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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Myosin, light chain 2, regulatory, cardiac, slow

myosin light chain 2, MLC2v, MLC2, MYL2
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using myosin light chain 2 antibodies
Tea flavonoids and cardiovascular health.
Supplier
Zhang Baohong, In PLoS ONE, 2009
... Rabbit anti-MLC2 (FL-172) antibody (against whole MRLC) was obtained from Santa Cruz Biotechnology, Inc ...
Domain analysis of alpha-actinin reveals new aspects of its association with F-actin during cytokinesis.
Supplier
Hotchin Neil A., In PLoS ONE, 2009
... Polyclonal MLC2 antibody (catalog #: 3672) was purchased from Cell Signaling (Danvers, MA) ...
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions.
Supplier
Parsons Maddy, In PLoS ONE, 2008
... anti-β1 integrin (BD Biosciences); mouse anti-alpha tubulin, rabbit anti-calnexin and rabbit anti-fibronectin (Sigma Aldrich); rabbit anti-phospho-myosin light chain 2 (Ser19) (Cell Signaling Technology, Inc., Danvers, MA), ...
PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells
Supplier
Bourne Henry R. et al., In The Journal of Cell Biology, 2004
... Mouse monoclonal antibody against myosin light chain 2 phosphorylated at S19 (p-MLC2) was from Cell Signaling Technology ...
Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts.
Supplier
Rutherford Suzannah, In PLoS ONE, 2002
... MLC2v-Cre/ZEG double heterozygous transgenic mice were generated by ...
Papers on myosin light chain 2
AMPK regulates mitotic spindle orientation through phosphorylation of myosin regulatory light chain.
GeneRIF
Marcus et al., Atlanta, United States. In Mol Cell Biol, 2012
AMPK mediates spindle pole-associated pMRLC(ser19) to control spindle orientation via regulation of actin cortex-astral microtubule attachments
Gene duplication and conversion events shaped three homologous, differentially expressed myosin regulatory light chain (MLC2) genes.
GeneRIF
Wansink et al., Nijmegen, Netherlands. In Eur J Cell Biol, 2012
MLC2 isoforms play a role in tumorigenesis.
Effect of selenium on the interaction between daunorubicin and cardiac myosin.
GeneRIF
Wang et al., Wuhan, China. In Biol Trace Elem Res, 2012
Results show that the binding force between selenium and cardiac myosin (CM), which consists of two heavy chains (MHC) and two pairs of light chains: MLC1 and MLC2, was 100 times stronger than that of daunorubicin (DNR) and CM.
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.
GeneRIF
Chen et al., Los Angeles, United States. In J Clin Invest, 2012
Mlc2 phosphorylation regulates actin-myosin interactions in striated muscle contraction. It is important for feedback control of calcium-dependent thin-filament activation. Dephosphorylation can play a critical role in heart failure.
Smooth muscle myosin light chain kinase efficiently phosphorylates serine 15 of cardiac myosin regulatory light chain.
GeneRIF
Ajtai et al., Rochester, United States. In Biochem Biophys Res Commun, 2012
These data demonstrate that smMLCK is a specific and efficient kinase for the in vitro phosphorylation of MYL2, cardiac, and smooth muscle myosin.
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