gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Mar 2015.

Hexosaminidase A

N-acetyl-beta-D-glucosaminidase, beta-N-Acetylhexosaminidase, beta-hexosaminidase, HAT, N-acetyl-beta-glucosaminidase, hexosaminidase
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq, Jul 2009] (from NCBI)
Top mentioned proteins: Histone, CAN, ACID, MAST, p300
Papers using N-acetyl-beta-D-glucosaminidase antibodies
Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts
Supplier
Grant Seth G N et al., In Molecular Systems Biology, 2003
... The HAT tag was amplified by PCR (PCR1) using 1 ng of the pHAT20 vector (Clontech) as a template with the ...
Papers on N-acetyl-beta-D-glucosaminidase
Gallic Acid Decreases Inflammatory Cytokine Secretion Through Histone Acetyltransferase/Histone Deacetylase Regulation in High Glucose-Induced Human Monocytes.
New
Yun et al., Seoul, South Korea. In J Med Food, 25 Apr 2015
It also significantly reduced CREB-binding protein/p300 (CBP/p300, a NF-κB coactivator) gene expression, acetylation levels, and CBP/p300 histone acetyltransferase (HAT) activity.
Inhibitory effect of the branches of Hovenia dulcis Thunb. and its constituent pinosylvin on the activities of IgE-mediated mast cells and passive cutaneous anaphylaxis in mice.
New
Nho et al., Kangnŭng, South Korea. In Food Funct, 25 Apr 2015
In antigen-stimulated RBL-2H3 cells, HDB inhibited the secretion of β-hexosaminidase (indicating the inhibition of degranulation) and histamine release; decreased expression and production of the inflammatory mediators, cyclooxygenase-2 and prostaglandin E2, and cytokines interleukin-4 and tumor necrosis factor-α; and suppressed activation of nuclear factor κB, a transcription factor involved in the response to cytokines.
Effect of ascorbic acid on colistin-associated nephrotoxicity: A preliminary clinical study.
New
Thamlikitkul et al., Bangkok, Thailand. In Antimicrob Agents Chemother, 23 Apr 2015
Additionally, urinary neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl-beta-D-glucosaminidase (NAG) were measured as markers of renal damage, and plasma concentrations of colistin were quantified.
Bis(monoacylglycero)phosphate: A secondary storage lipid in the gangliosidoses.
New
Seyfried et al., Boston, United States. In J Lipid Res, 20 Apr 2015
The gangliosidoses are a group of neurodegenerative lysosomal storage diseases involving the accumulation of either GM1 or GM2 gangliosides resulting from inherited deficiencies in β-galactosidase or β-hexosaminidase, respectively.
Integrating Epigenetic Modulators into NanoScript for Enhanced Chondrogenesis of Stem Cells.
New
Lee et al., In J Am Chem Soc, 19 Apr 2015
To this end, we first conjugated CTB onto NanoScript which initiated a time-dependent increase in histone acetyltransferace (HAT) activity.
The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: A review.
Review
New
Hekmatdoost et al., Tehrān, Iran. In Gene, 19 Mar 2015
The HDAC-mediated increase in histone affinity to DNA causes DNA condensation, preventing transcription, whereas HAT-acetylated chromatin is transcriptionally active.
O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?
Review
New
van Aalten et al., Dundee, United Kingdom. In J Biol Chem, Jan 2015
O-GlcNAc signaling is regulated by an opposing pair of enzymes: O-GlcNAc transferase installs and O-GlcNAcase (OGA) removes the modification from proteins.
[Clinical implication of urinary protein markers in diabetic nephropathy and interventional effects of Chinese herbal medicine].
Review
New
Yao et al., In Zhongguo Zhong Yao Za Zhi, Jul 2014
One is newfound, including kidney injury molecule-1 (Kim-1), neutrophil getatinase-associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP) and cystatin C (CysC); the other one is classical, including beta2 microglobulin (beta2-MG), retinal binding protein (RBP) and N-acetyl-beta-D-glucosaminidase (NAG).
Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions.
New
Impact
Wang et al., Jena, Germany. In Cell Stem Cell, Jun 2014
Here, we show that the histone acetyltransferase (HAT) cofactor transformation/transcription domain-associated protein (Trrap) specifically regulates activation of cell-cycle genes, thereby integrating discrete cell-intrinsic programs of cell-cycle progression and epigenetic regulation of gene transcription in order to control neurogenesis.
Reactivity of nitrido complexes of ruthenium(VI), osmium(VI), and manganese(V) bearing Schiff base and simple anionic ligands.
New
Impact
Lau et al., Hong Kong, Hong Kong. In Acc Chem Res, Mar 2014
Moreover, the addition of various nucleophiles (Nu) to Ru(VI)≡N initially generate the ruthenium(IV) imido species Ru(IV)-N(Nu), a new class of hydrogen-atom transfer (HAT) reagents.
Coactivator recruitment of AhR/ARNT1.
Review
Shibasaki et al., Tokyo, Japan. In Int J Mol Sci, 2013
Another common feature of NRs is their dependence on coactivators, which bridge the basic transcriptional machinery and other cofactors to the target genes, in order to initiate transcription and to unwind histone-bound DNA for exposing additional promoter recognition sites via their histone acetyltransferase (HAT) function.
Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.
Impact
Hancock et al., Philadelphia, United States. In Nat Med, 2013
We now report that conditional deletion or pharmacologic inhibition of one HAT, p300 (also known as Ep300 or KAT3B), in Foxp3(+) T(reg) cells increased T cell receptor-induced apoptosis in T(reg) cells, impaired T(reg) cell suppressive function and peripheral T(reg) cell induction, and limited tumor growth in immunocompetent but not in immunodeficient mice.
Anion-π interactions in supramolecular architectures.
Impact
Dunbar et al., College Station, United States. In Acc Chem Res, 2013
Finally, we explored the reactions of the extended π-acidic heterocycle HAT(CN)6 (1,4,5,8,9,12-hexaazatriphenylene-hexacarbonitrile) with the Cl(-), Br(-), I(-) ions which lead to highly colored solutions/crystals.
GM2 gangliosidoses in Spain: analysis of the HEXA and HEXB genes in 34 Tay-Sachs and 14 Sandhoff patients.
GeneRIF
Spanish GM2 Working Group et al., Barcelona, Spain. In Gene, 2012
identified 27 different mutations, 14 of which were novel, in the HEXA gene and 14 different mutations, 8 of which unreported until now, in the HEXB gene, and attempted to correlate these mutations with the clinical presentation of the patients
O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-β-D-glucosaminidase silencing on cell phenotype and transcriptome.
GeneRIF
Khalaila et al., Beersheba, Israel. In J Biol Chem, 2012
O-linked beta-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-beta-D-glucosaminidase silencing on cell phenotype and transcriptome.
Molecular analysis of HEXA gene in Argentinean patients affected with Tay-Sachs disease: possible common origin of the prevalent c.459+5A>G mutation.
GeneRIF
Dardis et al., Udine, Italy. In Gene, 2012
HEXA gene in Argentinean patients affected with Tay-Sachs disease, overall 14 different mutations were identified, 8 of them were novel and lead to premature stop codons, drastic residues changes or a splicing defect.
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Impact
Horn et al., London, United Kingdom. In Nature, 2012
Dyes and arsenical compounds that displayed selectivity against trypanosomes were central to this work, and the drugs that emerged remain in use for treating human African trypanosomiasis (HAT).
Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.
GeneRIF
Soilleux et al., Göttingen, Germany. In Plos One, 2011
TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host.
Prediction of bladder cancer based on urinary content of MGEA5 and OGT mRNA level.
GeneRIF
Lipinski et al., Łódź, Poland. In Clin Lab, 2011
Analysis of urinary content of MGEA5 and OGT may be useful for bladder cancer diagnostics.
Epigenetics and chromatin remodeling play a role in lung disease.
Review
Adcock et al., Utrecht, Netherlands. In Tanaffos, 2010
Transcriptional coactivators possess intrinsic histone acetyltransferase activity and this activity drives inflammatory gene expression.
share on facebooktweetadd +1mail to friends