Synthetic Mononuclear Nonheme Iron-Oxygen Intermediates.
Seoul, South Korea. In Acc Chem Res, 23 Aug 2015
In the case of iron-superoxo complexes, an iron(III)-superoxo complex, [(TAML)Fe(III)(O2)](2-), is described, including its crystal structure and reactivities in electrophilic and nucleophilic oxidative reactions, and its properties are compared with those of a chromium(III)-superoxo complex, [(TMC)Cr(III)(O2)(Cl)](+), with respect to its reactivities in hydrogen atom transfer (HAT) and oxygen atom transfer (OAT) reactions.
Dieckol, a phlorotannin of Ecklonia cava, suppresses IgE-mediated mast cell activation and passive cutaneous anaphylactic reaction.
Tokyo, Japan. In Exp Dermatol, 21 Aug 2015
Binding of IgE to FcεRI receptors, followed by the crosslinkage of the IgE with the antigen, leads to the mast cell activation and secretion of preformed chemical mediators such as lipid mediators (leukotrienes and prostaglandins), granular contents (β-hexosaminidase and histamine), and inflammatory cytokines (interleukin [IL]-4, IL-6, IL-13, and tumor necrosis factor [TNF]-α), which initiates and exacerbates allergic inflammation (2,3,S3-6).
Early markers of obesity-related renal injury in childhood.
Los Angeles, United States. In Pediatr Nephrol, Jan 2015
Goknar et al. (Pediatric Nephrology 2014; doi: 10.1007/s00467-014-2829-0 ) recently evaluated early urine renal injury markers, namely, microalbuminuria, N-acetyl-beta-D-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin, and kidney injury molecule (KIM)-1, in obese children.
Altering cancer transcriptomes using epigenomic inhibitors.
Los Angeles, United States. In Epigenetics Chromatin, Dec 2014
CONCLUSION: Our results suggest that treatment with a general HAT inhibitor causes similar effects on the transcriptome as does treatment with a CBP-specific inhibitor and that epigenetic inhibition affects the WNT pathway in HCT116 cells and the cholesterol biosynthesis pathway in PANC1 cells.
Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.
Philadelphia, United States. In Nat Med, 2013
We now report that conditional deletion or pharmacologic inhibition of one HAT, p300 (also known as Ep300 or KAT3B), in Foxp3(+) T(reg) cells increased T cell receptor-induced apoptosis in T(reg) cells, impaired T(reg) cell suppressive function and peripheral T(reg) cell induction, and limited tumor growth in immunocompetent but not in immunodeficient mice.
Anion-π interactions in supramolecular architectures.
College Station, United States. In Acc Chem Res, 2013
Finally, we explored the reactions of the extended π-acidic heterocycle HAT(CN)6 (1,4,5,8,9,12-hexaazatriphenylene-hexacarbonitrile) with the Cl(-), Br(-), I(-) ions which lead to highly colored solutions/crystals.