Salivary Gland Cancers: Biology and Systemic Therapy.
In Oncology (williston Park), 15 Nov 2015
For example, in mucoepidermoid carcinomas, one of the most common types of malignant salivary gland tumors, a commonly seen genetic translocation [t(11;19)(q21;p13), which involves the CRTC1 and MAML2 genes] has been found to be associated with improved survival, making it a possible prognostic marker.
Sestrin2 is a leucine sensor for the mTORC1 pathway.
Cambridge, United States. In Science, 08 Nov 2015
UNASSIGNED: Leucine is a proteogenic amino acid that also regulates many aspects of mammalian physiology, in large part by activating the mTOR complex 1 (mTORC1) protein kinase, a master growth controller.
mTOR in Brain Physiology and Pathologies.
Montpellier, France. In Physiol Rev, 31 Oct 2015
mTOR is a serine/threonine kinase found in two functionally distinct complexes, mTORC1 and mTORC2, which are differentially regulated by a great number of nutrients such as glucose and amino acids, energy (oxygen and ATP/AMP content), growth factors, hormones, and neurotransmitters.
Metabolic regulation of natural killer cells.
Dublin, Ireland. In Biochem Soc Trans, Sep 2015
The mammalian target of rapamcyin (mTOR) complex 1 (mTORC1) has been identified as a key metabolic regulator that promotes glycolytic metabolism in multiple immune cell subsets.
Glutaminolysis activates Rag-mTORC1 signaling.
Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.