Biological monitoring of IFN-β therapy in Multiple Sclerosis.
Orbassano, Italy. In Cytokine Growth Factor Rev, Apr 2015
A consistent number of studies have demonstrated that quantification of Myxovirus-induced protein A (MxA) is a valid biomarker to detect immune-pharmacological non responders after one year of treatment.
Mx GTPases: dynamin-like antiviral machines of innate immunity.
Freiburg, Germany. In Trends Microbiol, Mar 2015
We focus on new structural and functional insights and discuss recent data revealing that human MxA (MX1) provides a safeguard against introduction of avian influenza A viruses (FLUAV) into the human population.
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.
London, United Kingdom. In Nature, 2013
Finally, human MX1 (also known as MXA), a closely related protein that has long been recognized as a broadly acting inhibitor of RNA and DNA viruses, including the orthomyxovirus influenza A virus, does not affect HIV-1, whereas MX2 is ineffective against influenza virus.
Translating the brain transcriptome in neuroAIDS: from non-human primates to humans.
Omaha, United States. In J Neuroimmune Pharmacol, 2012
Differential expression of mRNAs involved in inflammation and immune response are a common finding in both monkey and human samples - even in HIV infected people on combination antiretroviral therapy, a shared set of genes is upregulated in the brains of both infected monkeys and humans: B2M, IFI44, IFIT3, MX1, STAT1.