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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Multiple endocrine neoplasia I

Multiple Endocrine Neoplasia, MEN1
This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: MEN, HAD, CAN, AGE, RET
Papers on Multiple Endocrine Neoplasia
Histologic and Molecular Profile of Pediatric Insulinomas: Evidence of a Paternal Parent-of-Origin Effect.
New
Stanley et al., Philadelphia, United States. In J Clin Endocrinol Metab, Feb 2016
Features of MEN1 syndrome were present in 5 of the 12, including 4 cases with heterozygous mutations of MEN1 on 11q.
Impact of delay in diagnosis in outcomes in MEN1: results from the Dutch MEN1 study group.
New
Valk et al., Utrecht, Netherlands. In J Clin Endocrinol Metab, Feb 2016
OBJECTIVE: Identifying a germline mutation in the MEN1 gene in an index case has consequences for a whole family.
Presence of the RET Cys634Tyr mutation and Gly691Ser functional polymorphism in Iranian families with multiple endocrine neoplasia type 2A.
New
Mosavi et al., In Hormones (athens), Feb 2016
PURPOSE: Multiple Endocrine Neoplasia type 2A (MEN2A) is a complex autosomal dominant inherited syndrome characterized by medullary thyroid carcinoma (MTC), pheochromocytoma and primary parathyroid hyperplasia.
Active Surveillance versus Surgery of Nonfunctioning Pancreatic Neuroendocrine Neoplasms ≤2 cm in MEN1 Patients.
New
Falconi et al., Milano, Italy. In Neuroendocrinology, Feb 2016
BACKGROUND: Aim of this study was to evaluate the efficacy of a conservative treatment for NF-PNEN ≤2 cm in MEN1-affected patients compared with a surgical treatment.
Multiple endocrine neoplasia type 1 associated with a new germline Men1 mutation in a family with atypical tumor phenotype.
New
Laubner et al., In Hormones (athens), Feb 2016
BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant hereditary disorder associated with the development of endocrine tumors due to reduced expression of the tumor suppressor protein menin.
Multiple endocrine neoplasia type 1 (MEN1): An update of 208 new germline variants reported in the last nine years.
Review
New
Capoluongo et al., Roma, Italy. In Cancer Genet, Jan 2016
UNASSIGNED: This review will focus on the germline MEN1 mutations that have been reported in patients with MEN1 and other hereditary endocrine disorders from 2007 to September 2015.
[News in diagnostics and therapy of multiple endocrine neoplasia type 1].
Review
New
Starý, In Vnitr Lek, Oct 2015
MEN1 syndrome is an autosomal dominant disorder caused by mutation in the men in gene located on the 11th chromosome.
Multiple Endocrine Neoplasia, Type 1: Imaging Solutions to Clinical Questions.
Review
New
Smirniotopoulos et al., Bethesda, United States. In Curr Probl Diagn Radiol, Oct 2015
UNASSIGNED: The common clinical presentations of multiple endocrine neoplasia, type 1 (MEN1) often lead to predictable clinical questions that can be answered with imaging.
Familial syndromes associated with neuroendocrine tumours.
Review
Ruchała et al., Poznań, Poland. In Contemp Oncol (pozn), 2014
Two of these are considered to be major factors predisposing to benign and malignant endocrine tumours, designated multiple endocrine neoplasia type 1 and type 2 (MEN1 and MEN2).
Pheochromocytomas in Multiple Endocrine Neoplasia Type 2.
Review
Robinson et al., Sydney, Australia. In Recent Results Cancer Res, 2014
Over 30% of PCs are associated with germline mutations, including re-arranged in transfection (RET) mutations seen in multiple endocrine neoplasia type 2 (MEN2) syndromes.
Integrated genomic characterization of adrenocortical carcinoma.
Impact
Bertherat et al., Paris, France. In Nat Genet, 2014
We performed exome sequencing and SNP array analysis of 45 ACCs and identified recurrent alterations in known driver genes (CTNNB1, TP53, CDKN2A, RB1 and MEN1) and in genes not previously reported in ACC (ZNRF3, DAXX, TERT and MED12), which we validated in an independent cohort of 77 ACCs.
Accelerated proliferation and differential global gene expression in pancreatic islets of five-week-old heterozygous Men1 mice: Men1 is a haploinsufficient suppressor.
GeneRIF
Skogseid et al., Uppsala, Sweden. In Endocrinology, 2012
Data show that numerous genes were differentially expressed in the endocrine pancreas of 5-wk-old heterozygous multiple endocrine neoplasia 1 protein (Men1) mice.
The regulatory network menin-microRNA 26a as a possible target for RNA-based therapy of bone diseases.
GeneRIF
Brandi et al., Florence, Italy. In Nucleic Acid Ther, 2012
Silencing of MEN1 mRNA resulted in a down regulation of miR-26a and chromatin immunoprecipitation showed that menin occupies the miR-26-a gene promoter, thus inducing gene expression.
MEN1 and pituitary adenomas.
Review
GeneRIF
Delemer, Reims, France. In Ann Endocrinol (paris), 2012
MEN1 and pituitary adenomas.
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Impact
GeneRIF
Lei et al., Ann Arbor, United States. In Nature, 2012
crystal structures of human menin in its free form and in complexes with MLL1 or with JUND, or with an MLL1-LEDGF heterodimer
A novel menin gene deletional mutation in a little series of Italian patients affected by apparently sporadic multiple endocrine neoplasia type 1 syndrome.
GeneRIF
Castellano et al., Brescia, Italy. In J Endocrinol Invest, 2012
A novel menin gene deletional mutation in a little series of Italian patients affected by apparently sporadic multiple endocrine neoplasia type 1.
Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors.
GeneRIF
Jothi et al., Bethesda, United States. In Plos One, 2011
a possible role for menin-dependent H3K4me3 at these genes in the initiation and progression of sporadic pancreatic endocrine tumors
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
Impact
GeneRIF
Papadopoulos et al., Baltimore, United States. In Science, 2011
identification of mutations in pancreatic neuroendocrine tumors; 44% had somatic inactivating mutations in MEN1; 43% had mutations in genes encoding DAXX and ATRX; clinically, mutations in MEN1 and DAXX/ATRX genes were associated with better prognosis
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.
Impact
GeneRIF
Cleary et al., Stanford, United States. In Cell, 2005
MEN1 is an essential oncogenic cofactor for MLL-associated leukemogenesis.
Prognostic value of initial fasting serum gastrin levels in patients with Zollinger-Ellison syndrome.
Impact
Alexander et al., Bethesda, United States. In J Clin Oncol, 2001
RESULTS: In patients with sporadic ZES, but not in those with multiple endocrine neoplasia type 1 (MEN-1) and ZES, there was a significant relationship between the level of initial FSG and tumor size and location of primary tumor, frequency of lymph node and liver metastases, and survival.
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