Knockdown of Lmo7 inhibits chick myogenesis.
Rio de Janeiro, Brazil. In Febs Lett, Feb 2016
Knockdown of Lmo7 using siRNA specific to chick reduces the number and width of myotubes and the number of MyoD positive-myoblasts.
Reprogramming cells with synthetic proteins.
Guangzhou, China. In Asian J Androl, May 2015
Engineering approaches focused on Oct4, MyoD, Sox17, Nanog and Mef2c and range from chimeric TFs with added transactivation domains, designer transcription activator-like effectors to activate endogenous TFs to reprogramming TFs with rationally engineered DNA recognition principles.
[Reprogramming of somatic cells. Problems and solutions].
In Tsitologiia, 2013
The possibility of direct conversion of one differentiated cell type to another was first shown in the 80s of the last century in experiments on the conversion of fibroblasts into myoblasts by ectopic expression of the transcription factor MyoD. Surprisingly, this technology has remained unclaimed in cell biology for a long time.
Finding MyoD with a little help from my friends.
Boston, United States. In Nat Cell Biol, 2012
Findings indicate that MyoD activates the expression of other muscle regulators such as MEF2 and myogenin, which are necessary for induction of the skeletal muscle differentiation program.