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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mucin 4, cell surface associated

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MUC1, Asialoglycoprotein Receptor, MUC5AC, MUC2, CAN
Papers on MUC4
Possible prediction of the response of esophageal squamous cell carcinoma to neoadjuvant chemotherapy based on gene expression profiling.
Chen et al., Beijing, China. In Oncotarget, Jan 2016
IHC was conducted to examine the expression of selected target markers MUC4, MUC13, and MUC20 in 186 ESCC resection samples and the relationships between their expression and tumor regression grade was analyzed.
Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes.
Gruber et al., Brno, Czech Republic. In Structure, Jan 2016
SMC/kleisin complexes form elongated annular structures, which are critical for chromosome segregation, genome maintenance, and the regulation of gene expression.
Effect of Stratification on Surface Properties of Corneal Epithelial Cells.
Murphy et al., Davis, United States. In Invest Ophthalmol Vis Sci, Jan 2016
RESULTS: hTCEpi cells expressed the three main ocular mucins (MUC1, MUC4, and MUC16) with a maximum between days 1 and 3 of the stratification process.
Clinical impacts of a micropapillary pattern in lung adenocarcinoma: a review.
Yuan et al., Hangzhou, China. In Onco Targets Ther, Dec 2015
Molecular markers, including vimentin, napsin A, phosphorylated c-Met, cytoplasmic maspin, Notch-1, MUC1, and tumoral CD10, may have higher expression in MPPAC than other subtypes; conversely, markers such as MUC4 and surfactant apoprotein A have lower expression in MPPAC.
CA-125, but not galectin-3, complements CA 19-9 for discriminating ductal adenocarcinoma versus non-malignant pancreatic diseases.
Pigny et al., Lille, France. In Pancreatology, Dec 2015
METHODS: We evaluated by immunohistochemistry the expression of MUC4, MUC16 (CA-125) and galectin-3 in 31 pancreatic adenocarcinomas.
A Comprehensive Outline of Trastuzumab Resistance Biomarkers in HER2 Overexpressing Breast Cancer.
Győrffy et al., Budapest, Hungary. In Curr Cancer Drug Targets, 2014
These include HER2 amplification, impaired access to the binding site (p95HER2, Δ16HER-2, MUC4), augmented signaling through other ERBB family receptors (HER1, HER3, HER4) and their ligands, activation of HER2 targets by alternate heterodimers (EphA2, IGF-1R, GDF15, MUC1*), signaling triggered by downstream members (PIK3CA, PTEN, SRC, mTOR), altered expression of cell cycle and apoptotic regulators (CDKs, p27(kip1), Bcl-2), hormone receptor status, resistance to antibody-dependent cellular cytotoxicity (FcγR), and altered miRNA expression signatures.
Transmembrane Mucin Expression and Function in Embryo Implantation and Placentation.
Carson et al., Houston, United States. In Adv Anat Embryol Cell Biol, 2014
Three major TMs have been identified in uterine epithelia of multiple species: MUC1, MUC4, and MUC16.
Primary sclerosing epithelioid fibrosarcoma of kidney with variant histomorphologic features: report of 2 cases and review of the literature.
Aki et al., Ankara, Turkey. In Diagn Pathol, 2014
Immunohistochemically, vimentin, bcl-2 and MUC4 were diffusely positive in both.
α1-Adrenoceptors relate Ca(2+) modulation and protein secretions in rat lacrimal gland.
Saino et al., Japan. In Biomed Res, 2014
The RT-PCR results showed that MUC1, MUC4, MUC5AC, MUC5B, and MUC16 were expressed in acinar cells.
Transcriptome analysis reveals mucin 4 to be highly associated with periodontitis and identifies pleckstrin as a link to systemic diseases.
Yucel-Lindberg et al., Huddinge, Sweden. In Sci Rep, 2014
The most highly up-regulated gene was mucin 4 (MUC4), and its protein product was confirmed to be over-expressed in periodontitis.
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.
Huang et al., San Francisco, United States. In Cell, 2014
Using this method, we have studied telomere dynamics during elongation or disruption, the subnuclear localization of the MUC4 loci, the cohesion of replicated MUC4 loci on sister chromatids, and their dynamic behaviors during mitosis.
Role of MUC4-NIDO domain in the MUC4-mediated metastasis of pancreatic cancer cells.
Batra et al., Omaha, United States. In Oncogene, 2012
MUC4-NIDO domain significantly contributes to the MUC4-mediated metastasis of PC cells
Upregulation of mucin4 in ER-positive/HER2-overexpressing breast cancer xenografts with acquired resistance to endocrine and HER2-targeted therapies.
Schiff et al., Houston, United States. In Breast Cancer Res Treat, 2012
Breast tumors acquiring resistance to endocrine therapy exhibited a distinct phenotype including upregulation of MUC4.
Mathematical modelling unravels regulatory mechanisms of interferon-γ-induced STAT1 serine-phosphorylation and MUC4 expression in pancreatic cancer cells.
Rateitschak et al., Rostock, Germany. In Iet Syst Biol, 2012
In addition, our results propose that unphosphorylated or serine-phosphorylated STAT1 can act as transcription factors of MUC4.
MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells.
Singh et al., Mobile, United States. In Carcinogenesis, 2011
findings establish miR-150 as a novel regulator of MUC4 and a tumor suppressor miRNA in pancreatic cancer
The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways.
Van Seuningen et al., Lille, France. In Plos One, 2011
ErbB2 and MUC4, which interact physically, activate different intracellular signalling pathways to regulate biological properties of CAPAN-2 pancreatic cancer cells
Recruitment of condensin to replication origin regions by ParB/SpoOJ promotes chromosome segregation in B. subtilis.
Errington et al., Newcastle upon Tyne, United Kingdom. In Cell, 2009
In Bacillus subtilis, two protein complexes have been implicated in this process: the ParAB homologs, Soj and Spo0J, and the bacterial Smc/ScpAB complex, also called condensin.
Dynamic localization of bacterial and plasmid chromosomes.
Hiraga, Kumamoto, Japan. In Annu Rev Genet, 1999
The MukFEB complex of E. coli and Smc of B. subtilis appear to participate in the reorganization of bacterial sister chromosomes.
Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon.
Takahashi et al., Boston, United States. In Nat Med, 1999
Because the asialoglycoprotein (ASGP) receptor is specifically expressed in the liver at high density, the ASGP receptor-binding domain was generated within an N-glycosylated human IFN-beta molecule by the removal of sialic acid to direct this cytokine to the liver.
Intracellular receptor sorting during endocytosis: comparative immunoelectron microscopy of multiple receptors in rat liver.
Schwartz et al., In Cell, 1984
Using double-label quantitative immunoelectron microscopy on ultrathin cryosections of rat liver, we have compared the endocytotic pathways of the receptors for asialoglycoprotein (ASGP-R), mannose-6-phosphate ligands (MP-R), and polymeric IgA (IgA-R).
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