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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Jul 2015.

CREB regulated transcription coactivator 1

mTORC1, TORC1, CRTC1, MECT1
Top mentioned proteins: mTOR, Akt, mTORC2, V1a, CAN
Papers using mTORC1 antibodies
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer.
Supplier
Hochman Shawn, In PLoS ONE, 2001
... To clone TORC1-GFP fusion protein expression construct, TORC1 coding sequence was amplified from pGEM-rTORC1 and inserted into pEGFP-N1 vector (Clontech) between HindIII and EcoRI ...
The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
Supplier
Maedler Kathrin, In PLoS ONE, 1992
... INS-1E and islet extracts were used for analysis of mTORC1 signaling, protein biosynthesis, ER stress markers and ...
Papers on mTORC1
mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis.
New
Brantley-Sieders et al., Nashville, United States. In Plos Genet, 31 Jul 2015
These effects were recapitulated with a pharmacological dual inhibitor of mTORC1/mTORC2, but not upon genetic disruption of mTORC1 function via Raptor deletion.
Beneficial effects of early mTORC1 inhibition after traumatic brain injury.
New
D'Arcangelo et al., United States. In J Neurotrauma, 30 Jul 2015
UNASSIGNED: The mTORC1 signaling pathway mediates many aspects of cell growth and regeneration, and is upregulated after moderate to severe traumatic brain injury (TBI).
mTORC2 balances Akt activation and eIF2alpha serine 51 phosphorylation to promote survival under stress.
New
Koromilas et al., Cerveteri, Italy. In Mol Cancer Res, 30 Jul 2015
UNASSIGNED: The mammalian target of rapamycin (mTOR) nucleates two complexes, namely mTOR complex 1 and 2 (mTORC1 and mTORC2), which are implicated in cell growth, survival, metabolism and cancer.
Yvh1 protein phosphatase is required for pre-autophagosomal structure formation after TORC1 inactivation.
New
Ushimaru et al., Shizuoka, Japan. In Biosci Biotechnol Biochem, 30 Jul 2015
Upon nutrient depletion or rapamycin treatment, target of rapamycin complex 1 (TORC1) becomes inactive, inducing PAS formation and autophagy.
Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes.
New
Earnshaw et al., Ottawa, Canada. In J Cell Biol, 29 Jul 2015
In this study, we report that Mio, a highly conserved member of the SEACAT/GATOR2 complex necessary for the activation of mTORC1 kinase, plays a critical role in mitotic spindle formation and subsequent chromosome segregation by regulating the proper concentration of active key mitotic kinases Plk1 and Aurora A at centrosomes and spindle poles.
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues and energy status, and pathways through which it attenuates degenerative disease.
Review
New
Hayes et al., Philadelphia, United States. In Free Radic Biol Med, 26 Jul 2015
The ability of Keap1 to repress Nrf2 can be attenuated by p62/sequestosome-1 in a mechanistic target of rapamycin complex 1 (mTORC1)-dependent manner, thereby allowing re-feeding after fasting to increase Nrf2-target gene expression.
Antioxidant function of Sestrins mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1.
Review
New
Bae et al., Seoul, South Korea. In Free Radic Biol Med, 24 Jul 2015
In the second pathway, Sestrins block mTORC1 activation and thereby attenuate ROS accumulation.
Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.
New
Impact
Kemper et al., Basel, Switzerland. In Immunity, 16 Jul 2015
Furthermore, CD46 activation simultaneously drove expression of LAMTOR5, which mediated assembly of the AA-sensing Ragulator-Rag-mTORC1 complex and increased glycolysis and oxidative phosphorylation (OXPHOS), required for cytokine production.
Complementing T Cells' Functions: Bringing in Metabolism Matters.
New
Impact
Cho et al., Nashville, United States. In Immunity, 16 Jul 2015
(2015) provide evidence of a mechanism by which the complement stimulates sustained mTORC1 activation and regulates cellular metabolism.
Ambra1 at a glance.
Review
New
Cecconi et al., Roma, Italy. In J Cell Sci, 01 Jul 2015
It acts in an early step of mammalian target of rapamycin complex 1 (mTORC1)-dependent autophagy by favouring formation of the autophagosome core complex.
Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming.
New
Impact
Pei et al., Guangzhou, China. In Nat Cell Biol, 30 Jun 2015
This process occurs independently of p53 activation, and is mediated by the synergistic downregulation of mechanistic target of rapamycin complex 1 (mTORC1) and the induction of autophagy-related genes.
Mammalian target of rapamycin and tuberous sclerosis complex.
Review
New
Wataya-Kaneda, Ōsaka, Japan. In J Dermatol Sci, May 2015
mTOR forms two distinct complexes, mTORC1 and mTORC2.
mTOR signaling in melanoma: oncogene-induced pseudo-senescence?
New
Impact
Sharpless et al., Chapel Hill, United States. In Cancer Cell, Feb 2015
In this issue of Cancer Cell, Damsky and colleagues suggest activation of mTORC1 and mTORC2 is required for OIS evasion in human melanomas harboring oncogenic BRAF mutations.
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
New
Impact
Bosenberg et al., New Haven, United States. In Cancer Cell, Feb 2015
mTORC1 activation through Stk11 (Lkb1) loss abrogates growth arrest of Braf(V600E) melanocytic nevi, but is insufficient for complete progression to melanoma.
L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia.
Review
New
Holst et al., Australia. In Am J Cancer Res, Dec 2014
They show increased expression in many cancers, and are critical for control of protein translation and cell growth through the mTORC1 pathway.
Glutaminolysis activates Rag-mTORC1 signaling.
GeneRIF
Hall et al., Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.
Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus.
Impact
GeneRIF
Martin et al., Los Angeles, United States. In Cell, 2012
Results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucleus about synaptic activity.
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.
GeneRIF
Sun et al., Los Angeles, United States. In Cell Cycle, 2012
Inhibition of TORC1 retards, and to some extent reverses, phenotypic indicators of cellular senescence.
Phospholipase D and mTORC1: nutrients are what bring them together.
GeneRIF
Thomas et al., Cincinnati, United States. In Sci Signal, 2012
Studies indicate that phospholipase D (PLD) as a mediator of nutrients to mTORC1.
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
GeneRIF
Manning et al., Boston, United States. In Sci Signal, 2012
Data suggest that increased activation of mTORC1 can promote carcinogenesis.
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