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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Myxovirus

MxA, MX-1
In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, Interferon-beta, POLYMERASE, ACID
Papers using MxA antibodies
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
Supplier
Chiba Tomoki et al., In The Journal of Cell Biology, 2002
... Mx1-Cre transgenic mice to produce ...
Papers on MxA
Protease inhibitors partially overcome the interferon nonresponse phenotype in patients with chronic hepatitis C.
New
Feld et al., Little Rock, United States. In J Viral Hepat, Jan 2016
Liver biopsy tissue from consecutive patients treated with boceprevir or telaprevir with peginterferon and ribavirin was stained for myxovirus A (MxA).
Upregulation of the Suppressors of Cytokine Signaling 1 and 3 Is Associated with Arrest of Phosphorylated-STAT1 Nuclear Importation and Reduced Innate Response in Denguevirus-Infected Macrophages.
New
Reyes-Leyva et al., Metepec, Mexico. In Viral Immunol, Jan 2016
UNASSIGNED: To clarify whether the suppressors of cytokine signaling (SOCS) are associated with denguevirus (DENV) evasion of the antiviral response, we analyzed the expression kinetics of SOCS1 and SOCS3 and of the antiviral genes MxA and OAS during DENV infection of U937 macrophages that were or not treated with interferon (IFN)-α.
Marker Exchange Mutagenesis of mxaF Encoding for the Large Subunit of Mxa-Methanol Dehydrogenase in Methylosinus trichosporium OB3b.
New
Semrau et al., Ann Arbor, United States. In Appl Environ Microbiol, Jan 2016
More recently, it was discovered that multiple forms of methanol dehydrogenase also exist in methanotrophs, Mxa-MeDH and Xox-MeDH, and the expression of these alternative forms is regulated by the availability of cerium.
[Computational Pharmacological Study on Clopidogrel Metabolism Enzymes Influenced by Fufang Danshen Dripping Pill].
New
Tan et al., In Zhong Yao Cai, May 2015
RESULT: 1 MX1 (CES1), 3NXU (CYP450 3A4), 4GQS (CYP450 2C19), 2HI4 (CYP450 1A2) and 3IBD(CYP450 2B6) as well as THA, RIT, OXU, Chlorzoxazone and CPZ were used as receptors and cutoff for each target respectively.
Biological monitoring of IFN-β therapy in Multiple Sclerosis.
Review
New
Caldano et al., Orbassano, Italy. In Cytokine Growth Factor Rev, Apr 2015
A consistent number of studies have demonstrated that quantification of Myxovirus-induced protein A (MxA) is a valid biomarker to detect immune-pharmacological non responders after one year of treatment.
Mx GTPases: dynamin-like antiviral machines of innate immunity.
Review
New
Kochs et al., Freiburg, Germany. In Trends Microbiol, Mar 2015
We focus on new structural and functional insights and discuss recent data revealing that human MxA (MX1) provides a safeguard against introduction of avian influenza A viruses (FLUAV) into the human population.
Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling.
Ho et al., Taiwan. In Viruses, 2014
This study examined the mechanism underlying this phenomenon by measuring the expression of antiviral genes-tumor necrosis factor alpha (TNF-α) and GTPase myxovirus resistance 1 (MX1)-in G6PD-knockdown cells upon human coronavirus 229E (HCoV-229E) and enterovirus 71 (EV71) infection.
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.
Impact
Malim et al., London, United Kingdom. In Nature, 2013
Finally, human MX1 (also known as MXA), a closely related protein that has long been recognized as a broadly acting inhibitor of RNA and DNA viruses, including the orthomyxovirus influenza A virus, does not affect HIV-1, whereas MX2 is ineffective against influenza virus.
Detection of new biallelic polymorphisms in the human MxA gene.
GeneRIF
Cornet et al., Liège, Belgium. In Mol Biol Rep, 2012
Four new polymorphisms in the human MxA gene were identified.
Type 1 IFN-induced protein MxA and plasmacytoid dendritic cells in lesions of morphea.
GeneRIF
Dutz et al., Vancouver, Canada. In Exp Dermatol, 2012
study demonstrates the expression of type 1 IFN-related protein MxA and plasmacytoid plasmacytoid dendritic cells in lesional but not in non-lesional biopsies of morphea
Translating the brain transcriptome in neuroAIDS: from non-human primates to humans.
Review
Fox et al., Omaha, United States. In J Neuroimmune Pharmacol, 2012
Differential expression of mRNAs involved in inflammation and immune response are a common finding in both monkey and human samples - even in HIV infected people on combination antiretroviral therapy, a shared set of genes is upregulated in the brains of both infected monkeys and humans: B2M, IFI44, IFIT3, MX1, STAT1.
MxA expression induced by α-defensin in healthy human periodontal tissue.
GeneRIF
Pichyangkul et al., Bangkok, Thailand. In Eur J Immunol, 2012
a novel pathway of human MxA induction, which is initiated by an endogenous antimicrobial peptide, namely alpha-defensin.
Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival.
GeneRIF
Katze et al., Seattle, United States. In J Virol, 2012
Mice with a functional Mx1 generate a strong antiviral state by downregulating key modulator molecules associated with influenza virus lethality.
Estrogen-related MxA transcriptional variation in hepatitis C virus-infected patients.
GeneRIF
Abdelaziz et al., Cairo, Egypt. In Transl Res, 2012
In HCV-infected patients the peripheral blood mononuclear cells from premenopausal women showed the highest MxA gene expression compared to both postmenopausal females and males before and after IFN stimulation.
Epidemiologic and genetic characteristics of alopecia areata (part 2).
Review
Ahmed et al., Buraydah, Saudi Arabia. In Acta Dermatovenerol Alp Panonica Adriat, 2011
MX1 is another new candidate gene in AA.
The role of host genetics in susceptibility to influenza: a systematic review.
Review
Baillie et al., Vietnam. In Plos One, 2011
The Mx genes encoding interferon inducible proteins are the best studied but their relevance to susceptibility in humans is unknown.
Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function.
Impact
GeneRIF
Daumke et al., Berlin, Germany. In Immunity, 2011
demonstrated that the intra- and intermolecular domain interplay between the bundle signaling element and stalk was essential for oligomerization and the antiviral function of MxA
Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis.
Impact
Sørensen et al., Amsterdam, Netherlands. In Lancet Neurol, 2010
The panel believed that information about NAbs and other markers of biological activity of interferons (ie, myxovirus resistance protein A [MxA]) can be integrated with clinical and imaging indicators to guide individual treatment decisions.
Structural basis of oligomerization in the stalk region of dynamin-like MxA.
Impact
GeneRIF
Daumke et al., Berlin, Germany. In Nature, 2010
the crystal structure of the stalk of human MxA, which folds into a four-helical bundle; this structure tightly oligomerizes in the crystal in a criss-cross pattern involving three distinct interfaces and one loop
Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance.
Impact
Morrison et al., Ann Arbor, United States. In Cell Stem Cell, 2009
To test this, we conditionally deleted N-cadherin from HSCs and other hematopoietic cells in adult Mx-1-Cre(+)N-cadherin(fl/-) mice.
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