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Myosin IXB

MYO9B, myosin IXB
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Rhodopsin, Actin, IBD, RhoGAP, MAGI-2
Papers on MYO9B
The motorized RhoGAP myosin IXb (Myo9b) in leukocytes regulates experimental autoimmune encephalomyelitis induction and recovery.
Bähler et al., Münster, Germany. In J Neuroimmunol, Jun 2015
Myo9b regulates leukocyte migration by controlling RhoA signaling.
Lack of genetic association between the MYO9B locus and schizophrenia in a Chinese population.
Zhang et al., Changchun, China. In Psychiatr Genet, Apr 2015
Jungerius et al. (2008) have reported that the myosin IXB (MYO9B) gene is strongly associated with susceptibility to schizophrenia in a Dutch population.
Association between the MYO9B polymorphisms and celiac disease risk: a meta-analysis.
Xie et al., Nanning, China. In Int J Clin Exp Med, 2014
BACKGROUND: There is no consensus regarding the association between polymorphisms in the myosin IXB (MYO9B) gene and celiac disease (CD) risk.
Mouse macrophages completely lacking Rho subfamily GTPases (RhoA, RhoB, and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and altered motility.
Hanley et al., Münster, Germany. In J Biol Chem, 2014
Furthermore, genetic deletion of RhoB partially reversed the motility defect of macrophages lacking the RhoGAP (Rho GTPase-activating protein) myosin IXb (Myo9b).
The JNK1/JNK3 interactome--contributions by the JNK3 unique N-terminus and JNK common docking site residues.
Bogoyevitch et al., Melbourne, Australia. In Biochem Biophys Res Commun, 2014
ΔN JNK3α1), and interaction evaluation in the yeast two-hybrid system defined the interacting partners as either JNK1-specific interactors (ATF7, FUS, KCNE4, PIAS1, SHANK1, TKT), typical JBD-dependent interactors shared by JNK1α1 and JNK3α1 (AKAP6, BMPR2, EEF1A1, GFAP, GRIP2, GTF2F1, HDAC2, MAP1B, MYO9B, PTPN2, RABGAP1, RUSC2, SUMO1, SYPL1, TOPBP1, ZNF668), or JNK3-specific partners (ATXN1, NNAT, PTGDS) dependent on interaction with the JNK3 N-terminal extension.
Myosin IXb variants and their pivotal role in maintaining the intestinal barrier: a study in Crohn's disease.
Büning et al., Berlin, Germany. In Scand J Gastroenterol, 2014
BACKGROUND: Myosin IXb (MYO9B) is involved in the regulation of epithelial barrier function.
Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
Tai et al., Singapore, Singapore. In Diabetes, 2014
Ten variants showed associations that reached genome-wide significance in the discovery data set, of which nine (four novel variants at TMEM79 [P value = 1.3 × 10(-23)], HBS1L/MYB [8.5 × 10(-15)], MYO9B [9.0 × 10(-12)], and CYBA [1.1 × 10(-8)] as well as five variants at loci that had been previously identified [CDKAL1, G6PC2/ABCB11, GCK, ANK1, and FN3KI]) showed consistent evidence of association in replication data sets.
Association of MYO9B gene polymorphisms with inflammatory bowel disease in Chinese Han population.
Xu et al., Hefei, China. In World J Gastroenterol, 2014
AIM: To explore the association of MYO9B gene polymorphisms with clinical phenotypes and intestinal permeability of individuals with inflammatory bowel disease (IBD) in China.
Dendritic cell motility and T cell activation requires regulation of Rho-cofilin signaling by the Rho-GTPase activating protein myosin IXb.
Grabbe et al., Münster, Germany. In J Immunol, 2014
In this article, we show that murine DCs that lack myosin IXB (Myo9b), a motorized negative regulator of RhoA signaling, exhibit increased Rho signaling activity and downstream acto-myosin contractility, and inactivation of the Rho target protein cofilin, an actin-depolymerizing factor.
The RhoGAP activity of myosin IXB is critical for osteoclast podosome patterning, motility, and resorptive capacity.
Lee et al., Columbus, United States. In Plos One, 2013
Myosin IXB (Myo9b) is a unique actin-based motor protein that contains a RhoGAP domain, which, like other RhoGAPs, is inhibitory to Rho signaling.
Association analysis of genetic variants in the myosin IXB gene in acute pancreatitis.
Dutch Pancreatitis Study Group et al., Utrecht, Netherlands. In Plos One, 2012
The myosin IXB (MYO9B) gene and the two tight-junction adaptor genes, PARD3 and MAGI2, have been linked to gastrointestinal permeability.
A role for myosin IXb, a motor-RhoGAP chimera, in epithelial wound healing and tight junction regulation.
Mooseker et al., New Haven, United States. In Mol Biol Cell, 2012
critical roles for Myo9b during epithelial wound healing and maintenance of tight junction integrity-key functions that may be altered in patients with Myo9b-linked inflammatory bowel disease.
No association observed between schizophrenia and non-HLA coeliac disease genes: integration with the initial MYO9B association with coeliac disease.
Wei et al., Inverness, United Kingdom. In Am J Med Genet B Neuropsychiatr Genet, 2011
we performed genetic analysis of the MYO9B gene and the IL-2/IL-21 locus by genotyping SNPs that have been previously associated with coeliac disease or schizophrenia found no evidence for association with these two loci.
Replication of genetic variation in the MYO9B gene in Crohn's disease.
Muise et al., Toronto, Canada. In Hum Immunol, 2011
These data demonstrate an association of MYO9B with ileal CD.
Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility.
Bähler et al., Münster, Germany. In Proc Natl Acad Sci U S A, 2010
Data identify the "motorized Rho inhibitor" Myo9b as a key molecular component required for spatially coordinated cell shape changes and motility.
Association analysis of myosin IXB and type 1 diabetes.
Alizadeh et al., Leiden, Netherlands. In Hum Immunol, 2010
gene polymorphism is associated with type i diabetes in Dutch but not in Brotosh population
Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect.
Wijmenga et al., Utrecht, Netherlands. In Nat Genet, 2005
Individuals homozygous with respect to the at-risk allele have a 2.3-times higher risk of celiac disease (P = 1.55 x 10(-5)).
Understanding the molecular basis of celiac disease: what genetic studies reveal.
Wijmenga et al., Utrecht, Netherlands. In Ann Med, 2005
Besides the well known involvement of the HLA class II histocompatibility antigen (HLA)-DQ2.5 and -DQ8 heterodimers (encoded by particular combinations of the HLA-DQA1 and -DQB1 gene) in CD and the minor contribution of the CTLA-4 gene, recently the myosin IXB (MYO9B) gene has also been found to be genetically associated.
Native Myosin-IXb is a plus-, not a minus-end-directed motor.
Mooseker et al., New Haven, United States. In Nat Cell Biol, 2003
Myosin-IXb (Myo9b) is a single-headed, processive motor that contains a Rho-GTPase-activating protein (GAP) domain within its tail.
Myosin IXb is a single-headed minus-end-directed processive motor.
Ikebe et al., Worcester, United States. In Nat Cell Biol, 2002
Here, we report that myosin IXb, a single-headed myosin, moves processively on actin filaments.
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