Gene polymorphisms and oral cancer risk in tobacco habitués.
Mumbai, India. In Tumour Biol, Dec 2015
The SNPs rs2124437 (RASGRP3), rs1335022 (GRIK2), rs4512367 (PREX2), rs4748011 (CCDC3), and rs1435218 (LNX1) were analyzed in 500 histopathologically confirmed oral cancers and 500 healthy controls with a minimum of 10 years of tobacco usage.
PDZRN4 acts as a suppressor of cell proliferation in human liver cancer cell lines.
Shanghai, China. In Cell Biochem Funct, Oct 2015
Recently, some reports show that Ligand of Numb Protein-X 1 (LNX1) could be a suppressor gene in gliomas, while our current research has firstly shown that PDZ domain containing ring finger 4 (PDZRN4), another member of LNX family, could also be a potential suppressor in hepatocellular carcinoma (HCC).
Evaluating the Association between Keratoconus and Reported Genetic Loci in a Han Chinese Population.
Qingdao, China. In Ophthalmic Genet, Jun 2015
SNPs rs4954218 (Near RAB3GAP1 (5')), rs4894535 (FNDC3B), rs2956540 (LOX), rs3735520 (Near HGF (5')), rs1324183 (MPDZ-NF1B), rs1536482 (RXRA-COL5A1), rs7044529 (COL5A1), rs2721051 (Near FOXO1 (3')), rs9938149 (BANP-ZNF469) and rs6050307 (VSX1) were assessed for their association with KC.
Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models.
Portland, United States. In Alcohol Clin Exp Res, 2011
Analyses of neuronal activation associated with alcohol withdrawal and site-directed lesions in mice implicate the rostroventral caudate putamen, a ventrolateral segment of the DMS, in genetically determined differences in risk for alcohol withdrawal involved in physical association of the multi-PDZ domain protein, MPDZ, with 5-HT(2C) receptors and/or NR2B.
NG2 cells: Properties, progeny and origin.
Mainz, Germany. In Brain Res Rev, 2010
The C-terminal PDZ-binding motif of the NG2 protein binds several PDZ proteins including Mupp1, Syntenin and the Glutamate Receptor Interacting Protein (GRIP).