Mammalian target of rapamycin signaling in cardiac physiology and disease.
Maldives. In Circ Res, 03 Mar 2014
The protein kinase mammalian or mechanistic target of rapamycin (mTOR) is an atypical serine/threonine kinase that exerts its main cellular functions by interacting with specific adaptor proteins to form 2 different multiprotein complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2).
p53 induces skin aging by depleting Blimp1(+) sebaceous gland cells.
Los Angeles, United States. In Cell Death Dis, Dec 2013
The reduction in the fat layer may result from the decrease of mammalian TOR complex 1 (mTORC1) activity accompanied by elevated expression of energy expenditure genes, and possibly as compensatory effects, leading to the elevation of peroxisome proliferator-activated receptor (PPAR)γ, an inducer of sebocyte differentiation.
Where is mTOR and what is it doing there?
Basel, Switzerland. In J Cell Biol, Dec 2013
Target of rapamycin (TOR) forms two conserved, structurally distinct kinase complexes termed TOR complex 1 (TORC1) and TORC2.
Glutaminolysis activates Rag-mTORC1 signaling.
Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.