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CREB regulated transcription coactivator 2

mTORC2, TORC2, CRTC2
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: mTORC1, mTOR, Akt, PI3K, V1a
Papers on mTORC2
Rictor is required for optimal bone accrual in response to anti-sclerostin therapy in the mouse.
New
Long et al., Nanjing, China. In Bone, Feb 2016
Because we have previously shown that Rictor-dependent mTORC2 activity contributes to Wnt signaling, we test here whether Rictor is required for Scl-Ab to promote bone anabolism.
mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue.
New
Hall et al., Basel, Switzerland. In Embo Mol Med, Feb 2016
Mammalian target of rapamycin complex 2 (mTORC2) mediates insulin-stimulated glucose uptake in metabolic tissues, but its role in NST is unknown.
Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation.
New
Sui et al., Winston-Salem, United States. In J Mol Cell Biol, Feb 2016
We also determine that YY1-promoted mTORC2 access to AKT leads to its phosphorylation at S473.
Mechanistic Target of Rapamycin Complex 1 (mTORC1) and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation.
New
Lama et al., United States. In J Biol Chem, Feb 2016
Here we investigate the role of mTOR complex 1 (mTORC1) and mTORC2 in regulating MC collagen expression, a hallmark of fibrotic disease.
mTOR, cardiomyocytes and inflammation in cardiac hypertrophy.
Review
New
Brink et al., Basel, Switzerland. In Biochim Biophys Acta, Feb 2016
mTOR has distinct functions depending on its assembly in the structurally distinct multiprotein complexes mTORC1 or mTORC2.
Architecture of human mTOR complex 1.
New
Impact
Maier et al., Zürich, Switzerland. In Science, Feb 2016
Target of rapamycin (TOR), a conserved protein kinase and central controller of cell growth, functions in two structurally and functionally distinct complexes: TORC1 and TORC2.
The cytotoxic T cell proteome and its shaping by the kinase mTOR.
New
Impact
Cantrell et al., Cambridge, United Kingdom. In Nat Immunol, Jan 2016
mTORC1 repressed PtdIns(3,4,5)P3 production and determined the requirement for mTORC2 in activation of the kinase Akt.
Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases.
Review
New
Perl, Syracuse, United States. In Nat Rev Rheumatol, Jan 2016
Subsequently, its molecular target (mTOR) was identified as a component of two interacting complexes, mTORC1 and mTORC2, that regulate T-cell lineage specification and macrophage differentiation.
Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism.
Review
New
Costa et al., Porto, Portugal. In Prog Lipid Res, Jan 2016
In the past decade, studies in S. cerevisiae have unraveled a functional association between the Target of Rapamycin (TOR) pathway and sphingolipids, showing that both TOR Complex 1 (TORC1) and TOR Complex 2 (TORC2) branches control temporal and spatial aspects of sphingolipid metabolism in response to physiological and environmental cues.
Replication of the Shrimp Virus WSSV Depends on Glutamate-Driven Anaplerosis.
New
Wang et al., Tainan City, Taiwan. In Plos One, Dec 2015
A series of inhibition experiments suggested that the up-regulation of GDH is regulated by mTORC2, and that the PI3K-mTORC1 pathway is not involved.
Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network.
New
Impact
Cavé et al., Paris, France. In Nat Genet, Nov 2015
Multiple concomitant genetic hits targeting the RAS pathway were identified in 13 of 78 cases (17%), disproving the concept of mutually exclusive RAS pathway mutations and defining new pathways activated in JMML involving phosphoinositide 3-kinase (PI3K) and the mTORC2 complex through RAC2 mutation.
Identification of an oncogenic RAB protein.
New
Impact
Sawyers et al., New York City, United States. In Science, Nov 2015
RAB35 functions downstream of growth factor receptors and upstream of PDK1 and mTORC2 and copurifies with PI3K in immunoprecipitation assays.
mTORC2-Akt signaling axis is implicated in myocardial compensation and fibrosis.
Review
New
Hajj Hussein et al., Charleston, United States. In J Biol Regul Homeost Agents, Oct 2015
Several studies have focused on the significance of mTORC1 in cardiomyocyte survival, questioning the role of mTORC2.
mTOR in Brain Physiology and Pathologies.
Review
New
Impact
Marin et al., Montpellier, France. In Physiol Rev, Oct 2015
mTOR is a serine/threonine kinase found in two functionally distinct complexes, mTORC1 and mTORC2, which are differentially regulated by a great number of nutrients such as glucose and amino acids, energy (oxygen and ATP/AMP content), growth factors, hormones, and neurotransmitters.
Signaling crosstalk between the mTOR complexes.
Review
Proud et al., Southampton, United Kingdom. In Translation (austin), 2013
It exists within two highly conserved multi-protein complexes known as mTORC1 and 2 mTORC2.
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.
Impact
GeneRIF
Wu et al., New Haven, United States. In Nat Cell Biol, 2012
PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12 in fibroblasts and pulmonary fibrosis.
Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses.
GeneRIF
Platanias et al., Chicago, United States. In Proc Natl Acad Sci U S A, 2012
mTORC2 complexes function in the induction of type I IFN responses, suggesting a critical role for mTORC2-mediated signals in IFN signaling.
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
Impact
GeneRIF
Hall et al., Basel, Switzerland. In Cell Metab, 2012
Expression of constitutively active Akt2 in mTORC2-deficient hepatocytes restored both glucose flux and lipogenesis.
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis.
Impact
GeneRIF
Loewith et al., Martinsried, Germany. In Nat Cell Biol, 2012
discoveries reveal a homeostasis mechanism in which TORC2 responds to plasma membrane stress to mediate compensatory changes in cellular lipid synthesis and hence modulates the composition of the plasma membrane
Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.
GeneRIF
Boothby et al., Nashville, United States. In J Exp Med, 2012
mTORC2 is crucial for Notch signaling to regulate Akt and NF-kappaB.
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