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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Myosin, light chain 2, regulatory, cardiac, slow

myosin light chain 2, MLC2v, MLC2, MYL2
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Actin, V1a, HAD, FasT
Papers using myosin light chain 2 antibodies
Tea flavonoids and cardiovascular health.
Supplier
Zhang Baohong, In PLoS ONE, 2009
... Rabbit anti-MLC2 (FL-172) antibody (against whole MRLC) was obtained from Santa Cruz Biotechnology, Inc ...
Domain analysis of alpha-actinin reveals new aspects of its association with F-actin during cytokinesis.
Supplier
Hotchin Neil A., In PLoS ONE, 2009
... Polyclonal MLC2 antibody (catalog #: 3672) was purchased from Cell Signaling (Danvers, MA) ...
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions.
Supplier
Parsons Maddy, In PLoS ONE, 2008
... anti-β1 integrin (BD Biosciences); mouse anti-alpha tubulin, rabbit anti-calnexin and rabbit anti-fibronectin (Sigma Aldrich); rabbit anti-phospho-myosin light chain 2 (Ser19) (Cell Signaling Technology, Inc., Danvers, MA), ...
PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells
Supplier
Bourne Henry R. et al., In The Journal of Cell Biology, 2004
... Mouse monoclonal antibody against myosin light chain 2 phosphorylated at S19 (p-MLC2) was from Cell Signaling Technology ...
Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts.
Supplier
Rutherford Suzannah, In PLoS ONE, 2002
... MLC2v-Cre/ZEG double heterozygous transgenic mice were generated by ...
Papers on myosin light chain 2
Human heart cell proteins interacting with a C-terminally truncated 2A protein of coxsackie B3 virus: identification by the yeast two-hybrid system.
New
Xia et al., Nanchang, China. In Virus Genes, 19 Feb 2016
Choosing the 2A mutant with 17 aa deletion at the C-terminus as the bait protein, four interactive cellular proteins were identified, including TIMP4, MYL2, COX7C, and ENO1.
Effect of obesity on the association between MYL2 (rs3782889) and high-density lipoprotein cholesterol among Korean men.
New
Sull et al., Seoul, South Korea. In J Hum Genet, 14 Feb 2016
Several genome-wide association studies that have examined HDL cholesterol levels have implicated myosin light chain 2 regulatory cardiac slow (MYL2) as a possible causal factor.
Propofol administration to the fetal-maternal unit reduces cardiac oxidative stress in preterm lambs subjected to prenatal asphyxia and cardiac arrest.
New
Kramer et al., Maastricht, Netherlands. In Pediatr Res, 13 Feb 2016
This was accompanied by less degradation of MLC2 but higher p38MAPK level and in echocardiography with a trend toward a higher median left ventricular fractional shortening.
Endothelin-1/endothelin A receptor axis activates RhoA GTPase in epithelial ovarian cancer.
New
Rosanò et al., Roma, Italy. In Life Sci, 08 Feb 2016
The phosphorylation of myosin light chain 2 (MLC2) was evaluated by immunoblotting.
RasGRF2 controls nuclear migration in postnatal retinal cone photoreceptors.
New
Santos et al., Salamanca, Spain. In J Cell Sci, 07 Feb 2016
Mechanistically, the generation of this phenotype involved disruption of the outer limiting membrane (OLM), and intrusion into the PS layer, of cone nuclei displaying significant perinuclear accumulation of signaling molecules known to participate in nuclear migration and cytoskeletal reorganization such as PAR3, PAR6, and activated, phosphorylated forms of PAK, MLC2 and VASP.
HO-1/CO system and embryonic stem cell differentiation and maturation into cardiomyocytes.
New
Piantadosi et al., Durham, United States. In Antioxid Redox Signal, 04 Feb 2016
HO-1/CO over-expression increases cardiac gene expression for MLC2a, MLC2v, ANP, MHC-, and sarcomere α-actinin and the major mitochondrial fusion regulators Mfn2 and Immt.
RhoA-mediated MLC2 regulates actin dynamics for cytokinesis in meiosis.
New
Sun et al., Nanjing, China. In Cell Cycle, 23 Jan 2016
Myosin light chain2 (MLC2) phosphorylation plays pivotal roles in smooth muscle contraction, stress fiber formation, cell motility and cytokinesis.
Differential Expression Levels of Integrin α6 Enable the Selective Identification and Isolation of Atrial and Ventricular Cardiomyocytes.
Eckardt et al., Bergisch Gladbach, Germany. In Plos One, 2014
We discovered that the expression level of this surface marker correlates with the intracellular subtype-specific expression of MLC-2a and MLC-2v on the single cell level and thereby enables the discrimination of cardiomyocyte subtypes by flow cytometry.
Genetic profile of hypertrophic cardiomyopathy in Tunisia: Is it different?
Olivotto et al., Monastir, Tunisia. In Glob Cardiol Sci Pract, 2014
Using the Illumina platform, a panel of 12 genes was analyzed including myosin binding protein C (MYBPC3), beta-myosin heavy chain (MYH7), regulatory and essential light chains (MYL2 and MYL3), troponin-T (TNNT2), troponin-I (TNNI3), troponin-C (TNNC1), alpha-tropomyosin (TPM1), alpha-actin (ACTC1), alpha-actinin-2 (ACTN2) as well as alfa-galactosidase (GLA), 5'-AMP-activated protein (PKRAG2), transthyretin (TTR) and lysosomal-associated membrane protein-2 (LAMP2) for exclusion of phenocopies.
Immunosuppressant MPA Modulates Tight Junction through Epigenetic Activation of MLCK/MLC-2 Pathway via p38MAPK.
Asif et al., Göttingen, Germany. In Front Physiol, 2014
Recently, we reported the MPA induced tight junctions (TJs) deregulation which involves MLCK/MLC-2 pathway.
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.
Impact
Sahai et al., London, United Kingdom. In Nat Cell Biol, 2013
YAP regulates the expression of several cytoskeletal regulators, including ANLN and DIAPH3, and controls the protein levels of MYL9 (also known as MLC2).
Gene duplication and conversion events shaped three homologous, differentially expressed myosin regulatory light chain (MLC2) genes.
GeneRIF
Wansink et al., Nijmegen, Netherlands. In Eur J Cell Biol, 2012
MLC2 isoforms play a role in tumorigenesis.
AMPK regulates mitotic spindle orientation through phosphorylation of myosin regulatory light chain.
GeneRIF
Marcus et al., Atlanta, United States. In Mol Cell Biol, 2012
AMPK mediates spindle pole-associated pMRLC(ser19) to control spindle orientation via regulation of actin cortex-astral microtubule attachments
Effect of selenium on the interaction between daunorubicin and cardiac myosin.
GeneRIF
Wang et al., Wuhan, China. In Biol Trace Elem Res, 2012
Results show that the binding force between selenium and cardiac myosin (CM), which consists of two heavy chains (MHC) and two pairs of light chains: MLC1 and MLC2, was 100 times stronger than that of daunorubicin (DNR) and CM.
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.
GeneRIF
Chen et al., Los Angeles, United States. In J Clin Invest, 2012
Mlc2 phosphorylation regulates actin-myosin interactions in striated muscle contraction. It is important for feedback control of calcium-dependent thin-filament activation. Dephosphorylation can play a critical role in heart failure.
Smooth muscle myosin light chain kinase efficiently phosphorylates serine 15 of cardiac myosin regulatory light chain.
GeneRIF
Ajtai et al., Rochester, United States. In Biochem Biophys Res Commun, 2012
These data demonstrate that smMLCK is a specific and efficient kinase for the in vitro phosphorylation of MYL2, cardiac, and smooth muscle myosin.
Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis.
Impact
Treisman et al., London, United Kingdom. In Nat Cell Biol, 2009
Two of these, MYH9 (NMHCIIa) and MYL9 (MLC2), are also required for invasion and lung colonization.
Shared genetic causes of cardiac hypertrophy in children and adults.
Impact
Seidman et al., Boston, United States. In N Engl J Med, 2008
We sequenced eight genes: MYH7, MYBPC3, TNNT2, TNNI3, TPM1, MYL3, MYL2, and ACTC.
Energy-dependent regulation of cell structure by AMP-activated protein kinase.
Impact
Chung et al., Taejŏn, South Korea. In Nature, 2007
Interestingly, the regulatory site of non-muscle myosin regulatory light chain (MRLC; also known as MLC2) was directly phosphorylated by AMPK.
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