GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
CREB regulated transcription coactivator 1
mTORC1, TORC1, CRTC1, MECT1
Sponsored links
Papers using
mTORC1
antibodies
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer.
Supplier
In PLoS ONE, 2001
... To clone TORC1-GFP fusion protein expression construct, TORC1 coding sequence was amplified from pGEM-rTORC1 and inserted into pEGFP-N1 vector (Clontech) between HindIII and EcoRI ...
The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
Supplier
In PLoS ONE, 1992
... INS-1E and islet extracts were used for analysis of mTORC1 signaling, protein biosynthesis, ER stress markers and ...
Papers on
mTORC1
Conditional deletion of Tsc1 impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice.
New
Cincinnati, United States. In Mol Hum Reprod, 07 Apr 2013
Heightened mammalian target of rapamycin complex 1 (mTORC1) activity by genetic deletion of its direct inhibitor, Tsc1, is associated with aberrant development and dysfunction of the female reproductive tract in mice.
Rapamycin Reverses Pulmonary-Artery Smooth-Muscle-Cell Proliferation in Pulmonary Hypertension.
New
Créteil, France. In Am J Respir Cell Mol Biol, 07 Apr 2013
The mTOR pathway involves two independent complexes, mTORC1 and mTORC2, which phosphorylate S6K and Akt, respectively, and differ in their sensitivity to rapamycin.
Nutrient signaling to mTOR and cell growth.
New
San Diego, United States. In Trends Biochem Sci, 01 Apr 2013
mTOR comprises two complexes, termed mTORC1 and mTORC2.
mTORC1 Signaling Drives Inflammation-Associated Tumor Growth.
New
In Cancer Discov, 31 Mar 2013
GP130-driven mTORC1 activation promotes inflammation-associated gastrointestinal tumorigenesis.
Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy.
New
Impact
Oxford, United Kingdom. In Nat Med, 24 Mar 2013
Overexpression of hamartin increased resistance to OGD by inducing productive autophagy through an mTORC1-dependent mechanism.
Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1.
New
Impact
Boston, United States. In Science, 21 Mar 2013
The mechanistic target of rapamycin complex 1 (mTORC1) is a protein kinase that senses growth signals to regulate anabolic growth and proliferation.
Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis.
New
Impact
Basel, Switzerland. In Science, 21 Mar 2013
mTORC1 indirectly phosphorylated CAD-S1859 through S6 kinase (S6K).
Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling.
New
Impact
Zürich, Switzerland. In Cell, 14 Mar 2013
Here, we show that during cellular stress the dual specificity kinase DYRK3 regulates the stability of P-granule-like structures and mTORC1 signaling.
LRP6 Enhances Glucose Metabolism by Promoting TCF7L2-Dependent Insulin Receptor Expression and IGF Receptor Stabilization in Humans.
New
Impact
New Haven, United States. In Cell Metab, 05 Mar 2013
Further investigations showed that the LRP6(R611C) mutation diminishes TCF7L2-dependent transcription of the IR while it increases the stability of IGFR and enhances mTORC1 activity.
Akt Regulates TNFα Synthesis Downstream of RIP1 Kinase Activation during Necroptosis.
New
Boston, United States. In Plos One, Dec 2012
Akt controls necroptosis through downstream targeting of mammalian Target of Rapamycin complex 1 (mTORC1).
Modulation of translation and induction of autophagy by bacterial exoproducts.
Review
New
Mainz, Germany. In Med Microbiol Immunol, Nov 2012
This triggers amino acid-sensitive eIF2α-kinase GCN2, as well as energy sensor AMPK, and deactivates mTORC1.
Amino acids and mTORC1: from lysosomes to disease.
Review
New
Cambridge, United States. In Trends Mol Med, Sep 2012
mTOR complex 1 (mTORC1) integrates signals arising from nutrients, energy, and growth factors, but how exactly these signals are propagated await to be fully understood.
Dissecting mammalian target of rapamycin to promote longevity.
Review
New
Sunnyvale, United States. In Rejuvenation Res, Jun 2012
Treatment with rapamycin, an inhibitor of mammalian target of rapamycin complex 1 (mTORC1) can increase mammalian life span.
Calcineurin mediates the gonadotropin-releasing hormone effect on expression of both subunits of the follicle-stimulating hormone through distinct mechanisms.
GeneRIF
Haifa, Israel. In Mol Cell Biol, 2011
TORC1 increases the Gonadotropin-releasing hormone activation of the Follicle Stimulating Hormone promoter and works synergistically with Nur77 and/or CREB.
Regulation of adipocyte autophagy--the potential anti-obesity mechanism of high density lipoprotein and ApolipoproteinA-I.
Review
Changsha, China. In Lipids Health Dis, 2011
HDL and apoA-I could activate PI3K-Akt-mTORC1 signaling which negatively regulates autophagy.
[TOR-centric concept of regulation mitogenic, metabolic and energetic signal processing in cell].
Review
In Tsitologiia, 2011
Mammalian kinase (mTOR) exists in two complexes: the rapamycin-sensitive TORC1 and rapamycin resistant mTORC2, controlling in the cell different programs.
Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma.
GeneRIF
Dallas, United States. In Mol Cancer Res, 2011
clear-cell renal cell carcinoma become refractory to REDD1-induced mTORC1 inhibition and shed light into the development of clear-cell renal cell carcinoma
Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma.
GeneRIF
Nagoya, Japan. In Histopathology, 2011
mucoepidermoid carcinoma of the salivary glands positive for CRTC1-MAML2 or CRTC3-MAML2 fusion formed a favourable tumour subset that was distinct from fusion-negative cases
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.
GeneRIF
Boston, United States. In Mol Cell, 2011
Deletion of Rac1 in primary cells using an inducible-Cre/Lox approach inhibits basal and growth-factor activation of both mTORC1 and mTORC2.
Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells.
GeneRIF
Philadelphia, United States. In Plos One, 2010
These findings indicate that the combined inhibition of mTORC1 and MNK may prove beneficial in the treatment of cutaneous T-cell lymphoma and other malignancies.
