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Myosin, heavy chain 2, skeletal muscle, adult

myosin heavy chain IIA, MYH2, MyHC-IIa, myosin-2, MHC-2a
Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009] (from NCBI)
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Top mentioned proteins: IIa, Actin, MHA, FasT, HAD
Papers on myosin heavy chain IIA
Effects of intergenic single nucleotide polymorphisms in the fast myosin heavy chain cluster on muscle fiber characteristics and meat quality in Berkshire pigs.
Hong et al., Seoul, South Korea. In Meat Sci, Dec 2015
The fast MyHC gene cluster on porcine chromosome 12 contains MYH2, MYH1, and MYH4, which encode three fast MyHC isoforms expressed in adult skeletal muscle.
Early effect of Botox-A injection into the masseter muscle of rats: functional and histological evaluation.
Kim et al., Seoul, South Korea. In Maxillofac Plast Reconstr Surg, Dec 2015
All animals were sacrificed at 14 days after BTX injection, and the specimens underwent hematoxylin and eosin stain and immunohistochemical staining for myosin type II (MYH2).
Modeling the roles of protein kinase Cβ and η in single-cell wound repair.
Edelstein-Keshet et al., Melbourne, Australia. In Mol Biol Cell, Dec 2015
Wounded cells such as Xenopus oocytes respond to damage by assembly and closure of an array of actin filaments and myosin-2 controlled by Rho GTPases, including Rho and Cdc42.
Nonmuscle myosin heavy chain IIA mediates Epstein-Barr virus infection of nasopharyngeal epithelial cells.
Zeng et al., Guangzhou, China. In Proc Natl Acad Sci U S A, Oct 2015
We also identified nonmuscle myosin heavy chain IIA (NMHC-IIA) as another NPEC protein important for efficient EBV infection.
MYH9 nephropathy.
Young Lee et al., Ch'ŏnan, South Korea. In Kidney Res Clin Pract, Mar 2015
MYH9-related disorder is an autosomal dominant disease caused by a mutation in the MYH9 gene, which encodes nonmuscle myosin heavy chain IIA (NMMHC-IIA).
Oxidative stress participates in quadriceps muscle dysfunction during the initiation of osteoarthritis in rats.
Jou et al., Tainan City, Taiwan. In Int J Clin Exp Pathol, 2014
Quadriceps muscle dysfunction was evaluated by assessing muscular interleukin-6, citrate synthase activity, and myosin heavy chain IIa mRNA expression levels.
Developmental MYH3 Myopathy Associated with Expression of Mutant Protein and Reduced Expression Levels of Embryonic MyHC.
Tajsharghi et al., Göteborg, Sweden. In Plos One, 2014
Involvement of the ubiquitin proteasome system was investigated in patients with p.Thr178Ile mutations in MYH3 and MYH2.
Association of a novel in-frame deletion mutation of the MYH9 gene with end-stage renal failure: case report and review of the literature.
Kunishima et al., In Clin Nephrol, 2013
These diseases are caused by mutations in the MYH9 gene that encodes nonmuscle myosin heavy chain IIA.
Nonmuscle myosin-2: mix and match.
Manstein et al., Hannover, Germany. In Cell Mol Life Sci, 2013
Members of the nonmuscle myosin-2 (NM-2) family of actin-based molecular motors catalyze the conversion of chemical energy into directed movement and force thereby acting as central regulatory components of the eukaryotic cytoskeleton.
Myosinopathies: pathology and mechanisms.
Oldfors et al., Göteborg, Sweden. In Acta Neuropathol, 2013
Dominant or recessive mutations affecting the type IIa MyHC (MYH2) are associated with early-onset myopathies with variable muscle weakness and ophthalmoplegia as a consistent finding.
Myosin heavy chain composition of the human genioglossus muscle.
Sokoloff et al., Atlanta, United States. In J Speech Lang Hear Res, 2012
The human genioglossus muscle is composed of conventional myosin heavy chain isoforms and 3 primary myosin hevy chain phenotypes.
Effects of ageing and endurance exercise training on alpha-actinin isoforms in rat plantaris muscle.
Akema et al., Kawasaki, Japan. In Acta Physiol (oxf), 2011
After physical training, the proportion of type IIb MyHC was lower in old animals than in adult animals. Endurance training produced a fast-to-slow shift within type II MyHC isoforms in both adult and old animals.
The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.
Ling et al., Malmö, Sweden. In Mol Genet Metab, 2011
the expression levels of the MHC genes are associated with age and both PGC-1alpha and PGC-1beta and indicate that the MHC genes may to some extent be used to determine fibre-type composition in human skeletal muscle.
MYH9 related platelet disorders - often unknown and misdiagnosed.
Greinacher et al., Greifswald, Germany. In Klin Padiatr, 2011
Located on chromosome 22, the MYH9 gene encodes the motorprotein non-muscular myosin heavy chain IIA (NMMHCIIA).
Overexpression of myosin-IIB in the brain of a rat model of streptozotocin-induced diabetes.
Espindola et al., Uberlândia, Brazil. In J Neurol Sci, 2011
myosin-IIB protein and mRNA are expressed at high levels in diabetic brains
Correlation of dysfunction of nonmuscle myosin IIA with increased induction of Cyp1a1 in Hepa-1 cells.
Kikuchi et al., Morioka, Japan. In Biochim Biophys Acta, 2011
Increase of CYP1A1-mRNA was due to nonmuscle myosin II inhibition.
Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1.
Kawaguchi et al., Tokyo, Japan. In Nature, 2010
Here we show that non-muscle myosin heavy chain IIA (NMHC-IIA), a subunit of non-muscle myosin IIA (NM-IIA), functions as an HSV-1 entry receptor by interacting with gB.
Advances in the understanding of MYH9 disorders.
Saito et al., Nagoya, Japan. In Curr Opin Hematol, 2010
PURPOSE OF REVIEW: MYH9 disorders are autosomal dominant macrothrombocytopenias with leukocyte inclusion bodies caused by mutations in MYH9, the gene for the nonmuscle myosin heavy chain IIA.
Regulation of cytokinesis by Rho GTPase flux.
Bement et al., Madison, United States. In Nat Cell Biol, 2009
In animal cells, cytokinesis is powered by a contractile ring of actin filaments (F-actin) and myosin-2.
A single class II myosin modulates T cell motility and stopping, but not synapse formation.
Krummel et al., San Francisco, United States. In Nat Immunol, 2004
Here we show that nonmuscle myosin heavy chain IIA, or MyH9, is the only class II myosin expressed in T cells and is associated with the uropod during crawling.
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