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Myogenic differentiation 1

MyoD, MyoD1
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Myogenin, CAN, Myf5, PAX7, HAD
Papers using MyoD antibodies
A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss
Dhar M. S. et al., In Journal of Nutrition and Metabolism, 2010
... MyoD and Atp10c were from Qiagen (Valencia, CA) ...
Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient mice.
Agarwal Sudha, In PLoS ONE, 2009
... , and MyoD-hBcl-2 transgenic mice that overexpress human ...
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2
Chen Jie et al., In The Journal of Cell Biology, 2006
... The antibodies were obtained from the following sources: anti-tubulin was obtained from Abcam, anti-MyoD (5.8A) was obtained from Imgenex, antibodies against HDAC4, mTOR, ...
Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population
Simon András et al., In The Journal of Cell Biology, 2003
... Invitrogen), rabbit polyclonal anti-H3P antibody (Upstate Biotechnology), rat monoclonal anti-BrdU IgG (Trichem ApS), rabbit polyclonal anti-MyoD antibody (Santa Cruz Biotechnology, Inc.), anti-WE3 monoclonal IgG ...
The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure
Martins-Green Manuela et al., In The Journal of Cell Biology, 1998
... used were: anti–α-SMA (Sigma-Aldrich); anti-TGFβ 1,2,3 (R&D Systems); antivimentin, antidesmin, antimyosin heavy chain (Hybridoma Bank); anti-myoD (Santa Cruz Biotechnology, Inc.); anti–mouse horseradish peroxidase, ...
Papers on MyoD
Exercise training alters DNA-methylation patterns in genes related to muscle growth and differentiation in mice.
Schürmann et al., Potsdam, Germany. In Am J Physiol Endocrinol Metab, 24 Apr 2015
Interestingly, a transcription factor binding site enrichment study discovered significantly enriched occurrence of CpG methylation in the binding sites of the myogenic regulatory factors MyoD and myogenin.
Oncofetal expression of Wilms' tumor 1 (WT1) protein in human fetal, adult and neoplastic skeletal muscle tissues.
Parenti et al., Catania, Italy. In Acta Histochem, 20 Apr 2015
The comparative evaluation of the immunohistochemical findings revealed that WT1 cytoplasmic expression in rhabdomyosarcoma may represent an ontogenetic reversal, and this nuclear transcription factor can also be considered an oncofetal protein which can be exploitable as an additional, highly sensitive immunomarker, together with desmin, myogenin and MyoD1, of this tumor.
Apoptosis and differentiation of Xenopus tail-derived myoblasts by thyroid hormone.
Ito et al., Sagamihara, Japan. In J Mol Endocrinol, 19 Apr 2015
Interestingly, the T3 treatment also enhanced myoD transcripts, but decreased the amounts of myogenin mRNA and myosin heavy chain.
Klhl31 attenuates β-catenin dependent Wnt signaling and regulates embryo myogenesis.
Münsterberg et al., Norwich, United Kingdom. In Dev Biol, 18 Apr 2015
The knock-down of Klhl31 in developing somites, using antisense morpholinos (MO), led to an expansion of Pax3, Myf5, MyoD and myogenin expression domains and an increase in the number of mitotic cells in the dermomyotome and myotome.
Conversion of MyoD to a Neurogenic Factor: Binding Site Specificity Determines Lineage.
Tapscott et al., Seattle, United States. In Cell Rep, 17 Apr 2015
UNASSIGNED: MyoD and NeuroD2, master regulators of myogenesis and neurogenesis, bind to a "shared" E-box sequence (CAGCTG) and a "private" sequence (CAGGTG or CAGATG, respectively).
Intracellular inactivation of thyroid hormone is a survival mechanism for muscle stem cell proliferation and lineage progression.
Salvatore et al., Napoli, Italy. In Cell Metab, Jan 2015
The execution of this proapoptotic program requires an intact FoxO3/MyoD axis, both genes positively regulated by intracellular TH.
The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.
Camargo et al., Boston, United States. In Cancer Cell, Sep 2014
YAP1-TEAD1 upregulate pro-proliferative and oncogenic genes and maintain the ERMS differentiation block by interfering with MYOD1 and MEF2 pro-differentiation activities.
Primary cutaneous epithelioid rhabdomyosarcoma: a rare, recently described entity with review of the literature.
Billings et al., Cleveland, United States. In J Cutan Pathol, Jul 2014
By immunohistochemistry, tumor cells were diffusely and strongly positive for desmin and MYOD1.
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.
Ladanyi et al., New York City, United States. In Nat Genet, Jun 2014
Whereas ARMS tumors typically contain translocations generating PAX3-FOXO1 or PAX7-FOXO1 fusions that block terminal myogenic differentiation, no functionally comparable genetic event has been found in ERMS tumors.
Gene regulatory networks and transcriptional mechanisms that control myogenesis.
Rigby et al., Paris, France. In Dev Cell, Mar 2014
Myogenic determination and subsequent differentiation depend on members of the MyoD family.
Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature.
Kalfarentzos et al., Shanghai, China. In World J Surg Oncol, 2013
Tumor cells were negative for muscle-specific actin, epithelial membrane antigen, smooth muscle actin, cytokeratin pan, S100, desmin, glial fibrillary acidic protein, myogenin, MyoD1 and F8.
[Interactions of proliferation and differentiation signaling pathways in myogenesis].
Grzelkowska-Kowalczyk et al., Warsaw, Poland. In Postepy Hig Med Dosw (online), 2013
Conversely, the myogenic factor MyoD seems to cooperate with cell cycle inhibitors leading to inhibition of cell cycle progress and commitment to the differentiation process.
[Regulation of differentiation of mesenchymal stem cells by the Hippo pathway effectors TAZ/YAP].
Teng et al., Harbin, China. In Yi Chuan, 2013
It has been reported that the lineage-specific transcriptional factors including Runt related transcription factor 2 (RUNX2), Peroxisome proliferator-activator receptor gamma (PPARgamma) and Myogenic differentiation 1 (MyoD) may play key regulatory roles among the differentiation of MSCs.
Coordination of satellite cell activation and self-renewal by Par-complex-dependent asymmetric activation of p38α/β MAPK.
Olwin et al., Boulder, United States. In Cell Stem Cell, 2012
Asymmetric localization of the Par complex activates p38α/β MAPK in only one daughter cell, inducing MyoD, which permits cell cycle entry and generates a proliferating myoblast.
Interplay between two myogenesis-related proteins: TBP-interacting protein 120B and MyoD.
Tamura et al., Chiba, Japan. In Gene, 2012
results suggest that MyoD and TIP120B potentiate each other at gene expression and post-translation levels, respectively, which may promote myogenesis cooperatively
Snail regulates MyoD binding-site occupancy to direct enhancer switching and differentiation-specific transcription in myogenesis.
Rudnicki et al., Ottawa, Canada. In Mol Cell, 2012
In primary myoblasts, snail-HDAC1/2 repressive complex binds and excludes MyoD from its targets.
Myo/Nog cells in normal, wounded and tumor-bearing skin.
George-Weinstein et al., In Exp Dermatol, 2012
Myo/Nog cells are the primary source of noggin in telogen hair follicles.
Muscle function and running activity in mouse models of hereditary muscle dystrophy: impact of double knockout for dystrophin and the transcription factor MyoD.
Gielen et al., Leipzig, Germany. In Muscle Nerve, 2012
mdx:myoD(-/-) is not a suitable model to study exercise-induced effects on dystrophic muscles
Finding MyoD with a little help from my friends.
Lassar, Boston, United States. In Nat Cell Biol, 2012
Findings indicate that MyoD activates the expression of other muscle regulators such as MEF2 and myogenin, which are necessary for induction of the skeletal muscle differentiation program.
Polycomb-repressed genes have permissive enhancers that initiate reprogramming.
Jones et al., Los Angeles, United States. In Cell, 2012
Using MYOD1, study shows that an nucleosome-depleted region at the minimal enhancer region allows reprogramming to be initiated, which occurs in response to signals such as the forced expression of Myod1 in fibroblasts.
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