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Myosin IXA

MYO9A, myosin IXA
This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Actin, Rhodopsin, GAP, BBS4, RhoGAP
Papers on MYO9A
Molecular etiology of arthrogryposis in multiple families of mostly Turkish origin.
Lupski et al., In J Clin Invest, Feb 2016
Deleterious variants in candidate arthrogryposis-causing genes (fibrillin 3 [FBN3], myosin IXA [MYO9A], and pleckstrin and Sec7 domain containing 3 [PSD3]) were identified in 3 families (6.2%).
Rho GAP myosin IXa is a regulator of kidney tubule function.
Bähler et al., Münster, Germany. In Am J Physiol Renal Physiol, Oct 2015
Mammalian class IX myosin Myo9a is a single-headed, actin-dependent motor protein with Rho GTPase-activating protein activity that negatively regulates Rho GTPase signaling.
Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats.
Csont et al., Szeged, Hungary. In Cardiovasc Diabetol, 2012
myosin IXA; aggrecan1), signal transduction (e.g.
Regulation of collective cell migration by RhoGAP myosin IXA.
Omelchenko, New York City, United States. In Small Gtpases, 2012
One of these is myosin IXA, a member of class IX, single-headed actin motors having a conserved RhoGAP domain.
Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions.
Hall et al., New York City, United States. In Curr Biol, 2012
Depletion of myosin-IXA in collectively migrating cells led to altered organization of the actin cytoskeleton and tension-dependent disruption of cell-cell adhesions, followed by an inability to form new adhesions resulting in cell scattering.
A genome-wide scan of selective sweeps in two broiler chicken lines divergently selected for abdominal fat content.
Li et al., Harbin, China. In Bmc Genomics, 2011
A number of genes in the significant core regions, including RB1, BBS7, MAOA, MAOB, EHBP1, LRP2BP, LRP1B, MYO7A, MYO9A and PRPSAP1, were detected.
Cellular functions of class IX myosins in epithelia and immune cells.
Xu et al., Münster, Germany. In Biochem Soc Trans, 2011
Mammals contain two class IX myosins, Myo9a and Myo9b.
Myosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus.
Bähler et al., Münster, Germany. In Mol Biol Cell, 2009
Myo9a is a critical regulator of Rho-dependent and -independent signaling mechanisms that guide epithelial differentiation.
DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1.
Riazuddin et al., Lahore, Pakistan. In Hum Genet, 2005
MYO9A, NR2E3, BBS4, and TMC3 are among the candidate genes in the DFNB48 region.
The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23.
Duhl et al., United States. In Genomics, 1999
Using a positional cloning approach for identifying the BBS4 (chromosome 15) gene, we identified and cloned an unconventional myosin gene, myosin IXA (HGMW-approved symbol MYO9A).
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