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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

HECT, UBA and WWE domain containing 1

Mule, ARF-BP1, HUWE1, HectH9, ARF-binding protein, UREB1
This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type. [provided by RefSeq, Nov 2009] (from NCBI)
Papers using Mule antibodies
Bcl2 inhibits abasic site repair by down-regulating APE1 endonuclease activity
Deng Xingming et al., In Molecular Cancer, 2007
... Anti-Mule antibody was purchased from Bethyl Laboratories, INC ...
Emerging roles for ubiquitin and protein degradation in neuronal function
Schuman Erin M. et al., In Frontiers in Molecular Neuroscience, 2006
... (Billerica, MA, USA); PSMD9 (sc-10670), 14-3-3γ (sc-731) from Santa Cruz Biotechnology (Santa Cruz, CA, USA); HUWE1 (A300-486A) from Bethyl (Montgomery, TX, USA); tubulin ...
Papers on Mule
Copy-number gains of HUWE1 due to replication- and recombination-based rearrangements.
Marynen et al., Leuven, Belgium. In Am J Hum Genet, 2012
Increased dosage of HUWE1 causes nonsyndromic intellectual disability.
HUWE1 ubiquitinates MyoD and targets it for proteasomal degradation.
Ciechanover et al., Haifa, Israel. In Biochem Biophys Res Commun, 2012
the involvement of HUWE1 in the ubiquitination and proteasomal degradation of MyoD was described.
The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.
Mak et al., Toronto, Canada. In J Exp Med, 2012
Mule regulates the ATM-p53 axis to maintain B cell homeostasis under both steady-state and stress conditions.
Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination.
Hübscher et al., Zürich, Switzerland. In Proc Natl Acad Sci U S A, 2012
The E3 ligase Mule mediates the degradation of Pol lambda and the control of Pol lambda levels by Mule has functional consequences for the ability of mammalian cells to deal with 8-oxo-G lesions.
The double life of MULE in preeclamptic and IUGR placentae.
Caniggia et al., Toronto, Canada. In Cell Death Dis, 2011
In PE, MULE preferentially targeted p53 for degradation, allowing accumulation of pro-apoptotic Mcl-1 isoforms. In IUGR, however, MULE targeted pro-survival Mcl-1, allowing p53 to accumulate and exert its apoptotic function.
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