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Hexosaminidase A

N-acetyl-beta-D-glucosaminidase, beta-N-Acetylhexosaminidase, beta-hexosaminidase, HAT, N-acetyl-beta-glucosaminidase, hexosaminidase
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq, Jul 2009] (from NCBI)
Top mentioned proteins: Histone, CAN, MAST, ACID, p300
Papers using N-acetyl-beta-D-glucosaminidase antibodies
Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts
Supplier
Grant Seth G N et al., In Molecular Systems Biology, 2003
... The HAT tag was amplified by PCR (PCR1) using 1 ng of the pHAT20 vector (Clontech) as a template with the ...
Papers on N-acetyl-beta-D-glucosaminidase
Iopromide in combination with IFN-γ induces the activation of HMC-1 cells via IL-4 and MCP-1 expression.
New
Lee et al., Pusan, South Korea. In Cell Immunol, 05 Feb 2015
An evaluation of mast cell activator secretion revealed that IFN-γ- or IL-4-pretreated HMC-1 cells released dramatically increased levels of β-hexosaminidase and histamine when stimulated with iopromide.
Epigenetic linkage of aging, cancer and nutrition.
Review
New
Tollefsbol et al., Birmingham, United States. In J Exp Biol, 01 Feb 2015
Dietary compounds such as sulforaphane (SFN) found in cruciferous vegetables and epigallocatechin-3-gallate (EGCG) in green tea exhibit the ability to affect various epigenetic mechanisms such as DNA methyltransferase (DNMT) inhibition, histone modifications via histone deacetylase (HDAC), histone acetyltransferase (HAT) inhibition, or noncoding RNA expression.
Metabolomic-Based Strategies for Anti-Parasite Drug Discovery.
Review
New
Barrett et al., Glasgow, United Kingdom. In J Biomol Screen, 31 Jan 2015
They have helped to determine the MOA of eflornithine, half of the gold standard combination therapy in use against human African trypanosomiasis (HAT), as well as the mechanism of resistance to this drug.
Inhibition of the IgE-Mediated Activation of RBL-2H3 Cells by TIPP, a Novel Thymic Immunosuppressive Pentapeptide.
New
Wang et al., Jinan, China. In Int J Mol Sci, 31 Dec 2014
Release of β-hexosaminidase and histamine, intracellular calcium, membrane ruffling, mRNA levels of cytokines, cyclooxygenase-2 (COX-2) expression, and activation of mitogen-activated protein kinases (MAP kinases) and NF-κB were determined by colorimetric assay, fluorescence spectrophotometer, confocal fluorescence microscope, quantification PCR, and Western blot, respectively.
The first family with Tay-Sachs disease in Cyprus: Genetic analysis reveals a nonsense (c.78G>A) and a silent (c.1305C>T) mutation and allows preimplantation genetic diagnosis.
New
Drousiotou et al., Nicosia, Cyprus. In Meta Gene, 31 Dec 2014
Tay-Sachs disease (TSD) is a recessively inherited neurodegenerative disorder caused by mutations in the HEXA gene resulting in β-hexosaminidase A (HEX A) deficiency and neuronal accumulation of GM2 ganglioside.
Mass Spectrometric Analysis of Whole Secretome and Amylase-precipitated Secretome Proteins from Streptococcus gordonii.
New
Scannapieco et al., Buffalo, United States. In J Proteomics Bioinform, Oct 2014
Hypothetical protein (SGO_0483), cation-transporting ATPase YfgQ (Aha1), isocitrate dehydrogenase (Icd), sortase A (SrtA), beta-N-acetylhexosaminidase (SGO_0405), peptide chain release factor 1(PrfA) and cardiolipin synthase (SGO_2037) were precipitated by amylase from the KS1 culture supernatant.
[Clinical implication of urinary protein markers in diabetic nephropathy and interventional effects of Chinese herbal medicine].
Review
New
Yao et al., In Zhongguo Zhong Yao Za Zhi, Jul 2014
One is newfound, including kidney injury molecule-1 (Kim-1), neutrophil getatinase-associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP) and cystatin C (CysC); the other one is classical, including beta2 microglobulin (beta2-MG), retinal binding protein (RBP) and N-acetyl-beta-D-glucosaminidase (NAG).
Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions.
New
Impact
Wang et al., Jena, Germany. In Cell Stem Cell, Jun 2014
Here, we show that the histone acetyltransferase (HAT) cofactor transformation/transcription domain-associated protein (Trrap) specifically regulates activation of cell-cycle genes, thereby integrating discrete cell-intrinsic programs of cell-cycle progression and epigenetic regulation of gene transcription in order to control neurogenesis.
Reactivity of nitrido complexes of ruthenium(VI), osmium(VI), and manganese(V) bearing Schiff base and simple anionic ligands.
New
Impact
Lau et al., Hong Kong, Hong Kong. In Acc Chem Res, Mar 2014
Moreover, the addition of various nucleophiles (Nu) to Ru(VI)≡N initially generate the ruthenium(IV) imido species Ru(IV)-N(Nu), a new class of hydrogen-atom transfer (HAT) reagents.
Inhibitory Effect on β -Hexosaminidase Release from RBL-2H3 Cells of Extracts and Some Pure Constituents of Benchalokawichian, a Thai Herbal Remedy, Used for Allergic Disorders.
Itharat et al., Khlong Luang, Thailand. In Evid Based Complement Alternat Med, 2013
Inhibitory effect on the release of β-hexosaminidase from RBL-2H3 cells was used to determine antiallergic activity.
Comparison of protein acetyltransferase action of CRTAase with the prototypes of HAT.
Review
Raj et al., Delhi, India. In Scientificworldjournal, 2013
CR like HAT-1, CBP, and p300 mediated the acylation of RP utilizing acetyl CoA and propionyl CoA as the substrates.
Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.
Impact
Hancock et al., Philadelphia, United States. In Nat Med, 2013
We now report that conditional deletion or pharmacologic inhibition of one HAT, p300 (also known as Ep300 or KAT3B), in Foxp3(+) T(reg) cells increased T cell receptor-induced apoptosis in T(reg) cells, impaired T(reg) cell suppressive function and peripheral T(reg) cell induction, and limited tumor growth in immunocompetent but not in immunodeficient mice.
Anion-π interactions in supramolecular architectures.
Impact
Dunbar et al., College Station, United States. In Acc Chem Res, 2013
Finally, we explored the reactions of the extended π-acidic heterocycle HAT(CN)6 (1,4,5,8,9,12-hexaazatriphenylene-hexacarbonitrile) with the Cl(-), Br(-), I(-) ions which lead to highly colored solutions/crystals.
GM2 gangliosidoses in Spain: analysis of the HEXA and HEXB genes in 34 Tay-Sachs and 14 Sandhoff patients.
GeneRIF
Spanish GM2 Working Group et al., Barcelona, Spain. In Gene, 2012
identified 27 different mutations, 14 of which were novel, in the HEXA gene and 14 different mutations, 8 of which unreported until now, in the HEXB gene, and attempted to correlate these mutations with the clinical presentation of the patients
O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-β-D-glucosaminidase silencing on cell phenotype and transcriptome.
GeneRIF
Khalaila et al., Beersheba, Israel. In J Biol Chem, 2012
O-linked beta-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-beta-D-glucosaminidase silencing on cell phenotype and transcriptome.
Molecular analysis of HEXA gene in Argentinean patients affected with Tay-Sachs disease: possible common origin of the prevalent c.459+5A>G mutation.
GeneRIF
Dardis et al., Udine, Italy. In Gene, 2012
HEXA gene in Argentinean patients affected with Tay-Sachs disease, overall 14 different mutations were identified, 8 of them were novel and lead to premature stop codons, drastic residues changes or a splicing defect.
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Impact
Horn et al., London, United Kingdom. In Nature, 2012
Dyes and arsenical compounds that displayed selectivity against trypanosomes were central to this work, and the drugs that emerged remain in use for treating human African trypanosomiasis (HAT).
Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.
GeneRIF
Soilleux et al., Göttingen, Germany. In Plos One, 2011
TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host.
Prediction of bladder cancer based on urinary content of MGEA5 and OGT mRNA level.
GeneRIF
Lipinski et al., Łódź, Poland. In Clin Lab, 2011
Analysis of urinary content of MGEA5 and OGT may be useful for bladder cancer diagnostics.
Epigenetics and chromatin remodeling play a role in lung disease.
Review
Adcock et al., Utrecht, Netherlands. In Tanaffos, 2010
Transcriptional coactivators possess intrinsic histone acetyltransferase activity and this activity drives inflammatory gene expression.
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