Myostatin: expanding horizons.
Singapore, Singapore. In Iubmb Life, Aug 2015
Myostatin is a secreted growth and differentiation factor that belongs to the TGF-β superfamily.
Muscle wasting in disease: molecular mechanisms and promising therapies.
Haifa, Israel. In Nat Rev Drug Discov, 2015
However, several promising therapeutic agents are in development, and major advances in our understanding of the cellular mechanisms that regulate the protein balance in muscle include the identification of several cytokines, particularly myostatin, and a common transcriptional programme that promotes muscle wasting.
Cancer as a Proinflammatory Environment: Metastasis and Cachexia.
São Paulo, Brazil. In Mediators Inflamm, 2014
The aim of the present review is to address the role of ghrelin, myostatin, leptin, HIF, IL-6, TNF-α, and ANGPTL-4 in the regulation of energy balance, tumour development, and tumoural cell invasion.
Plasma and muscle myostatin in relation to type 2 diabetes.
Copenhagen, Denmark. In Plos One, 2011
high muscular expression of myostatin is associated to impaired metabolism, systemic inflammation, obesity and poor fitness level in healthy subjects. These associations are disrupted in patients with type 2 diabetes