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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mucin 6, oligomeric mucus/gel-forming

The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract (summary by Toribara et al., 1993 [PubMed 7680650]).[supplied by OMIM, Dec 2010] (from NCBI)
Top mentioned proteins: MUC5AC, MUC2, MUC1, MUC4, CDX2
Papers on MUC6
Tubular Pyloric Gland Adenoma of the Left and Right Hepatic Ducts: Report of a Unique Case With Immunohistochemical and Molecular Studies.
Albores-Saavedra et al., Thessaloníki, Greece. In Int J Surg Pathol, Feb 2016
The tumor cells expressed MUC6 and MUC5AC.
Seminal epithelium in prostate biopsy can mimic malignant and premalignant prostatic lesions.
Martínez-Benítez et al., Mexico. In Actas Urol Esp, Jan 2016
In the biopsies in which the seminal epithelium resembled malignant or premalignant lesions, immunohistochemical studies were conducted that included prostate-specific antigen and MUC6.
A Detailed Immunohistochemical Analysis of a Large Series of Cervical and Vaginal Gastric-type Adenocarcinomas.
McCluggage et al., Melbourne, Australia. In Am J Surg Pathol, Jan 2016
Markers included were cytokeratin (CK)7, CK20, CDX2, carcinoembryonic antigen, CA125, CA19.9, p16, estrogen receptor, progesterone receptor, MUC6, PAX8, PAX2, p53, hepatocyte nuclear factor 1 beta, carbonic anhydrase IX, human epidermal receptor 2 (HER2), and mismatch repair (MMR) proteins.
Foamy gland changes in gastric-type endocervical neoplasia.
Tan et al., Perth, Australia. In Pathology, Dec 2015
These cases were MUC6 positive and p16 negative on immunohistochemistry while HPV was not detected.
Histologic differentiation and mucin phenotype in white opaque substance-positive gastric neoplasias.
Murakami et al., Ōita, Japan. In Endosc Int Open, Dec 2015
Tissue phenotypes were immunohistochemically classified as intestinal (I), gastrointestinal (GI), and gastric (G) using antibodies against CD10, MUC2, MUC5AC and MUC6.
Clinicopathological characterisation of duodenal adenocarcinoma with high CD44 variant 9 expression.
Ota et al., Matsumoto, Japan. In Pathology, Dec 2015
CD44v9 expression was analysed together with that of MUC2, MUC5AC, and MUC6 by immunohistochemistry. High levels of CD44v9 expression weakly correlated with inflammatory cell infiltration (r = 0.431, p = 0.020) and MUC6 expression (r = 0.425, p = 0.022).
Polymorphisms in mucin genes in the development of gastric cancer.
Jia et al., Baotou, China. In World J Gastrointest Oncol, Dec 2015
Normal gastric mucosa shows expression of MUC1, MUC5AC and MUC6 that is specific to cell type.
Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature.
Chen et al., Nanjing, China. In Dis Esophagus, Dec 2015
Both of the two layer cells were positive for HMWCK and negative for CK20, p53, CDX2, MUC5AC, MUC6, MUC2 and MUC1.
Pseudomyxoma-type Invasion in Gastrointestinal Adenocarcinomas of Endometrium and Cervix: A Report of 2 Cases.
Nogales et al., Parma, Italy. In Int J Gynecol Pathol, Dec 2015
Immunohistochemically, both tumors had a gastrointestinal phenotype coexpressing cytokeratins 7 and 20, CDX2, villin, MUC2, MUC5AC, and MUC6 and were negative for human papillomavirus, analyzed by real-time polymerase chain reaction.
Expression of adipophilin in gastric epithelial neoplasia is associated with intestinal differentiation and discriminates between adenoma and adenocarcinoma.
Sasaki et al., Tokyo, Japan. In Virchows Arch, Dec 2015
Immunohistochemistry for adipophilin was performed, and phenotypic marker expression was determined by immunohistostaining with MUC2, MUC5AC, CD10, MUC6, and villin.
TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review).
Hoffmann, Magdeburg, Germany. In Int J Oncol, Sep 2015
The peptide TFF2 (formerly 'spasmolytic polypeptide'), a member of the trefoil factor family (TFF) containing two TFF domains, is mainly expressed together with the mucin MUC6 in the gastric epithelium and duodenal Brunner's glands.
Gastric pyloric gland adenoma.
Park et al., Dallas, United States. In Arch Pathol Lab Med, Jun 2015
Immunohistochemically, the neoplastic cells label with markers of gastric pyloric gland differentiation, including MUC6 and MUC5AC.
Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas.
Colina-Ruizdelgado et al., Madrid, Spain. In World J Gastrointest Oncol, 2014
Two pathways have been suggested: gastric phenotype corresponds to less aggressive uncommitted cells (MUC1 -, MUC2 -, MUC5AC +, MUC6 +) with the capacity to evolve to intestinal phenotype (intestinal pathway) (MUC1 -, MUC2 +, MUC5AC +, MUC6 - or weak +) or pancreatobiliary /oncocytic phenotypes (pyloropancreatic pathway) (MUC1 +, MUC 2-, MUC5AC +, MUC 6 +) becoming more aggressive.
Gastric carcinoma with an invasive micropapillary carcinoma component showing HER2 gene amplification and CD10 expression: a case report and review of the literature.
Terasaki et al., Shizuoka, Japan. In Pathol Int, 2014
Immunohistochemistry revealed that the tumor showed an entirely intestinal mucin phenotype, being positive only for CD10 and negative for MUC2, MUC5AC, and MUC6.
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
Leung et al., San Diego, United States. In Nat Genet, 2014
We identified previously known (TP53, ARID1A and CDH1) and new (MUC6, CTNNA2, GLI3, RNF43 and others) significantly mutated driver genes.
Genetic variation in MUC1, MUC2 and MUC6 genes and evolution of gastric cancer precursor lesions in a long-term follow-up in a high-risk area in Spain.
Sala et al., l'Hospitalet de Llobregat, Spain. In Carcinogenesis, 2012
No significant association was found with variants in the MUC6 gene and evolution of gastric cancer precursor lesions.
Divergent expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in dysplasia and intramucosal adenocarcinomas with intestinal and foveolar morphology: is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett Esophagus?
Lauwers et al., Boston, United States. In Am J Surg Pathol, 2012
Report Divergent expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in dysplasia and intramucosal adenocarcinomas with intestinal and foveolar morphology and roles in neoplastic progression.
Polymorphisms in MUC1, MUC2, MUC5B and MUC6 genes are not associated with the risk of chronic atrophic gastritis.
Brenner et al., Heidelberg, Germany. In Eur J Cancer, 2012
Polymorphisms in MUC1, MUC2, MUC5B and MUC6 genes are not associated with the risk of chronic atrophic gastritis.
MUC6 mucin expression inhibits tumor cell invasion.
Harris et al., Chicago, United States. In Exp Cell Res, 2011
results suggest that MUC6 may inhibit invasion of tumor cells through the basement membrane of the pancreatic duct and slow the development of infiltrating carcinoma.
MUC expression in hyperplastic and serrated colonic polyps: lack of specificity of MUC6.
Odze et al., Rochester, United States. In Am J Surg Pathol, 2011
use of MUC6 to differentiate hyperplastic polyps from sessile serrated adenoma/polyps (SSA/P) or SSA/P with dysplasia in individual cases is not reliable because of a lack of specificity.
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