Growth factor signaling to mTORC1 by amino acid-laden macropinosomes.
Ann Arbor, United States. In J Cell Biol, 05 Nov 2015
UNASSIGNED: The rapid activation of the mechanistic target of rapamycin complex-1 (mTORC1) by growth factors is increased by extracellular amino acids through yet-undefined mechanisms of amino acid transfer into endolysosomes.
mTOR in Brain Physiology and Pathologies.
Montpellier, France. In Physiol Rev, 31 Oct 2015
mTOR is a serine/threonine kinase found in two functionally distinct complexes, mTORC1 and mTORC2, which are differentially regulated by a great number of nutrients such as glucose and amino acids, energy (oxygen and ATP/AMP content), growth factors, hormones, and neurotransmitters.
Regulation of mTORC1 by PI3K signaling.
Boston, United States. In Trends Cell Biol, 30 Sep 2015
The class I phosphoinositide 3-kinase (PI3K)-mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) signaling network directs cellular metabolism and growth.
Milk--A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation.
Osnabrück, Germany. In Int J Mol Sci, Dec 2014
Based on own translational research of the biochemical and hormonal effects of cow's milk consumption in humans, this review presents milk as a signaling system of mammalian evolution that activates the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1), the pivotal regulator of translation.
Glutaminolysis activates Rag-mTORC1 signaling.
Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.