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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Oct 2014.

Mechanistic target of rapamycin

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: Akt, PI3K, V1a, CAN, p70S6K
Papers using mTOR antibodies
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth
Lisanti Michael P. et al., In Cell Cycle, 2010
... anti-phospho-AMPK (#2531, Cell Signaling), anti-AMPK (#2532, Cell Signaling), anti-LKB (#sc-32245 (Ley 37D/G6); Santa Cruz Biotech), anti-mTOR (#2983; Cell Signaling), anti-phospho-mTOR (#2971; Cell Signaling) ...
Bioengineering approaches to study multidrug resistance in tumor cells
Munshi Hidayatullah G., In PLoS ONE, 2010
... , a PI3K and mTOR inhibitor was purchased from Cayman Chemical (Ann Arbor, MI).
ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice.
Beaudoin Claude, In PLoS ONE, 2009
... phosphorylated Akt (Ser473), phosphorylated mTOR (Ser2448), phosphorylated IR-β (Tyr1345) and β-actin, as well as the mTOR inhibitor, rapamycin, were all obtained from Cell Signaling Technology (Danvers, MA) ...
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death
Rocchi S et al., In Cell Death & Disease, 2008
... , mTOR, S6 ribosomal antibodies were from Cell Signaling (Berverly, MA, USA) ...
Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway
Das Gobardhan, In PLoS ONE, 2008
... (sc- 7159) and β-actin (sc-130657) were purchased from Santa Cruz Biotechnology Inc., California, USA and mTOR (#2983) was procured from Cell Signaling Technology Inc., Danvers, MA, ...
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Papers on mTOR
Gynecologic Cancer InterGroup (GCIG) Consensus Review for Clear Cell Carcinoma of the Ovary.
Oza et al., Tokyo, Japan. In Int J Gynecol Cancer, 30 Nov 2014
Considering the frequent PIK3CA mutation in CCC, dual inhibitors targeting PI3K, AKT in the mTOR pathway, are promising.
Restoration of Autophagy Alleviates Hepatic ER stress and Impaired Insulin Signalling Transduction in High Fructose-Fed Male Mice.
Ye et al., Melbourne, Australia. In Endocrinology, 24 Nov 2014
Intriguingly, hepatic autophagy was suppressed as a result of activation of mammalian target of rapamycin (mTOR).
SKLB-M8 Induces Apoptosis Through the AKT/mTOR Signaling Pathway in Melanoma Models and Inhibits Angiogenesis With Decrease of ERK1/2 Phosphorylation.
Chen et al., China. In J Pharmacol Sci, 21 Nov 2014
Flow cytometory analysis showed that SKLB-M8 induced G2/M arrest in three melanoma cell lines, and western blotting demonstrated that SKLB-M8 down-regulated the expression of cdc2, up-regulated p53 in A2058 and CHL-1 cells, and triggered cell apoptosis through down-regulating AKT and phosphorylated mTOR (p-mTOR).
Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy.
Miyamoto et al., San Diego, United States. In Cell Death Differ, 17 Nov 2014
This review summarizes recent advances in understanding the protective role of HK-II, controlling cellular growth, preventing mitochondrial death pathway and enhancing autophagy, with a particular focus on the interaction between HK-II and Akt/mTOR pathway to integrate metabolic status with the control of cell survival.Cell Death and Differentiation advance online publication, 17 October 2014; doi:10.1038/cdd.2014.173.
Suppression of Feedback Loops Mediated by PI3K/mTOR Induces Multiple Overactivation of Compensatory Pathways: An Unintended Consequence Leading to Drug Resistance.
Sinnet-Smith et al., Los Angeles, United States. In Mol Cancer Ther, 16 Nov 2014
The PI3K/AKT/mTOR pathway is aberrantly stimulated in many cancer cells and thus it has emerged as a target for therapy.
Response and acquired resistance to everolimus in anaplastic thyroid cancer.
Lorch et al., Cambridge, United States. In N Engl J Med, 09 Nov 2014
Everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), is effective in treating tumors harboring alterations in the mTOR pathway.
Let-7 Coordinately Suppresses Components of the Amino Acid Sensing Pathway to Repress mTORC1 and Induce Autophagy.
La Spada et al., San Diego, United States. In Cell Metab, 07 Nov 2014
Autophagy is regulated by the mTOR signaling pathway-the focal point for integration of metabolic information, with mTORC1 playing a central role in balancing biosynthesis and catabolism.
Defining the role of common variation in the genomic and biological architecture of adult human height.
Frayling et al., Tartu, Estonia. In Nat Genet, 05 Nov 2014
We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid.
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.
Netea et al., Nijmegen, Netherlands. In Science, 26 Oct 2014
Trained monocytes display high glucose consumption, high lactate production, and a high ratio of nicotinamide adenine dinucleotide (NAD(+)) to its reduced form (NADH), reflecting a shift in metabolism with an increase in glycolysis dependent on the activation of mammalian target of rapamycin (mTOR) through a dectin-1-Akt-HIF-1α (hypoxia-inducible factor-1α) pathway.
The Histidine Transporter SLC15A4 Coordinates mTOR-Dependent Inflammatory Responses and Pathogenic Antibody Production.
Toyama-Sorimachi et al., Tokyo, Japan. In Immunity, 18 Oct 2014
SLC15A4 loss disturbed the endolysosomal pH regulation and probably the v-ATPase integrity, and these changes were associated with disruption of the mTOR pathway, leading to failure of the IFN regulatory factor 7 (IRF7)-IFN-I regulatory circuit.
Clinical significance of mTOR and eIF4E expression in invasive ductal carcinoma.
Chen et al., In Tumori, 30 Sep 2014
Mammalian target of rapamycin (mTOR) is one of the serine-threonine protein kinases and plays an important regulatory role in cell growth.
Targeting the PI3K/AKT/mTOR pathway: potential for lung cancer treatment.
Perez-Soler et al., United States. In Lung Cancer Manag, Feb 2014
UNLABELLED: The PI3K/AKT/mTOR pathway is commonly activated in non-small-cell lung cancer.
Tumor Suppression and Promotion by Autophagy.
Quest et al., Santiago, Chile. In Biomed Res Int, Dec 2013
Specifically, tumor suppressor genes that negatively regulate mTOR, such as PTEN, AMPK, LKB1, and TSC1/2 stimulate autophagy while, conversely, oncogenes that activate mTOR, such as class I PI3K, Ras, Rheb, and AKT, inhibit autophagy, suggesting that autophagy is a tumor suppressor mechanism.
RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders.
Malagelada et al., Barcelona, Spain. In Front Cell Neurosci, Dec 2013
Mechanistic target of Rapamycin (mTOR) pathway regulates essential processes directed to preserve cellular homeostasis, such as cell growth, proliferation, survival, protein synthesis and autophagy.
Computer-Aided Targeting of the PI3K/Akt/mTOR Pathway: Toxicity Reduction and Therapeutic Opportunities.
Wang et al., Shenzhen, China. In Int J Mol Sci, Dec 2013
UNLABELLED: The PI3K/Akt/mTOR pathway plays an essential role in a wide range of biological functions, including metabolism, macromolecular synthesis, cell growth, proliferation and survival.
The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice.
Fu et al., Tianjin, China. In Biochim Biophys Acta, 2012
Our results provide new insights into the mechanism by which AMPK/mTOR/S6K1 signaling axis mediates the physiological process of exercise-induced insulin sensitization.
Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells.
Alwine et al., Philadelphia, United States. In Genes Dev, 2012
mTORC1 activation requires dynein-dependent transport to a position in the cell where it can be activated
Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice.
Pearce et al., United States. In J Immunol, 2012
mTOR is a molecular target for augmenting dendritic cell survival and activation, a novel approach for enhancing the efficacy of therapeutic autologous DC vaccination.
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons.
Jan et al., San Francisco, United States. In Neuron, 2012
Our study reveals that an increase in mTOR signaling in hypothalamic pro-opiomelanocortin neurons contributes to age-dependent obesity
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor.
Mohr et al., New York City, United States. In Genes Dev, 2012
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor.
More papers using mTOR antibodies
Cytoprotective effect of polypeptide from Chlamys farreri on neuroblastoma (SH-SY5Y) cells following HO exposure involves scavenging ROS and inhibition JNK phosphorylation.
Sozzani Silvano, In PLoS ONE, 2008
... monoclonal antibodies to HIF-1α, mTOR and β-actin as well as rabbit polyclonal antibody against phospho-S2448 mTOR were from Abcam (Cambridge, UK) ...
TSC2 deficiency increases PTEN via HIF1alpha
Tsilibary Effie C., In PLoS ONE, 2008
... (Ser-65) 4EBP-1, phospho-GSK3β, GSK3β, phospho-tuberin (Thr 1462), tuberin, phospho-PRAS40 (Thr 246), PRAS40, phospho-mTOR (Ser-2448) and mTOR antibodies were purchased from Cell Signaling, Boston, MA ...
Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes.
Jin Dong-Yan, In PLoS ONE, 2007
... (Y416) rabbit polyclonal, anti-pAkt HM (S473), anti-pAkt A-loop (T308), anti-Akt rabbit polyclonal, anti-Rictor rabbit polyclonal, anti-mTOR rabbit polyclonal and anti-pPDK1 (S241) rabbit polyclonal antibodies were from Cell Signaling Technology (Beverly, MA, USA) ...
Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo
Bruni Paola et al., In Biochimie, 2006
... Phospho-ERK1/2, pan ERK1/2, phosphorylated mTOR (Ser 2448) antibodies were from Cell Signaling Technology, Inc ...
Generation of a conditional disruption of the Tsc2 gene
Sahin Mustafa et al., In Nature neuroscience, 2006
... phospho-TSC2 (T1462), Rheb, phospho-S6K1 (T389), total S6K1, phospho-S6 (S235/236), total S6, phospho-Akt (S473), phospho-4E-BP1 (T37/46), phospho-mTOR (S2481) (Cell Signaling), TSC2, EphA4, ephrin-A2, ephrin-A5, ...
Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN.
Pal Soumitro, In PLoS ONE, 2005
... (Ser-473 and Thr-308), phospho-S6 kinase (Thr-389), phospho-tuberin (Thr-1462), phospho-mTOR (Ser-2448), phospho-p65 (Ser-536), Akt, S6 kinase, mTOR and tuberin were purchased from Cell Signaling, Boston, MA ...
Cellular targets of gefitinib.
Zhang Lin, In PLoS ONE, 2004
... (LC3) (Cell Signaling Technology, #2775), ATG5 (Cell Signaling Technology, #2630), ATG7 (Cell Signaling Technology, #2631), phospho-mTOR (S2448) (Cell Signaling Technology, #2971), total mTOR ...
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Navarro Alfons, In PLoS ONE, 2003
... Anti-cleaved PARP, anti-phospho-p53 at Ser15, anti-p53, anti-phospho-AMPK at Thr172, anti-mTOR, and anti-phospho-mTOR at Ser2448 antibodies were obtained from Cell Signaling (Danvers, MA, USA) ...
TNF-alpha–accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism.
Cookson Mark, In PLoS ONE, 2001
... IPs were performed with 6 µg of mTOR (Santa Cruz), Rictor or Raptor (Bethyl), or control goat (Santa ...
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