GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
MVD, MPD, mevalonate pyrophosphate decarboxylase
The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008] (from
Gurgel Rocha et al., Salvador, Brazil. In Tumour Biol, Feb 2016
Endothelial cells were found to express SHH, IHH, and GLI1 within CD105+ vessels, and a positive correlation between infiltrating macrophage density (IMD) and microvascular density (MVD) was observed in cases of OSCC and TM.
Klijanienko et al., Athens, Greece. In Expert Opin Ther Targets, Jun 2015
EXPERT OPINION: The available data suggest that microvessel density (MVD) evaluation may be capable of discriminating between benign and malignant SGTs, while the use of CD105 antibody seems to be the most suitable.
We observed that preoperative treatment with finasteride can decrease total blood loss, blood loss per gram of resected prostate tissue, hemoglobin level alteration, microvessel density (MVD), and vascular endothelial growth factor level.
Stegmaier et al., Boston, United States. In Cancer Cell, 2014
In a FLT3-ITD in vivo model, SYK is indispensable for myeloproliferative disease (MPD) development, and SYK overexpression promotes overt transformation to AML and resistance to FLT3-ITD-targeted therapy.
Shannon et al., San Francisco, United States. In Nature, 2009
We compared the effects of inhibitors of MEK in a myeloproliferative disorder (MPD) initiated by inactivating Nf1 in mouse bone marrow and in acute myeloid leukaemias (AMLs) in which cooperating mutations were induced by retroviral insertional mutagenesis.
Loh et al., Stanford, United States. In Cancer Cell, 2008
Using flow cytometry, we observed a specific evoked STAT5 signaling signature in a subset of samples from patients suspected of having juvenile myelomonocytic leukemia (JMML), an aggressive MPD with a challenging clinical presentation during active disease.
Tsuji et al., Fukuyama, Japan. In Biol Pharm Bull, 2001
Distribution of mevalonate pyrophosphate decarboxylase is significantly reduced in the liver as well as brain of the stroke-prone spontaneously hypertensive rat from the age of two weeks, compared to that of the normotensive Wistar Kyoto strain.