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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 27 Aug 2015.

Hexosaminidase A

N-acetyl-beta-D-glucosaminidase, beta-N-Acetylhexosaminidase, beta-hexosaminidase, HAT, N-acetyl-beta-glucosaminidase, hexosaminidase
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq, Jul 2009] (from NCBI)
Top mentioned proteins: Histone, CAN, MAST, ACID, p300
Papers using N-acetyl-beta-D-glucosaminidase antibodies
Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts
Supplier
Grant Seth G N et al., In Molecular Systems Biology, 2003
... The HAT tag was amplified by PCR (PCR1) using 1 ng of the pHAT20 vector (Clontech) as a template with the ...
Papers on N-acetyl-beta-D-glucosaminidase
Comparative analysis of cerebrospinal fluid from the meningo-encephalitic stage of T. b. gambiense and rhodesiense sleeping sickness patients using TMT quantitative proteomics.
New
Sanchez et al., Genève, Switzerland. In Data Brief, 30 Sep 2015
Sleeping sickness (human African trypanosomiasis - HAT) is a deadly neglected tropical disease affecting mainly rural communities in sub-Saharan Africa.
Time-resolved luminescence biosensor for continuous activity detection of protein acetylation-related enzymes based on DNA-sensitized terbium(III) probes.
New
Yao et al., In Anal Chem, 26 Sep 2015
HAT-catalyzed acetylation remarkably reduces the positive charge of the peptides and diminishes the peptide/DNA interaction, resulting in the signal on detection via recovery of DNA-sensitized Tb3+ luminescence.
The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation.
New
Shi et al., Taiwan. In J Biol Chem, 25 Sep 2015
UTX demethylates H3K27me3 and subsequently interacts with the histone acetyltransferase (HAT) protein CBP, resulting in increased H3K27 acetylation (H3K27ac), a histone transcriptional active mark.
The Set3 Complex Antagonizes the MYST Acetyltransferase Esa1 in the DNA Damage Response.
New
Pillus et al., San Diego, United States. In Mol Cell Biol, 24 Sep 2015
Acetylation is controlled by complexes containing opposing lysine acetyltransferase (KAT/HAT) and deacetylase (KDAC/HDAC) activities.
Synthetic Mononuclear Nonheme Iron-Oxygen Intermediates.
New
Impact
Nam, Seoul, South Korea. In Acc Chem Res, 18 Sep 2015
In the case of iron-superoxo complexes, an iron(III)-superoxo complex, [(TAML)Fe(III)(O2)](2-), is described, including its crystal structure and reactivities in electrophilic and nucleophilic oxidative reactions, and its properties are compared with those of a chromium(III)-superoxo complex, [(TMC)Cr(III)(O2)(Cl)](+), with respect to its reactivities in hydrogen atom transfer (HAT) and oxygen atom transfer (OAT) reactions.
The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: a review.
Review
New
Hekmatdoost et al., Tehrān, Iran. In Gene, Jun 2015
The HDAC-mediated increase in histone affinity to DNA causes DNA condensation, preventing transcription, whereas HAT-acetylated chromatin is transcriptionally active.
Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy.
Review
New
Gilmore et al., Boston, United States. In Genes Cancer, May 2015
In addition to their role in normal B and T cells, dysregulation of HAT and HDAC activity is associated with a variety of B- and T-cell malignancies.
Early markers of obesity-related renal injury in childhood.
Review
New
Mak et al., Los Angeles, United States. In Pediatr Nephrol, Jan 2015
Goknar et al. (Pediatric Nephrology 2014; doi: 10.1007/s00467-014-2829-0 ) recently evaluated early urine renal injury markers, namely, microalbuminuria, N-acetyl-beta-D-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin, and kidney injury molecule (KIM)-1, in obese children.
O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?
Review
New
van Aalten et al., Dundee, United Kingdom. In J Biol Chem, Jan 2015
O-GlcNAc signaling is regulated by an opposing pair of enzymes: O-GlcNAc transferase installs and O-GlcNAcase (OGA) removes the modification from proteins.
Angiopoietin/Tie2 Dysbalance Is Associated with Acute Kidney Injury after Cardiac Surgery Assisted by Cardiopulmonary Bypass.
New
van Meurs et al., Groningen, Netherlands. In Plos One, Dec 2014
Systemic levels of Ang1, Ang2, and sTie2 were measured in plasma and the AKI markers albumin, kidney injury molecule-1 (KIM-1) and N-acetyl-beta-D-glucosaminidase (NAG) were measured in the urine.
Epigenetic therapy of cancer with histone deacetylase inhibitors.
Review
New
Saldanha et al., Bengaluru, India. In J Cancer Res Ther, Jul 2014
The enzymes Histone Acetyl Transferase (HAT) and Histone Deacetylase (HDAC) control the level of acetylation of histones and thereby alter gene expression.
Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions.
New
Impact
Wang et al., Jena, Germany. In Cell Stem Cell, Jun 2014
Here, we show that the histone acetyltransferase (HAT) cofactor transformation/transcription domain-associated protein (Trrap) specifically regulates activation of cell-cycle genes, thereby integrating discrete cell-intrinsic programs of cell-cycle progression and epigenetic regulation of gene transcription in order to control neurogenesis.
Reactivity of nitrido complexes of ruthenium(VI), osmium(VI), and manganese(V) bearing Schiff base and simple anionic ligands.
New
Impact
Lau et al., Hong Kong, Hong Kong. In Acc Chem Res, Mar 2014
Moreover, the addition of various nucleophiles (Nu) to Ru(VI)≡N initially generate the ruthenium(IV) imido species Ru(IV)-N(Nu), a new class of hydrogen-atom transfer (HAT) reagents.
Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.
Impact
Hancock et al., Philadelphia, United States. In Nat Med, 2013
We now report that conditional deletion or pharmacologic inhibition of one HAT, p300 (also known as Ep300 or KAT3B), in Foxp3(+) T(reg) cells increased T cell receptor-induced apoptosis in T(reg) cells, impaired T(reg) cell suppressive function and peripheral T(reg) cell induction, and limited tumor growth in immunocompetent but not in immunodeficient mice.
Anion-π interactions in supramolecular architectures.
Impact
Dunbar et al., College Station, United States. In Acc Chem Res, 2013
Finally, we explored the reactions of the extended π-acidic heterocycle HAT(CN)6 (1,4,5,8,9,12-hexaazatriphenylene-hexacarbonitrile) with the Cl(-), Br(-), I(-) ions which lead to highly colored solutions/crystals.
GM2 gangliosidoses in Spain: analysis of the HEXA and HEXB genes in 34 Tay-Sachs and 14 Sandhoff patients.
GeneRIF
Spanish GM2 Working Group et al., Barcelona, Spain. In Gene, 2012
identified 27 different mutations, 14 of which were novel, in the HEXA gene and 14 different mutations, 8 of which unreported until now, in the HEXB gene, and attempted to correlate these mutations with the clinical presentation of the patients
O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-β-D-glucosaminidase silencing on cell phenotype and transcriptome.
GeneRIF
Khalaila et al., Beersheba, Israel. In J Biol Chem, 2012
O-linked beta-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-beta-D-glucosaminidase silencing on cell phenotype and transcriptome.
Molecular analysis of HEXA gene in Argentinean patients affected with Tay-Sachs disease: possible common origin of the prevalent c.459+5A>G mutation.
GeneRIF
Dardis et al., Udine, Italy. In Gene, 2012
HEXA gene in Argentinean patients affected with Tay-Sachs disease, overall 14 different mutations were identified, 8 of them were novel and lead to premature stop codons, drastic residues changes or a splicing defect.
Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.
GeneRIF
Soilleux et al., Göttingen, Germany. In Plos One, 2011
TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host.
Prediction of bladder cancer based on urinary content of MGEA5 and OGT mRNA level.
GeneRIF
Lipinski et al., Łódź, Poland. In Clin Lab, 2011
Analysis of urinary content of MGEA5 and OGT may be useful for bladder cancer diagnostics.
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