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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interferon regulatory factor 4

MUM1, IRF4, interferon regulatory factor 4
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: bcl-6, p27, bcl-2, HAD, CAN
Papers using MUM1 antibodies
Regulation of Lymphocyte Apoptosis by Interferon Regulatory Factor 4 (IRF-4)
Supplier
Pernis Alessandra B. et al., In The Journal of Experimental Medicine, 2001
... The rabbit polyclonal antiserum against IRF-4 was obtained from Santa Cruz Biotechnology, Inc ...
Skeletal complications in hairy cell leukemia: diagnosis and therapy
Supplier
Sohani Aliyah R. et al., In Journal of Hematopathology, 1987
... Mum1Dako Corporation, Carpinteria, CA ...
Papers on MUM1
Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation.
New
Impact
Busslinger et al., Vienna, Austria. In Nat Immunol, Feb 2016
It directly activated genes, which led to increased expression of the plasma cell regulator IRF4 and proteins involved in immunoglobulin secretion.
Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response.
New
Impact
Nutt et al., Australia. In Nat Immunol, Feb 2016
The transcription factors Blimp-1 and IRF4 are essential for the generation of plasma cells; however, their function in mature plasma cells has remained elusive.
TIPE2, a negative regulator of TLR signaling, regulates p27 through IRF4-induced signaling.
New
Liu et al., Jinan, China. In Oncol Rep, Feb 2016
To determine the mechanism employed by TIPE2 in gastric cell carcinogenesis, a TIPE2-expressing plasmid was introduced into gastric cell lines, and microarray and western blot analysis revealed that TIPE2 selectively upregulates the expression of interferon regulatory factor 4 (IRF4).
Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages.
New
Qin et al., Key West, United States. In Cancer Res, Feb 2016
miR-125a functioned downstream of Notch signaling to reciprocally influence polarization of M1 and M2 macrophages by regulating FIH1 and IRF4, respectively.
IRF4 and IRF8 Act in CD11c+ Cells To Regulate Terminal Differentiation of Lung Tissue Dendritic Cells.
New
Kovats et al., Oklahoma City, United States. In J Immunol, Feb 2016
Conventional DC (cDC) subsets, CD11b(-) (cDC1s) or CD11b(+) (cDC2s), arise via distinct networks of transcription factors involving IFN regulatory factor 4 (IRF4) and IRF8, and are specialized for unique functional responses.
Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses.
New
Impact
McKenzie et al., Columbia, United States. In Nat Immunol, Jan 2016
ILC2-derived interleukin 13 (IL-13) is critical for eliciting production of the TH2 cell-attracting chemokine CCL17 by IRF4(+)CD11b(+)CD103(-) dendritic cells (DCs).
Transcriptional regulation of T cell metabolism.
Review
New
Weinmann et al., Birmingham, United States. In Mol Immunol, Dec 2015
The current data suggest that key transcription factors involved in T cell specialization decisions, including T-bet, Bcl-6, HIF1, IRF4 and Myc, link the selective programming of cellular metabolism with fate decisions.
Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.
New
Toren et al., Tel Aviv-Yafo, Israel. In Bmc Genomics, Dec 2015
CONCLUSIONS: Our findings provide the first high-resolution genome-wide view of chromosomal changes in hemangioblastoma and identify 23 candidate genes: EGFR, PRDM16, PTPN11, HOXD11, HOXD13, FLT3, PTCH, FGFR1, FOXP1, GPC3, HOXC13, HOXC11, MKL1, CHEK2, IRF4, GPHN, IKZF1, RB1, HOXA9, and micro RNA, such as hsa-mir-196a-2 for hemangioblastoma pathogenesis.
Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates.
New
Chang et al., San Diego, United States. In Sci Rep, Dec 2015
Here, we show that deletion of both aPKC isoforms resulted in a deficit in asymmetric divisions, increasing the proportion of daughter cells that inherit high amounts of effector fate-associated molecules, IL-2Rα, T-bet, IFNγR, and interferon regulatory factor 4 (IRF4).
Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8.
New
Impact
Singh et al., Cincinnati, United States. In Nat Immunol, Dec 2015
Here we identified a double-negative feedback loop between the transcription factors IRF4 and IRF8 that regulated the initial developmental bifurcation of activated B cells as well as the GC response.
Integrated molecular analysis of adult T cell leukemia/lymphoma.
New
Impact
Ogawa et al., Kyoto, Japan. In Nat Genet, Nov 2015
Other notable features include a predominance of activating mutations (in PLCG1, PRKCB, CARD11, VAV1, IRF4, FYN, CCR4 and CCR7) and gene fusions (CTLA4-CD28 and ICOS-CD28).
Synchronizing transcriptional control of T cell metabolism and function.
Review
New
Impact
Kallies et al., Melbourne, Australia. In Nat Rev Immunol, Oct 2015
T cell receptor (TCR)-induced transcription factors, in particular MYC and interferon-regulatory factor 4 (IRF4), cooperate with canonical nutrient-sensing pathways to integrate antigen-specific and metabolic signals to appropriately modulate adaptive immune responses.
Mechanisms of Action of Lenalidomide in B-Cell Non-Hodgkin Lymphoma.
Review
New
Impact
Morschhauser et al., London, United Kingdom. In J Clin Oncol, Oct 2015
Tumoricidal effects of lenalidomide are associated with reduced interferon regulatory factor 4, a downstream target of cereblon.
[Human herpesvirus 8-negative primary effusion lymphoma-like lymphoma with t(8;14)(q24;q32)].
Review
New
Aiba et al., In Rinsho Ketsueki, Aug 2015
The pathological examination of the pleural effusion showed proliferation of atypical large lymphoid cells, which were positive for CD19, CD20, CD10, CD38, CD7, BCL2 and BCL6 but negative for CD5, CD30, MUM1, surface immunoglobulin, HHV-8 and EBV.
Concurrent Epstein-Barr virus associated NK/T cell lymphoma after immunosuppressive therapy for aplastic anemia: report of a case and review of literature.
Review
Miao et al., Nanjing, China. In Int J Clin Exp Pathol, 2014
Increased heterotypic lymphocytes had been detected in the left side of parotid gland demonstrated as cCD3(+), CD56(+), GranB(+), TIA-1(+), MUM-1(+), KI-67 (50%-75%)(++), Bcl-6(-), MPO(-) by immunohistochemistry, and in-situ hybridization (ISH) indicated EBER positive.
Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.
GeneRIF
Chen-Kiang et al., New York City, United States. In Blood, 2012
Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.
Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma.
Impact
GeneRIF
Staudt et al., Bethesda, United States. In Cancer Cell, 2012
Data show that in a cereblon-dependent fashion, lenalidomide downregulates IRF4 and SPIB, transcription factors that together prevent IFNbeta production.
Elevated interferon regulatory factor 4 levels in patients with allergic asthma.
GeneRIF
Yang et al., Wuhan, China. In J Asthma, 2012
The levels of IRF4 were elevated in allergic asthmatics compared with those in healthy controls. IRF4 may play a role in facilitating the differentiation of Th2 and Th17 cells at least at the transcriptional level.
Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation.
GeneRIF
Lohoff et al., Marburg an der Lahn, Germany. In Proc Natl Acad Sci U S A, 2012
Data show that germinal centers (GCs) were absent in Peyer's patches of naive Irf4(-/-) mice.
Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity.
GeneRIF
Pernis et al., New York City, United States. In J Exp Med, 2012
DEF6 and SWAP-70 are differentially used at distinct stages of B cell differentiation to selectively control the ability of IRF4 to regulate IL-21 responsiveness in a stage-specific manner.
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