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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Sep 2015.

CREB regulated transcription coactivator 1

mTORC1, TORC1, CRTC1, MECT1
Top mentioned proteins: mTOR, Akt, mTORC2, V1a, CAN
Papers using mTORC1 antibodies
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer.
Supplier
Hochman Shawn, In PLoS ONE, 2001
... To clone TORC1-GFP fusion protein expression construct, TORC1 coding sequence was amplified from pGEM-rTORC1 and inserted into pEGFP-N1 vector (Clontech) between HindIII and EcoRI ...
The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
Supplier
Maedler Kathrin, In PLoS ONE, 1992
... INS-1E and islet extracts were used for analysis of mTORC1 signaling, protein biosynthesis, ER stress markers and ...
Papers on mTORC1
mTOR in Brain Physiology and Pathologies.
Review
New
Impact
Marin et al., Montpellier, France. In Physiol Rev, 31 Oct 2015
mTOR is a serine/threonine kinase found in two functionally distinct complexes, mTORC1 and mTORC2, which are differentially regulated by a great number of nutrients such as glucose and amino acids, energy (oxygen and ATP/AMP content), growth factors, hormones, and neurotransmitters.
5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells.
New
Foster et al., New York City, United States. In Cell Cycle, 01 Oct 2015
AICAR by itself is able to suppress mTOR complex 1 (mTORC1), but also stimulates a feedback activation of mTORC2, which activates the survival kinase Akt.
The vacuole/lysosome is required for cell-cycle progression.
New
Weisman et al., Ann Arbor, United States. In Elife, 01 Oct 2015
Furthermore, this role for the vacuole in cell-cycle progression requires an intact TORC1-SCH9 pathway that can only signal from a mature vacuole.
Regulation of mTORC1 by PI3K signaling.
Review
New
Cantley et al., Boston, United States. In Trends Cell Biol, 30 Sep 2015
The class I phosphoinositide 3-kinase (PI3K)-mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) signaling network directs cellular metabolism and growth.
Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis.
New
Bakal et al., London, United Kingdom. In Open Biol, 30 Sep 2015
TORC1 promotes phospholipid anabolism by slowing S/G2 progression.
Docosahexaenoic Acid Inhibits Proteolytic Processing of Sterol Regulatory Element-binding Protein-1c (SREBP-1c) via Activation of AMP-activated Kinase.
New
Elam et al., Memphis, United States. In Biochim Biophys Acta, 28 Sep 2015
We further show that this effect of DHA is mediated both via activation of AMP-activated protein kinase (AMPK) and by inhibition of mechanistic target of rapamycin complex 1 (mTORC1).
Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.
New
Impact
Ivashkiv et al., New York City, United States. In Nat Immunol, 31 Aug 2015
We found that IFN-γ regulated the metabolism and mRNA translation of human macrophages by targeting the kinases mTORC1 and MNK, both of which converge on the selective regulator of translation initiation eIF4E.
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
New
Impact
Campisi et al., Novato, United States. In Nat Cell Biol, 31 Aug 2015
Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice.
The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.
New
Impact
Thompson et al., New York City, United States. In Cell, 16 Aug 2015
Lysosomal degradation of extracellular proteins can sustain cell survival and induce activation of mTORC1 but fails to elicit significant cell accumulation.
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues and energy status, and pathways through which it attenuates degenerative disease.
Review
New
Hayes et al., Philadelphia, United States. In Free Radic Biol Med, Jul 2015
The ability of Keap1 to repress Nrf2 can be attenuated by p62/sequestosome-1 in a mechanistic target of rapamycin complex 1 (mTORC1)-dependent manner, thereby allowing re-feeding after fasting to increase Nrf2-target gene expression.
Antioxidant function of Sestrins mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1.
Review
New
Bae et al., Seoul, South Korea. In Free Radic Biol Med, Jul 2015
In the second pathway, Sestrins block mTORC1 activation and thereby attenuate ROS accumulation.
Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.
New
Impact
Kemper et al., Basel, Switzerland. In Immunity, Jul 2015
Furthermore, CD46 activation simultaneously drove expression of LAMTOR5, which mediated assembly of the AA-sensing Ragulator-Rag-mTORC1 complex and increased glycolysis and oxidative phosphorylation (OXPHOS), required for cytokine production.
Milk-A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation.
Review
New
Melnik, Osnabrück, Germany. In Int J Mol Sci, Dec 2014
Based on own translational research of the biochemical and hormonal effects of cow's milk consumption in humans, this review presents milk as a signaling system of mammalian evolution that activates the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1), the pivotal regulator of translation.
SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathway.
New
Mao et al., Suzhou, China. In Sci Rep, Dec 2014
Further studies showed that SC06-decreased mTOR activation was associated with the downregulation of Raptor, a key component of the mTORC1 complex.
Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice.
New
Proud et al., Newcastle, Australia. In Sci Signal, Dec 2014
The kinase AKT and the kinase complex mTORC1 may play key roles in carcinogenesis and are components of signaling pathways that also contain PTEN and LKB1.
Glutaminolysis activates Rag-mTORC1 signaling.
GeneRIF
Hall et al., Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.
Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus.
Impact
GeneRIF
Martin et al., Los Angeles, United States. In Cell, 2012
Results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucleus about synaptic activity.
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.
GeneRIF
Sun et al., Los Angeles, United States. In Cell Cycle, 2012
Inhibition of TORC1 retards, and to some extent reverses, phenotypic indicators of cellular senescence.
Phospholipase D and mTORC1: nutrients are what bring them together.
GeneRIF
Thomas et al., Cincinnati, United States. In Sci Signal, 2012
Studies indicate that phospholipase D (PLD) as a mediator of nutrients to mTORC1.
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
GeneRIF
Manning et al., Boston, United States. In Sci Signal, 2012
Data suggest that increased activation of mTORC1 can promote carcinogenesis.
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