1A.02: MICRORNA-208A AND ITS HOST GENE CARDIAC MYOSIN HEAVY CHAIN MYH6 ARE INVOLVED IN HYPERTROPHIC HEART DYSFUNCTION.
Bratislava, Slovakia. In J Hypertens, 30 Jun 2015
Relative expressions of cardiac myosin heavy chains (MYH6, MYH7, MYH7B), markers of cardiac damage (natriuretic peptides ANP, BNP) and heart-related microRNAs miR-1, miR-133a, miR-208a, miR-499 were analyzed using quantitative real-time PCR in samples from left ventricle, microRNAs also in venous blood.
Genetic mutations and mechanisms in dilated cardiomyopathy.
Chicago, United States. In J Clin Invest, 2013
Mutations in the genes encoding the thick filament components myosin heavy chain and myosin binding protein C (MYH7 and MYBPC3) together explain 75% of inherited HCMs, leading to the observation that HCM is a disease of the sarcomere.
Myosinopathies: pathology and mechanisms.
Göteborg, Sweden. In Acta Neuropathol, 2013
Myopathies with scapuloperoneal, distal or limb-girdle muscle weakness including entities, such as myosin storage myopathy and Laing distal myopathy are the result of usually dominant mutations in the gene for slow/β cardiac MyHC (MYH7).
Mechanisms of disease: hypertrophic cardiomyopathy.
Kiel, Germany. In Nat Rev Cardiol, 2012
Interestingly, most of these genes encode sarcomeric proteins, such as myosin-7 (also known as cardiac muscle β-myosin heavy chain; MYH7), cardiac myosin-binding protein C (MYBPC3), and cardiac muscle troponin T (TNNT2).