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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


Myopalladin, MYPN
Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: CARP, titin, V1a, Desmin, hAM
Papers on Myopalladin
Targeted next-generation sequencing of candidate genes reveals novel mutations in patients with dilated cardiomyopathy.
Xia et al., Kunming, China. In Int J Mol Med, Dec 2015
The candidate genes that may cause DCM include MYBPC3, MYH6, MYH7, LMNA, TNNT2, TNNI3, MYPN, MYL3, TPM1, SCN5A, DES, ACTC1 and RBM20.
Disturbance in Z-disk mechanosensitive proteins induced by a persistent mutant myopalladin causes familial restrictive cardiomyopathy.
Purevjav et al., Tokyo, Japan. In J Am Coll Cardiol, 2015
Myopalladin (MYPN) is a messenger molecule that links structural and gene regulatory molecules via translocation from the Z-disk and I-bands to the nucleus in cardiomyocytes.
SNPs of MYPN and TTN genes are associated to meat and carcass traits in Italian Large White and Italian Duroc pigs.
Russo et al., Reggio nell'Emilia, Italy. In Mol Biol Rep, 2013
Myopalladin (MYPN) and titin (TTN) play key roles in skeletal muscle structural organisation and for this reason they may be functional candidates for meat production traits in pigs.
Novel mutations in the sarcomeric protein myopalladin in patients with dilated cardiomyopathy.
German Competence Network Heart Failure et al., Göttingen, Germany. In Eur J Hum Genet, 2013
The objective of this study was to search for novel disease-associated mutations in the two human titin-binding proteins myopalladin and its amino-terminal-interacting partner cardiac ankyrin-repeat protein (CARP).
Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations.
Towbin et al., Cincinnati, United States. In Hum Mol Genet, 2012
Two nonsense and 13 missense MYPN variants were identified in subjects with hypertrophic, dilated and/or restrictive cardiomyopathy.
Analysis of the Z-disc genes PDLIM3 and MYPN in patients with hypertrophic cardiomyopathy.
Semsarian et al., In Int J Cardiol, 2011
mutations in PDLIM3 and MYPN are infrequent in hypertrophic cardiomyopathies
A novel polymorphism of the MYPN gene and its association with meat quality traits in Bos taurus.
Guo et al., China. In Genet Mol Res, 2009
Myopalladin (MYPN) is a multifunctional protein that maintains sarcomeric integrity and regulates Z-line structure.
Effect of botulinum toxin A-induced paralysis and exercise training on mechanosensing and signalling gene expression in juvenile rat gastrocnemius muscle.
Smith et al., Auckland, New Zealand. In Exp Physiol, 2008
Tcap, Myopalladin and Atrogin1 were not, or were no longer responsive to the altered mechanical stimuli after 3 weeks of Btx or Ex.
Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy.
Villard et al., Paris, France. In Cardiovasc Res, 2008
myopalladin gene is a new gene associated with dilated cardiomyopathy and observed mutations in 3-4% of cases in a population. of European descent.
Associations of functional candidate genes derived from gene-expression profiles of prenatal porcine muscle tissue with meat quality and muscle deposition.
Ponsuksili et al., Germany. In Anim Genet, 2007
Ten genes (ANK1, bR10D1, CA3, EPOR, HMGA2, MYPN, NME1, PDGFRA, ERC1, TTN), whose candidacy for meat-quality and carcass traits arises from their differential expression in prenatal muscle development, were examined for association in 1700 performance-tested fattening pigs of commercial purebred and crossbred herds of Duroc, Pietrain, Pietrain x (Landrace x Large White), Duroc x (Landrace x Large White) as well as in an experimental F(2) population based on a reciprocal cross of Duroc and Pietrain.
Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin.
Wang et al., Bethesda, United States. In Febs Lett, 2003
myopalladin plays a signaling role in targeting and orienting nebulin during sarcomere assembly
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