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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Hexosaminidase A

N-acetyl-beta-D-glucosaminidase, beta-N-Acetylhexosaminidase, beta-hexosaminidase, HAT, N-acetyl-beta-glucosaminidase, hexosaminidase
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq, Jul 2009] (from NCBI)
Top mentioned proteins: Histone, CAN, ACID, MAST, p300
Papers using N-acetyl-beta-D-glucosaminidase antibodies
Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts
Grant Seth G N et al., In Molecular Systems Biology, 2003
... The HAT tag was amplified by PCR (PCR1) using 1 ng of the pHAT20 vector (Clontech) as a template with the ...
Papers on N-acetyl-beta-D-glucosaminidase
Effects of Fluoride on the Expression of Beclin1 and mTOR in Ameloblasts.
Liu et al., In Cells Tissues Organs, 13 Dec 2015
HAT-7 cells were incubated with various concentrations of NaF, and autophagic vacuoles were studied by transmission electron microscopy.
Molecular basis for histone acetyltransferase regulation by binding partners, associated domains, and autoacetylation.
Marmorstein et al., In Acs Chem Biol, 11 Dec 2015
This review focuses on what is currently understood at the molecular level of HAT regulation as it occurs via binding partners, associated domains, and autoacetylation.
Tuning Reactivity and Selectivity in Hydrogen Atom Transfer from Aliphatic C-H Bonds to Alkoxyl Radicals: Role of Structural and Medium Effects.
Bietti et al., Roma, Italy. In Acc Chem Res, 06 Dec 2015
UNASSIGNED: Hydrogen atom transfer (HAT) is a fundamental reaction that takes part in a wide variety of chemical and biological processes, with relevant examples that include the action of antioxidants, damage to biomolecules and polymers, and enzymatic and biomimetic reactions.
A Balancing Act: Stability versus Reactivity of Mn(O) Complexes.
Goldberg et al., Baltimore, United States. In Acc Chem Res, 20 Nov 2015
The rate enhancement for hydrogen atom transfer (HAT) may derive from the higher redox potential for the π-radical cation complex, while the large rate decrease seen for OAT may come from a decrease in electrophilicity for an Mn(IV)(O) versus Mn(V)(O) complex.
Histone Acetylation Enzymes Coordinate Metabolism and Gene Expression.
Zhou et al., Orsay, France. In Trends Plant Sci, 31 Oct 2015
Importantly, key metabolites, such as acetyl-CoA and NAD(+), are involved in protein acetylation and deacetylation processes, and their cellular levels may regulate the activity of histone acetyltransferases (HAT) and deacetylases (HDAC).
Synthetic mononuclear nonheme iron-oxygen intermediates.
Nam, Seoul, South Korea. In Acc Chem Res, Sep 2015
In the case of iron-superoxo complexes, an iron(III)-superoxo complex, [(TAML)Fe(III)(O2)](2-), is described, including its crystal structure and reactivities in electrophilic and nucleophilic oxidative reactions, and its properties are compared with those of a chromium(III)-superoxo complex, [(TMC)Cr(III)(O2)(Cl)](+), with respect to its reactivities in hydrogen atom transfer (HAT) and oxygen atom transfer (OAT) reactions.
The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: a review.
Hekmatdoost et al., Tehrān, Iran. In Gene, Jun 2015
The HDAC-mediated increase in histone affinity to DNA causes DNA condensation, preventing transcription, whereas HAT-acetylated chromatin is transcriptionally active.
Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy.
Gilmore et al., Boston, United States. In Genes Cancer, May 2015
In addition to their role in normal B and T cells, dysregulation of HAT and HDAC activity is associated with a variety of B- and T-cell malignancies.
Tip60 complex binds to active Pol II promoters and a subset of enhancers and co-regulates the c-Myc network in mouse embryonic stem cells.
Tora et al., Illkirch-Graffenstaden, France. In Epigenetics Chromatin, Dec 2014
BACKGROUND: Tip60 (KAT5) is the histone acetyltransferase (HAT) of the mammalian Tip60/NuA4 complex.
Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1.
Li et al., Hefei, China. In Sci Rep, Dec 2014
Here, we report that p300, which has histone acetyltransferase (HAT) activity, interacts with and acetylates RORγt at its K81 residue.
Deacetylation of chromatin and gene expression regulation: a new target for epigenetic therapy.
La Thangue et al., Oxford, United Kingdom. In Crit Rev Oncog, Dec 2014
Histone acetyl transferase (HAT) is referred to as the writer of this process, whereas histone deacetylase (HDAC) is the eraser of this lysine modification.
Enhancer of Acetyltransferase Chameau (EAChm) Is a Novel Transcriptional Co-Activator.
Ito et al., Nagasaki, Japan. In Plos One, Dec 2014
Acetylation of nucleosomal histones by diverse histone acetyltransferases (HAT) plays pivotal roles in many cellular events.
Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions.
Wang et al., Jena, Germany. In Cell Stem Cell, Jun 2014
Here, we show that the histone acetyltransferase (HAT) cofactor transformation/transcription domain-associated protein (Trrap) specifically regulates activation of cell-cycle genes, thereby integrating discrete cell-intrinsic programs of cell-cycle progression and epigenetic regulation of gene transcription in order to control neurogenesis.
Reactivity of nitrido complexes of ruthenium(VI), osmium(VI), and manganese(V) bearing Schiff base and simple anionic ligands.
Lau et al., Hong Kong, Hong Kong. In Acc Chem Res, Mar 2014
Moreover, the addition of various nucleophiles (Nu) to Ru(VI)≡N initially generate the ruthenium(IV) imido species Ru(IV)-N(Nu), a new class of hydrogen-atom transfer (HAT) reagents.
GM2 gangliosidoses in Spain: analysis of the HEXA and HEXB genes in 34 Tay-Sachs and 14 Sandhoff patients.
Spanish GM2 Working Group et al., Barcelona, Spain. In Gene, 2012
identified 27 different mutations, 14 of which were novel, in the HEXA gene and 14 different mutations, 8 of which unreported until now, in the HEXB gene, and attempted to correlate these mutations with the clinical presentation of the patients
O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-β-D-glucosaminidase silencing on cell phenotype and transcriptome.
Khalaila et al., Beersheba, Israel. In J Biol Chem, 2012
O-linked beta-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-beta-D-glucosaminidase silencing on cell phenotype and transcriptome.
Molecular analysis of HEXA gene in Argentinean patients affected with Tay-Sachs disease: possible common origin of the prevalent c.459+5A>G mutation.
Dardis et al., Udine, Italy. In Gene, 2012
HEXA gene in Argentinean patients affected with Tay-Sachs disease, overall 14 different mutations were identified, 8 of them were novel and lead to premature stop codons, drastic residues changes or a splicing defect.
Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.
Soilleux et al., Göttingen, Germany. In Plos One, 2011
TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host.
Prediction of bladder cancer based on urinary content of MGEA5 and OGT mRNA level.
Lipinski et al., Łódź, Poland. In Clin Lab, 2011
Analysis of urinary content of MGEA5 and OGT may be useful for bladder cancer diagnostics.
Objective Diagnosis of Chronic Alcohol Abuse - Determination of Carbohydrate-Deficient Transferrin (CDT) with Capillary Electrophoresis.
Cittadini et al., Roma, Italy. In Forensic Sci Rev, 2000
The present paper reviews briefly in terms of diagnostic sensitivity and specificity the most important conventional markers of chronic alcohol abuse - e.g., γ-glutamyl transferase (GGT), erythrocyte mean corpuscular volume (MCV), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) - as well as those more recently proposed, namely aldehyde dehydrogenase (ALDH), high density lipoprotein cholesterol, serum triglycerides, urate, fatty acid ethyl and methyl esters, phosphatidylethanol, dolichols, β-hexosaminidase and protein acetaldehyde adducts.
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