mTOR signalling, embryogenesis and the control of lung development.
Saint Andrews, United Kingdom. In Semin Cell Dev Biol, 04 Nov 2014
UNLABELLED: The existence of a nutrient sensitive "autocatakinetic" regulator of embryonic tissue growth has been hypothesised since the early 20(th) century, beginning with pioneering work on the determinants of fetal size by the Australian physiologist, Thorburn Brailsford-Robertson. We now know that the mammalian target of rapamycin complexes (mTORC1 and 2) perform this essential function in all eukaryotic tissues by balancing nutrient and energy supply during the first stages of embryonic cleavage, the formation of embryonic stem cell layers and niches, the highly specified programmes of tissue growth during organogenesis and, at birth, paving the way for the first few breaths of life.
Driving neural regeneration through the mammalian target of rapamycin.
Newark, United States. In Neural Regen Res, Sep 2014
mTOR is a component of the protein complexes mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2) that are ubiquitous throughout the body and control multiple functions such as gene transcription, metabolism, cell survival, and cell senescence.
Glutaminolysis activates Rag-mTORC1 signaling.
Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.