Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes.
Ottawa, Canada. In J Cell Biol, 29 Jul 2015
In this study, we report that Mio, a highly conserved member of the SEACAT/GATOR2 complex necessary for the activation of mTORC1 kinase, plays a critical role in mitotic spindle formation and subsequent chromosome segregation by regulating the proper concentration of active key mitotic kinases Plk1 and Aurora A at centrosomes and spindle poles.
Ambra1 at a glance.
Roma, Italy. In J Cell Sci, 01 Jul 2015
It acts in an early step of mammalian target of rapamycin complex 1 (mTORC1)-dependent autophagy by favouring formation of the autophagosome core complex.
Glutaminolysis activates Rag-mTORC1 signaling.
Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.