Mutator and MULE Transposons.
In Microbiol Spectr, Apr 2015
The Mutator system of transposable elements (TEs) is a highly mutagenic family of transposons in maize.
The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma.
Winnipeg, Canada. In Mol Brain, 2014
We propose the hypothesis that proteasomal activity is essential to regulate the critical transition between proliferating granule cells and differentiated granule cells and that proteasome dysfunction may lead to MB. Proteasome dysfunction could also account for various mutations in MBs resulting from deficiencies in DNA checkpoint and repair mechanisms prior to development of MBs.Data showing a role for the ubiquitin ligases β-TrCP, FBW7, Huwe1, and SKP2 in MBs suggest the possibility of a classification of MBs based on the expression (over expression or under expression) of specific ubiquitin ligases which function as oncogenes, tumor suppressors or cell cycle regulators.
Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay.
Liverpool, United Kingdom. In Front Genet, 2013
For example, we have shown that the E3 ubiquitin ligase Mule, the tumor suppressor protein ARF, and the deubiquitylation enzyme USP47 modulate DNA repair by controlling cellular levels of DNA polymerase β, and also that polynucleotide kinase phosphatase levels are controlled by ATM-dependant phosphorylation and Cul4A-DDB1-STRAP-dependent ubiquitylation.
The double life of MULE in preeclamptic and IUGR placentae.
Toronto, Canada. In Cell Death Dis, 2011
In PE, MULE preferentially targeted p53 for degradation, allowing accumulation of pro-apoptotic Mcl-1 isoforms. In IUGR, however, MULE targeted pro-survival Mcl-1, allowing p53 to accumulate and exert its apoptotic function.