Cellular Recognition and Repair of Monofunctional-Intercalative Platinum-DNA Adducts.
Winston-Salem, United States. In Chem Res Toxicol, Dec 2015
At the same dose, P1-A1, but not cisplatin, elicited a distinct requirement for DNA double-strand break repair and stalled replication fork repair, which caused nuclear fluorescent staining related to high levels of MUS81, a specialized repair endonuclease, and phosphorylated histone protein γ-H2AX.
Holliday junction resolution: regulation in space and time.
London, United Kingdom. In Dna Repair (amst), 2014
A conserved network of core cell-cycle kinases and phosphatases modulate HJ metabolism by exerting spatial and temporal control over the activities of two structure-selective nucleases: yeast Mus81-Mms4 (human MUS81-EME1) and Yen1 (human GEN1).
A blooming resolvase at chromosomal fragile sites.
In Nat Cell Biol, 2013
Now CFS expression is shown to reflect the activity of the MUS81-EME1 resolvase complex which cooperates with the dissolving action of the BLM helicase to prevent uncontrolled chromosome breakage and to promote genome integrity.
MUS81 promotes common fragile site expression.
Oxford, United Kingdom. In Nat Cell Biol, 2013
Here, we report that the DNA structure-specific nuclease MUS81-EME1 localizes to CFS loci in early mitotic cells, and promotes the cytological appearance of characteristic gaps or breaks observed at CFSs in metaphase chromosomes.