Capping protein regulators fine-tune actin assembly dynamics.
Saint Louis, United States. In Nat Rev Mol Cell Biol, 2014
These proteins, including CARMIL (capping protein, ARP2/3 and myosin I linker), CD2AP (CD2-associated protein) and the WASH (WASP and SCAR homologue) complex subunit FAM21, recruit CP to specific subcellular locations and modulate its actin-capping activity via allosteric effects.
Myosin I can act as a molecular force sensor.
Philadelphia, United States. In Science, 2008
Sensing molecular tension is crucial for a wide array of cellular processes. Myosin I dramatically alters its motile properties in response to tension.