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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Myosin light chain kinase

myosin light chain kinase, MLCK
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using myosin light chain kinase antibodies
Nuclear actin dynamics–from form to function.
Supplier
Tyagi Anil Kumar, In PLoS ONE, 2007
... Phospho-specific and nonphospho-specific antibodies against MLCK and the catalytic subunit of MLCP (MYPT) were obtained from Santa Cruz Biotechnology.
Papers on myosin light chain kinase
Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle.
GeneRIF
Somlyo et al., Charlottesville, United States. In J Biol Chem, 2012
Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle.
Novel role for non-muscle myosin light chain kinase (MLCK) in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation, and reactive oxygen species generation in lung endothelium.
GeneRIF
Natarajan et al., Chicago, United States. In J Biol Chem, 2012
MLCK is essential for the translocation and association of cortactin and p47phox.
Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation.
GeneRIF
Han et al., Cincinnati, United States. In Embo Mol Med, 2012
Deletion of MLCK restored intestinal barrier function in STAT5 knockout mice, and facilitated mucosal wound healing(MLCK)
Hypermethylated FAM5C and MYLK in serum as diagnosis and pre-warning markers for gastric cancer.
GeneRIF
Liu et al., Shanghai, China. In Dis Markers, 2011
Hypermethylated FAM5C and MYLK in serum are strongly associated with the development of gastric cancer and can be used as potential biomarkers for diagnosis and pre-warning.
Myosin light-chain kinase is necessary for membrane homeostasis in cochlear inner hair cells.
GeneRIF
Zhu et al., Nanjing, China. In Plos One, 2011
Myosin light-chain kinase is necessary for maintaining the membrane stability of inner hair cells.
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