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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

CREB regulated transcription coactivator 1

mTORC1, TORC1, CRTC1, MECT1
Top mentioned proteins: mTOR, Akt, mTORC2, CAN, V1a
Papers using mTORC1 antibodies
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer.
Supplier
Hochman Shawn, In PLoS ONE, 2001
... To clone TORC1-GFP fusion protein expression construct, TORC1 coding sequence was amplified from pGEM-rTORC1 and inserted into pEGFP-N1 vector (Clontech) between HindIII and EcoRI ...
The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
Supplier
Maedler Kathrin, In PLoS ONE, 1992
... INS-1E and islet extracts were used for analysis of mTORC1 signaling, protein biosynthesis, ER stress markers and ...
Papers on mTORC1
Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet.
New
Blagosklonny et al., Buffalo, United States. In Aging Cell, Aug 2014
Fasting levels of cardiac and hepatic p-S6, a marker of mTORC1 activity, were lower in weekly treatment group compared with control mice.
mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse.
New
Ron et al., San Francisco, United States. In J Neurochem, Jul 2014
The mammalian (or mechanistic) target of rapamycin (mTOR) complex 1 (mTORC1) is a serine and threonine kinase that regulates cell growth, survival, and proliferation.
Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.
New
Boulton et al., London, United Kingdom. In Cell Rep, May 2014
The R2TP cochaperone complex plays a critical role in the assembly of multisubunit machines, including small nucleolar ribonucleoproteins (snoRNPs), RNA polymerase II, and the mTORC1 and SMG1 kinase complexes, but the molecular basis of substrate recognition remains unclear.
Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination.
New
Macklin et al., Newark, United States. In J Neurosci, Apr 2014
mTOR functions through two distinct complexes, mTOR complex 1 (mTORC1) and mTORC2, by binding to either Raptor or Rictor, respectively.
Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation.
New
Impact
Langenau et al., Boston, United States. In Cancer Cell, Apr 2014
Akt pathway activation was acquired in a subset of these evolved clones, which increased the number of leukemia-propagating cells through activating mTORC1, elevated growth rate likely by stabilizing the Myc protein, and rendered cells resistant to dexamethasone, which was reversed by combined treatment with an Akt inhibitor.
Environmental signaling through the mechanistic target of rapamycin complex 1: mTORC1 goes nuclear.
Review
New
Laribee et al., Memphis, United States. In Cell Cycle, Apr 2014
Mechanistic target of rapamycin complex 1 (mTORC1) is a well-known regulator of cell growth and proliferation in response to environmental stimuli and stressors.
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
New
Impact
Manning et al., Boston, United States. In Cell, Mar 2014
mTORC1 promotes cell growth in response to nutrients and growth factors.
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.
New
Impact
Teleman et al., Heidelberg, Germany. In Cell, Mar 2014
TOR complex 1 (TORC1) is a potent anabolic regulator of cellular growth and metabolism.
mTORC1: turning off is just as important as turning on.
New
Impact
Hall et al., Basel, Switzerland. In Cell, Mar 2014
mTORC1 is activated primarily on the lysosome.
The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
New
Impact
Mani et al., New Haven, United States. In Cell Metab, Mar 2014
Further investigation showed that LRP6(R611C) mutation triggers hepatic de novo lipogenesis, lipid and cholesterol biosynthesis, and apoB secretion by an Sp1-dependent activation of IGF1, AKT, and both mTORC1 and mTORC2.
Mammalian target of rapamycin signaling in cardiac physiology and disease.
Review
New
Sadoshima et al., Maldives. In Circ Res, Mar 2014
The protein kinase mammalian or mechanistic target of rapamycin (mTOR) is an atypical serine/threonine kinase that exerts its main cellular functions by interacting with specific adaptor proteins to form 2 different multiprotein complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2).
Integration of signals generated by nutrients, hormones, and exercise in skeletal muscle.
Review
New
Kimball, Paraguay. In Am J Clin Nutr, Jan 2014
Initially, individual pathways through which the 3 anabolic signals act to modulate mTORC1 signaling will be discussed, followed by a summation of evidence showing an additive effect of the regulators.
Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension.
Review
New
Demir et al., Göteborg, Sweden. In Int J Cell Biol, Dec 2013
However, whereas vacuolar-ATPases have recently been suggested to control both Ras-cAMP-PKA- and TORC1-mediated nutrient signaling, neither the physiological benefits of a proposed role for peroxiredoxins in H2O2-signaling nor downstream targets regulated are known.
p53 induces skin aging by depleting Blimp1+ sebaceous gland cells.
New
Xu et al., Los Angeles, United States. In Cell Death Dis, Dec 2013
The reduction in the fat layer may result from the decrease of mammalian TOR complex 1 (mTORC1) activity accompanied by elevated expression of energy expenditure genes, and possibly as compensatory effects, leading to the elevation of peroxisome proliferator-activated receptor (PPAR)γ, an inducer of sebocyte differentiation.
Where is mTOR and what is it doing there?
Review
New
Hall et al., Basel, Switzerland. In J Cell Biol, Dec 2013
Target of rapamycin (TOR) forms two conserved, structurally distinct kinase complexes termed TOR complex 1 (TORC1) and TORC2.
Glutaminolysis activates Rag-mTORC1 signaling.
GeneRIF
Hall et al., Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.
Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus.
Impact
GeneRIF
Martin et al., Los Angeles, United States. In Cell, 2012
Results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucleus about synaptic activity.
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.
GeneRIF
Sun et al., Los Angeles, United States. In Cell Cycle, 2012
Inhibition of TORC1 retards, and to some extent reverses, phenotypic indicators of cellular senescence.
Phospholipase D and mTORC1: nutrients are what bring them together.
GeneRIF
Thomas et al., Cincinnati, United States. In Sci Signal, 2012
Studies indicate that phospholipase D (PLD) as a mediator of nutrients to mTORC1.
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
GeneRIF
Manning et al., Boston, United States. In Sci Signal, 2012
Data suggest that increased activation of mTORC1 can promote carcinogenesis.
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