GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Aug 2016.
Mtq2, Mtq2p, N6-DNA-methyltransferase, HemK2
This gene encodes protein methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Mar 2012] (from
Zhang et al., Berkeley, United States. In Environ Health Perspect, 2011
N6AMT1 converted monomethylarsonous acid to dimethylarsonic acid when overexpressed in UROtsa human urothelial cells. It is expressed in many human tissues at variable levels, supporting a potential participation in arsenic metabolism in vivo.
Sherman et al., Rochester, United States. In J Biol Chem, 2006
Mtq2p methylates Sup45p the mtq2-Delta had multiple phenotypes, including cold sensitivity and sensitivity to translation fidelity antibiotics paromomycin and geneticin, to high salt and calcium concentrations, to polymyxin B, and to caffeine