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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2016.

Myeloperoxidase

myeloperoxidase, MPO
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Interleukin-6, CAN, HAD, V1a
Papers using myeloperoxidase antibodies
Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease.
Supplier
Ikezu Tsuneya, In PLoS ONE, 2007
... anti-MAP2 (sigma) 1/2000, mouse anti-PSD95 (ABR) 1/500, mouse anti-GFAP (clone GA5, Cell Signaling) 1/1000, mouse anti-MPO (Abcam a16886-50) 1/200, biotinylated mouse ...
A systematic review of Iranian medicinal plants useful in diabetes mellitus
Supplier
Abdollahi Mohammad et al., In Archives of Medical Science : AMS, 2007
... thiobarbituric acid reactive substances (TBARS), total antioxidant power (ferric reducing ability of pancreas; FRAP), myeloperoxidase (MPO), protein, and sample preparation for histological assay were purchased from Merck Chemical Co ...
Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
Supplier
Gao Bin et al., In International Journal of Biological Sciences, 2005
... Anti-Mcl-1 antibody (Abcam, Cambridge, MA), anti-VMP1 antibody (Enzo Life Sciences, Farmingdale, NY), and anti-MPO antibody (Biocare Medical, Concord, CA) were also ...
Hypochlorous acid damages erythrocyte membrane proteins and alters lipid bilayer structure and fluidity
Supplier
Wehkamp Jan, In PLoS ONE, 2000
... Rabbit anti-human MPO antibody (Dako) was used at 1∶300 ...
Phenotype correction in retinal pigment epithelium in murine mucopolysaccharidosis VII by adenovirus-mediated gene transfer
Supplier
Rodriguez-Boulan Enrique et al., In The Journal of Experimental Medicine, 1994
... Myeloperoxidase antiserum was from Dako.
Papers on myeloperoxidase
Dividing the Janus vasculitis? Pathophysiology of eosinophilic granulomatosis with polyangitis.
Review
New
Mouthon et al., Paris, France. In Autoimmun Rev, Feb 2016
It is commonly divided into two phenotypes depending on the presence of ANCAs targeting myeloperoxidase (MPO).
Bivalirudin in Acute Coronary Syndromes.
New
Impact
Shah, In N Engl J Med, Feb 2016
Bivalirudin enhances the vascular sequestration of neutrophil-derived myeloperoxidase, which has the effect of accelerating the consumption of nitric oxide and depressing its bioavailability.(2)
Bivalirudin in Acute Coronary Syndromes.
New
Impact
In N Engl J Med, Feb 2016
Bivalirudin enhances the vascular sequestration of neutrophil-derived myeloperoxidase, which has the effect of accelerating the consumption of nitric oxide and depressing its bioavailability.(2)
Bivalirudin in Acute Coronary Syndromes.
New
Impact
Bednarek et al., In N Engl J Med, Feb 2016
Bivalirudin enhances the vascular sequestration of neutrophil-derived myeloperoxidase, which has the effect of accelerating the consumption of nitric oxide and depressing its bioavailability.(2)
Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats.
New
Dong et al., Xi'an, China. In Fundam Clin Pharmacol, Feb 2016
Myeloperoxidase (MPO), superoxide dismutase (SOD) and malondialdehyde (MDA) levels were detected to evaluate the inflammatory and oxidative stress status.
Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice.
New
Jiang et al., Yantai, China. In Inflammation, Feb 2016
The levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were determined using enzyme-linked immunosorbent assay (ELISA) kits.
Carrageenan-induced inflammation promotes ROS generation and neutrophil extracellular trap formation in a mouse model of peritonitis.
New
Donadio et al., Porto Alegre, Brazil. In Eur J Immunol, Feb 2016
Carrageenan induced NET release by viable neutrophils with neutrophil elastase (NE) and myeloperoxidase (MPO) expressed on DNA fibers.
Native low density lipoprotein promotes lipid raft formation in macrophages.
New
Wu et al., Wuhan, China. In Mol Med Report, Feb 2016
Confocal microscopic analysis revealed that lipid rafts were aggregated or clustered in the membrane, which were colocalized with myeloperoxidase (MPO) upon native LDL stimulation; however, in the presence of methyl‑β‑cyclodextrin (MβCD), LDL‑stimulated aggregation, translocation, and colocalization of lipid rafts components was abolished..
Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease.
Review
New
Sorsa et al., Helsinki, Finland. In Innate Immun, Jan 2016
Thus, neutrophil-derived biomarkers, including myeloperoxidase, may activate proteolytic destructive cascades that are involved in subsequent immune-pathological events associated with both periodontitis and CHD.
Antioxidant Effects of Probiotics in Experimentally Induced Peritonitis.
New
Salman et al., İstanbul, Turkey. In Surg Infect (larchmt), Jan 2016
On the fifth day after surgery, all rats were killed, and tissue samples from the terminal ileum were obtained to evaluate the activities of myeloperoxidase (MPO), malondialdehyde (MDA), and glutathione (GSH).
ANCA-Associated Systemic Vasculitis Presenting With Hypertrophic Spinal Pachymeningitis: A Report of 2 Cases and Review of Literature.
Review
New
Zhao et al., Beijing, China. In Medicine (baltimore), Nov 2015
Reports of hypertrophic pachymeningitis associated with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) localized exclusively in the spine were quite rare.
Eosinophilic Granulomatosis With Polyangiitis With Thrombotic Microangiopathy: Is Simultaneous Systemic Lupus Erythematosus Associated With Clinical Manifestations?: A Case Report and Review of the Literature.
Review
New
Kawakami et al., Nagasaki, Japan. In Medicine (baltimore), Nov 2015
Although several case reports have described patients with TMA associated with ANCA-associated vasculitis except for EGPA, there are no previous case reports of EGPA associated with TMA.A 71-year-old Japanese man was diagnosed with EGPA based on his asthma, eosinophilia, lung opacity, refractory sinusitis, and positive myeloperoxidase-ANCA.
Interstitial Lung Disease with ANCA-associated Vasculitis.
Review
Yamanaka et al., Tokyo, Japan. In Clin Med Insights Circ Respir Pulm Med, 2014
There is significant predominance of myeloperoxidase (MPO)-ANCA and MPA in patients with AAV and ILD.
Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense.
Impact
Penninger et al., Vienna, Austria. In Nat Genet, 2014
Functional analysis confirmed marked defects in neutrophil migration in response to Candida albicans infection and impaired formation of cytotoxic granules, as well as defective myeloperoxidase release and killing of Candida albicans.
Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage.
Impact
Zeiser et al., Freiburg, Germany. In Nat Med, 2014
We analyzed neutrophil infiltration of the mouse ileum after allo-HCT by in vivo myeloperoxidase imaging and found that infiltration levels were dependent on the local microbial flora and were not detectable under germ-free conditions.
Serum myeloperoxidase activity and oxidative stress in patients with acute brucellosis.
GeneRIF
Taskın et al., Van, Turkey. In Clin Biochem, 2012
Results indicate that increased myeloperoxidase activity and decreased catalase activity is associated with increased oxidative stress, which may have a role in atherosclerotic processes in brucellosis patients.
Deconstruction of activity-dependent covalent modification of heme in human neutrophil myeloperoxidase by multistage mass spectrometry (MS(4)).
GeneRIF
Vajdos et al., United States. In Biochemistry, 2012
Peptide mapping detected modification in a labile peptide-heme-peptide fragment of the enzyme, accompanied by a mass increase of 252.08 Da. The loss of two hydrogen atoms was consistent with mechanism-based oxidative coupling.
Menopausal status modifies breast cancer risk associated with the myeloperoxidase (MPO) G463A polymorphism in Caucasian women: a meta-analysis.
GeneRIF
Ozcelik et al., Baguio, Philippines. In Plos One, 2011
The MPO G463A polymorphism places post-menopausal women at risk for breast cancer, where this effect is modified by diet.
Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice.
GeneRIF
Kagan et al., Morgantown, United States. In Plos One, 2011
Results provide evidence for the participation of myeloperoxidase (MPO) - one of the key-orchestrators of inflammatory response.
Elevated serum myeloperoxidase activities are significantly associated with the prevalence of ACS and High LDL-C levels in CHD patients.
GeneRIF
Tu et al., Chongqing, China. In J Atheroscler Thromb, 2011
study provides epidemiological evidence that elevated serum MPO activities are significantly associated with the prevalence of ACS and high LDL-C levels in CHD patients, and MPO may be a potential early warning marker for ACS
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