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Hexosaminidase A

N-acetyl-beta-D-glucosaminidase, beta-N-Acetylhexosaminidase, beta-hexosaminidase, HAT, N-acetyl-beta-glucosaminidase, hexosaminidase
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq, Jul 2009] (from NCBI)
Top mentioned proteins: Histone, CAN, ACID, MAST, p300
Papers using N-acetyl-beta-D-glucosaminidase antibodies
Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts
Supplier
Grant Seth G N et al., In Molecular Systems Biology, 2003
... The HAT tag was amplified by PCR (PCR1) using 1 ng of the pHAT20 vector (Clontech) as a template with the ...
Papers on N-acetyl-beta-D-glucosaminidase
Combined effects of thermal stress and Cd on lysosomal biomarkers and transcription of genes encoding lysosomal enzymes and HSP70 in mussels, Mytilus galloprovincialis.
New
Marigómez et al., Spain. In Aquat Toxicol, 30 Apr 2014
Semi-quantitative PCR was applied to reveal the changes elicited by the different experimental conditions in hexosaminidase (hex), β-glucuronidase (gusb), cathepsin L (ctsl) and heat shock protein 70 (hsp70) gene transcription levels.
Piperine inhibits type II phosphatidylinositol 4-kinases: a key component in phosphoinositides turnover.
New
Subrahmanyam et al., Mumbai, India. In Mol Cell Biochem, 27 Apr 2014
Concomitantly, pretreatment of RBL-2H3 cells with piperine also inhibited IgE-induced β-hexosaminidase release in RBL-2H3 cells.
Nanofiber-Coated Drug Eluting Stent for the Stabilization of Mast Cells.
New
Lee et al., Kansas City, United States. In Pharm Res, 25 Apr 2014
The degranulation rates of MCs were determined by measurement of the extracellular levels of hydrogen peroxide and the released amounts of β-hexosaminidase from the activated-MCs (a-MCs).
Purine metabolite and energy charge analysis of Trypanosoma brucei cells in different growth phases using an optimized ion-pair RP-HPLC/UV for the quantification of adenine and guanine pools.
New
Perozzo et al., Genève, Switzerland. In Exp Parasitol, 19 Apr 2014
UNLABELLED: Human African trypanosomiasis (HAT) is caused by the protozoan parasite Trypanosoma brucei.
Tissue-specific inactivation of HAT cofactor TRRAP reveals its essential role in B cells.
New
Khamlichi et al., Toulouse, France. In Cell Cycle, 18 Apr 2014
UNLABELLED: The transformation/transcription domain-associated protein (TRRAP) is a common component of many histone acetyltransferase (HAT) complexes.
Keep-ING Balance: Tumor Suppression by Epigenetic Regulation.
Review
New
Riabowol et al., Berlin, Germany. In Febs Lett, 13 Apr 2014
The ING (inhibitor of growth) proteins (ING1 - ING5) have emerged as a versatile family of growth regulators, phospholipid effectors, histone mark sensors and core components of HDAC1/2 - and several HAT chromatin-modifying complexes.
Reactivity of Nitrido Complexes of Ruthenium(VI), Osmium(VI), and Manganese(V) Bearing Schiff Base and Simple Anionic Ligands.
New
Impact
Lau et al., Hong Kong, Hong Kong. In Acc Chem Res, 18 Mar 2014
Moreover, the addition of various nucleophiles (Nu) to Ru(VI)≡N initially generate the ruthenium(IV) imido species Ru(IV)-N(Nu), a new class of hydrogen-atom transfer (HAT) reagents.
Mammalian DNA repair: HATs and HDACs make their mark through histone acetylation.
Review
New
Miller et al., Austin, United States. In Mutat Res, Oct 2013
With the cloning and identification of transcription associated histone acetyltransferase (HAT) and histone deacetylase (HDAC) enzymes that write and erase the histone acetylation mark respectively, it was realized that this histone modification could be dynamically regulated.
Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.
New
Impact
Hancock et al., Philadelphia, United States. In Nat Med, Sep 2013
We now report that conditional deletion or pharmacologic inhibition of one HAT, p300 (also known as Ep300 or KAT3B), in Foxp3(+) T(reg) cells increased T cell receptor-induced apoptosis in T(reg) cells, impaired T(reg) cell suppressive function and peripheral T(reg) cell induction, and limited tumor growth in immunocompetent but not in immunodeficient mice.
Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda.
Review
New
Okedi et al., New Haven, United States. In Trends Parasitol, Aug 2013
Uganda has both forms of human African trypanosomiasis (HAT): the chronic gambiense disease in the northwest and the acute rhodesiense disease in the south.
Secreted proteases of Trypanosoma brucei gambiense: possible targets for sleeping sickness control?
Review
New
Geiger et al., Montpellier, France. In Biofactors, Jul 2013
Human African trypanosomiasis (HAT) is caused by trypanosomes of the species Trypanosoma brucei and belongs to the neglected tropical diseases.
Anion-π interactions in supramolecular architectures.
New
Impact
Dunbar et al., College Station, United States. In Acc Chem Res, May 2013
Finally, we explored the reactions of the extended π-acidic heterocycle HAT(CN)6 (1,4,5,8,9,12-hexaazatriphenylene-hexacarbonitrile) with the Cl(-), Br(-), I(-) ions which lead to highly colored solutions/crystals.
The SLC3 and SLC7 families of amino acid transporters.
Review
New
Palacín et al., Bern, Switzerland. In Mol Aspects Med, Apr 2013
Furthermore, the role of the HAT 4F2hc/LAT1 in tumor growth and the application of LAT1 inhibitors and PET tracers for reduction of tumor progression and imaging of tumors are discussed.
GM2 gangliosidoses in Spain: analysis of the HEXA and HEXB genes in 34 Tay-Sachs and 14 Sandhoff patients.
GeneRIF
Spanish GM2 Working Group et al., Barcelona, Spain. In Gene, 2012
identified 27 different mutations, 14 of which were novel, in the HEXA gene and 14 different mutations, 8 of which unreported until now, in the HEXB gene, and attempted to correlate these mutations with the clinical presentation of the patients
O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-β-D-glucosaminidase silencing on cell phenotype and transcriptome.
GeneRIF
Khalaila et al., Beersheba, Israel. In J Biol Chem, 2012
O-linked beta-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-beta-D-glucosaminidase silencing on cell phenotype and transcriptome.
Molecular analysis of HEXA gene in Argentinean patients affected with Tay-Sachs disease: possible common origin of the prevalent c.459+5A>G mutation.
GeneRIF
Dardis et al., Udine, Italy. In Gene, 2012
HEXA gene in Argentinean patients affected with Tay-Sachs disease, overall 14 different mutations were identified, 8 of them were novel and lead to premature stop codons, drastic residues changes or a splicing defect.
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Impact
Horn et al., London, United Kingdom. In Nature, 2012
Dyes and arsenical compounds that displayed selectivity against trypanosomes were central to this work, and the drugs that emerged remain in use for treating human African trypanosomiasis (HAT).
Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.
GeneRIF
Soilleux et al., Göttingen, Germany. In Plos One, 2011
TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host.
Prediction of bladder cancer based on urinary content of MGEA5 and OGT mRNA level.
GeneRIF
Lipinski et al., Łódź, Poland. In Clin Lab, 2011
Analysis of urinary content of MGEA5 and OGT may be useful for bladder cancer diagnostics.
Inactivating mutations of acetyltransferase genes in B-cell lymphoma.
Impact
Dalla-Favera et al., New York City, United States. In Nature, 2011
Overall, about 39% of diffuse large B-cell lymphoma and 41% of follicular lymphoma cases display genomic deletions and/or somatic mutations that remove or inactivate the HAT coding domain of these two genes.
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