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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

CREB regulated transcription coactivator 1

mTORC1, TORC1, CRTC1, MECT1
Top mentioned proteins: mTOR, Akt, mTORC2, V1a, CAN
Papers using mTORC1 antibodies
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer.
Supplier
Hochman Shawn, In PLoS ONE, 2001
... To clone TORC1-GFP fusion protein expression construct, TORC1 coding sequence was amplified from pGEM-rTORC1 and inserted into pEGFP-N1 vector (Clontech) between HindIII and EcoRI ...
The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
Supplier
Maedler Kathrin, In PLoS ONE, 1992
... INS-1E and islet extracts were used for analysis of mTORC1 signaling, protein biosynthesis, ER stress markers and ...
Papers on mTORC1
Subcellular Distribution and Activity of Mechanistic Target of Rapamycin in Aged Retinal Pigment Epithelium.
New
Chen et al., Galveston, United States. In Invest Ophthalmol Vis Sci, 09 Jan 2015
Methods: Activity of mTOR complex 1 (mTORC1) was monitored by measuring phosphorylation status of its downstream effector protein S6, in either cultured human RPE cells or RPE explants prepared from mice at different ages.
No evidence for human papillomavirus infection in focal cortical dysplasia IIb.
New
Blumcke et al., Erlangen, Germany. In Ann Neurol, 08 Jan 2015
UNLABELLED: Objective: The aetiology of Focal Cortical Dysplasia Type IIb (FCDIIb) remains enigmatic in patients suffering from drug-resistant epilepsy, and an aberrant activation of the mammalian target of rapamycin complex 1 signalling pathway (mTORC1) was detectedin this developmental brain malformation.
L-type amino acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of t-cell lymphoblastic lymphoma/t-cell acute lymphoblastic leukemia.
New
Peyron et al., Nice, France. In Leukemia, 08 Jan 2015
JPH203 interfered with constitutive activation of mTORC1 and Akt, decreased expression of c-myc and triggered an Unfolded Protein Response mediated by the CHOP transcription factor associated with cell death.
AMPK-Sensing Energy while Talking to Other Signaling Pathways.
Review
New
Impact
Hardie, Dundee, United Kingdom. In Cell Metab, 02 Jan 2015
Along with the mechanistic target of rapamycin complex-1 (mTORC1), AMPK may have been one of the earliest signaling pathways to have arisen during eukaryotic evolution.
Mammalian target of rapamycin inhibition in hepatocellular carcinoma.
Review
New
Wu et al., New York City, United States. In World J Hepatol, 27 Dec 2014
There are several important upstream and downstream signals in the mTOR pathway, and alternative tumor-promoting pathways are known to exist beyond mTORC1 inhibition in HCC.
Rab1A Is an mTORC1 Activator and a Colorectal Oncogene.
New
Impact
Zheng et al., New Brunswick, United States. In Cancer Cell, 10 Dec 2014
Here we describe the identification of Rab1 as a conserved regulator of AA signaling to mTORC1.
Regulation of rDNA transcription in response to growth factors, nutrients and energy.
Review
New
Kang et al., Melbourne, Australia. In Gene, 08 Dec 2014
Critical controllers in these sensing networks, which mediate growth factor activation of ribosomal DNA transcription, include the PI3K/AKT/mTORC1, RAS/RAF/ERK pathways and MYC transcription factor.
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.
New
Impact
Sansom et al., Paris, France. In Nature, 05 Dec 2014
Here we show in mice that mTOR complex 1 (mTORC1) activity is absolutely required for the proliferation of Apc-deficient (but not wild-type) enterocytes, revealing an unexpected opportunity for therapeutic intervention.
mTOR signaling in tumorigenesis.
Review
New
Wei et al., Boston, United States. In Biochim Biophys Acta, 01 Dec 2014
Thus, in this review, we summarize available genetic mouse models for mTORC1 and mTORC2 components, as well as characterized mTOR upstream regulators and downstream targets, and assign a potential oncogenic or tumor suppressive role for each evaluated molecule.
Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy.
New
Impact
La Spada et al., San Diego, United States. In Cell Metab, 07 Nov 2014
Autophagy is regulated by the mTOR signaling pathway-the focal point for integration of metabolic information, with mTORC1 playing a central role in balancing biosynthesis and catabolism.
Leucine as a treatment for muscle wasting: A critical review.
Review
New
Koopman et al., Melbourne, Australia. In Clin Nutr, 07 Nov 2014
During amino acid abundance increased activity of mTORC1 drives protein synthesis and growth.
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.
New
Impact
Li et al., New York City, United States. In Cell, Oct 2014
Mechanistic target of rapamycin complex 1 (mTORC1) integrates diverse environmental signals to control cellular growth and organismal homeostasis.
mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation.
New
Morley et al., Brighton, United Kingdom. In Cell Cycle, Sep 2014
Previously we have shown that the mTORC1 signaling inhibitor, RAD001, decreased protein synthesis rates, delayed C2C12 myoblast differentiation, decreased p70S6K activity but did not affect the hypermodification of 4E-BP1.
Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells.
New
Rozengurt et al., Los Angeles, United States. In Plos One, Dec 2013
Furthermore, berberine dose-dependently inhibited mTORC1 (phosphorylation of S6K at Thr389 and S6 at Ser240/244) and ERK activation in PDAC cells stimulated by insulin and neurotensin or fetal bovine serum.
[Subependymal Giant Cell Astrocytoma Associated with Tuberous Sclerosis Complex -  Pharmacological Treatment using mTOR Inhibitors.]
New
Zitterbart, In Klin Onkol, Dec 2013
The pathogenic activation of mTORC1 leads to the development of subependymal giant cell astrocytomas in patients with tuberous sclerosis complex.
Glutaminolysis activates Rag-mTORC1 signaling.
GeneRIF
Hall et al., Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.
Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus.
Impact
GeneRIF
Martin et al., Los Angeles, United States. In Cell, 2012
Results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucleus about synaptic activity.
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.
GeneRIF
Sun et al., Los Angeles, United States. In Cell Cycle, 2012
Inhibition of TORC1 retards, and to some extent reverses, phenotypic indicators of cellular senescence.
Phospholipase D and mTORC1: nutrients are what bring them together.
GeneRIF
Thomas et al., Cincinnati, United States. In Sci Signal, 2012
Studies indicate that phospholipase D (PLD) as a mediator of nutrients to mTORC1.
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
GeneRIF
Manning et al., Boston, United States. In Sci Signal, 2012
Data suggest that increased activation of mTORC1 can promote carcinogenesis.
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