Therapeutic Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats.
Muscat, Oman. In Cell Physiol Biochem, Feb 2016
RESULTS: Adenine lowered creatinine clearance and elevated the concentrations of urea, creatinine, plasma neutrophil gelatinase-associated lipocalin and urinary N-Acetyl-beta-D-glucosaminidase activity, and increased the concentrations of the uremic toxin indoxyl sulfate, in addition to some inflammatory cytokines.
A Balancing Act: Stability versus Reactivity of Mn(O) Complexes.
Baltimore, United States. In Acc Chem Res, Nov 2015
The rate enhancement for hydrogen atom transfer (HAT) may derive from the higher redox potential for the π-radical cation complex, while the large rate decrease seen for OAT may come from a decrease in electrophilicity for an Mn(IV)(O) versus Mn(V)(O) complex.
Histone Acetylation Enzymes Coordinate Metabolism and Gene Expression.
Orsay, France. In Trends Plant Sci, Oct 2015
Importantly, key metabolites, such as acetyl-CoA and NAD(+), are involved in protein acetylation and deacetylation processes, and their cellular levels may regulate the activity of histone acetyltransferases (HAT) and deacetylases (HDAC).
Synthetic mononuclear nonheme iron-oxygen intermediates.
Seoul, South Korea. In Acc Chem Res, Sep 2015
In the case of iron-superoxo complexes, an iron(III)-superoxo complex, [(TAML)Fe(III)(O2)](2-), is described, including its crystal structure and reactivities in electrophilic and nucleophilic oxidative reactions, and its properties are compared with those of a chromium(III)-superoxo complex, [(TMC)Cr(III)(O2)(Cl)](+), with respect to its reactivities in hydrogen atom transfer (HAT) and oxygen atom transfer (OAT) reactions.