Keep-ING Balance: Tumor Suppression by Epigenetic Regulation.
Berlin, Germany. In Febs Lett, 13 Apr 2014
The ING (inhibitor of growth) proteins (ING1 - ING5) have emerged as a versatile family of growth regulators, phospholipid effectors, histone mark sensors and core components of HDAC1/2 - and several HAT chromatin-modifying complexes.
Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.
Philadelphia, United States. In Nat Med, Sep 2013
We now report that conditional deletion or pharmacologic inhibition of one HAT, p300 (also known as Ep300 or KAT3B), in Foxp3(+) T(reg) cells increased T cell receptor-induced apoptosis in T(reg) cells, impaired T(reg) cell suppressive function and peripheral T(reg) cell induction, and limited tumor growth in immunocompetent but not in immunodeficient mice.
Anion-π interactions in supramolecular architectures.
College Station, United States. In Acc Chem Res, May 2013
Finally, we explored the reactions of the extended π-acidic heterocycle HAT(CN)6 (1,4,5,8,9,12-hexaazatriphenylene-hexacarbonitrile) with the Cl(-), Br(-), I(-) ions which lead to highly colored solutions/crystals.
The SLC3 and SLC7 families of amino acid transporters.
Bern, Switzerland. In Mol Aspects Med, Apr 2013
Furthermore, the role of the HAT 4F2hc/LAT1 in tumor growth and the application of LAT1 inhibitors and PET tracers for reduction of tumor progression and imaging of tumors are discussed.