Ambra1 at a glance.
Roma, Italy. In J Cell Sci, Jul 2015
It acts in an early step of mammalian target of rapamycin complex 1 (mTORC1)-dependent autophagy by favouring formation of the autophagosome core complex.
Glutaminolysis activates Rag-mTORC1 signaling.
Basel, Switzerland. In Mol Cell, 2012
We demonstrate that glutamine in combination with leucine activates mammalian TORC1 (mTORC1) by enhancing glutaminolysis and alpha-ketoglutarate production.