Architecture of human mTOR complex 1.
Zürich, Switzerland. In Science, Feb 2016
Target of rapamycin (TOR), a conserved protein kinase and central controller of cell growth, functions in two structurally and functionally distinct complexes: TORC1 and TORC2.
Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism.
Porto, Portugal. In Prog Lipid Res, Jan 2016
In the past decade, studies in S. cerevisiae have unraveled a functional association between the Target of Rapamycin (TOR) pathway and sphingolipids, showing that both TOR Complex 1 (TORC1) and TOR Complex 2 (TORC2) branches control temporal and spatial aspects of sphingolipid metabolism in response to physiological and environmental cues.
Identification of an oncogenic RAB protein.
New York City, United States. In Science, Nov 2015
RAB35 functions downstream of growth factor receptors and upstream of PDK1 and mTORC2 and copurifies with PI3K in immunoprecipitation assays.
mTOR in Brain Physiology and Pathologies.
Montpellier, France. In Physiol Rev, Oct 2015
mTOR is a serine/threonine kinase found in two functionally distinct complexes, mTORC1 and mTORC2, which are differentially regulated by a great number of nutrients such as glucose and amino acids, energy (oxygen and ATP/AMP content), growth factors, hormones, and neurotransmitters.