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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Aug 2015.

CREB regulated transcription coactivator 1

mTORC1, TORC1, CRTC1, MECT1
Top mentioned proteins: mTOR, Akt, mTORC2, V1a, CAN
Papers using mTORC1 antibodies
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer.
Supplier
Hochman Shawn, In PLoS ONE, 2001
... To clone TORC1-GFP fusion protein expression construct, TORC1 coding sequence was amplified from pGEM-rTORC1 and inserted into pEGFP-N1 vector (Clontech) between HindIII and EcoRI ...
The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
Supplier
Maedler Kathrin, In PLoS ONE, 1992
... INS-1E and islet extracts were used for analysis of mTORC1 signaling, protein biosynthesis, ER stress markers and ...
Papers on mTORC1
Rheb signaling and tumorigenesis: mTORC1 and new horizons.
New
Castro et al., Concepción, Chile. In Int J Cancer, 01 Sep 2015
UNASSIGNED: Rheb is a conserved small GTPase that belongs to the Ras superfamily, and is mainly involved in activation of cell growth through stimulation of mTORC1 activity.
Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.
New
Impact
Ivashkiv et al., New York City, United States. In Nat Immunol, 31 Aug 2015
We found that IFN-γ regulated the metabolism and mRNA translation of human macrophages by targeting the kinases mTORC1 and MNK, both of which converge on the selective regulator of translation initiation eIF4E.
Mammalian target of rapamycin and tuberous sclerosis complex.
Review
New
Wataya-Kaneda, Ōsaka, Japan. In J Dermatol Sci, 31 Aug 2015
mTOR forms two distinct complexes, mTORC1 and mTORC2.
Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes.
New
Haimovich et al., Philadelphia, United States. In J Immunol, 31 Aug 2015
UNASSIGNED: LPS-induced TLR4 activation alters cellular bioenergetics and triggers proteolytic cleavage of AMPKα and HIF-1α expression in leukocytes.
Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthood.
New
Liu et al., Göteborg, Sweden. In Hum Reprod Update, 30 Aug 2015
Several molecules and pathways operating in both the somatic pfGCs and oocytes, such as the phosphatidylinositol 3 kinase (PI3K) and the mechanistic target of rapamycin complex 1 (mTORC1) pathways, have been shown to be important for primordial follicle activation.
Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise.
New
Baar et al., Davis, United States. In J Physiol, 30 Aug 2015
UNASSIGNED: The purpose of this study was to investigate the role of the mechanistic target of rapamycin complex 1 (mTORC1) in the regulation of myofibrillar (MyoPS) and mitochondrial (MitoPS) protein synthesis following endurance exercise.
Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex.
New
Kim et al., Philadelphia, United States. In Cell Rep, 28 Aug 2015
Likewise, mTORC1 activation by Rheb overexpression generates similar neuronal and Reelin-Dab1 signaling defects, and directly upregulates Cul5 expression.
The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.
New
Impact
Thompson et al., New York City, United States. In Cell, 16 Aug 2015
Lysosomal degradation of extracellular proteins can sustain cell survival and induce activation of mTORC1 but fails to elicit significant cell accumulation.
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
New
Impact
Campisi et al., Novato, United States. In Nat Cell Biol, 06 Aug 2015
Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice.
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues and energy status, and pathways through which it attenuates degenerative disease.
Review
New
Hayes et al., Philadelphia, United States. In Free Radic Biol Med, 26 Jul 2015
The ability of Keap1 to repress Nrf2 can be attenuated by p62/sequestosome-1 in a mechanistic target of rapamycin complex 1 (mTORC1)-dependent manner, thereby allowing re-feeding after fasting to increase Nrf2-target gene expression.
Antioxidant function of Sestrins mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1.
Review
New
Bae et al., Seoul, South Korea. In Free Radic Biol Med, 24 Jul 2015
In the second pathway, Sestrins block mTORC1 activation and thereby attenuate ROS accumulation.
Complementing T Cells' Functions: Bringing in Metabolism Matters.
New
Impact
Cho et al., Nashville, United States. In Immunity, 16 Jul 2015
(2015) provide evidence of a mechanism by which the complement stimulates sustained mTORC1 activation and regulates cellular metabolism.
Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses.
New
Impact
Kemper et al., Basel, Switzerland. In Immunity, 16 Jul 2015
Furthermore, CD46 activation simultaneously drove expression of LAMTOR5, which mediated assembly of the AA-sensing Ragulator-Rag-mTORC1 complex and increased glycolysis and oxidative phosphorylation (OXPHOS), required for cytokine production.
Ambra1 at a glance.
Review
New
Cecconi et al., Roma, Italy. In J Cell Sci, Jul 2015
It acts in an early step of mammalian target of rapamycin complex 1 (mTORC1)-dependent autophagy by favouring formation of the autophagosome core complex.
L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia.
Review
New
Holst et al., Australia. In Am J Cancer Res, Dec 2014
They show increased expression in many cancers, and are critical for control of protein translation and cell growth through the mTORC1 pathway.
Glutaminolysis activates Rag-mTORC1 signaling.
GeneRIF
Hall et al., Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.
Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus.
Impact
GeneRIF
Martin et al., Los Angeles, United States. In Cell, 2012
Results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucleus about synaptic activity.
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.
GeneRIF
Sun et al., Los Angeles, United States. In Cell Cycle, 2012
Inhibition of TORC1 retards, and to some extent reverses, phenotypic indicators of cellular senescence.
Phospholipase D and mTORC1: nutrients are what bring them together.
GeneRIF
Thomas et al., Cincinnati, United States. In Sci Signal, 2012
Studies indicate that phospholipase D (PLD) as a mediator of nutrients to mTORC1.
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
GeneRIF
Manning et al., Boston, United States. In Sci Signal, 2012
Data suggest that increased activation of mTORC1 can promote carcinogenesis.
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