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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Myostatin

myostatin, Compact, MSTN
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, HAD, Insulin, V1a
Papers on myostatin
The Compact Body Plan of Tardigrades Evolved by the Loss of a Large Body Region.
New
Goldstein et al., Chapel Hill, United States. In Curr Biol, Feb 2016
Based on our results, we reconstruct a last common ancestor of Panarthropoda that had a relatively elongate body plan like most arthropods and onychophorans, rather than a compact, tardigrade-like body plan.
Investigation of an SFOV hybrid gamma camera for thyroid imaging.
New
Perkins et al., Leicester, United Kingdom. In Phys Med, Feb 2016
UNASSIGNED: The Hybrid Compact Gamma Camera (HCGC) is a small field of view (SFOV) portable hybrid gamma-optical camera intended for small organ imaging at the patient bedside.
Skeletal muscle atrophy: disease-induced mechanisms may mask disuse atrophy.
Review
New
Karatzaferi et al., Tríkala, Greece. In J Muscle Res Cell Motil, Feb 2016
This review discusses the intricate network of interacting signalling pathways including Atrogin-1/MAFbx, IGF1-Akt, myostatin, glucocorticoids, NF-kB, MAPKs and caspases that seem to regulate disuse atrophy but also share common activation patterns in other states of muscle loss such as sarcopenia or cachexia.
Development of thiamine and pyridoxine loaded ferulic acid-grafted chitosan microspheres for dietary supplementation.
New
Ravishankar et al., Cochin, India. In J Food Sci Technol, Jan 2016
Compact microspheres with smooth surfaces and no apparent cracks or pores were observed under scanning electron microscope.
Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease.
Review
New
Lüscher et al., Zürich, Switzerland. In Eur Heart J, Jan 2016
GDF11, a member of TGFβ superfamily with homology to myostatin also retards the aging process via yet unknown mechanisms.
Skeletal muscle mass adjusted by height correlated better with muscular functions than that adjusted by body weight in defining sarcopenia.
New
Yang et al., Taipei, Taiwan. In Sci Rep, Dec 2015
Serum myostatin levels correlated positively with gait speed (r = 0.142, p = 0.007) after adjustment for gender.
Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice.
New
Impact
Pap et al., Münster, Germany. In Nat Med, Sep 2015
Deletion of the myostatin gene (Mstn) in mice leads to muscle hypertrophy, and animal studies support the concept that myostatin is a negative regulator of muscle growth and regeneration.
Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training.
Review
New
Adams et al., Leipzig, Germany. In J Cachexia Sarcopenia Muscle, Sep 2015
members of the ubiquitin-proteasome system and myostatin) or repressed (e.g.
GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.
New
Impact
Glass et al., Cambridge, United States. In Cell Metab, Aug 2015
The role of TGF-β molecules myostatin and GDF11 in regeneration is unclear.
Observation of the rare B(s)(0) →µ+µ− decay from the combined analysis of CMS and LHCb data.
New
Impact
CMS and LHCb collaborations, In Nature, Jul 2015
The CMS (Compact Muon Solenoid) and LHCb (Large Hadron Collider beauty) collaborations have performed a joint analysis of the data from proton–proton collisions that they collected in 2011 at a centre-of-mass energy of seven teraelectronvolts and in 2012 at eight teraelectronvolts.
Galaxy evolution. Isolated compact elliptical galaxies: stellar systems that ran away.
New
Impact
Zolotukhin et al., Cambridge, United States. In Science, May 2015
Compact elliptical galaxies form a rare class of stellar system (~30 presently known) characterized by high stellar densities and small sizes and often harboring metal-rich stars.
Muscle wasting in disease: molecular mechanisms and promising therapies.
Review
Impact
Goldberg et al., Haifa, Israel. In Nat Rev Drug Discov, 2015
However, several promising therapeutic agents are in development, and major advances in our understanding of the cellular mechanisms that regulate the protein balance in muscle include the identification of several cytokines, particularly myostatin, and a common transcriptional programme that promotes muscle wasting.
Cancer as a Proinflammatory Environment: Metastasis and Cachexia.
Review
Nascimento et al., São Paulo, Brazil. In Mediators Inflamm, 2014
The aim of the present review is to address the role of ghrelin, myostatin, leptin, HIF, IL-6, TNF-α, and ANGPTL-4 in the regulation of energy balance, tumour development, and tumoural cell invasion.
Expression of recombinant myostatin propeptide pPIC9K-Msp plasmid in Pichia pastoris.
Xie et al., Shihezi, China. In Genet Mol Res, 2014
Myostatin propeptide can inhibit the biological activity of myostatin protein and promote muscle growth.
Myostatin is a novel tumoral factor that induces cancer cachexia.
GeneRIF
Sharma et al., Singapore, Singapore. In Biochem J, 2012
Myostatin induces cancer cachexia.
Alterations of maternal serum and placental follistatin-like 3 and myostatin in pre-eclampsia.
GeneRIF
Dong et al., Hangzhou, China. In J Obstet Gynaecol Res, 2012
Data suggest that serum levels of myostatin are higher in pre-eclampsia than in controls; placental expression of myostatin is also increased in pre-eclampsia compared with controls; no differences were observed between mild and severe pre-eclampsia.
MicroRNA-27a promotes myoblast proliferation by targeting myostatin.
GeneRIF
Chen et al., China. In Biochem Biophys Res Commun, 2012
these results suggest that miR-27a promotes myoblast proliferation through targeting myostatin.
Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin.
GeneRIF
Gregorevic et al., Australia. In J Cell Biol, 2012
regulation of Smad3- and mTOR-dependent events by follistatin occurred independently of overexpression or knockout of myostatin, a key repressor of muscle development that can regulate Smad3 and mTOR signaling and that is itself inhibited by follistatin
Plasma and muscle myostatin in relation to type 2 diabetes.
GeneRIF
Plomgaard et al., Copenhagen, Denmark. In Plos One, 2011
high muscular expression of myostatin is associated to impaired metabolism, systemic inflammation, obesity and poor fitness level in healthy subjects. These associations are disrupted in patients with type 2 diabetes
Double Muscling in Cattle: Genes, Husbandry, Carcasses and Meat.
Review
Fiems, Belgium. In Animals (basel), 2011
Molecular biology has enabled the identification of the mechanisms whereby inactive myostatin increases skeletal muscle growth in double-muscled (DM) animals.
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