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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

CREB regulated transcription coactivator 1

mTORC1, TORC1, CRTC1, MECT1
Top mentioned proteins: mTOR, Akt, mTORC2, V1a, ACID
Papers using mTORC1 antibodies
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer.
Supplier
Hochman Shawn, In PLoS ONE, 2001
... To clone TORC1-GFP fusion protein expression construct, TORC1 coding sequence was amplified from pGEM-rTORC1 and inserted into pEGFP-N1 vector (Clontech) between HindIII and EcoRI ...
The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
Supplier
Maedler Kathrin, In PLoS ONE, 1992
... INS-1E and islet extracts were used for analysis of mTORC1 signaling, protein biosynthesis, ER stress markers and ...
Papers on mTORC1
Nocturnal frontal lobe epilepsy caused by a mutation in the GATOR1 complex gene NPRL3.
New
Steinlein et al., Oldenburg, Germany. In Epilepsia, Feb 2016
UNASSIGNED: Mutations in NPRL3, one of three genes that encode proteins of the mTORC1-regulating GATOR1 complex, have recently been reported to cause cortical dysplasia with focal epilepsy.
Dopamine D2 receptors gate generalization of conditioned threat responses through mTORC1 signaling in the extended amygdala.
New
Valjent et al., Montpellier, France. In Mol Psychiatry, Feb 2016
Finally, we identify the mTORC1 cascade activation as an important molecular event by which D2R mediates its effects.
Rag GTPase in amino acid signaling.
Review
New
Kim et al., Seoul, South Korea. In Amino Acids, Feb 2016
Compelling evidence suggests that Rag heterodimer (RagA/B and RagC/D) plays an important role in amino acid signaling toward mechanistic target of rapamycin complex 1 (mTORC1), which is a central player in the control of cell growth in response to a variety of environmental cues, including growth factors, cellular energy/oxygen status, and amino acids.
Role of Ingested Amino Acids and Protein in the Promotion of Resistance Exercise-Induced Muscle Protein Anabolism.
Review
New
Rasmussen et al., Galveston, United States. In J Nutr, Feb 2016
Supplementation of protein/AAs with RE exhibited clear protein dose-dependent effects on translational regulation (protein synthesis) through mammalian target of rapamycin complex 1 (mTORC1) signaling, which was most apparent through increases in p70 ribosomal protein S6 kinase 1 (S6K1) phosphorylation, compared with postexercise recovery in the fasted or carbohydrate-fed state.
Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway.
New
Moreno et al., Salamanca, Spain. In Curr Biol, Feb 2016
In the presence of nutrients, greatwall (Ppk18) protein kinase is inhibited by TORC1 and PP2A·B55 is active.
mTOR, cardiomyocytes and inflammation in cardiac hypertrophy.
Review
New
Brink et al., Basel, Switzerland. In Biochim Biophys Acta, Feb 2016
mTOR has distinct functions depending on its assembly in the structurally distinct multiprotein complexes mTORC1 or mTORC2.
Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals.
Review
New
Miyamoto et al., San Diego, United States. In J Mol Cell Cardiol, Feb 2016
In this review, we discuss recent progress in our understanding of regulation of autophagy and its crosstalk with metabolic signaling, with a focus on the nutrient-sensing mTOR complex1 (mTORC1) pathway.
Architecture of human mTOR complex 1.
New
Impact
Maier et al., Zürich, Switzerland. In Science, Feb 2016
Target of rapamycin (TOR), a conserved protein kinase and central controller of cell growth, functions in two structurally and functionally distinct complexes: TORC1 and TORC2.
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.
New
Impact
Sabatini et al., Cambridge, United States. In Science, Feb 2016
Eukaryotic cells coordinate growth with the availability of nutrients through the mechanistic target of rapamycin complex 1 (mTORC1), a master growth regulator.
The cytotoxic T cell proteome and its shaping by the kinase mTOR.
New
Impact
Cantrell et al., Cambridge, United Kingdom. In Nat Immunol, Jan 2016
We used high-resolution mass spectrometry to map the cytotoxic T lymphocyte (CTL) proteome and the effect of the metabolic checkpoint kinase mTORC1 on CTLs.
The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity.
New
Noda et al., Ōsaka, Japan. In Febs Lett, Jan 2016
In this study, we found that MTMR3 interacted with mTORC1, an evolutionarily conserved serine/threonine kinase complex, which regulates cell growth and autophagy in response to environmental stimuli.
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.
New
Impact
Fitzgibbon et al., Cambridge, United States. In Nat Genet, Jan 2016
More than half of the mutations preferentially co-occurred with mutations in ATP6V1B2 and ATP6AP1, which encode components of the vacuolar H(+)-ATP ATPase (V-ATPase) known to be necessary for amino acid-induced activation of mTORC1.
Aging Reduces the Activation of the mTORC1 Pathway after Resistance Exercise and Protein Intake in Human Skeletal Muscle: Potential Role of REDD1 and Impaired Anabolic Sensitivity.
New
Deldicque et al., Louvain-la-Neuve, Belgium. In Nutrients, Dec 2015
In conclusion, we show that the activation of the mTORC1 pathway is reduced in skeletal muscle of older subjects after resistance exercise and protein ingestion compared with young subjects, which could be partially due to an increased expression of REDD1 and an impaired anabolic sensitivity.
Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling.
New
Impact
Guan et al., Cincinnati, United States. In Cancer Cell, Dec 2015
We generated a mouse model with inducible endothelial-cell-specific deletion of Tsc1 to examine mTORC1 signaling in lymphangiosarcoma.
Signaling crosstalk between the mTOR complexes.
Review
Proud et al., Southampton, United Kingdom. In Translation (austin), 2013
It exists within two highly conserved multi-protein complexes known as mTORC1 and 2 mTORC2.
Glutaminolysis activates Rag-mTORC1 signaling.
GeneRIF
Hall et al., Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.
Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus.
Impact
GeneRIF
Martin et al., Los Angeles, United States. In Cell, 2012
Results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucleus about synaptic activity.
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.
GeneRIF
Sun et al., Los Angeles, United States. In Cell Cycle, 2012
Inhibition of TORC1 retards, and to some extent reverses, phenotypic indicators of cellular senescence.
Phospholipase D and mTORC1: nutrients are what bring them together.
GeneRIF
Thomas et al., Cincinnati, United States. In Sci Signal, 2012
Studies indicate that phospholipase D (PLD) as a mediator of nutrients to mTORC1.
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
GeneRIF
Manning et al., Boston, United States. In Sci Signal, 2012
Data suggest that increased activation of mTORC1 can promote carcinogenesis.
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