Steenbergen et al., Sapporo, Japan. In Circ Res, 20 Mar 2014
The protective effect of IPC was lost by pretreatment with dual mTORC inhibitors but not with rapamycin, a mTORC1 inhibitor, which indicates the fundamental role of mTORC2 activation in cardioprotection.
Mani et al., New Haven, United States. In Cell Metab, 04 Mar 2014
Further investigation showed that LRP6(R611C) mutation triggers hepatic de novo lipogenesis, lipid and cholesterol biosynthesis, and apoB secretion by an Sp1-dependent activation of IGF1, AKT, and both mTORC1 and mTORC2.
Bordey et al., Newcastle upon Tyne, United Kingdom. In Plos One, Dec 2013
Supplementation of eCSF nanovesicles to a mixed culture containing eNSCs activated the IGF-mammalian target of rapamycin complex 1 (mTORC1) pathway in eNSCs and expanded the pool of proliferative eNSCs.
Shackelford, Los Angeles, United States. In J Carcinog, 2012
The LKB1/AMPK signalling pathway suppresses mammalian target of rapamycin complex 1 (mTORC1), an essential regulator of cell growth in all eukaryotes that is deregulated in a majority of human cancers.
Deldicque, Leuven, Belgium. In Front Physiol, 2012
It is proposed that ER stress can: (1) directly impact muscle mass as one fate of prolonged and unresolved ER stress is cell death and; (2) indirectly create a state of anabolic resistance by inhibiting the mammalian target of rapamycin complex 1 (mTORC1) pathway.