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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Mar 2015.

CREB regulated transcription coactivator 1

mTORC1, TORC1, CRTC1, MECT1
Top mentioned proteins: mTOR, Akt, mTORC2, V1a, CAN
Papers using mTORC1 antibodies
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer.
Supplier
Hochman Shawn, In PLoS ONE, 2001
... To clone TORC1-GFP fusion protein expression construct, TORC1 coding sequence was amplified from pGEM-rTORC1 and inserted into pEGFP-N1 vector (Clontech) between HindIII and EcoRI ...
The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
Supplier
Maedler Kathrin, In PLoS ONE, 1992
... INS-1E and islet extracts were used for analysis of mTORC1 signaling, protein biosynthesis, ER stress markers and ...
Papers on mTORC1
The expanding role of mTOR in cancer cell growth and proliferation.
Review
New
Roux et al., Montréal, Canada. In Mutagenesis, 31 Mar 2015
As part of the mTOR complex 1 (mTORC1), mTOR regulates cell growth by promoting the biosynthesis of proteins, lipids and nucleic acids.
rpS6 regulates blood-testis barrier dynamics through Arp3-mediated actin microfilament organization in rat Sertoli cells - an in vitro study.
New
Cheng et al., New York City, United States. In Endocrinology, 25 Mar 2015
Ribosomal protein S6 (rpS6), a downstream molecule of mTORC1, participates in this process via a yet-to-be defined mechanism.
Identification of Rictor as a Novel Substrate of Polo-like kinase 1.
New
Liu et al., West Lafayette, United States. In Cell Cycle, 25 Mar 2015
In particular, recent reports suggest the existence of a molecular and functional link between Plk1 and the mammalian target of rapamycin (mTOR) pathway, which controls cell growth and proliferation via the raptor-mTOR (TORC1) and rictor-mTOR (TORC2) protein complexes.
Inhibition of Wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mTOR.
New
Ju et al., Hangzhou, China. In Hepatology, 23 Mar 2015
The enhanced liver regeneration in Wip1 deficient mice was due to the activation of mammalian target of rapamycin complex 1 (mTORC1) pathway.
NMDA Receptor Activation Regulates Sociability by its Effect on mTOR Signaling Activity.
Review
New
Deutsch et al., Norfolk, United States. In Prog Neuropsychopharmacol Biol Psychiatry, 19 Mar 2015
UNASSIGNED: Tuberous Sclerosis Complex is one example of a syndromic form of autism spectrum disorder associated with disinhibited activity of mTORC1 in neurons (e.g., cerebellar Purkinje cells).
mTORC1 Activation Blocks Braf(V600E)-Induced Growth Arrest but Is Insufficient for Melanoma Formation.
New
Impact
Bosenberg et al., New Haven, United States. In Cancer Cell, 12 Feb 2015
mTORC1 activation through Stk11 (Lkb1) loss abrogates growth arrest of Braf(V600E) melanocytic nevi, but is insufficient for complete progression to melanoma.
mTOR Signaling in Melanoma: Oncogene-Induced Pseudo-Senescence?
New
Impact
Sharpless et al., Chapel Hill, United States. In Cancer Cell, 12 Feb 2015
In this issue of Cancer Cell, Damsky and colleagues suggest activation of mTORC1 and mTORC2 is required for OIS evasion in human melanomas harboring oncogenic BRAF mutations.
Metabolism. Differential regulation of mTORC1 by leucine and glutamine.
New
Impact
Guan et al., San Diego, United States. In Science, 09 Feb 2015
The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates environmental and intracellular signals to regulate cell growth.
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
New
Impact
Sabatini et al., Cambridge, United States. In Science, 09 Feb 2015
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that responds to multiple environmental cues.
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
New
Impact
Superti-Furga et al., Vienna, Austria. In Nature, 07 Feb 2015
The mechanistic target of rapamycin complex 1 (mTORC1) integrates the presence of growth factors, energy levels, glucose and amino acids to modulate metabolic status and cellular responses.
Why should cancer biologists care about tRNAs? tRNA synthesis, mRNA translation and the control of growth.
Review
New
Grewal, Calgary, Canada. In Biochim Biophys Acta, Jan 2015
First, I review how oncogenes and tumour suppressor signalling pathways, such as the PI3 kinase/TORC1, Ras/ERK, Myc, p53 and Rb pathways, regulate Pol III and tRNA synthesis.
Autophagy in DNA Damage Response.
Review
New
Blasiak et al., Łódź, Poland. In Int J Mol Sci, Dec 2014
Autophagy can be activated in response to DNA-damaging agents, but the exact mechanism underlying this activation is not fully understood, although it is suggested that it involves the inhibition of mammalian target of rapamycin complex 1 (mTORC1).
Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance.
Review
New
Mischel et al., San Diego, United States. In Cancer Biol Med, Dec 2014
mTOR kinase exists in two multi-protein complexes, namely, mTORC1 and mTORC2.
Effects of a brief high-fat diet and acute exercise on the mTORC1 and IKK/NF-κB pathways in rat skeletal muscle.
New
Cartee et al., Ann Arbor, United States. In Appl Physiol Nutr Metab, Dec 2014
Our first aim was to determine whether a brief (2 weeks) high-fat diet (HFD) that caused muscle insulin resistance would activate the mammalian target of rapamycin complex 1 (mTORC1) and/or inhibitor of κB kinase/nuclear factor κB (IKK/NF-κB) pathways, which are potentially linked to induction of insulin resistance.
[The role of mTOR in the regulation of skeletal muscle metabolism].
New
In Fiziol Cheloveka, Sep 2014
It exists in two mTOR protein complexes mTORC1 and mTORC2 with various sensitivity to the inhibitory effect of rapamycin.
Glutaminolysis activates Rag-mTORC1 signaling.
GeneRIF
Hall et al., Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.
Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus.
Impact
GeneRIF
Martin et al., Los Angeles, United States. In Cell, 2012
Results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucleus about synaptic activity.
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.
GeneRIF
Sun et al., Los Angeles, United States. In Cell Cycle, 2012
Inhibition of TORC1 retards, and to some extent reverses, phenotypic indicators of cellular senescence.
Phospholipase D and mTORC1: nutrients are what bring them together.
GeneRIF
Thomas et al., Cincinnati, United States. In Sci Signal, 2012
Studies indicate that phospholipase D (PLD) as a mediator of nutrients to mTORC1.
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
GeneRIF
Manning et al., Boston, United States. In Sci Signal, 2012
Data suggest that increased activation of mTORC1 can promote carcinogenesis.
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