Saturated fatty acids trigger TLR4-mediated inflammatory response.
Viçosa, Brazil. In Atherosclerosis, Jan 2016
Those molecules can induce TLR4 inflammatory response by MyD88-dependent and/or MyD88-independent pathways that, in turn, promotes the expression of proinflammatory transcript factors such as factor nuclear kappa B (NF-κB), which plays a crucial role in the induction of inflammatory mediators (cytokines, chemokines, or costimulatory molecules) implicated in the development and progression of many chronic diseases.
CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.
Beijing, China. In Nat Med, Oct 2015
In addition, the antitumor effects of CD47 blockade required expression of the cytosolic DNA sensor STING, but neither MyD88 nor TRIF, in CD11c+ cells, suggesting that cytosolic sensing of DNA from tumor cells is enhanced by anti-CD47 treatment, further bridging the innate and adaptive responses.
MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.
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Boston, United States. In N Engl J Med, 2012
MYD88 L265P is a commonly recurring mutation in patients with Waldenstrom's macroglobulinemia that can be useful in differentiating Waldenstrom's macroglobulinemia and non-IgM LPL from B-cell disorders that have some of the same features.