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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Myosin VIIA and Rab interacting protein

MyRIP, Slac2-c
human and mouse homologs form a complex with Rab27A and Myosin VIIa; involved in melanosome trafficking to the actin cytoskeleton [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Actin, V1a, Rab5, L-N, Insulin
Papers on MyRIP
Interaction between MyRIP and the actin cytoskeleton regulates Weibel-Palade body trafficking and exocytosis.
New
Carter et al., Paris, France. In J Cell Sci, Jan 2016
Myosin Va (MyoVa) is recruited to WPBs by a Rab27A-MyRIP complex and is thought to be the prime mediator of actin binding, however, direct MyRIP-actin interactions can also occur.
Rab27a GTPase modulates L-type Ca2+ channel function via interaction with the II-III linker of CaV1.3 subunit.
New
Strauß et al., Regensburg, Germany. In Cell Signal, Nov 2015
Physical binding of heterologously expressed Rab27a with Ca(V)1.3 channels was shown by co-localization in immunocytochemistry as well as co-immunoprecipitation which was abolished after deletion of a MyRIP-homologous amino acid sequence at the II-III linker of the Ca(V)1.3
Interplay between Rab27a effectors in pancreatic β-cells.
Review
New
Kimura et al., Ōita, Japan. In World J Diabetes, May 2015
In pancreatic β-cells, GTP-bound Rab27a regulates insulin secretion at the pre-exocytotic stages via its GTP-specific effectors such as Exophilin8/Slac2-c/MyRIP and Slp4/Granuphilin.
HIF1A as a major vascular endothelial growth factor regulator: do its polymorphisms have an association with age-related macular degeneration?
Yildirim et al., Denizli, Turkey. In Clin Experiment Ophthalmol, 2015
The associations of AMD and polymorphisms of genes CFH, SKIV2L and MYRIP were also studied.
Copy number variation associated with meiotic arrest in idiopathic male infertility.
O'Bryan et al., Melbourne, Australia. In Fertil Steril, 2015
One containing the MYRIP gene and a second containing LRRC4C and the long noncoding RNA LOC100507205.
The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells.
Yu et al., Wenzhou, China. In Sci Rep, 2014
We further identified a new target Myrip in the Cdr1as/miR-7 pathway that regulates insulin granule secretion, and also another target Pax6 that enhances insulin transcription.
Integrated microRNA-mRNA analysis of pancreatic ductal adenocarcinoma.
Ren et al., Tianjin, China. In Genet Mol Res, 2014
The node degree of hsa-miR-200c, hsa-miR-429, and hsa-miR-200b (miRNA), and EFNB2, MYRIP, and PHF17 (mRNA) were extremely high in the miRNA-mRNA network, indicating that these miRNA and mRNA may play a key role in the development of pancreatic cancer.
Circadian pathway genes in relation to glioma risk and outcome.
Egan et al., Tampa, United States. In Cancer Causes Control, 2014
METHODS: Subjects were genotyped for 17 candidate single nucleotide polymorphisms in ARNTL, CRY1, CRY2, CSNK1E, KLHL30, NPAS2, PER1, PER3, CLOCK, and MYRIP.
Identification of rare variants for hypertension with incorporation of linkage information.
Hsu et al., New Haven, United States. In Bmc Proc, 2013
KCNAB1 (p = 5.8E-4), and MYRIP (p = 5.79E-6).
An improved strategy for easy process monitoring and advanced purification of recombinant proteins.
Elm'selmi et al., Cergy-Pontoise, France. In Mol Biotechnol, 2013
In this work, a multifunctional expression cassette, termed Multitags, combining different and complementary functionalities, was designed and used to monitor the expression and the purification of two model proteins (Pfu DNA polymerase and Myosin-VIIa- and Rab-Interracting protein : MyRIP).
MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway.
Váradi et al., Bristol, United Kingdom. In Mol Biol Cell, 2012
Myosin- and Rab-interacting protein (MyRIP), which belongs to the protein kinase A (PKA)-anchoring family, is implicated in hormone secretion.
The interplay between the Rab27A effectors Slp4-a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis.
Carter et al., London, United Kingdom. In Blood, 2012
siRNA knockdown of Slp4-a, MyRIP, Rab3B, Rab3D, Rab27A, or Rab3B/Rab27A, or overexpression of EGFP-Slp4-a or EGFP-MyRIP showed that Slp4-a is a positive and MyRIP a negative regulator of WPB exocytosis and that Rab27A alone mediates these effects.
Myrip couples the capture of secretory granules by the actin-rich cell cortex and their attachment to the plasma membrane.
GeneRIF
Desnos et al., Rennes, France. In J Neurosci, 2012
Myrip couples the retention of secretory granules in the cell cortex, their transport to the plasma membrane, and their attachment to the plasma membrane, thus promoting secretion.
Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells.
GeneRIF
Gerke et al., Münster, Germany. In Traffic, 2011
A Rab27a/MyRIP/myosin Va complex is involved in linking von-Willebrand factor (Vwf) to the peripheral actin cytoskeleton of endothelial cells to allow full maturation and prevent premature secretion of vWF.
Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis.
GeneRIF
Izumi et al., Maebashi, Japan. In Mol Biol Cell, 2011
Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.
GeneRIF
Iyengar et al., Cleveland, United States. In Genes Immun, 2010
A new potentially protective effect was identified at rs2679798 in MYRIP.
Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport.
GeneRIF
Hume et al., Coimbra, Portugal. In Pigment Cell Melanoma Res, 2009
Myrip is a versatile Rab27a-associated myosin-activating protein that mediates cellular activation of MyoVa and MyoVIIa via non-overlapping domains.
Griscelli syndrome: a model system to study vesicular trafficking.
Review
Lambert et al., Gent, Belgium. In Pigment Cell Melanoma Res, 2009
As the small GTPase Rab27a is able to interact with multiple effectors, including Slp2-a and Myrip, we report on their presumed role in melanosome transport.
The melanosome as a model to study organelle motility in mammals.
Review
Seabra et al., London, United Kingdom. In Pigment Cell Res, 2004
In the retinal pigment epithelium, a similar complex formed by Rab27a, a melanophilin homolog called MyRIP and myosin VIIa is probably responsible for the tethering of melanosomes to the actin cytoskeleton.
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