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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 26 Nov 2014.

Myosin, light chain 2, regulatory, cardiac, slow

myosin light chain 2, MLC2v, MLC2, MYL2
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Actin, V1a, HAD, FasT
Papers using myosin light chain 2 antibodies
Tea flavonoids and cardiovascular health.
Supplier
Zhang Baohong, In PLoS ONE, 2009
... Rabbit anti-MLC2 (FL-172) antibody (against whole MRLC) was obtained from Santa Cruz Biotechnology, Inc ...
Domain analysis of alpha-actinin reveals new aspects of its association with F-actin during cytokinesis.
Supplier
Hotchin Neil A., In PLoS ONE, 2009
... Polyclonal MLC2 antibody (catalog #: 3672) was purchased from Cell Signaling (Danvers, MA) ...
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions.
Supplier
Parsons Maddy, In PLoS ONE, 2008
... anti-β1 integrin (BD Biosciences); mouse anti-alpha tubulin, rabbit anti-calnexin and rabbit anti-fibronectin (Sigma Aldrich); rabbit anti-phospho-myosin light chain 2 (Ser19) (Cell Signaling Technology, Inc., Danvers, MA), ...
PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells
Supplier
Bourne Henry R. et al., In The Journal of Cell Biology, 2004
... Mouse monoclonal antibody against myosin light chain 2 phosphorylated at S19 (p-MLC2) was from Cell Signaling Technology ...
Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts.
Supplier
Rutherford Suzannah, In PLoS ONE, 2002
... MLC2v-Cre/ZEG double heterozygous transgenic mice were generated by ...
Papers on myosin light chain 2
Identification of novel risk genes associated with type 1 diabetes mellitus using a genome-wide gene-based association analysis.
New
Lei et al., Suzhou, China. In J Diabetes Investig, 30 Nov 2014
In particular, seven genes including four non-human leukocyte antigen (HLA) genes (RASIP1, STRN4, BCAR1 and MYL2) are replicated in at least one independent population and also differentially expressed in peripheral blood mononuclear cells or monocytes.
Mutation Analysis of the Main Hypertrophic Cardiomyopathy Genes Using Multiplex Amplification and Semiconductor Next-Generation Sequencing.
New
Coto et al., Davao, Philippines. In Circ J, 22 Nov 2014
The purpose was to develop a next-generation sequencing (NGS) procedure for the main HCM genes.Methods and Results:Multiplex amplification of the coding exons ofMYH7,MYBPC3,TNNT2,TNNI3,ACTC1,TNNC1,MYL2,MYL3, andTPM1was designated, followed by NGS with the Ion Torrent PGM (Life Technologies).
Proteomic Analysis of Human Fetal Atria and Ventricle.
New
Gramolini et al., In J Proteome Res, 17 Nov 2014
Several previously characterised cardiac chamber-enriched proteins were identified in this study including atrial isoform of myosin light chain 2 (MYL7), atrial natriuretic peptide (NPPA), connexin 40 (GJA5), and peptidylglycine alpha-amidating monooxygenase (PAM) for atria, and ventricular isoforms of myosin light chains (MYL2 and MYL3), myosin heavy chain 7 (MYH7), and connexin 43 (GJA1) for ventricle.
O-GlcNAcylation, contractile protein modifications and calcium affinity in skeletal muscle.
Review
New
Bastide et al., Lille, France. In Front Physiol, Dec 2013
In particular, the O-GlcNAcylation level of the phosphoprotein myosin light chain 2 seems to be crucial in the modulation of the calcium activation properties, and should be responsible for changes in calcium properties observed in functional atrophy.
PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.
New
Lu et al., Houston, United States. In Nat Commun, Dec 2013
Here, we found that Aurora B phosphorylates PKM2, but not PKM1, at T45; this phosphorylation is required for PKM2's localization and interaction with myosin light chain 2 (MLC2) in the contractile ring region of mitotic cells during cytokinesis.
The Actin Targeting Compound Chondramide Inhibits Breast Cancer Metastasis via Reduction of Cellular Contractility.
New
Zahler et al., München, Germany. In Plos One, Dec 2013
On the signaling level, RhoA activity is decreased by Chondramide accompanied by reduced MLC-2 and the stretch induced guanine nucleotide exchange factor Vav2 activation.
Molecular pathways: MERTK signaling in cancer.
Review
New
Graham et al., Chapel Hill, United States. In Clin Cancer Res, Nov 2013
These include the mitogen-activated protein kinase and phosphoinositide 3-kinase pathways, as well as regulation of signal transducer and activator of transcription family members, migration-associated proteins including the focal adhesion kinase and myosin light chain 2, and prosurvival proteins such as survivin and Bcl-2.
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.
New
Impact
Sahai et al., London, United Kingdom. In Nat Cell Biol, Jun 2013
YAP regulates the expression of several cytoskeletal regulators, including ANLN and DIAPH3, and controls the protein levels of MYL9 (also known as MLC2).
Intracellular regulation of matrix metalloproteinase-2 activity: new strategies in treatment and protection of heart subjected to oxidative stress.
Review
Sawicki, Saskatoon, Canada. In Scientifica (cairo), 2012
One such mechanism involves the proteolytic degradation of contractile proteins, such as troponin I (TnI), myosin heavy chain, titin, and the myosin light chains (MLC1 and MLC2) by matrix metalloproteinase-2 (MMP-2).
Biochemical and physiological regulation of cardiac myocyte contraction by cardiac-specific myosin light chain kinase.
Review
Kitakaze et al., Ōsaka, Japan. In Circ J, 2012
Cardiac-specific myosin light chain kinase (cMLCK) is the kinase predominantly responsible for the maintenance of the basal level of phosphorylation of cardiac myosin light chain 2 (MLC2), which it phosphorylates at Ser-15.
Gene duplication and conversion events shaped three homologous, differentially expressed myosin regulatory light chain (MLC2) genes.
GeneRIF
Wansink et al., Nijmegen, Netherlands. In Eur J Cell Biol, 2012
MLC2 isoforms play a role in tumorigenesis.
AMPK regulates mitotic spindle orientation through phosphorylation of myosin regulatory light chain.
GeneRIF
Marcus et al., Atlanta, United States. In Mol Cell Biol, 2012
AMPK mediates spindle pole-associated pMRLC(ser19) to control spindle orientation via regulation of actin cortex-astral microtubule attachments
Effect of selenium on the interaction between daunorubicin and cardiac myosin.
GeneRIF
Wang et al., Wuhan, China. In Biol Trace Elem Res, 2012
Results show that the binding force between selenium and cardiac myosin (CM), which consists of two heavy chains (MHC) and two pairs of light chains: MLC1 and MLC2, was 100 times stronger than that of daunorubicin (DNR) and CM.
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.
GeneRIF
Chen et al., Los Angeles, United States. In J Clin Invest, 2012
Mlc2 phosphorylation regulates actin-myosin interactions in striated muscle contraction. It is important for feedback control of calcium-dependent thin-filament activation. Dephosphorylation can play a critical role in heart failure.
Smooth muscle myosin light chain kinase efficiently phosphorylates serine 15 of cardiac myosin regulatory light chain.
GeneRIF
Ajtai et al., Rochester, United States. In Biochem Biophys Res Commun, 2012
These data demonstrate that smMLCK is a specific and efficient kinase for the in vitro phosphorylation of MYL2, cardiac, and smooth muscle myosin.
Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis.
Impact
Treisman et al., London, United Kingdom. In Nat Cell Biol, 2009
Two of these, MYH9 (NMHCIIa) and MYL9 (MLC2), are also required for invasion and lung colonization.
The slow force response to stretch in atrial and ventricular myocardium from human heart: functional relevance and subcellular mechanisms.
Review
Pieske et al., Graz, Austria. In Prog Biophys Mol Biol, 2008
Furthermore, stretch increased phosphorylation of atrial myosin light chain 2 (MLC2) and inhibition of myosin light chain kinase (MLCK) attenuated the SFR in atrium and ventricle.
Shared genetic causes of cardiac hypertrophy in children and adults.
Impact
Seidman et al., Boston, United States. In N Engl J Med, 2008
We sequenced eight genes: MYH7, MYBPC3, TNNT2, TNNI3, TPM1, MYL3, MYL2, and ACTC.
Energy-dependent regulation of cell structure by AMP-activated protein kinase.
Impact
Chung et al., Taejŏn, South Korea. In Nature, 2007
Interestingly, the regulatory site of non-muscle myosin regulatory light chain (MRLC; also known as MLC2) was directly phosphorylated by AMPK.
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