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Myosin IC

myosin I, NMI
This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, CAN, ATPase, ACID, V1a
Papers on myosin I
CARMIL2 is a novel molecular connection between vimentin and actin essential for cell migration and invadopodia formation.
Cooper et al., Saint Louis, United States. In Mol Biol Cell, Jan 2016
We report here that CARMIL2 (capping protein, Arp2/3, myosin-I linker 2) provides such a molecular link.
Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing.
Kwiatkowski et al., Cincinnati, United States. In Plos Genet, Nov 2015
10-15% of TSC individuals have no mutation identified (NMI) after thorough conventional molecular diagnostic assessment.
Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegans.
Hardin et al., Madison, United States. In Development, Nov 2015
Further, we identify a novel polarizing cue, CRML-1, which is the ortholog of human capping Arp2/3 myosin I linker (CARMIL), that localizes to the nonprotrusive lateral edges of dorsal cells.
The prognostic significance of p53, p63 and her2 expression in non-muscle-invasive bladder cancer in relation to treatment with bacille Calmette-Guerin.
Hegazy et al., Cairo, Egypt. In Arab J Urol, Sep 2015
OBJECTIVE: To investigate whether the immunohistochemical expression of p53, p63 and her2/neu is correlated with the prognosis of tumour recurrence and progression in patients with non-muscle invasive (NMI) bladder cancer.
Myosin-II-mediated cell shape changes and cell intercalation contribute to primitive streak formation.
Weijer et al., Dresden, Germany. In Nat Cell Biol, Apr 2015
Use of class specific myosin inhibitors and gene-specific knockdown shows that apical contraction and intercalation are myosin II dependent and also reveal critical roles for myosin I and myosin V family members in the assembly of junctional myosin II cables.
Prognostic significance of survivin, β-catenin and p53 expression in urothelial carcinoma.
Aydin et al., İstanbul, Turkey. In Bosn J Basic Med Sci, 2014
We investigated the prognostic expressions of those biomarkers in UC (n=147) and in non-muscle invasive UC (NMI-UC) (n=113), using tissue microarray and immunohistochemistry. Spearman's correlation analysis and multivariate Cox regression analyses were used for statistical interpretation.
Capping protein regulators fine-tune actin assembly dynamics.
Cooper et al., Saint Louis, United States. In Nat Rev Mol Cell Biol, 2014
These proteins, including CARMIL (capping protein, ARP2/3 and myosin I linker), CD2AP (CD2-associated protein) and the WASH (WASP and SCAR homologue) complex subunit FAM21, recruit CP to specific subcellular locations and modulate its actin-capping activity via allosteric effects.
Down-regulated claudin-7 immunoexpression in urothelial carcinoma of the urinary bladder.
Kanayama et al., Asyūţ, Egypt. In Arab J Urol, 2013
MATERIALS AND METHODS: This study included 68 specimens of UC of the bladder, comprising 35 with non-muscle-invasive (NMI), stage Ta-T1, and 33 with muscle-invasive (MI) tumours, T2-T4, and 26 of normal urothelium (NU).
Regulation and control of myosin-I by the motor and light chain-binding domains.
Ostap et al., Philadelphia, United States. In Trends Cell Biol, 2013
Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes.
CKIP-1: a scaffold protein and potential therapeutic target integrating multiple signaling pathways and physiological functions.
Zhang et al., Beijing, China. In Ageing Res Rev, 2013
The PH domain-containing casein kinase 2 interacting protein-1 (CKIP-1, also known as PLEKHO1) acts as a scaffold protein mediating interactions with multiple proteins, including CK2α, CPα, AP-1/c-Jun, Akt, ATM, IFP35/Nmi and Smurf1.
Wearing of complete dentures reduces slow fibre and enhances hybrid fibre fraction in masseter muscle.
Eržen et al., Ljubljana, Slovenia. In J Oral Rehabil, 2012
adaptive response to reduced masticatory load was lower numerical and area proportion of MyHC-1 expressing fibres and higher numerical proportion of hybrid fibres in edentulous compared with dentate subjects
Combining molecular and pathologic data to prognosticate non-muscle-invasive bladder cancer.
van Rhijn, Amsterdam, Netherlands. In Urol Oncol, 2012
Non-muscle-invasive (NMI) bladder cancer (BC) is a chronic disease with varying oncologic outcomes requiring frequent follow-up and repeated treatments.
Myosin heavy chain composition of the human genioglossus muscle.
Sokoloff et al., Atlanta, United States. In J Speech Lang Hear Res, 2012
The human genioglossus muscle is composed of conventional myosin heavy chain isoforms and 3 primary myosin heavy chain phenotypes.
The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.
Ling et al., Malmö, Sweden. In Mol Genet Metab, 2011
the expression levels of the MHC genes are associated with age and both PGC-1alpha and PGC-1beta and indicate that the MHC genes may to some extent be used to determine fibre-type composition in human skeletal muscle.
Myosin 1b promotes the formation of post-Golgi carriers by regulating actin assembly and membrane remodelling at the trans-Golgi network.
Coudrier et al., Paris, France. In Nat Cell Biol, 2011
Actin and myosin 1 regulate organelle shape and uncover an important function for myosin 1b in the initiation of post-Golgi carrier formation by regulating actin assembly and remodelling trans-Golgi network membranes.
Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane.
Nihalani et al., Philadelphia, United States. In Mol Cell Biol, 2011
Myo1c plays a critical role in the translocation of Neph1 complexes in podocytes. Myo1c's ability to interact with membranes, F-actin, Neph1, and nephrin indicates that it actively contributes to the dynamic organization of the filtration slit.
Nuclear spectrin-like proteins are structural actin-binding proteins in plants.
Moreno Díaz de la Espina et al., Madrid, Spain. In Biol Cell, 2011
BACKGROUND INFORMATION: Although actin is a relevant component of the plant nucleus, only three nuclear ABPs (actin-binding proteins) have been identified in plants to date: cofilin, profilin and nuclear myosin I.
Myosin I can act as a molecular force sensor.
Ostap et al., Philadelphia, United States. In Science, 2008
Sensing molecular tension is crucial for a wide array of cellular processes. Myosin I dramatically alters its motile properties in response to tension.
Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules.
Fu et al., San Diego, United States. In Cell, 2008
Here, we report that ligand induces rapid interchromosomal interactions among subsets of estrogen receptor alpha-bound transcription units, with a dramatic reorganization of nuclear territories requiring nuclear actin/myosin-I transport machinery, dynein light chain 1 (DLC1), and a specific subset of transcriptional coactivators and chromatin remodeling complexes.
Apoptin: therapeutic potential of an early sensor of carcinogenic transformation.
Noteborn et al., Leiden, Netherlands. In Annu Rev Pharmacol Toxicol, 2007
Apoptin targets include DEDAF, Nur77, Nmi, Hippi, and the potential drug target APC1.
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