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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 May 2015.

CREB regulated transcription coactivator 1

mTORC1, TORC1, CRTC1, MECT1
Top mentioned proteins: mTOR, Akt, mTORC2, V1a, CAN
Papers using mTORC1 antibodies
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer.
Supplier
Hochman Shawn, In PLoS ONE, 2001
... To clone TORC1-GFP fusion protein expression construct, TORC1 coding sequence was amplified from pGEM-rTORC1 and inserted into pEGFP-N1 vector (Clontech) between HindIII and EcoRI ...
The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
Supplier
Maedler Kathrin, In PLoS ONE, 1992
... INS-1E and islet extracts were used for analysis of mTORC1 signaling, protein biosynthesis, ER stress markers and ...
Papers on mTORC1
Proline-rich AKT substrate of 40-kDa (PRAS40) in the pathophysiology of cancer.
New
Tiwari et al., Stockton, United States. In Biochem Biophys Res Commun, 20 Jun 2015
The proline-rich AKT substrate of 40-kDa (PRAS40), also known as AKT substrate 1 (AKT1S1), lies at the crossroads of these cascades and inhibits the activity of the mTOR complex 1 (mTORC1) kinase.
Inflammatory mechanisms contribute to the neurological manifestations of tuberous sclerosis complex.
New
Wong et al., Saint Louis, United States. In Neurobiol Dis, 20 Jun 2015
Real-time quantitative RT-PCR, immunohistochemistry, and western blotting demonstrated increased expression of specific cytokines and chemokines, particularly IL-1β and CXCL10, in the neocortex and hippocampus of Tsc1(GFAP)CKO mice, which was reversed by treatment with a mammalian target of rapamycin complex 1 (mTORC1) inhibitor.
Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK.
New
Yin et al., Jinan, China. In Biochem Biophys Res Commun, 19 Jun 2015
We showed that autophagy was induced in an mTORC1-dependent way and plays a protective role against PA-induced apoptosis, which was verified by pretreatment with 3-methyladenine (3MA) and rapamycin.
TNF compromises lysosome acidification and reduces α-synuclein degradation via autophagy in dopaminergic cells.
New
Liu et al., Suzhou, China. In Exp Neurol, 19 Jun 2015
Co-treatment with mammalian target of rapamycin kinase complex 1 (mTORC1) inhibitor PP242, which activated transcription factor EB (TFEB) signaling and lysosome biogenesis, partially rescued the accumulation of α-SYN in PC12 cells and midbrain neurons.
Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways.
New
Huang et al., Nanjing, China. In Neuropharmacology, 19 Jun 2015
It appeared that both mTORC1 and mTORC2 were involved in the inhibitory activity of rapamycin, as silencing raptor, rictor or raptor/rictor enhanced rapamycin's blockage of Cd-induced cell death.
Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming.
New
Impact
Pei et al., Guangzhou, China. In Nat Cell Biol, 18 Jun 2015
This process occurs independently of p53 activation, and is mediated by the synergistic downregulation of mechanistic target of rapamycin complex 1 (mTORC1) and the induction of autophagy-related genes.
Beyond indigestion: emerging roles for lysosome-based signaling in human disease.
Review
New
Ferguson, New Haven, United States. In Curr Opin Cell Biol, 04 Jun 2015
This is illustrated by the discovery of a growing number of lysosome-localized proteins that respond to changes in growth factor and nutrient availability to regulate mTORC1 signaling as well as the identification of MiT/TFE transcription factors (MITF, TFEB and TFE3) as proteins that shuttle between lysosomes and the nucleus to elicit a transcriptional response to ongoing changes in lysosome status.
SEA you later alli-GATOR - a dynamic regulator of the TORC1 stress response pathway.
Review
New
Rout et al., New York City, United States. In J Cell Sci, 01 Jun 2015
The highly conserved target of rapamycin complex 1 (TORC1) controls eukaryotic cell growth and response to a variety of signals, including nutrients, hormones and stresses, and plays the key role in the regulation of autophagy.
The complex modulation of lysosomal degradation pathways by cannabinoid receptor 1 and 2.
Review
New
Behl et al., Mainz, Germany. In Life Sci, 20 May 2015
A variety of these signaling pathways are integrated by the mammalian target of rapamycin complex 1 (mTORC1) that acts as an inhibitor of autophagy.
Do airborne biogenic chemicals interact with the PI3K/Akt/mTOR cell signalling pathway to benefit human health and wellbeing in rural and coastal environments?
Review
New
Moore, Truro, United Kingdom. In Environ Res, 27 Apr 2015
The "biogenics" hypothesis formulated here is that regular exposure to low concentrations of mixtures of natural compounds and toxins in natural environments confers pleiotropic health benefits by inhibiting the activities of interconnected cell signalling systems, particularly PI3K/Akt/mTORC1.
A review of potential metabolic etiologies of the observed association between red meat consumption and development of type 2 diabetes mellitus.
Review
New
Clifton et al., Australia. In Metabolism, 19 Apr 2015
BCAAs may induce insulin resistance via the mammalian target of rapamycin complex 1 (mTORC1) and ribosomal protein S6 kinase β 1 (S6k1)-associated pathways.
mTOR signaling in melanoma: oncogene-induced pseudo-senescence?
New
Impact
Sharpless et al., Chapel Hill, United States. In Cancer Cell, Feb 2015
In this issue of Cancer Cell, Damsky and colleagues suggest activation of mTORC1 and mTORC2 is required for OIS evasion in human melanomas harboring oncogenic BRAF mutations.
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
New
Impact
Bosenberg et al., New Haven, United States. In Cancer Cell, Feb 2015
mTORC1 activation through Stk11 (Lkb1) loss abrogates growth arrest of Braf(V600E) melanocytic nevi, but is insufficient for complete progression to melanoma.
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
New
Impact
Sabatini et al., Cambridge, United States. In Science, Feb 2015
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that responds to multiple environmental cues.
Metabolism. Differential regulation of mTORC1 by leucine and glutamine.
New
Impact
Guan et al., San Diego, United States. In Science, Feb 2015
The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates environmental and intracellular signals to regulate cell growth.
Glutaminolysis activates Rag-mTORC1 signaling.
GeneRIF
Hall et al., Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.
Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus.
Impact
GeneRIF
Martin et al., Los Angeles, United States. In Cell, 2012
Results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucleus about synaptic activity.
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.
GeneRIF
Sun et al., Los Angeles, United States. In Cell Cycle, 2012
Inhibition of TORC1 retards, and to some extent reverses, phenotypic indicators of cellular senescence.
Phospholipase D and mTORC1: nutrients are what bring them together.
GeneRIF
Thomas et al., Cincinnati, United States. In Sci Signal, 2012
Studies indicate that phospholipase D (PLD) as a mediator of nutrients to mTORC1.
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
GeneRIF
Manning et al., Boston, United States. In Sci Signal, 2012
Data suggest that increased activation of mTORC1 can promote carcinogenesis.
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