Rag GTPase in amino acid signaling.
Seoul, South Korea. In Amino Acids, Feb 2016
Compelling evidence suggests that Rag heterodimer (RagA/B and RagC/D) plays an important role in amino acid signaling toward mechanistic target of rapamycin complex 1 (mTORC1), which is a central player in the control of cell growth in response to a variety of environmental cues, including growth factors, cellular energy/oxygen status, and amino acids.
Architecture of human mTOR complex 1.
Zürich, Switzerland. In Science, Feb 2016
Target of rapamycin (TOR), a conserved protein kinase and central controller of cell growth, functions in two structurally and functionally distinct complexes: TORC1 and TORC2.
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.
Cambridge, United States. In Nat Genet, Jan 2016
More than half of the mutations preferentially co-occurred with mutations in ATP6V1B2 and ATP6AP1, which encode components of the vacuolar H(+)-ATP ATPase (V-ATPase) known to be necessary for amino acid-induced activation of mTORC1.
Glutaminolysis activates Rag-mTORC1 signaling.
Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.