Genetic analysis in 418 index patients with idiopathic dilated cardiomyopathy: overview of 10 years' experience.
Groningen, Netherlands. In Eur J Heart Fail, 24 Feb 2013
Other mutations were found in: MYH7, DES, TNNT2, DMD, TPM1, DMPK, SCN5A, SGCB (homozygous), and TNNI3.
Genetic mutations and mechanisms in dilated cardiomyopathy.
Chicago, United States. In J Clin Invest, 02 Feb 2013
Mutations in the genes encoding the thick filament components myosin heavy chain and myosin binding protein C (MYH7 and MYBPC3) together explain 75% of inherited HCMs, leading to the observation that HCM is a disease of the sarcomere.
Mechanisms of disease: hypertrophic cardiomyopathy.
Kiel, Germany. In Nat Rev Cardiol, Feb 2012
Interestingly, most of these genes encode sarcomeric proteins, such as myosin-7 (also known as cardiac muscle β-myosin heavy chain; MYH7), cardiac myosin-binding protein C (MYBPC3), and cardiac muscle troponin T (TNNT2).