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Mucin 5AC, oligomeric mucus/gel-forming

MUC5AC, Gastric Mucin, Leb
a secretory mucin expressed in the airway;expression is associated with mucous cell differentiation [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: MUC2, MUC6, MUC1, HAD, CAN
Papers on MUC5AC
The Chronic and Short-Term Effects of Gefinitib on Airway Remodeling and Inflammation in a Mouse Model of Asthma.
Li et al., Xi'an, China. In Cell Physiol Biochem, Feb 2016
METHODS: Pathological changes of OVA sensitization of BALB/c mice were measured by H&E and PAS staining; pEGFR, Bcl-2 and Bax expression was measured by western blot; ELISA was used to measure the level of muc5ac, IL-13 and IFN-x03B3;; TUNEL staining was used to detect goblet cell apoptosis.
Effects of Autologous Serum Eye Drops on Conjunctival Expression of MUC5AC in Patients With Ocular Surface Disorders.
Suárez-Cortés et al., Madrid, Spain. In Cornea, Feb 2016
PURPOSE: To assess the effects of autologous serum eye drops on conjunctival expression of the mucin gene MUC5AC by means of quantitative reverse transcription polymerase chain reaction (RT-qPCR).
Effect of Titanium Dioxide Nanoparticle Exposure on the Ocular Surface: An Animal Study.
Kim et al., Seoul, South Korea. In Ocul Surf, Feb 2016
Ocular surface staining (n=5 for each group) was performed with rose bengal dye, tear secretion (n=5) was measured using the phenol red thread test, lactic dehydrogenase (LDH) activity (n=5) and MUC5AC levels (n=5) were measured in tears, and the area of the conjunctival goblet cells (n=5) was measured through impression cytology and scanning electron microscopy 24 hours after the last TiO2 instillation.
Adenocarcinoma arising in urinary bladder endocervicosis.
Ono et al., Seto, Japan. In Pathol Int, Feb 2016
Immunohistochemically, the endocervicosis was positive for cytokeratin (CK) 7, AE1/AE3, CAM5.2, HBME1, CA19-9, and estrogen receptor (ER), and negative for CK20, CDX2, progesterone receptor (PR), MUC5AC, and β-catenin.
Intraductal Papillary Mucinous Neoplasms Often Contain Epithelium From Multiple Subtypes and/or Are Unclassifiable.
Longacre et al., Stanford, United States. In Am J Surg Pathol, Jan 2016
Immunohistochemistry for CDX2, MUC2, and MUC5AC was performed on cases where the histologic subtype could not be determined on routine hematoxylin and eosin (H&E) sections.
Polymorphisms in mucin genes in the development of gastric cancer.
Jia et al., Baotou, China. In World J Gastrointest Oncol, Dec 2015
Normal gastric mucosa shows expression of MUC1, MUC5AC and MUC6 that is specific to cell type.
Altered Mucin and Glycoprotein Expression in Dry Eye Disease.
McNamara et al., Berkeley, United States. In Optom Vis Sci, Sep 2015
RESULTS: Although consistent decreases in MUC5AC and altered expression of membrane-bound mucins have been noted in both Sjögren and non-Sjögren dry eye, many reports of altered mucins in dry eye are contradictory.
Gastric pyloric gland adenoma.
Park et al., Dallas, United States. In Arch Pathol Lab Med, Jun 2015
Immunohistochemically, the neoplastic cells label with markers of gastric pyloric gland differentiation, including MUC6 and MUC5AC.
Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice.
Johnston et al., London, United Kingdom. In Lancet, Mar 2015
By contrast, fluticasone increased MUC5AC proteins (158·2 arbitrary units [29·9] vs 107·6 [7·1], p=0·0165) and MUC5B proteins (623·8 arbitrary units [231·9] vs 413·5 [70·5], p=0·0476) in BAL at day 7 post infection.
Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas.
Colina-Ruizdelgado et al., Madrid, Spain. In World J Gastrointest Oncol, 2014
Two pathways have been suggested: gastric phenotype corresponds to less aggressive uncommitted cells (MUC1 -, MUC2 -, MUC5AC +, MUC6 +) with the capacity to evolve to intestinal phenotype (intestinal pathway) (MUC1 -, MUC2 +, MUC5AC +, MUC6 - or weak +) or pancreatobiliary /oncocytic phenotypes (pyloropancreatic pathway) (MUC1 +, MUC 2-, MUC5AC +, MUC 6 +) becoming more aggressive.
Muc5b is required for airway defence.
Evans et al., Houston, United States. In Nature, 2014
MUC5AC and MUC5B are evolutionarily conserved genes that encode structurally related mucin glycoproteins, the principal macromolecules in airway mucus.
Cigarette smoke induces MUC5AC protein expression through the activation of Sp1.
Harper et al., Pittsburgh, United States. In J Biol Chem, 2012
CS induces MUC5AC gene transcription predominantly through increased Sp1 nuclear protein levels and increased Sp1 binding to its promoter region.
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.
Li et al., Atlanta, United States. In J Biol Chem, 2012
PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway.
Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells.
Bercik et al., Hamilton, Canada. In Lab Invest, 2012
Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells
Chronic Aspergillus fumigatus exposure upregulates the expression of mucin 5AC in the airways of asthmatic rats.
Liu et al., Weifang, China. In Exp Lung Res, 2012
Chronic exposure to A. fumigatus upregulates the expression of MUC5AC.
Upregulation of Intestinal Mucin Expression by the Probiotic Bacterium E. coli Nissle 1917.
Hafez, Aţ Ţā'if, Saudi Arabia. In Probiotics Antimicrob Proteins, 2012
Incubation of HT-29 cells with EcN lead to a contact time-dependent rise in mRNA levels of the MUC2, MUC3, MUC5AC, and MUC5A.
Triiodothyronine represses MUC5AC expression by antagonizing Sp1 binding to its promoter in human bronchial epithelial HBE16 cells.
Perelman et al., Chongqing, China. In J Biomed Biotechnol, 2011
By RT-PCR and ELISA, results showed that T3 inhibited MUC5AC mRNA expression and protein secretion in HBE16 cells, and further analysis demonstrated that T3 repressed MUC5AC expression, in part due to inhibition of Sp1 binding to the promoter.
Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.
Schmid et al., München, Germany. In Cancer Cell, 2007
Microarray data in mice revealed an IPMN signature and IPMNs expressed MUC1 and MUC5AC but not MUC2, similar to human pancreatobiliary IPMNs.
Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging.
Borén et al., Umeå, Sweden. In Science, 1998
Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen.
Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens.
Normark et al., Saint Louis, United States. In Science, 1994
Soluble glycoproteins presenting the Leb antigen or antibodies to the Leb antigen inhibited bacterial binding.
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