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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Opioid receptor, mu 1

mu-opioid receptor, MOR, OPRM1
This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Alternatively spliced transcript variants have been found for this gene, however, many of these variants may be NMD candidates. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, kappa-opioid receptor, ACID
Papers on mu-opioid receptor
Potent Mu-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological and Structural Evaluation.
New
Dooley et al., In J Med Chem, Feb 2016
UNASSIGNED: To optimize the structure of a mu-opioid receptor ligand, analogs H-Tyr-c[D-Lys-Xxx-Tyr-Gly] were synthesized and their biological activity were tested.
Daily morphine administration increases impulsivity in rats responding under a 5-choice serial reaction time task.
New
France et al., San Antonio, United States. In Br J Pharmacol, Feb 2016
BACKGROUND AND PURPOSE: Repeated administration of a mu opioid receptor agonist can enhance some forms of impulsivity (e.g., delay discounting); however, it is unclear whether repeated administration impacts motor impulsivity.
Contribution of adrenomedullin to the switch of G protein coupled μ-opioid receptors from Gi to Gs in the spinal dorsal horn following chronic morphine exposure in rats.
New
Hong et al., Fuzhou, China. In Br J Pharmacol, Feb 2016
This study investigated the possible involvement of AM in morphine-evoked alteration of μ-opioid receptors (MOR)-coupled G proteins.
Endomorphin Analog Analgesics with Reduced Abuse Liability, Respiratory Depression, Motor Impairment, Tolerance, and Glial Activation.
New
Fasold et al., New Orleans, United States. In Neuropharmacology, Jan 2016
UNASSIGNED: Opioids acting at the mu opioid receptor (MOR) are the most effective analgesics, however adverse side effects severely limit their use.
The pharmacogenetics of opioid therapy in the management of postpartum pain: a systematic review.
Review
New
Koren et al., Toronto, Canada. In Pharmacogenomics, Jan 2016
This systematic review reveals that CYP2D6, OPRM1 A118G, UGT2B7 C802T and ABCB1 G2677AT may contribute to postpartum analgesia or adverse events.
Emerging treatments in neurogastroenterology: eluxadoline - a new therapeutic option for diarrhea-predominant IBS.
Review
New
Lacy, United States. In Neurogastroenterol Motil, Jan 2016
This unmet need led to the development of eluxadoline, a mu-opioid receptor agonist/delta-opioid receptor antagonist/kappa-receptor agonist.
Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration.
New
Janecka et al., Łódź, Poland. In Eur J Med Chem, Jan 2016
UNASSIGNED: Cyclic pentapeptide Tyr-c[D-Lys-Phe-Phe-Asp]NH2, based on the structure of endomorphin-2 (EM-2), which shows high affinity to the μ-opioid receptor (MOR) and a very strong antinociceptive activity in mice was used as a parent compound for the structure-activity relationship studies.
▼Naloxegol for opioid-induced constipation.
Review
New
In Drug Ther Bull, Dec 2015
▼Naloxegol (Moventig-AstraZeneca) is a peripherally acting mu-opioid receptor antagonist licensed for the treatment of opioid-induced constipation in adults who have had an inadequate response to laxative treatment.(1)
Multitarget opioid ligands in pain relief: New players in an old game.
Review
New
Pasquinucci et al., Catania, Italy. In Eur J Med Chem, Dec 2015
Analgesic opioid drugs, and mainly MOR agonists such as morphine, are broadly employed for pain management.
Clinical Implications of Opioid Pharmacogenomics in Patients With Cancer.
Review
New
McLeod et al., Asheville, United States. In Cancer Control, Oct 2015
RESULTS: In patients with cancer-related pain, genetic variation in OPRM1, COMT, and ABCB1 is associated with response to morphine, which is the most well-studied opioid.
Opiate pharmacology and relief of pain.
Review
Impact
Pasternak, New York City, United States. In J Clin Oncol, 2014
Evidence suggests that these variable responses among patients have a biologic basis and are likely to involve both biased agonism and the many mu opioid receptor subtypes that have been cloned.
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
Impact
Taylor et al., Lexington, United States. In Science, 2013
We found that tissue injury produced μ-opioid receptor (MOR) constitutive activity (MOR(CA)) that repressed spinal nociceptive signaling for months.
Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome.
Impact
Davis et al., Boston, United States. In Jama, 2013
Single-nucleotide polymorphisms (SNPs) in the μ-opioid receptor (OPRM1), multidrug resistance (ABCB1), and catechol-o-methyltransferase (COMT) genes are associated with risk for opioid addiction in adults.
Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.
Review
Impact
Christie et al., Portland, United States. In Pharmacol Rev, 2013
Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective drugs known for acute relief of severe pain.
Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P and μ-opioid receptors in the spinal cord of mice.
GeneRIF
Uezono et al., Tokyo, Japan. In Anesthesiology, 2012
the up-regulation of substance P and down-regulation of mu-opioid receptor seen in the dorsal root ganglia may be, at least in part, responsible for the abdominal pain-like state associated with peritoneal carcinomatosis
Mu-opioid receptors and dietary protein stimulate a gut-brain neural circuitry limiting food intake.
Impact
Mithieux et al., Lyon, France. In Cell, 2012
In vitro, peptides and protein digests behave as MOR antagonists in competition experiments.
Pain intensity the first year after lumbar disc herniation is associated with the A118G polymorphism in the opioid receptor mu 1 gene: evidence of a sex and genotype interaction.
GeneRIF
Gjerstad et al., Oslo, Norway. In J Neurosci, 2012
The present data suggest that OPRM1 G allele increases the pain intensity in women, but has a protective effect in men the first year after disc herniation.
Association of µ-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: a systematic review and meta-analysis.
Review
GeneRIF
Laso et al., Ourense, Spain. In Addict Biol, 2012
The results show that the G allele polymorphism of OPRM1 moderates the affect of naloxone in alcohol dependence
A118G mu opioid receptor polymorphism among drug addicts in Malaysia.
GeneRIF
Navaratnam et al., Malaysia. In J Integr Neurosci, 2012
A significant association was observed between A118G polymorphism in mu opioid receptor gene and drug addiction.
Influence of the OPRM1 gene polymorphism upon children's degree of withdrawal and brain activation in response to facial expressions.
GeneRIF
Battaglia et al., Milano, Italy. In Dev Cogn Neurosci, 2012
Results show that children carrying one or two copies of OPRM1 allele display withdrawn behavior
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