journal of Cell Biology, 1997
... N-cad–YFP was constructed by subcloning the N-cadherin cDNA fragment from N-cad–GFP into the AgeI and XhoI sites of pEYFP-N1 (CLONTECH Laboratories, Inc.) ...
Technical considerations for studying cancer metastasis in vivo
Supplier
Šmarda Jan et al., In Molecular Cancer, 1996
... by SDS-PAGE and analyzed by immunoblotting with anti-Slug (9585, Cell Signaling), anti-vimentin (13.2, Sigma) and anti-N-cadherin (610920, BD Biosciences) antibodies ...
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