gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Muscle, skeletal, receptor tyrosine kinase

MuSK, MLK
This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: Agrin, CAN, HAD, JNK, AP-1
Papers using MuSK antibodies
A guided tour into subcellular colocalization analysis in light microscopy.
Supplier
Klymkowsky Michael, In PLoS ONE, 2005
... Sigma, 1/1000), Phosphotyrosine (clone 4G10, Millipore, 1/500), Myosin heavy chain 1 (MyHCI, monoclonal, Sigma, 1/1000) and MuSK (polyclonal, Abcam, 1/200) ...
Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction
Supplier
Feng Guoping et al., In The Journal of Cell Biology, 1998
... Anti-MuSK C-19 (Santa Cruz Biotechnology, Inc.), anti-MuSK N-19 (Santa ...
Papers on MuSK
Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.
New
Oetjen et al., Göttingen, Germany. In Cell Signal, Feb 2016
Within its kinase domain DLK shares high homology with the mixed lineage kinase (MLK) 3, which is activated by tumor necrosis factor (TNF) α and interleukin (IL)-1β, known prediabetic signals.
Myopathic changes detected by quantitative electromyography in patients with MuSK and AChR positive myasthenia gravis.
New
Lavrnic et al., Belgrade, Serbia. In J Clin Neurosci, Feb 2016
UNASSIGNED: Myopathic changes are frequent a electrophysiological finding in patients with muscle specific tyrosine kinase (MuSK) positive myasthenia gravis (MG).
Association of HLA class II (DRB1, DQA1, DQB1) alleles and haplotypes with myasthenia gravis and its subgroups in the Iranian population.
New
Nafissi et al., Tehrān, Iran. In J Neurol Sci, Jan 2016
OR=4.28) was predisposing for anti-muscle specific tyrosine kinase (MuSK) antibody-positive MG.
Forced expression of muscle specific kinase slows postsynaptic acetylcholine receptor loss in a mouse model of MuSK myasthenia gravis.
New
Phillips et al., Sydney, Australia. In Physiol Rep, Dec 2015
We investigated the influence of postsynaptic tyrosine kinase signaling in a mouse model of muscle-specific kinase (MuSK) myasthenia gravis (MG).
Myasthenia gravis: subgroup classification and therapeutic strategies.
Review
New
Impact
Verschuuren et al., Bergen, Norway. In Lancet Neurol, Oct 2015
Myasthenia gravis is an autoimmune disease that is characterised by muscle weakness and fatigue, is B-cell mediated, and is associated with antibodies directed against the acetylcholine receptor, muscle-specific kinase (MUSK), lipoprotein-related protein 4 (LRP4), or agrin in the postsynaptic membrane at the neuromuscular junction.
An update on laboratory diagnosis in myasthenia gravis.
Review
New
Frykman et al., Vancouver, Canada. In Clin Chim Acta, Oct 2015
They also describe the methods to measure each of the specific antibodies that have recently permitted to split the diagnosis: Abs to omega-conotoxin receptor in Lambert Eaton Myasthenic Syndrome (LEMS), abs to the acetylcholine receptor (AchR) in MG, Abs to muscle specific tyrosine kinase (MuSK) in Ab negative MG, and Abs to low molecular weight receptor related low-density lipo protein-4 (LRP-4).
The phosphatidylinositol 3-kinase/Akt and c-Jun N-terminal kinase signaling in cancer: Alliance or contradiction? (Review).
Review
New
Tony To et al., Hong Kong, Hong Kong. In Int J Oncol, Aug 2015
Activation of PI3K/Akt signaling can inhibit stress- and cytokine-induced JNK activation through Akt antagonizing and the formation of the JIP1-JNK module, as well as the activities of upstream kinases ASK1, MKK4/7 and MLK.
An update on laboratory diagnosis in myasthenia gravis.
Review
New
Frykman et al., Vancouver, Canada. In Clin Chim Acta, May 2015
They also describe the methods to measure each of the specific antibodies that have recently permitted to split the diagnosis: Abs to omega-conotoxin receptor in Lambert Eaton Myasthenic Syndrome (LEMS), abs to the acetylcholine receptor (AchR) in MG, Abs to muscle specific tyrosine kinase (MuSK) in Ab negative MG, and Abs to low molecular weight receptor related low-density lipo protein-4 (LRP-4).
Dental follicle mesenchymal stem cell administration ameliorates muscle weakness in MuSK-immunized mice.
Akkoç et al., İstanbul, Turkey. In J Neuroinflammation, 2014
Around 5-10 % of MG patients show antibodies to muscle-specific tyrosine kinase (MuSK).
Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation.
Glass et al., Cambridge, United States. In Mol Cell Biol, 2014
Crk and CrkL are noncatalytic adaptor proteins necessary for the formation of neuromuscular synapses which function downstream of muscle-specific kinase (MuSK), a receptor tyrosine kinase expressed in skeletal muscle, and the MuSK binding protein Dok-7.
Mouse models of myasthenia gravis.
Review
Phillips et al., Sydney, Australia. In Curr Pharm Des, 2014
Many of the remaining cases are due to antibodies against muscle specific tyrosine kinase (MuSK).
Neuromuscular disease. DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction.
Impact
Yamanashi et al., Tokyo, Japan. In Science, 2014
The muscle protein Dok-7 is essential for activation of the receptor kinase MuSK, which governs NMJ formation, and DOK7 mutations underlie familial limb-girdle myasthenia (DOK7 myasthenia), a neuromuscular disease characterized by small NMJs.
Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses.
Impact
Burden et al., New York City, United States. In Nature, 2012
Identification of these retrograde signals has proved elusive, but their production by muscle depends on the receptor tyrosine kinase, MuSK (muscle, skeletal receptor tyrosine-protein kinase), and Lrp4 (low-density lipoprotein receptor (LDLR)-related protein 4), an LDLR family member that forms a complex with MuSK, binds neural agrin and stimulates MuSK kinase activity.
The formation of complex acetylcholine receptor clusters requires MuSK kinase activity and structural information from the MuSK extracellular domain.
GeneRIF
Herbst et al., Vienna, Austria. In Mol Cell Neurosci, 2012
MuSK kinase activity is necessary for substrate-dependent acetylcholine receptor cluster formation
Initiation of synapse formation by Wnt-induced MuSK endocytosis.
GeneRIF
Granato et al., Philadelphia, United States. In Development, 2012
Data show that in vivo, wnt11r and wnt4a initiate MuSK translocation from muscle membranes to recycling endosomes and that this transition is crucial for AChR accumulation at future synaptic sites.
Biglycan is an extracellular MuSK binding protein important for synapse stability.
GeneRIF
Fallon et al., Providence, United States. In J Neurosci, 2012
Biglycan binding to MuSK rescues the unstable acetylcholine receptor clusters that are involved in neuromuscular junction formation and postsynaptic differentiation.
Development of a highly sensitive diagnostic assay for muscle-specific tyrosine kinase (MuSK) autoantibodies in myasthenia gravis.
GeneRIF
Tzartos et al., Athens, Greece. In J Neuroimmunol, 2012
The ability of immobilized MuSK extracellular domain to remove practically all anti-MuSK antibodies from patients' sera should prove invaluable for development of an antigen-specific therapeutic approach for MuSK myasthenia gravis.
Lrp4 is a receptor for Agrin and forms a complex with MuSK.
Impact
GeneRIF
Burden et al., New York City, United States. In Cell, 2008
These experiments indicate that Lrp4 is the long-sought and elusive receptor for Agrin and has a critical role in activating MuSK and stimulating neuromuscular synapse formation.
The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.
Impact
GeneRIF
Yamanashi et al., Tokyo, Japan. In Science, 2006
Dok-7 is essential for neuromuscular synaptogenesis through its interaction with MuSK
share on facebooktweetadd +1mail to friends