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Adaptor-related protein complex 2, mu 1 subunit

mu2, AP50
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, p15, ACID, HAD
Papers on mu2
Dimerization Mediated by a Divergent Forkhead-associated Domain Is Essential for the DNA Damage and Spindle Functions of Fission Yeast Mdb1.
Wei et al., Beijing, China. In J Biol Chem, Sep 2015
The FHA domain of the Drosophila homolog of MDC1, MU2, also forms a homodimer but utilizes a different dimer interface.
Flavonol glycosides and other phenolic compounds from Viola tianshanica and their anti-complement activities.
Cheng et al., Shanghai, China. In Pharm Biol, Jul 2015
Bioassay showed that 11 compounds inhibited the classical pathway and the alternative pathway with CH50 and AP50 values of 0.113-1.210
Clathrin-dependent endocytosis plays a predominant role in cellular uptake of double-stranded RNA in the red flour beetle.
Zhu et al., Manhattan, United States. In Insect Biochem Mol Biol, May 2015
By using an "RNAi of RNAi" strategy, we further demonstrated that suppression of each transcript of the four key genes encoding clathrin heavy chain (TcChc), clathrin coat assembly protein AP50 (TcAP50), vacuolar (H(+))-ATPase subunit H (TcVhaSFD) and a ras-related protein (TcRab7) in clathrin-dependent endocytosis by RNAi can significantly impair RNAi of TcLgl.
Anti-complement sesquiterpenes from Viola yedoensis.
Chen et al., Shanghai, China. In Fitoterapia, Mar 2015
The sesquiterpenes 1-3, and 5-9 exhibited anti-complement activity against the classical pathway (CP) and the alternative pathway (AP) with the CH50 and AP50 values ranging from 0.14 to 0.37mg/mL and 0.32 to 0.54mg/mL, respectively.
Unsupervised discrimination of motor unit action potentials using spectrograms.
Leong et al., In Conf Proc Ieee Eng Med Biol Soc, 2013
The difference in percentages of MU proportions between our method and the reference were 3% for MU1, 0.4% for MU2, and 12% for MU3.
Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1.
Ye et al., Beijing, China. In Febs Lett, 2012
As compared to the MDC1 forkhead-associated FHA) domain, the MU2 FHA domain dimerizes using a different and more stable interface and contains a degenerate phosphothreonine-binding pocket.
Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling.
Miyazono et al., Tokyo, Japan. In J Biochem, 2010
Arkadia complexes with clathrin adaptor AP2 mu2 subunit and regulates EGF signalling.
MU2 and HP1a regulate the recognition of double strand breaks in Drosophila melanogaster.
Mason et al., United States. In Plos One, 2010
The interplay between MU2 and HP1a is dynamic and may be different in euchromatin and heterochromatin during DNA break recognition and repair.
A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex.
Owen et al., Cambridge, United Kingdom. In Cell, 2010
The AP2 adaptor complex (alpha, beta2, sigma2, and mu2 subunits) crosslinks the endocytic clathrin scaffold to PtdIns4,5P(2)-containing membranes and transmembrane protein cargo.
[Hereditary complement C5 deficiency: study of 3 Tunisian adult cases and literature review].
Makni et al., Tunisia. In Tunis Med, 2010
METHODS: Functional activity of the classical and the alternative pathway of complement (CH50 and AP50 respectively) were measured according to standards haemolytic procedures.
Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.
Haucke et al., Berlin, Germany. In J Biol Chem, 2010
multiple interactions between PIPKI gamma-p90 and AP-2 lead to spatiotemporally controlled PI(4,5)P(2) synthesis during clathrin-mediated synaptic vesicle endocytosis.
Roles of AP-2 in clathrin-mediated endocytosis.
Kirchhausen et al., Boston, United States. In Plos One, 2009
These results suggest that AP-2 is essential for endocytic clathrin coated-pit and coated-vesicle formation.
Reversible reactions of ethylene with distannynes under ambient conditions.
Power et al., Davis, United States. In Science, 2009
We show here that treatment of the distannynes Ar(iPr4)SnSnAr(iPr4) [Ar(iPr4) = C6H3-2,6(C6H3-2,6-iPr2)2, 1] or Ar(iPr8)SnSnAr(iPr8) [Ar(iPr8) = C6H-2,6(C6H2-2,4,6-iPr3)2-3,5-iPr2, 2] with ethylene under ambient conditions affords the cycloadducts Ar(iPr4) Sn(mu2:nu1:n1-C2H4)2Sn Ar(iPr4 (3) or Ar(iPrs) Sn(mu2:nu1:nu1-C2H4)2Sn AriPrs (4) that were structurally and spectroscopically characterized.
Rotavirus and reovirus modulation of the interferon response.
Sherry, Raleigh, United States. In J Interferon Cytokine Res, 2009
First, the reovirus mu2 protein can induce an unusual nuclear accumulation of IRF9 and repress IFN-stimulated gene (ISG) expression, most likely by disrupting IRF9 function as part of the heterotrimeric transcription factor complex, ISGF3.
Regulation of Na,K-ATPase during acute lung injury.
Sznajder et al., Chicago, United States. In J Bioenerg Biomembr, 2007
This process promotes the alpha1-subunit recognition by the mu2 subunit of the adaptor protein-2 and its endocytosis trough a clathrin dependent mechanism.
Regulation of the clathrin-coated vesicle cycle by reversible phosphorylation.
Smythe et al., Sheffield, United Kingdom. In Biochem Soc Symp, 2004
Our work has focused on the role of phosphorylation of the mu2 subunit of AP-2 (adaptor protein 2), which appears to be necessary for efficient cargo recruitment.
Orthoreovirus and Aquareovirus core proteins: conserved enzymatic surfaces, but not protein-protein interfaces.
Nibert et al., Cambridge, United States. In Virus Res, 2004
Other evidence indicates that the Orthoreovirus mu2 and Aquareovirus VP5 proteins are homologous, suggesting that VP5 is a core protein as mu2 is known to be.
Signals for sorting of transmembrane proteins to endosomes and lysosomes.
Traub et al., Bethesda, United States. In Annu Rev Biochem, 2002
YXXO and DXXLL signals bind in an extended conformation to the mu2 subunit of AP-2 and the VHS domain of the GGAs, respectively.
Molecular architecture and functional model of the endocytic AP2 complex.
Owen et al., Cambridge, United Kingdom. In Cell, 2002
We describe the structure of the 200 kDa AP2 "core" (alpha trunk, beta2 trunk, mu2, and sigma2) complexed with the polyphosphatidylinositol headgroup mimic inositolhexakisphosphate at 2.6 A resolution.
A structural explanation for the recognition of tyrosine-based endocytotic signals.
Evans et al., Cambridge, United Kingdom. In Science, 1998
Many cell surface proteins are marked for endocytosis by a cytoplasmic sequence motif, tyrosine-X-X-(hydrophobic residue), that is recognized by the mu2 subunit of AP2 adaptors.
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