The biology of Mur ligases as an antibacterial target.
Montréal, Canada. In Mol Microbiol, 2014
The amide ligases MurC, MurD, MurE and MurF function with the same catalytic mechanism and share conserved amino acid regions and structural features that can conceivably be exploited for the design of inhibitors that simultaneously target more than one enzyme.
Glucocorticoid-induced skeletal muscle atrophy.
Brussels, Belgium. In Int J Biochem Cell Biol, 2013
The stimulation by GC of these two proteolytic systems is mediated through the increased expression of several Atrogenes ("genes involved in atrophy"), such as FOXO, Atrogin-1, and MuRF-1.
Atrogin-1, MuRF-1, and sarcopenia.
Ann Arbor, United States. In Endocrine, 2013
Atrogin-1 and MuRF-1 are two E3 ubiquitin ligases that are important regulators of ubiquitin-mediated protein degradation in skeletal muscle.