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Myogenic differentiation 1

MyoD, MyoD1
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Myogenin, CAN, Myf5, PAX7, HAD
Papers using MyoD antibodies
A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss
Supplier
Dhar M. S. et al., In Journal of Nutrition and Metabolism, 2010
... MyoD and Atp10c were from Qiagen (Valencia, CA) ...
Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient mice.
Supplier
Agarwal Sudha, In PLoS ONE, 2009
... , and MyoD-hBcl-2 transgenic mice that overexpress human ...
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2
Supplier
Chen Jie et al., In The Journal of Cell Biology, 2006
... The antibodies were obtained from the following sources: anti-tubulin was obtained from Abcam, anti-MyoD (5.8A) was obtained from Imgenex, antibodies against HDAC4, mTOR, ...
Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population
Supplier
Simon András et al., In The Journal of Cell Biology, 2003
... Invitrogen), rabbit polyclonal anti-H3P antibody (Upstate Biotechnology), rat monoclonal anti-BrdU IgG (Trichem ApS), rabbit polyclonal anti-MyoD antibody (Santa Cruz Biotechnology, Inc.), anti-WE3 monoclonal IgG ...
The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure
Supplier
Martins-Green Manuela et al., In The Journal of Cell Biology, 1998
... used were: anti–α-SMA (Sigma-Aldrich); anti-TGFβ 1,2,3 (R&D Systems); antivimentin, antidesmin, antimyosin heavy chain (Hybridoma Bank); anti-myoD (Santa Cruz Biotechnology, Inc.); anti–mouse horseradish peroxidase, ...
Papers on MyoD
Expression of myogenic regulatory factors in chicken embryos during somite and limb development.
New
Sweetman et al., Nottingham, United Kingdom. In J Anat, 16 Aug 2015
UNASSIGNED: The expression of the myogenic regulatory factors (MRFs), Myf5, MyoD, myogenin (Mgn) and MRF4 have been analysed during the development of chicken embryo somites and limbs.
G1/S Inhibitors and the SWI/SNF Complex Control Cell-Cycle Exit during Muscle Differentiation.
New
Impact
van den Heuvel et al., Utrecht, Netherlands. In Cell, 16 Aug 2015
Further genetic analyses support that SWI/SNF acts in concert with hlh-1 MyoD, antagonizes Polycomb-mediated transcriptional repression, and suppresses cye-1 Cyclin E transcription to arrest cell division of muscle precursors.
Intracellular inactivation of thyroid hormone is a survival mechanism for muscle stem cell proliferation and lineage progression.
New
Impact
Salvatore et al., Napoli, Italy. In Cell Metab, Jan 2015
The execution of this proapoptotic program requires an intact FoxO3/MyoD axis, both genes positively regulated by intracellular TH.
Epithelioid inflammatory myofibroblastic sarcoma with recurrence after extensive resection: significant clinicopathologic characteristics of a rare aggressive soft tissue neoplasm.
New
Zhao et al., Zhengzhou, China. In Int J Clin Exp Pathol, Dec 2014
They were positive for ALK, Desmin, SMA, CD30, but negative for AE1/AE3, LCA, CD2, CD3, CD5, CD7, S-100, CD34, CD31, EMA, MyoD1, and myogenin.
Acupuncture plus Low-Frequency Electrical Stimulation (Acu-LFES) Attenuates Diabetic Myopathy by Enhancing Muscle Regeneration.
New
Wang et al., Wenzhou, China. In Plos One, Dec 2014
The expression of Pax7, MyoD, myogenin and embryo myosin heavy chain (eMyHC) was significantly decreased in diabetic muscle vs. control muscle.
TIPS to manipulate myogenesis: retention of myoblast differentiation capacity using microsphere culture.
New
Day et al., London, United Kingdom. In Eur Cell Mater, Dec 2014
Switching from proliferation medium to differentiation medium for 7 days, resulted in increased protein expression of skeletal muscle cell contractile apparatus components, MyoD and skeletal muscle myosin heavy chain, compared with cells cultured on conventional culture plasticware for the same duration (p < 0.001).
Network Analysis for the Identification of Differentially Expressed Hub Genes Using Myogenin Knock-down Muscle Satellite Cells.
New
Choi et al., Kyŏngsan, South Korea. In Plos One, Dec 2014
Muscle, a multinucleate syncytium formed by the fusion of mononuclear myoblasts, arises from quiescent progenitors (satellite cells) via activation of muscle-specific transcription factors (MyoD, Myf5, myogenin: MYOG, and MRF4).
Role of skeletal muscle in mandible development.
Review
New
Kablar et al., Halifax, Canada. In Histol Histopathol, Nov 2014
Previous analysis of Myf5-/-:MyoD-/- mouse fetuses lacking skeletal muscle demonstrated the importance of muscle contraction and static loading in mouse skeletogenesis.
SMYD proteins: key regulators in skeletal and cardiac muscle development and function.
Review
New
Zhang et al., Baltimore, United States. In Anat Rec (hoboken), Sep 2014
Smyd1 is specifically expressed in muscle cells under the regulation of myogenic transcriptional factors of the MyoD and Mef2 families and the serum responsive factor.
The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.
New
Impact
Camargo et al., Boston, United States. In Cancer Cell, Sep 2014
YAP1-TEAD1 upregulate pro-proliferative and oncogenic genes and maintain the ERMS differentiation block by interfering with MYOD1 and MEF2 pro-differentiation activities.
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.
New
Impact
Ladanyi et al., New York City, United States. In Nat Genet, Jun 2014
Whereas ARMS tumors typically contain translocations generating PAX3-FOXO1 or PAX7-FOXO1 fusions that block terminal myogenic differentiation, no functionally comparable genetic event has been found in ERMS tumors.
DEC1/STRA13/SHARP2 and DEC2/SHARP1 coordinate physiological processes, including circadian rhythms in response to environmental stimuli.
Review
Noshiro et al., Hiroshima, Japan. In Curr Top Dev Biol, 2013
These DEC actions are mediated by the direct binding to the E-box elements in target genes or by protein-protein interactions with transcription factors such as HIF-1α, RXRα, MyoD, and STAT.
Molecular and cellular regulation of skeletal myogenesis.
Review
Tajbakhsh et al., Paris, France. In Curr Top Dev Biol, 2013
Since the seminal discovery of the cell-fate regulator Myod, studies in skeletal myogenesis have inspired the search for cell-fate regulators of similar potential in other tissues and organs.
[Reprogramming of somatic cells. Problems and solutions].
Review
Alenina et al., In Tsitologiia, 2013
The possibility of direct conversion of one differentiated cell type to another was first shown in the 80s of the last century in experiments on the conversion of fibroblasts into myoblasts by ectopic expression of the transcription factor MyoD. Surprisingly, this technology has remained unclaimed in cell biology for a long time.
Coordination of satellite cell activation and self-renewal by Par-complex-dependent asymmetric activation of p38α/β MAPK.
Impact
Olwin et al., Boulder, United States. In Cell Stem Cell, 2012
Asymmetric localization of the Par complex activates p38α/β MAPK in only one daughter cell, inducing MyoD, which permits cell cycle entry and generates a proliferating myoblast.
Interplay between two myogenesis-related proteins: TBP-interacting protein 120B and MyoD.
GeneRIF
Tamura et al., Chiba, Japan. In Gene, 2012
results suggest that MyoD and TIP120B potentiate each other at gene expression and post-translation levels, respectively, which may promote myogenesis cooperatively
Snail regulates MyoD binding-site occupancy to direct enhancer switching and differentiation-specific transcription in myogenesis.
GeneRIF
Rudnicki et al., Ottawa, Canada. In Mol Cell, 2012
In primary myoblasts, snail-HDAC1/2 repressive complex binds and excludes MyoD from its targets.
Myo/Nog cells in normal, wounded and tumor-bearing skin.
GeneRIF
George-Weinstein et al., In Exp Dermatol, 2012
Myo/Nog cells are the primary source of noggin in telogen hair follicles.
Muscle function and running activity in mouse models of hereditary muscle dystrophy: impact of double knockout for dystrophin and the transcription factor MyoD.
GeneRIF
Gielen et al., Leipzig, Germany. In Muscle Nerve, 2012
mdx:myoD(-/-) is not a suitable model to study exercise-induced effects on dystrophic muscles
Finding MyoD with a little help from my friends.
Impact
GeneRIF
Lassar, Boston, United States. In Nat Cell Biol, 2012
Findings indicate that MyoD activates the expression of other muscle regulators such as MEF2 and myogenin, which are necessary for induction of the skeletal muscle differentiation program.
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