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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mevalonate

MVD, MPD, mevalonate pyrophosphate decarboxylase
The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: vascular endothelial growth factor, CD34, HAD, CAN, CD31
Papers on MVD
Intermetallic Competition in the Fragmentation of Trimetallic Au-Zn-Alkali Complexes.
New
Niedner-Schatteburg et al., Kaiserslautern, Germany. In Chemistry, Feb 2016
Infrared multiple photon dissociation (IR-MPD) in combination with density functional theory (DFT) calculations reveal a μ(3) binding motif of all alkali ions to the three chlorido ligands.
Prognostic significance of thymidylate synthase (TS) expression in cutaneous malignant melanoma.
New
Ishikawa et al., In Neoplasma, Feb 2016
Tumor sections were stained by immunohistochemistry for TS, Ki-67, and microvessel density (MVD) determined by CD34.
Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation.
New
Gurgel Rocha et al., Salvador, Brazil. In Tumour Biol, Feb 2016
Endothelial cells were found to express SHH, IHH, and GLI1 within CD105+ vessels, and a positive correlation between infiltrating macrophage density (IMD) and microvascular density (MVD) was observed in cases of OSCC and TM.
High nuclear expression of Twist1 in the skeletal extramedullary disease of myeloma patients predicts inferior survival.
New
Zhang et al., Shijiazhuang, China. In Pathol Res Pract, Jan 2016
The microvessel density (MVD, P=0.004) was significantly higher in patients with high nuclear expression of Twist1 (Twist1-high) than in those with low expression.
Deciphering the anti-angiogenic effect of endostatin/cyclophosphamide to normalize tumor micrangium through notch signaling pathway in colon cancer.
New
Wang et al., Dalian, China. In World J Surg Oncol, Dec 2015
Microvessel density (MVD) was evaluated to detect micrangium following the treatment.
Angiogenesis in salivary gland tumors: from clinical significance to treatment.
Review
New
Klijanienko et al., Athens, Greece. In Expert Opin Ther Targets, Jun 2015
EXPERT OPINION: The available data suggest that microvessel density (MVD) evaluation may be capable of discriminating between benign and malignant SGTs, while the use of CD105 antibody seems to be the most suitable.
Is there a place for microsurgical vascular decompression of the brainstem for apparent essential blood hypertension? a review.
Review
Sindou, Lyon, France. In Adv Tech Stand Neurosurg, 2014
The first attempts at microvascular decompression (MVD) of the IX-Xth CNs together with the neighbouring VL brainstem was revealed promising.
Impact of preoperative 5α-reductase inhibitors on perioperative blood loss in patients with benign prostatic hyperplasia: a meta-analysis of randomized controlled trials.
Review
Ye et al., Shanghai, China. In Bmc Urol, 2014
We observed that preoperative treatment with finasteride can decrease total blood loss, blood loss per gram of resected prostate tissue, hemoglobin level alteration, microvessel density (MVD), and vascular endothelial growth factor level.
SYK is a critical regulator of FLT3 in acute myeloid leukemia.
Impact
Stegmaier et al., Boston, United States. In Cancer Cell, 2014
In a FLT3-ITD in vivo model, SYK is indispensable for myeloproliferative disease (MPD) development, and SYK overexpression promotes overt transformation to AML and resistance to FLT3-ITD-targeted therapy.
Can vascular endothelial growth factor and microvessel density be used as prognostic biomarkers for colorectal cancer? A systematic review and meta-analysis.
Review
Zhao et al., Harbin, China. In Scientificworldjournal, 2013
BACKGROUND: Vascular endothelial growth factor (VEGF) and microvessel density (MVD) are associated with greater incidence of metastases and decreased survival.
Possible prognostic and therapeutic significance of c-Kit expression, mast cell count and microvessel density in renal cell carcinoma.
Review
Ranieri et al., Bari, Italy. In Int J Mol Sci, 2013
We also focus on few studies that have evaluated the correlation between RCC proliferation, MC count and microvessel density (MVD), as hallmarks of tumor angiogenesis.
Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors.
Impact
Yamamoto et al., Shizuoka, Japan. In J Clin Oncol, 2010
microvessel density (MVD; P < .0001),
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.
Impact
Shannon et al., San Francisco, United States. In Nature, 2009
We compared the effects of inhibitors of MEK in a myeloproliferative disorder (MPD) initiated by inactivating Nf1 in mouse bone marrow and in acute myeloid leukaemias (AMLs) in which cooperating mutations were induced by retroviral insertional mutagenesis.
JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.
Impact
Passegué et al., San Francisco, United States. In Cancer Cell, 2009
Loss of the JunB/AP-1 transcription factor induces a myeloproliferative disease (MPD) arising from the hematopoietic stem cell (HSC) compartment.
Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure.
GeneRIF
Miziorko et al., Kansas City, United States. In Arch Biochem Biophys, 2009
functional importance of R161 and N17 in the binding and orientation of mevalonate diphosphate
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.
Impact
Loh et al., Stanford, United States. In Cancer Cell, 2008
Using flow cytometry, we observed a specific evoked STAT5 signaling signature in a subset of samples from patients suspected of having juvenile myelomonocytic leukemia (JMML), an aggressive MPD with a challenging clinical presentation during active disease.
Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation.
GeneRIF
Kaul et al., Tsukuba, Japan. In Biochem Biophys Res Commun, 2003
Results identify mevalonate pyrophosphate decarboxylase (MPD) as a binding partner of mortalin-2.
Difference in subcellular distribution between 45- and 37-kDa mevalonate pyrophosphate decarboxylase in rat liver.
GeneRIF
Tsuji et al., Fukuyama, Japan. In Biol Pharm Bull, 2001
The 45-kDa isoform of mevalonate pyrophosphate decarboxylase has been detected in the matrix of the liver peroxisomes, whereas the 37-kDa form localizes primarily to the liver cytosol.
Mevalonate pyrophosphate decarboxylase in stroke-prone spontaneously hypertensive rat is reduced from the age of two weeks.
GeneRIF
Tsuji et al., Fukuyama, Japan. In Biol Pharm Bull, 2001
Distribution of mevalonate pyrophosphate decarboxylase is significantly reduced in the liver as well as brain of the stroke-prone spontaneously hypertensive rat from the age of two weeks, compared to that of the normotensive Wistar Kyoto strain.
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