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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.


myostatin, Compact, MSTN
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on myostatin
Myostatin is a novel tumoral factor that induces cancer cachexia.
Sharma et al., Singapore, Singapore. In Biochem J, 2012
Myostatin induces cancer cachexia.
Alterations of maternal serum and placental follistatin-like 3 and myostatin in pre-eclampsia.
Dong et al., Hangzhou, China. In J Obstet Gynaecol Res, 2012
Data suggest that serum levels of myostatin are higher in pre-eclampsia than in controls; placental expression of myostatin is also increased in pre-eclampsia compared with controls; no differences were observed between mild and severe pre-eclampsia.
MicroRNA-27a promotes myoblast proliferation by targeting myostatin.
Chen et al., China. In Biochem Biophys Res Commun, 2012
these results suggest that miR-27a promotes myoblast proliferation through targeting myostatin.
Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin.
Gregorevic et al., Australia. In J Cell Biol, 2012
regulation of Smad3- and mTOR-dependent events by follistatin occurred independently of overexpression or knockout of myostatin, a key repressor of muscle development that can regulate Smad3 and mTOR signaling and that is itself inhibited by follistatin
Plasma and muscle myostatin in relation to type 2 diabetes.
Plomgaard et al., Copenhagen, Denmark. In Plos One, 2011
high muscular expression of myostatin is associated to impaired metabolism, systemic inflammation, obesity and poor fitness level in healthy subjects. These associations are disrupted in patients with type 2 diabetes
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