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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Major urinary protein 1

Mup-1, mitochondrial uncoupling protein 1
This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: UCP1, CAN, ACID, BAT, HAD
Papers on Mup-1
Regulation of human subcutaneous adipocyte differentiation by EID1.
New
Lizcano et al., Maebashi, Japan. In J Mol Endocrinol, Feb 2016
Transfection of EID1 into ADMSCs reduced triglyceride accumulation while increasing levels of thermogenic proteins, such as PGC1α, TFAM, and mitochondrial uncoupling protein 1 (UCP1), all of which are markers of energy expenditure and mitochondrial activity.
Overexpression of mitochondrial uncoupling protein 1 (UCP1) induces a hypoxic response in Nicotiana tabacum leaves.
New
Arruda et al., Campinas, Brazil. In J Exp Bot, Jan 2016
Mitochondrial uncoupling protein 1 (UCP1) decreases reactive oxygen species production under stress conditions by uncoupling the electrochemical gradient from ATP synthesis.
The molecular mechanism behind reactive aldehyde action on transmembrane translocations of proton and potassium ions.
New
Pohl et al., Vienna, Austria. In Free Radic Biol Med, Dec 2015
These caused the alteration of transport activity of mitochondrial uncoupling protein 1, potassium carrier valinomycin and ionophore CCCP.
17β-Trenbolone exposure programs metabolic dysfunction in larval medaka.
New
Nishida et al., Tsukuba, Japan. In Environ Toxicol, Jul 2015
Among the downregulated genes, angiopoietin-like 4 and mitochondrial uncoupling protein 1, which are inversely correlated with obesity, were detected in the TB treatments.
Major urinary protein 1 interacts with cannabinoid receptor type 1 in fatty acid-induced hepatic insulin resistance in a mouse hepatocyte model.
New
Ho et al., Taipei, Taiwan. In Biochem Biophys Res Commun, Jun 2015
Cannabinoid receptor type 1 (CB1R) and major urinary protein 1 (MUP1) are thought to play pivotal roles in mitochondrial dysfunction, liver steatosis and insulin resistance.
Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation.
New
Gracheva et al., Berkeley, United States. In Proc Natl Acad Sci U S A, Mar 2015
We report, using differential transcriptomics alongside immunohistologic and biochemical analyses, that neurons from thirteen-lined ground squirrels (Ictidomys tridecemlineatus) express mitochondrial uncoupling protein 1 (UCP1).
ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue.
Kajimura et al., Los Angeles, United States. In Cell Rep, 2015
The ability of BAT to dissipate energy is dependent on expression of mitochondrial uncoupling protein 1 (UCP1).
Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system.
Kawada et al., Uji, Japan. In Sci Rep, 2014
BAT-mediated thermogenesis is regulated by mitochondrial uncoupling protein 1 (UCP1) in classical brown and ectopic beige adipocytes, and is controlled by sympathetic nervous system (SNS).
Enhancing precursors availability in Pichia pastoris for the overproduction of S-adenosyl-L-methionine employing molecular strategies with process tuning.
Meenakshisundaram et al., Chennai, India. In J Biotechnol, 2014
For this purpose, S-adenosyl-l-methionine synthetase gene (sam2) was overexpressed in the present study, and we studied the effect of coexpression of methionine permease (mup1) and adenylate kinase (adk1) genes.
Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes.
Klingenspor et al., Freising, Germany. In Embo Rep, 2014
Thermogenesis in brown adipocytes, conferred by mitochondrial uncoupling protein 1 (UCP1), is receiving great attention because metabolically active brown adipose tissue may protect humans from metabolic diseases.
Interactions between the gut, the brain and brown adipose tissue function.
Review
Grefhorst et al., Rotterdam, Netherlands. In Front Horm Res, 2013
The mitochondrial uncoupling protein 1 is predominantly expressed in BAT and controls the thermogenetic properties of this tissue.
Brown adipose tissue thermogenesis in humans.
Review
Nuutila, Turku, Finland. In Diabetologia, 2013
In contrast to white adipocytes, which store energy, brown adipocytes generate heat via mitochondrial uncoupling protein 1, thereby acting as a defence against hypothermia and, potentially, obesity.
Mutation of high-affinity methionine permease contributes to selenomethionyl protein production in Saccharomyces cerevisiae.
GeneRIF
Jigami et al., Tsukuba, Japan. In Appl Environ Microbiol, 2010
The authors report the characterization of selenomethionine-resistant mutants of Saccharomyces cerevisiae and the identification of a mutant allele of the MUP1 gene encoding high-affinity methionine permease, which confers selenomethionine resistance.
PKA dynamics in a Drosophila learning center: coincidence detection by rutabaga adenylyl cyclase and spatial regulation by dunce phosphodiesterase.
GeneRIF
Preat et al., Paris, France. In Neuron, 2010
Dunce phosphodiesterase plays a major role in the spatial regulation of cAMP dynamics.
Major urinary protein regulation of chemical communication and nutrient metabolism.
Review
Rui et al., Ann Arbor, United States. In Vitam Horm, 2009
The major urinary protein (MUP) family members contain a conserved β-barrel structure with a characteristic central hydrophobic pocket.
SLC25A19 mutation as a cause of neuropathy and bilateral striatal necrosis.
GeneRIF
Elpeleg et al., Jerusalem, Israel. In Ann Neurol, 2009
a pathogenic missense mutation in the SLC25A19 gene was identifiedin 4 patients who suffered from recurrent episodes of flaccid paralysis and encephalopathy associated with bilateral striatal necrosis and chronic progressive polyneuropathy
Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice.
GeneRIF
Xu et al., Shanghai, China. In J Biol Chem, 2009
These findings raise the possibility that MUP-1 deficiency might contribute to the metabolic dysregulation in obese/diabetic mice.
Identification of MUP1 as a regulator for glucose and lipid metabolism in mice.
GeneRIF
Rui et al., Ann Arbor, United States. In J Biol Chem, 2009
MUP1 is a regulator for glucose and lipid metabolism in mice
A new look at UCP 1.
Review
Porter, Dublin, Ireland. In Biochim Biophys Acta, 2006
There has been a resurgence of interest in mitochondrial uncoupling protein 1 due to a desire to understand the regulation of the prominent role it plays in control of metabolic flux in brown adipose tissue and non-shivering thermogenesis, combined with the fact that UCP 1 acts as a paradigm for other novel less abundant uncoupling proteins.
Amish Lethal Microcephaly
Review
Biesecker et al., Seattle, United States. In Unknown Journal, 2003
SLC25A19 (also known as DNC or MUP1) is the only gene known to be associated with Amish lethal microcephaly.
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