GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 08 Dec 2016.
myostatin, Compact, MSTN
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq, Jul 2008] (from
Dong et al., Hangzhou, China. In J Obstet Gynaecol Res, 2012
Data suggest that serum levels of myostatin are higher in pre-eclampsia than in controls; placental expression of myostatin is also increased in pre-eclampsia compared with controls; no differences were observed between mild and severe pre-eclampsia.
Gregorevic et al., Australia. In J Cell Biol, 2012
regulation of Smad3- and mTOR-dependent events by follistatin occurred independently of overexpression or knockout of myostatin, a key repressor of muscle development that can regulate Smad3 and mTOR signaling and that is itself inhibited by follistatin
Plomgaard et al., Copenhagen, Denmark. In Plos One, 2011
high muscular expression of myostatin is associated to impaired metabolism, systemic inflammation, obesity and poor fitness level in healthy subjects. These associations are disrupted in patients with type 2 diabetes