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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Calpain 1,

mu-Cl, CAPN1, calcium-activated neutral proteinase
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: Calpain, CAN, V1a, endothelin receptor, ACID
Papers on mu-Cl
Calpain-3-mediated regulation of the Na(+)-Ca(2+) exchanger isoform 3.
New
Bindels et al., Nijmegen, Netherlands. In Pflugers Arch, Feb 2016
Since NCX3 is expressed in skeletal muscle, we evaluated the cleavage of different NCX3 splice variants by CAPN1 and CAPN3.
Calpain restrains the stem cells compartment in breast cancer.
New
Demarchi et al., Trieste, Italy. In Cell Cycle, Feb 2016
CAPNS1 is essential for the stability and function of ubiquitous CAPN1 and CAPN2.
Identification of genome-wide selection signatures in the Limousin beef cattle breed.
New
Bugno-Poniewierska et al., Poland. In J Anim Breed Genet, Dec 2015
Within these regions, a number of candidate genes associated inter alia with skeletal muscle growth (GDF15, BMP7, BMP4 and TGFB3) or postmortem proteolysis and meat maturation (CAPN1 and CAPN5) were annotated.
Association between functional candidate genes and organoleptic meat traits in intensively-fed beef.
New
Molina et al., Córdoba, Spain. In Meat Sci, Sep 2015
The aim of this study was to assess the associations between the single nucleotide polymorphisms in CAPN1, CAST, DGAT1, FABP4, LEP, RORC and SCD1 genes and the sensory meat quality in an intensively fed commercial population (Charolais, Limousin and Retinta breed).
BRCA1 deficiency in ovarian cancer is associated with alteration in expression of several key regulators of cell motility - A proteomics study.
Roy et al., Pittsburgh, United States. In Cell Cycle, 2014
We performed a quantitative proteomics study of EOC patient tumor tissues and identified changes in expression of several key regulators of actin cytoskeleton/cell adhesion and cell migration (CAPN1, 14-3-3, CAPG, PFN1, SPTBN1, CFN1) associated with loss of BRCA1 function.
Analysis of the genetic effects of CAPN1 gene polymorphisms on chicken meat tenderness.
Li et al., Yangzhou, China. In Genet Mol Res, 2014
The micromolar calcium-activated neutral protease gene (CAPN1) is a physiological candidate gene for meat tenderness.
Increased μ-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis.
Witkowski et al., Gdańsk, Poland. In Plos One, 2014
Significantly higher μ-calpain (CAPN1) gene transcription, protein amounts and activity (but not those of m-calpain), with calpastatin amount and transcription of its gene (CAST) greatly varying were observed in CD19(+) ALL blasts compared to control cells.
The normalisation of CAPN gene expression in M. pectoralis superficialis in broiler lines differing in growth rate and their relationship to breast muscle tenderness.
Połtowicz et al., Poland. In Br Poult Sci, 2014
The aim of this study was to assess mRNA abundance of calpain 1 (CAPN1) and calpain 3 (CAPN3) in breast muscle of 80 fast-growing (FG) and slow-growing broilers (SG) and relate gene expression in relation to growth and Warner Bratzler (WB) shear force of breast muscle.
A KCNJ10 mutation previously identified in the Russell group of terriers also occurs in Smooth-Haired Fox Terriers with hereditary ataxia and in related breeds.
Jäderlund et al., Uppsala, Sweden. In Acta Vet Scand, 2014
Recently, molecular genetic studies on the Russell group of terriers found independent mutations in KCNJ10 and CAPN1, each associated with a specific clinical subtype of inherited ataxia.
A New Insight into the Role of Calpains in Post-mortem Meat Tenderization in Domestic Animals: A review.
Review
Liu et al., China. In Asian-australas J Anim Sci, 2013
Abundant evidence has testified that calpains (CAPNs) including calpain I (CAPN1) and calpastatin (CAST) have the closest relationship with tenderness in livestock.
Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse.
GeneRIF
Clapham et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse.
Evidence supporting the role of calpain in the α-processing of amyloid-β precursor protein.
GeneRIF
Chen et al., United States. In Biochem Biophys Res Commun, 2012
APP secretion from the calpain overexpressing cells was robustly increased under both resting and stimulated conditions over wild-type cells.
17beta-estradiol induces both up-regulation and processing of cyclin E in a calpain-dependent manner in MCF-7 breast cancer cells.
GeneRIF
He et al., Guiyang, China. In Febs Lett, 2012
Results show that estrogen may contribute to both up-regulation and proteolysis of cyclin E through calpain in MCF-7 cells.
A facile synthesis of emodin derivatives, emodin carbaldehyde, citreorosein, and their 10-deoxygenated derivatives and their inhibitory activities on μ-calpain.
GeneRIF
Jahng et al., Kyŏngsan, South Korea. In Arch Pharm Res, 2012
Report synthesis of emodin derivatives, emodin carbaldehyde, citreorosein, and their 10-deoxygenated derivatives and their inhibitory activities on mu-calpain.
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.
GeneRIF
Rodrigues et al., Lisbon, Portugal. In Plos One, 2011
These results support a role for calpain 1 in repressing differentiation, thus maintaining a proliferative neural stem cell pool, and suggest that calpain 2 is involved in glial differentiation.
Impact of genetic insights into calpain biology.
Review
Ono et al., Tokyo, Japan. In J Biochem, 2011
Within the human genome, 15 genes (CAPN1-3, CAPN5-16) encode a calpain-like protease (CysPc) domain along with several different functional domains.
Calpain chronicle--an enzyme family under multidisciplinary characterization.
Review
Ono et al., Tokyo, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2010
It was also called CANP (Ca2+-activated neutral protease) as well as CASF, CDP, KAF, etc. until 1990.
Synthesis of a stable compound with fivefold bonding between two chromium(I) centers.
Impact
Power et al., Davis, United States. In Science, 2005
Here we show that the reduction of {Cr(mu-Cl)Ar'}2 [where Ar' indicates C6H3-2,6(C6H3-2,6-Pri2)2 and Pr indicates isopropyl] with a slight excess of potassium graphite has produced a stable compound with fivefold chromium-chromium (Cr-Cr) bonding.
Pathogenesis of myelin breakdown in demyelinating diseases: role of proteolytic enzymes.
Review
Banik, Charleston, United States. In Crit Rev Neurobiol, 1991
A calcium-activated neutral proteinase (calpain), which degrades MBP, was found to increase in activity in MS tissue and cerebrospinal fluid (CSF), and its presence in myelin suggests that myelin may be autodigested in demyelinating disease.
Muscular dystrophy and activation of proteinases.
Review
Pearson et al., In Muscle Nerve, 1978
In addition, a calcium-activated neutral proteinase is found to be significantly elevated in muscle from patients with Duchenne dystrophy.
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