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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Jul 2015.

Myosin, light chain 2, regulatory, cardiac, slow

myosin light chain 2, MLC2v, MLC2, MYL2
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Actin, V1a, HAD, FasT
Papers using myosin light chain 2 antibodies
Tea flavonoids and cardiovascular health.
Supplier
Zhang Baohong, In PLoS ONE, 2009
... Rabbit anti-MLC2 (FL-172) antibody (against whole MRLC) was obtained from Santa Cruz Biotechnology, Inc ...
Domain analysis of alpha-actinin reveals new aspects of its association with F-actin during cytokinesis.
Supplier
Hotchin Neil A., In PLoS ONE, 2009
... Polyclonal MLC2 antibody (catalog #: 3672) was purchased from Cell Signaling (Danvers, MA) ...
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions.
Supplier
Parsons Maddy, In PLoS ONE, 2008
... anti-β1 integrin (BD Biosciences); mouse anti-alpha tubulin, rabbit anti-calnexin and rabbit anti-fibronectin (Sigma Aldrich); rabbit anti-phospho-myosin light chain 2 (Ser19) (Cell Signaling Technology, Inc., Danvers, MA), ...
PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells
Supplier
Bourne Henry R. et al., In The Journal of Cell Biology, 2004
... Mouse monoclonal antibody against myosin light chain 2 phosphorylated at S19 (p-MLC2) was from Cell Signaling Technology ...
Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts.
Supplier
Rutherford Suzannah, In PLoS ONE, 2002
... MLC2v-Cre/ZEG double heterozygous transgenic mice were generated by ...
Papers on myosin light chain 2
Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease.
Review
New
Chen et al., San Diego, United States. In Gene, 10 Oct 2015
Myosin light chain-2 (MYL2, also called MLC-2) is an ~19kDa sarcomeric protein that belongs to the EF-hand calcium binding protein superfamily and exists as three major isoforms encoded by three distinct genes in mammalian striated muscle.
Regulation of sarcoma cell migration, invasion and invadopodia formation by AFAP1L1 through a phosphotyrosine-dependent pathway.
New
Ingley et al., Australia. In Oncogene, 27 Aug 2015
Through its interaction with Vav2, AFAP1L1 regulates Rac activity and downstream control of PAK1/2/3 (p21-activated kinases) phosphorylation of myosin light chain (MLC) kinase and MLC2.
Low-Intensity Pulsed Ultrasound Improves the Functional Properties of Cardiac Mesoangioblasts.
New
Gálvez et al., Madrid, Spain. In Stem Cell Rev, 23 Aug 2015
Mechanistically, LIPUS stimulation activated the BMP-Smad signalling pathway and increased the expression of myosin light chain-2 together with upregulation of β1 integrin and RhoA, highlighting a potentially important role for cytoskeleton reorganization.
Leukoencephalopathy associated with 11q24 deletion involving the gene encoding hepatic and glial cell adhesion molecule in two patients.
New
Kubota et al., Tokyo, Japan. In Eur J Med Genet, 17 Aug 2015
Mutations of the gene encoding hepatic and glial cell adhesion molecule (HEPACAM) located on 11q24 are related to one of the leukoencephalopathies: megalencephalic leukoencephalopathy with subcortical cysts type 2 (MLC2).
Simulated Microgravity Exerts an Age-Dependent Effect on the Differentiation of Cardiovascular Progenitors Isolated from the Human Heart.
New
Kearns-Jonker et al., Boulder, United States. In Plos One, Dec 2014
Von Willebrand Factor, an endothelial differentiation marker, and MLC2v and Troponin T, markers for cardiomyogenic differentiation, were elevated in expression in adult progenitors after simulated microgravity.
Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension.
New
Pearson et al., Melbourne, Australia. In Cardiovasc Diabetol, Dec 2014
ROCK targets several sarcomeric proteins including myosin light chain 2, myosin binding protein-C (MyBP-C), troponin I (TnI) and troponin T that all have important roles in regulating CB dynamics and contractility of the myocardium.
Getting the skinny on thick filament regulation in cardiac muscle biology and disease.
Review
New
Chen et al., San Diego, United States. In Trends Cardiovasc Med, May 2014
Key to these new findings is a growing body of evidence that point to an influential and, more recently, direct role for ventricular myosin light chain-2 (MLC2v) phosphorylation in regulating cardiac muscle contraction, function, and disease.
O-GlcNAcylation, contractile protein modifications and calcium affinity in skeletal muscle.
Review
Bastide et al., Lille, France. In Front Physiol, 2013
In particular, the O-GlcNAcylation level of the phosphoprotein myosin light chain 2 seems to be crucial in the modulation of the calcium activation properties, and should be responsible for changes in calcium properties observed in functional atrophy.
Synergistic effect of inhibitors of MMPs and ROS-dependent modifications of contractile proteins on protection hearts subjected to oxidative stress.
Review
Sawicki, Saskatoon, Canada. In Curr Pharm Des, 2013
Cardiac contractile proteins such as myosin light chain 1 and 2 (MLC1 and MLC2) and troponin I, play a significant role in the regulation of force development.
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.
Impact
Sahai et al., London, United Kingdom. In Nat Cell Biol, 2013
YAP regulates the expression of several cytoskeletal regulators, including ANLN and DIAPH3, and controls the protein levels of MYL9 (also known as MLC2).
Intracellular regulation of matrix metalloproteinase-2 activity: new strategies in treatment and protection of heart subjected to oxidative stress.
Review
Sawicki, Saskatoon, Canada. In Scientifica (cairo), 2012
One such mechanism involves the proteolytic degradation of contractile proteins, such as troponin I (TnI), myosin heavy chain, titin, and the myosin light chains (MLC1 and MLC2) by matrix metalloproteinase-2 (MMP-2).
Gene duplication and conversion events shaped three homologous, differentially expressed myosin regulatory light chain (MLC2) genes.
GeneRIF
Wansink et al., Nijmegen, Netherlands. In Eur J Cell Biol, 2012
MLC2 isoforms play a role in tumorigenesis.
AMPK regulates mitotic spindle orientation through phosphorylation of myosin regulatory light chain.
GeneRIF
Marcus et al., Atlanta, United States. In Mol Cell Biol, 2012
AMPK mediates spindle pole-associated pMRLC(ser19) to control spindle orientation via regulation of actin cortex-astral microtubule attachments
Effect of selenium on the interaction between daunorubicin and cardiac myosin.
GeneRIF
Wang et al., Wuhan, China. In Biol Trace Elem Res, 2012
Results show that the binding force between selenium and cardiac myosin (CM), which consists of two heavy chains (MHC) and two pairs of light chains: MLC1 and MLC2, was 100 times stronger than that of daunorubicin (DNR) and CM.
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.
GeneRIF
Chen et al., Los Angeles, United States. In J Clin Invest, 2012
Mlc2 phosphorylation regulates actin-myosin interactions in striated muscle contraction. It is important for feedback control of calcium-dependent thin-filament activation. Dephosphorylation can play a critical role in heart failure.
Smooth muscle myosin light chain kinase efficiently phosphorylates serine 15 of cardiac myosin regulatory light chain.
GeneRIF
Ajtai et al., Rochester, United States. In Biochem Biophys Res Commun, 2012
These data demonstrate that smMLCK is a specific and efficient kinase for the in vitro phosphorylation of MYL2, cardiac, and smooth muscle myosin.
Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis.
Impact
Treisman et al., London, United Kingdom. In Nat Cell Biol, 2009
Two of these, MYH9 (NMHCIIa) and MYL9 (MLC2), are also required for invasion and lung colonization.
Shared genetic causes of cardiac hypertrophy in children and adults.
Impact
Seidman et al., Boston, United States. In N Engl J Med, 2008
We sequenced eight genes: MYH7, MYBPC3, TNNT2, TNNI3, TPM1, MYL3, MYL2, and ACTC.
Energy-dependent regulation of cell structure by AMP-activated protein kinase.
Impact
Chung et al., Taejŏn, South Korea. In Nature, 2007
Interestingly, the regulatory site of non-muscle myosin regulatory light chain (MRLC; also known as MLC2) was directly phosphorylated by AMPK.
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