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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2014.

CREB regulated transcription coactivator 1

mTORC1, TORC1, CRTC1, MECT1
Top mentioned proteins: mTOR, Akt, mTORC2, V1a, CAN
Papers using mTORC1 antibodies
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer.
Supplier
Hochman Shawn, In PLoS ONE, 2001
... To clone TORC1-GFP fusion protein expression construct, TORC1 coding sequence was amplified from pGEM-rTORC1 and inserted into pEGFP-N1 vector (Clontech) between HindIII and EcoRI ...
The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
Supplier
Maedler Kathrin, In PLoS ONE, 1992
... INS-1E and islet extracts were used for analysis of mTORC1 signaling, protein biosynthesis, ER stress markers and ...
Papers on mTORC1
Oligodendrocyte Precursor Cell-Intrinsic Effect of Rheb1 Controls Differentiation and Mediates mTORC1-Dependent Myelination in Brain.
New
Xiao et al., Chengdu, China. In J Neurosci, 19 Dec 2014
Rheb1 is an immediate early gene that functions to activate mammalian target of rapamycin (mTor) selectively in complex 1 (mTORC1).
REDD2 Expression in Rat Skeletal Muscle Correlates with Nutrient-Induced Activation of mTORC1: Responses to Aging, Immobilization, and Remobilization.
New
Kimball et al., United States. In Am J Physiol Endocrinol Metab, 18 Dec 2014
1-3 days) immobilization-induced repression of mTORC1 signaling in hindlimb skeletal muscle of young (2 months old) rats that was associated with elevated expression of REDD1 and REDD2.
Mammalian Target of Rapamycin Complex 2 Regulates Invariant NK T Cell Development and Function Independent of Promyelocytic Leukemia Zinc-Finger.
New
Chang et al., Ann Arbor, United States. In J Immunol, 17 Dec 2014
UNLABELLED: The mammalian target of rapamycin (mTOR) senses and incorporates different environmental cues via the two signaling complexes mTOR complex 1 (mTORC1) and mTORC2.
Anticancer effects of metformin on neuroendocrine tumor cells in vitro.
New
Auernhammer et al., In Hormones (athens), 05 Dec 2014
Metformin suppressed mTORC1 signaling in all three tumor cell types, evidenced by suppression of 4EBP1, pP70S6K, and S6 phosphorylation, and was associated with compensatory AKT activity.
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.
New
Impact
Sansom et al., Paris, France. In Nature, 05 Dec 2014
Here we show in mice that mTOR complex 1 (mTORC1) activity is absolutely required for the proliferation of Apc-deficient (but not wild-type) enterocytes, revealing an unexpected opportunity for therapeutic intervention.
Suppression of Feedback Loops Mediated by PI3K/mTOR Induces Multiple Overactivation of Compensatory Pathways: An Unintended Consequence Leading to Drug Resistance.
Review
New
Sinnet-Smith et al., Los Angeles, United States. In Mol Cancer Ther, 16 Nov 2014
However, mTORC1 and S6K also mediate potent negative feedback loops that attenuate signaling via insulin/insulin growth factor receptor and other tyrosine kinase receptors.
Let-7 Coordinately Suppresses Components of the Amino Acid Sensing Pathway to Repress mTORC1 and Induce Autophagy.
New
Impact
La Spada et al., San Diego, United States. In Cell Metab, 07 Nov 2014
Autophagy is regulated by the mTOR signaling pathway-the focal point for integration of metabolic information, with mTORC1 playing a central role in balancing biosynthesis and catabolism.
Branched-chain amino acids in metabolic signalling and insulin resistance.
Review
New
Adams et al., United States. In Nat Rev Endocrinol, 07 Nov 2014
A hypothesized mechanism linking increased levels of BCAAs and T2DM involves leucine-mediated activation of the mammalian target of rapamycin complex 1 (mTORC1), which results in uncoupling of insulin signalling at an early stage.
mTOR signalling, embryogenesis and the control of lung development.
Review
New
Walker et al., Saint Andrews, United Kingdom. In Semin Cell Dev Biol, 04 Nov 2014
UNLABELLED: The existence of a nutrient sensitive "autocatakinetic" regulator of embryonic tissue growth has been hypothesised since the early 20(th) century, beginning with pioneering work on the determinants of fetal size by the Australian physiologist, Thorburn Brailsford-Robertson. We now know that the mammalian target of rapamycin complexes (mTORC1 and 2) perform this essential function in all eukaryotic tissues by balancing nutrient and energy supply during the first stages of embryonic cleavage, the formation of embryonic stem cell layers and niches, the highly specified programmes of tissue growth during organogenesis and, at birth, paving the way for the first few breaths of life.
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.
New
Impact
Li et al., New York City, United States. In Cell, 25 Oct 2014
Mechanistic target of rapamycin complex 1 (mTORC1) integrates diverse environmental signals to control cellular growth and organismal homeostasis.
Coordinated regulation of protein synthesis and degradation by mTORC1.
New
Impact
Manning et al., Boston, United States. In Nature, 18 Oct 2014
Mechanistic target of rapamycin complex 1 (mTORC1) promotes nutrient-consuming anabolic processes, such as protein synthesis.
The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism.
New
Impact
Lin et al., Xiamen, China. In Cell Metab, 02 Oct 2014
In this study we found, most surprisingly, that the late endosomal/lysosomal protein complex v-ATPase-Ragulator, essential for activation of mTORC1, is also required for AMPK activation.
Driving neural regeneration through the mammalian target of rapamycin.
Review
New
Maiese, Newark, United States. In Neural Regen Res, Sep 2014
mTOR is a component of the protein complexes mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2) that are ubiquitous throughout the body and control multiple functions such as gene transcription, metabolism, cell survival, and cell senescence.
Current Models of Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation by Growth Factors and Amino Acids.
Review
New
Wang et al., Hohhot, China. In Int J Mol Sci, Dec 2013
GTP-bound Rheb potentiates the catalytic activity of mTORC1.
Akt Inhibition Promotes ABCA1-Mediated Cholesterol Efflux to ApoA-I through Suppressing mTORC1.
New
Zha et al., Ottawa, Canada. In Plos One, Dec 2013
Furthermore, we provide evidence that mTORC1, a major downstream target of Akt, is also a negative regulator of cholesterol efflux.
Glutaminolysis activates Rag-mTORC1 signaling.
GeneRIF
Hall et al., Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.
Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus.
Impact
GeneRIF
Martin et al., Los Angeles, United States. In Cell, 2012
Results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucleus about synaptic activity.
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.
GeneRIF
Sun et al., Los Angeles, United States. In Cell Cycle, 2012
Inhibition of TORC1 retards, and to some extent reverses, phenotypic indicators of cellular senescence.
Phospholipase D and mTORC1: nutrients are what bring them together.
GeneRIF
Thomas et al., Cincinnati, United States. In Sci Signal, 2012
Studies indicate that phospholipase D (PLD) as a mediator of nutrients to mTORC1.
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
GeneRIF
Manning et al., Boston, United States. In Sci Signal, 2012
Data suggest that increased activation of mTORC1 can promote carcinogenesis.
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