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Mucin 2, oligomeric mucus/gel-forming

MUC2
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MUC5AC, MUC1, MUC6, HAD, CDX2
Papers on MUC2
Early detection of colonic dysplasia by magnetic resonance molecular imaging with a contrast agent raised against the colon cancer marker MUC5AC.
New
Robbe-Masselot et al., Lille, France. In Contrast Media Mol Imaging, Feb 2016
To accomplish this, we employed positive selection of the phage display library on MUC5AC purified from fresh human colonic adenomas in combination with negative selection of the phage library on purified human MUC2, which is predominantly found in normal colorectal tissues.
Tubular Pyloric Gland Adenoma of the Left and Right Hepatic Ducts: Report of a Unique Case With Immunohistochemical and Molecular Studies.
New
Albores-Saavedra et al., Thessaloníki, Greece. In Int J Surg Pathol, Feb 2016
MUC2, p53, and CDX2 were not expressed.
Application of recent advances in hydrodynamic methods for characterising mucins in solution.
New
Harding et al., Murcia, Spain. In Eur Biophys J, Jan 2016
In this study a combination of such methods was used to provide increased understanding of a preparation of porcine intestinal mucin (PIM), MUC2 mucin, in terms of both heterogeneity and quantification of conformational flexibility.
Intraductal Papillary Mucinous Neoplasms Often Contain Epithelium From Multiple Subtypes and/or Are Unclassifiable.
Review
New
Longacre et al., Stanford, United States. In Am J Surg Pathol, Jan 2016
Immunohistochemistry for CDX2, MUC2, and MUC5AC was performed on cases where the histologic subtype could not be determined on routine hematoxylin and eosin (H&E) sections.
Sodium alginate decreases the permeability of intestinal mucus.
New
Bajka et al., Norwich, United Kingdom. In Food Hydrocoll, Jan 2016
UNASSIGNED: In the small intestine the nature of the environment leads to a highly heterogeneous mucus layer primarily composed of the MUC2 mucin.
Histologic differentiation and mucin phenotype in white opaque substance-positive gastric neoplasias.
New
Murakami et al., Ōita, Japan. In Endosc Int Open, Dec 2015
Tissue phenotypes were immunohistochemically classified as intestinal (I), gastrointestinal (GI), and gastric (G) using antibodies against CD10, MUC2, MUC5AC and MUC6.
Polymorphisms in mucin genes in the development of gastric cancer.
Review
New
Jia et al., Baotou, China. In World J Gastrointest Oncol, Dec 2015
However, the specific pattern of MUC1, MUC5AC and MUC6 expression is changed in gastric carcinogenesis, accompanied by de novo expression of secreted MUC2.
Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype.
Review
New
Yasui et al., Hiroshima, Japan. In Cancer Sci, Aug 2015
MUC2, CDH17, REG4, DSC2 and ABCB1 are direct targets of CDX2.
New developments in goblet cell mucus secretion and function.
Review
New
Hansson et al., Göteborg, Sweden. In Mucosal Immunol, Jul 2015
The mucus system differs substantially between the small and large intestine, although it is built around MUC2 mucin polymers in both cases.
Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice.
Gou et al., Shenzhen, China. In Sci Rep, 2014
Here, we investigated the impact of mulberry fruit (MBF) extracts on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages, and the therapeutic efficacy of MBF diet in mice with dextran sulfate sodium (DSS)-induced acute colitis and MUC2(-/-) mice with colorectal cancer.
Immune Evasion Mechanisms of Entamoeba histolytica: Progression to Disease.
Review
Chadee et al., Calgary, Canada. In Front Microbiol, 2014
In most cases, this extracellular parasite colonizes the colon by high affinity binding to MUC2 mucin without disease symptoms, whereas in some cases, Eh triggers an aggressive inflammatory response upon invasion of the colonic mucosa.
Identification of Potential Biomarkers for Gut Barrier Failure in Broiler Chickens.
Escobar et al., Saint Charles, United States. In Front Vet Sci, 2014
Protein levels of endotoxin and α1-acid glycoprotein (AGP) in serum, as well as mRNA levels of interleukin (IL)-8, IL-1β, transforming growth factor (TGF)-β4, and fatty acid-binding protein (FABP) 6 were increased (P < 0.05) in GBF birds compared to CON birds; however, mRNA levels of FABP2, occludin, and mucin 2 (MUC2) were reduced by 34% (P < 0.05), 24% (P = 0.107), and 29% (P = 0.088), respectively, in GBF birds compared to CON birds.
Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.
Impact
Cerutti et al., New York City, United States. In Science, 2013
This mucus barrier is organized around the hyperglycosylated mucin MUC2.
Histamine regulates mucin expression through H1 receptor in airway epithelial cells.
GeneRIF
Rhee et al., South Korea. In Acta Otolaryngol, 2012
Histamine-induced MUC2 mRNA expression and mucin secretion were significantly suppressed by pretreatment with H1R antagonist.
Upregulation of Intestinal Mucin Expression by the Probiotic Bacterium E. coli Nissle 1917.
Hafez, Aţ Ţā'if, Saudi Arabia. In Probiotics Antimicrob Proteins, 2012
Incubation of HT-29 cells with EcN lead to a contact time-dependent rise in mRNA levels of the MUC2, MUC3, MUC5AC, and MUC5A.
Genetic variation in MUC1, MUC2 and MUC6 genes and evolution of gastric cancer precursor lesions in a long-term follow-up in a high-risk area in Spain.
GeneRIF
Sala et al., l'Hospitalet de Llobregat, Spain. In Carcinogenesis, 2012
The results indicate, for the first time, that genetic variability in the MUC2 gene is associated with evolution of gastric cancer precursor lesions.
Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin.
GeneRIF
Hansson et al., Göteborg, Sweden. In Proc Natl Acad Sci U S A, 2012
The MUC2-N aggregates were dissolved by removing Ca(2+) and raising pH.
Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2.
GeneRIF
Semenkovich et al., Saint Louis, United States. In Cell Host Microbe, 2012
FAS deficiency blocked the generation of palmitoylated Mucin 2, which must be S-palmitoylated at its N terminus for proper secretion and function.
MUC2 polymorphisms are associated with endometriosis development and infertility: a case-control study.
GeneRIF
Tsai et al., Taiwan. In Bmc Med Genet, 2011
Our data present MUC2 as a new candidate involved in development of endometriosis and related infertility
Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.
Impact
Schmid et al., München, Germany. In Cancer Cell, 2007
Microarray data in mice revealed an IPMN signature and IPMNs expressed MUC1 and MUC5AC but not MUC2, similar to human pancreatobiliary IPMNs.
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