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Tripartite motif containing 37

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, CD4, ACID, AGE
Papers using muL antibodies
A mitochondrial view of aging, reactive oxygen species and metastatic cancer
Ladiges Warren et al., In BMC Cancer, 2009
... FVB/N-Tg (MMTV-PyMT) 634 Mul/J transgenic males on a 100% FVB ...
Papers on muL
PGC-1α Overexpression via Local Transfection Attenuates Mitophagy Pathway in Muscle Disuse Atrophy.
Ji et al., Minneapolis, United States. In Free Radic Biol Med, Jan 2016
While mitochondrial biogenesis and antioxidant enzymes are decreased, all autophagic and mitophagic protein markers such as Beclin-1, Bnip3, PINK1, parkin, Mul 1 and the LC3II/LC3I ratio were increased in IM-RM muscle together with activation of FoxO pathway.
Effects of quercetin derivatives from mulberry leaves: Improved gene expression related hepatic lipid and glucose metabolism in short-term high-fat fed mice.
Shiwaku et al., Izumo, Japan. In Nutr Res Pract, Apr 2015
MATERIALS/METHODS: C57BL/6N mice were fed a high-fat diet, supplemented with either 0% (control), 1%, or 3% mulberry leaf powder (Mul) or 1% catechin powder for five days.
TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.
Green et al., Worcester, United States. In Nature, 2015
The TRIM37 (also known as MUL) gene is located in the 17q23 chromosomal region, which is amplified in up to ∼ 40% of breast cancers.
Hepatoprotective effect of mulberry (Morus nigra) leaves extract against methotrexate induced hepatotoxicity in male albino rat.
Tag, Suez, Egypt. In Bmc Complement Altern Med, 2014
The possible hepatoprotective effect of the administration of mulberry ethanolic extract (MUL) leaves against hepatotoxic effect of the anti-rheumatic drug, methotrexate (MTX) was evaluated in this study both vivo (using animal models) and in vitro (human hepatoma HepG2 cells).
Down-regulation of P-gp expression and function after Mulberroside A treatment: potential role of protein kinase C and NF-kappa B.
Bi et al., Guangzhou, China. In Chem Biol Interact, 2014
Mulberroside A (Mul A) is one of the main bioactive constituents of Sangbaipi, the dried root-bark of Morus alba L. (white mulberry), which is officially listed in the Chinese Pharmacopoeia.
Effect of hyperglycemia on insulin receptor signaling in the cultured retinal Müller glial cells.
Ola, Riyadh, Saudi Arabia. In Biochem Biophys Res Commun, 2014
In this study we utilized a well characterized cultured Muller cells (TR-MUL) where we found a high expression of insulin receptor molecules.
Deficient nitric oxide signalling impairs skeletal muscle growth and performance: involvement of mitochondrial dysregulation.
Clementi et al., Milano, Italy. In Skelet Muscle, 2013
Concomitantly, the Akt-FoxO3-mitochondrial E3 ubiquitin protein ligase 1 (Mul-1) axis was also dysregulated.
Binding free energy estimation for protein-ligand complex based on MM-PBSA with various partial charge models.
Li et al., Dalian, China. In Curr Pharm Des, 2012
The tested charges were calculated based on AM1 (Austin Method, version 1) - BCC (bond charge correction), MNDO (modified neglect of diatomic differential overlay), PM5 (Parameterisation Model, version 5), MUL (Mulliken), CM2 (Charge Model 2), CM3 (Charge Model 3), RESP (restrained electrostatic potential) and QM/MM (quantum mechanics/molecular mechanics) models.
TRPM6 and TRPM7: A Mul-TRP-PLIK-cation of channel functions.
Runnels, United States. In Curr Pharm Biotechnol, 2011
Unique among ion channels, TRPM6 and TRPM7 garnered much interest upon their discovery as the first ion channels to possess their own kinase domain.
Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study.
Bordignon et al., Milano, Italy. In Lancet Oncol, 2009
The primary study endpoint was immune reconstitution defined as circulating CD3+ count of 100 cells per muL or more for two consecutive observations.
Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas.
Butzow et al., Helsinki, Finland. In Mod Pathol, 2009
inherited biallelic inactivation of TRIM37 (Mulibrey nanism) predisposes to both mesenchymal and epithelial ovarian tumors and dysregulation of TRIM37 may also be involved in the pathogenesis of sporadic fibrothecomas.
Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial.
Arning et al., New York City, United States. In Lancet, 2009
METHODS: In this phase III, randomised, double-blind, placebo-controlled study, adults from 63 sites in 23 countries with chronic idiopathic thrombocytopenic purpura (ITP), platelet counts less than 30 000 per muL of blood, and one or more previous ITP treatment received standard care plus once-daily eltrombopag 50 mg (n=76) or placebo (n=38) for up to 6 weeks.
Once-daily atazanavir/ritonavir versus twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 48 week efficacy and safety results of the CASTLE study.
CASTLE Study Team et al., Paris, France. In Lancet, 2008
Mean increases from baseline in CD4 cell count were similar (203 cells per muL in the atazanavir/ritonavir group vs 219 cells per muL in the lopinavir/ritonavir group).
A novel mutation in TRIM37 is associated with mulibrey nanism in a Turkish boy.
Tekin et al., Ankara, Turkey. In Clin Dysmorphol, 2007
Mutation screening of the TRIM37 gene revealed that the proband had a homozygous two base pair deletion, c.1894_1895delGA, resulting in a frame-shift and a premature termination codon.
Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial.
Protocol 005 Team et al., Rio de Janeiro, Brazil. In Lancet, 2007
METHODS: HIV-infected patients with HIV-1 RNA viral load over 5000 copies per mL, CD4 cell counts over 50 cells per muL, and documented genotypic and phenotypic resistance to at least one nucleoside reverse transcriptase inhibitor, one non-nucleoside reverse transcriptase inhibitor, and one protease inhibitor were randomly assigned to receive raltegravir (200 mg, 400 mg, or 600 mg) or placebo orally twice daily in this multicentre, triple-blind, dose-ranging, randomised study.
Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism.
Lehesjoki et al., Helsinki, Finland. In Clin Genet, 2006
Novel mutations in the tumor necrosis factor receptor associated factor (TRAF) domain alter the subcellular localization of TRIM37, and are associated with Wilm's tumor in a patient with mulibrey nanism.
Tissue expression of the mulibrey nanism-associated Trim37 protein in embryonic and adult mouse tissues.
Lehesjoki et al., Helsinki, Finland. In Histochem Cell Biol, 2006
We here show that the mouse Trim37 gene presents several alternative splice variants, including a testis-specific transcript with an additional 3' exon.
Characterisation of the mulibrey nanism-associated TRIM37 gene: transcription initiation, promoter region and alternative splicing.
Lehesjoki et al., Helsinki, Finland. In Gene, 2006
TRIM37 expression is regulated by several mechanisms: through nonsense surveillance of non-functional transcripts, as well as through 3'UTR regulatory sequences and/or naturally occurring antisense RNAs especially in testis.
Advances in the cell biology of transport via the inner blood-retinal barrier: establishment of cell lines and transport functions.
Tomi et al., Toyama, Japan. In Biol Pharm Bull, 2005
Conditionally immortalized rat retinal capillary endothelial cells (TR-iBRB), pericytes (TR-rPCT) and Müller cell lines (TR-MUL) have been established from transgenic rats harboring the temperature-sensitive simian virus 40 large T-antigen gene.
Transposon mutagenesis of nuclear photosynthetic genes in Zea mays.
Miles et al., Columbia, United States. In Photosynth Res, 1988
The discovery of a new maize (Zea mays L.) transposon system, Mutator, and the cloning of the 1.4 kilobase transposon, Mul, have made feasible the isolation of nuclear photosynthetic genes which are recognized only by their mutant phenotype.
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