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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 16 Apr 2015.

CREB regulated transcription coactivator 1

mTORC1, TORC1, CRTC1, MECT1
Top mentioned proteins: mTOR, Akt, mTORC2, V1a, CAN
Papers using mTORC1 antibodies
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer.
Supplier
Hochman Shawn, In PLoS ONE, 2001
... To clone TORC1-GFP fusion protein expression construct, TORC1 coding sequence was amplified from pGEM-rTORC1 and inserted into pEGFP-N1 vector (Clontech) between HindIII and EcoRI ...
The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
Supplier
Maedler Kathrin, In PLoS ONE, 1992
... INS-1E and islet extracts were used for analysis of mTORC1 signaling, protein biosynthesis, ER stress markers and ...
Papers on mTORC1
Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against osteosarcoma.
New
Zhang et al., Jiangyin, China. In Cancer Biol Ther, 14 May 2015
At the molecular level, NVP-BEZ235 inhibited PI3K-AKT-mTORC1 activation and downregulated cyclin D1/cyclin B1 expressions, while increasing MEK/Erk phosphorylation in osteosarcoma cells.
mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.
New
Yu et al., Pittsburgh, United States. In Oncogene, 13 May 2015
mTOR complex 1 (mTORC1) is a major downstream target of the PI3K/ATK pathway and activates protein synthesis by phosphorylating key regulators of messenger RNA translation and ribosome synthesis.
The effects of resistance exercise training upon macro and micro-circulatory responses to feeding and skeletal muscle protein anabolism, in older men.
New
Williams et al., Derby, United Kingdom. In J Physiol, 13 May 2015
Akt/mTORC1) by immunoblotting from muscle biopsies.
Do airborne biogenic chemicals interact with the PI3K/Akt/mTOR cell signalling pathway to benefit human health and wellbeing in rural and coastal environments?
Review
New
Moore, Truro, United Kingdom. In Environ Res, 27 Apr 2015
The "biogenics" hypothesis formulated here is that regular exposure to low concentrations of mixtures of natural compounds and toxins in natural environments confers pleiotropic health benefits by inhibiting the activities of interconnected cell signalling systems, particularly PI3K/Akt/mTORC1.
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
New
Impact
Superti-Furga et al., Vienna, Austria. In Nature, 26 Apr 2015
The mechanistic target of rapamycin complex 1 (mTORC1) integrates the presence of growth factors, energy levels, glucose and amino acids to modulate metabolic status and cellular responses.
A review of potential metabolic etiologies of the observed association between red meat consumption and development of type 2 diabetes mellitus.
Review
New
Clifton et al., Australia. In Metabolism, 19 Apr 2015
BCAAs may induce insulin resistance via the mammalian target of rapamycin complex 1 (mTORC1) and ribosomal protein S6 kinase β 1 (S6k1)-associated pathways.
The expanding role of mTOR in cancer cell growth and proliferation.
Review
New
Roux et al., Montréal, Canada. In Mutagenesis, 31 Mar 2015
As part of the mTOR complex 1 (mTORC1), mTOR regulates cell growth by promoting the biosynthesis of proteins, lipids and nucleic acids.
NMDA Receptor Activation Regulates Sociability by its Effect on mTOR Signaling Activity.
Review
New
Deutsch et al., Norfolk, United States. In Prog Neuropsychopharmacol Biol Psychiatry, 19 Mar 2015
UNASSIGNED: Tuberous Sclerosis Complex is one example of a syndromic form of autism spectrum disorder associated with disinhibited activity of mTORC1 in neurons (e.g., cerebellar Purkinje cells).
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
New
Impact
Bosenberg et al., New Haven, United States. In Cancer Cell, Feb 2015
mTORC1 activation through Stk11 (Lkb1) loss abrogates growth arrest of Braf(V600E) melanocytic nevi, but is insufficient for complete progression to melanoma.
mTOR signaling in melanoma: oncogene-induced pseudo-senescence?
New
Impact
Sharpless et al., Chapel Hill, United States. In Cancer Cell, Feb 2015
In this issue of Cancer Cell, Damsky and colleagues suggest activation of mTORC1 and mTORC2 is required for OIS evasion in human melanomas harboring oncogenic BRAF mutations.
Metabolism. Differential regulation of mTORC1 by leucine and glutamine.
New
Impact
Guan et al., San Diego, United States. In Science, Feb 2015
The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates environmental and intracellular signals to regulate cell growth.
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
New
Impact
Sabatini et al., Cambridge, United States. In Science, Feb 2015
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that responds to multiple environmental cues.
The role of TORC1 in muscle development in Drosophila.
New
Bridges et al., Memphis, United States. In Sci Rep, Dec 2014
Previous studies suggest that mTORC1 plays a role in the formation of mature muscle from immature muscle precursor cells.
The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.
New
Paw et al., Boston, United States. In Sci Signal, Dec 2014
Inadequate NEAA uptake by pharmacologic inhibition or RNAi-mediated knockdown of LAT3 triggered a specific reduction in hemoglobin production in zebrafish embryos and murine erythroid cells through the mTORC1 (mammalian target of rapamycin complex 1)/4E-BP (eukaryotic translation initiation factor 4E-binding protein) pathway.
[The role of mTOR in the regulation of skeletal muscle metabolism].
Review
New
Akhmetov et al., In Fiziol Cheloveka, Sep 2014
It exists in two mTOR protein complexes mTORC1 and mTORC2 with various sensitivity to the inhibitory effect of rapamycin.
Glutaminolysis activates Rag-mTORC1 signaling.
GeneRIF
Hall et al., Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.
Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus.
Impact
GeneRIF
Martin et al., Los Angeles, United States. In Cell, 2012
Results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucleus about synaptic activity.
Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.
GeneRIF
Sun et al., Los Angeles, United States. In Cell Cycle, 2012
Inhibition of TORC1 retards, and to some extent reverses, phenotypic indicators of cellular senescence.
Phospholipase D and mTORC1: nutrients are what bring them together.
GeneRIF
Thomas et al., Cincinnati, United States. In Sci Signal, 2012
Studies indicate that phospholipase D (PLD) as a mediator of nutrients to mTORC1.
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
GeneRIF
Manning et al., Boston, United States. In Sci Signal, 2012
Data suggest that increased activation of mTORC1 can promote carcinogenesis.
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