gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


MYO18B, myosin XVIIIB
The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Actin, p16, p53, STEP
Papers on MYO18B
Gene amplification during myogenic differentiation.
Meese et al., Homburg, Germany. In Oncotarget, Feb 2016
After differentiation induction we found an increase in copy numbers of CDK4 gene at day 3, of NUP133 at days 4 and 7, and of MYO18B at day 4.
Genomic Characterization of Poorly Differentiated Neuroendocrine Carcinoma in a Pediatric Patient.
Carroll et al., New York City, United States. In J Pediatr Hematol Oncol, Jan 2016
We identified a somatic mutation in HRAS gene and LOH regions in NF2, MYO18B, and RUX3 genes.
A novel syndrome of Klippel-Feil anomaly, myopathy, and characteristic facies is linked to a null mutation in MYO18B.
Alkuraya et al., Riyadh, Saudi Arabia. In J Med Genet, Jun 2015
They shared a single founder autozygous interval in which whole exome sequencing revealed a truncating mutation in MYO18B.
Linkage disequilibrium and genomic scan to detect selective loci in cattle populations adapted to different ecological conditions in Ethiopia.
Kim et al., Ch'ŏngju, South Korea. In J Anim Breed Genet, 2014
Some of them are associated with candidate genes that are involved in metabolism (ATP2A3, CA2, MYO18B, SIK3, INPP4A, and IREB2), hypoxia response (BDNF, TFRC, and PML) and heat stress (PRKDC, CDK1, and TFDC).
Ethnic specificity of lupus-associated loci identified in a genome-wide association study in Korean women.
Bae et al., Seoul, South Korea. In Ann Rheum Dis, 2014
Of these, 16 candidates (PEX5L, TRAJ50, MYO18B, SOS1, ARHGAP26, SMURF1, CADPS, HAND1, FAM78B, DIAPH3, TBL1XR1, CSMD1, ZBTB20, C3orf21, HIPK1 and AP001042.1)
A population-specific uncommon variant in GRIN3A associated with schizophrenia.
Yoshikawa et al., Saitama, Japan. In Biol Psychiatry, 2013
Nominally significant association was observed in missense variants from FAAH, DNMT1, MYO18B, and CFB, with ORs of risk alleles ranging from 1.41 to 2.35.
A common variant in myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults.
Czamara et al., Bonn, Germany. In Transl Psychiatry, 2012
The identified variant encodes an amino-acid substitution in MYO18B, a protein with as yet unknown functions in the brain.
Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes.
Ling et al., Malmö, Sweden. In Diabetes, 2012
We found differential DNA methylation of genes in biological pathways including mitogen-activated protein kinase (MAPK), insulin, and calcium signaling (P ≤ 0.007) and of individual genes with known function in muscle, including MAPK1, MYO18B, HOXC6, and the AMP-activated protein kinase subunit PRKAB1 in skeletal muscle of FH(+) compared with FH(-) men.
Mutational profiling of cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma reveals a snapshot of their genomic landscapes.
Bardelli et al., Torino, Italy. In Hum Mutat, 2009
Only 4 of the breast/colorectal 'hill' type CAN genes (SMAD4, MYO18B, NAV3 and MMP2) were also mutated in melanoma and pancreatic carcinoma, while none was altered in glioblastoma.
[Myosins in nucleus].
Redowicz et al., Warsaw, Poland. In Postepy Biochem, 2008
Namely, nuclear form of myosin IC (NMI), myosin VI, myosin XVIB and myosin XVIIIB were found in nucleus.
Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations.
Yokota et al., Tokyo, Japan. In Genes Cells, 2008
Myo18B is a unique unconventional myosin that is predominantly expressed in myocytes and whose expression is essential for the development and/or maintenance of myofibrillar structure.
Unconventional myosins in muscle.
Redowicz, Warsaw, Poland. In Eur J Cell Biol, 2007
For example, a point mutation within the myosin VI gene leads to a cardiac dysfunction, and myosin XVIIIB (expressed predominantly in striated muscle) may be involved in muscle gene transcription.
HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth.
Yokota et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2007
Expression of HOMER2 enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 and MYO18B cooperate together in tumor suppression.
MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway.
Sutoh et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2006
Proteasome dysfunction by a proteasome inhibitor or siRNA-mediated knock-down of Sug1 caused the up-regulation of MYO18B protein and MYO18B was polyubiquitinated in vivo.
Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice.
Sone et al., Tokushima, Japan. In Oncol Res, 2005
The restored expression of MYO18B may be a useful therapeutic strategy for the treatment of locally advanced Malignant pleural mesothelioma(MPM)in humans.
Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer.
Yokota et al., Tokyo, Japan. In Int J Cancer, 2004
MYO18B alterations, including both epigenetic and genetic alterations, play an important role in ovarian carcinogenesis
Molecular footprints of human lung cancer progression.
Kohno et al., Tokyo, Japan. In Cancer Sci, 2004
Several other genes, such as K-ras, PTEN and MYO18B, are genetically altered less frequently than p53 and RB/p16 in lung cancer cells, suggesting that alterations in these genes are associated with further malignant progression or unique phenotypes in a subset of lung cancer cells.
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
Kohno et al., Tokyo, Japan. In Clin Exp Metastasis, 2002
Recently, we identified a novel myosin family gene, MYO18B, from the chromosome 22q12.1 region which shows frequent loss of heterozygosity in advanced lung cancer, and we found that this gene is inactivated in approximately 50% of lung cancers by deletions, mutations and methylation.
share on facebooktweetadd +1mail to friends