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Myogenic differentiation 1

MyoD, MyoD1
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Myogenin, CAN, Myf5, PAX7, HAD
Papers using MyoD antibodies
A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss
Dhar M. S. et al., In Journal of Nutrition and Metabolism, 2010
... MyoD and Atp10c were from Qiagen (Valencia, CA) ...
Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient mice.
Agarwal Sudha, In PLoS ONE, 2009
... , and MyoD-hBcl-2 transgenic mice that overexpress human ...
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2
Chen Jie et al., In The Journal of Cell Biology, 2006
... The antibodies were obtained from the following sources: anti-tubulin was obtained from Abcam, anti-MyoD (5.8A) was obtained from Imgenex, antibodies against HDAC4, mTOR, ...
Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population
Simon András et al., In The Journal of Cell Biology, 2003
... Invitrogen), rabbit polyclonal anti-H3P antibody (Upstate Biotechnology), rat monoclonal anti-BrdU IgG (Trichem ApS), rabbit polyclonal anti-MyoD antibody (Santa Cruz Biotechnology, Inc.), anti-WE3 monoclonal IgG ...
The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure
Martins-Green Manuela et al., In The Journal of Cell Biology, 1998
... used were: anti–α-SMA (Sigma-Aldrich); anti-TGFβ 1,2,3 (R&D Systems); antivimentin, antidesmin, antimyosin heavy chain (Hybridoma Bank); anti-myoD (Santa Cruz Biotechnology, Inc.); anti–mouse horseradish peroxidase, ...
Papers on MyoD
Enhanced MyoD-Induced Transdifferentiation to a Myogenic Lineage by Fusion to a Potent Transactivation Domain.
Gersbach et al., In Acs Synth Biol, 10 Jan 2015
In this study we demonstrate that protein engineering of the master transcription factor MyoD can enhance the conversion of human dermal fibroblasts and adult stem cells to a skeletal myocyte phenotype.
Variations in the Efficiency of Lineage Marking and Ablation Confound Distinctions between Myogenic Cell Populations.
Tajbakhsh et al., Paris, France. In Dev Cell, 08 Jan 2015
UNLABELLED: The myogenic regulatory genes Myf5, Mrf4, Myod, and Myogenin likely arose by gene duplications during evolution, presumably to address the more demanding requirements of the vertebrate body plan.
Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration.
Fukada et al., Suita, Japan. In Development, 05 Jan 2015
Here, we show that many Pax7(+)MyoD(-) cells locate both beneath and outside the basal lamina during myofiber maturation.
Kazinol-P from Broussonetia kazinoki enhances skeletal muscle differentiation via p38MAPK and MyoD.
Bae et al., Seoul, South Korea. In Biochem Biophys Res Commun, 04 Jan 2015
UNLABELLED: The activation of MyoD family transcription factors is critical for myogenic differentiation, which is fundamental to the regeneration of skeletal muscle after injury.
Intracellular inactivation of thyroid hormone is a survival mechanism for muscle stem cell proliferation and lineage progression.
Salvatore et al., Napoli, Italy. In Cell Metab, 02 Jan 2015
The execution of this proapoptotic program requires an intact FoxO3/MyoD axis, both genes positively regulated by intracellular TH.
The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.
Camargo et al., Boston, United States. In Cancer Cell, Sep 2014
YAP1-TEAD1 upregulate pro-proliferative and oncogenic genes and maintain the ERMS differentiation block by interfering with MYOD1 and MEF2 pro-differentiation activities.
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.
Ladanyi et al., New York City, United States. In Nat Genet, Jun 2014
Whereas ARMS tumors typically contain translocations generating PAX3-FOXO1 or PAX7-FOXO1 fusions that block terminal myogenic differentiation, no functionally comparable genetic event has been found in ERMS tumors.
Role of skeletal muscle in mandible development.
Kablar et al., Halifax, Canada. In Histol Histopathol, Jun 2014
Previous analysis of Myf5-/-:MyoD-/- mouse fetuses lacking skeletal muscle demonstrated the importance of muscle contraction and static loading in mouse skeletogenesis.
Gene regulatory networks and transcriptional mechanisms that control myogenesis.
Rigby et al., Paris, France. In Dev Cell, Mar 2014
Myogenic determination and subsequent differentiation depend on members of the MyoD family.
Motoneuronal and muscle-selective removal of ALS-related misfolded proteins.
Poletti et al., Milano, Italy. In Biochem Soc Trans, Dec 2013
MyoD, myogenin, atrogin-1, TGFβ1 (transforming growth factor β1) and components of the cell response to proteotoxicity [HSPB8 (heat shock 22kDa protein 8), Bag3 (Bcl-2-associated athanogene 3) and p62] are all up-regulated by mutSOD1 in skeletal muscle.
SIRT3, a Mitochondrial NAD+-Dependent Deacetylase, Is Involved in the Regulation of Myoblast Differentiation.
Wrutniak-Cabello et al., Montpellier, France. In Plos One, Dec 2013
The inhibition of SIRT3 expression mediated by the stable integration of SIRT3 short inhibitory RNA (SIRT3shRNA) in C2C12 myoblasts, resulted in: 1) abrogation of terminal differentiation - as evidenced by a marked decrease in the myoblast fusion index and a significant reduction of Myogenin, MyoD, Sirtuin 1 and Troponin T protein expression - restored upon MyoD overexpression; 2) a decrease in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and citrate synthase protein expression reflecting an alteration of mitochondrial density; and 3) an increased production of reactive oxygen species (ROS) mirrored by the decreased activity of manganese superoxide dismutase (MnSOD).
[Regulation of differentiation of mesenchymal stem cells by the Hippo pathway effectors TAZ/YAP].
Teng et al., Harbin, China. In Yi Chuan, Nov 2013
It has been reported that the lineage-specific transcriptional factors including Runt related transcription factor 2 (RUNX2), Peroxisome proliferator-activator receptor gamma (PPARgamma) and Myogenic differentiation 1 (MyoD) may play key regulatory roles among the differentiation of MSCs.
Spindle cell rhabdomyosarcoma: a brief diagnostic review and differential diagnosis.
Nodit et al., Knoxville, United States. In Arch Pathol Lab Med, Aug 2013
Immunohistochemical workup demonstrates sarcomeric differentiation with reactivity for desmin, myogenin, and MyoD1 markers.
Coordination of satellite cell activation and self-renewal by Par-complex-dependent asymmetric activation of p38α/β MAPK.
Olwin et al., Boulder, United States. In Cell Stem Cell, 2012
Asymmetric localization of the Par complex activates p38α/β MAPK in only one daughter cell, inducing MyoD, which permits cell cycle entry and generates a proliferating myoblast.
Interplay between two myogenesis-related proteins: TBP-interacting protein 120B and MyoD.
Tamura et al., Chiba, Japan. In Gene, 2012
results suggest that MyoD and TIP120B potentiate each other at gene expression and post-translation levels, respectively, which may promote myogenesis cooperatively
Snail regulates MyoD binding-site occupancy to direct enhancer switching and differentiation-specific transcription in myogenesis.
Rudnicki et al., Ottawa, Canada. In Mol Cell, 2012
In primary myoblasts, snail-HDAC1/2 repressive complex binds and excludes MyoD from its targets.
Myo/Nog cells in normal, wounded and tumor-bearing skin.
George-Weinstein et al., In Exp Dermatol, 2012
Myo/Nog cells are the primary source of noggin in telogen hair follicles.
Muscle function and running activity in mouse models of hereditary muscle dystrophy: impact of double knockout for dystrophin and the transcription factor MyoD.
Gielen et al., Leipzig, Germany. In Muscle Nerve, 2012
mdx:myoD(-/-) is not a suitable model to study exercise-induced effects on dystrophic muscles
Finding MyoD with a little help from my friends.
Lassar, Boston, United States. In Nat Cell Biol, 2012
Findings indicate that MyoD activates the expression of other muscle regulators such as MEF2 and myogenin, which are necessary for induction of the skeletal muscle differentiation program.
Polycomb-repressed genes have permissive enhancers that initiate reprogramming.
Jones et al., Los Angeles, United States. In Cell, 2012
Using MYOD1, study shows that an nucleosome-depleted region at the minimal enhancer region allows reprogramming to be initiated, which occurs in response to signals such as the forced expression of Myod1 in fibroblasts.
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