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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 27 Aug 2015.

Mechanistic target of rapamycin

mTOR, FRAP
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: Akt, PI3K, CAN, V1a, mTORC1
Papers using mTOR antibodies
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth
Supplier
Lisanti Michael P. et al., In Cell Cycle, 2010
... anti-phospho-AMPK (#2531, Cell Signaling), anti-AMPK (#2532, Cell Signaling), anti-LKB (#sc-32245 (Ley 37D/G6); Santa Cruz Biotech), anti-mTOR (#2983; Cell Signaling), anti-phospho-mTOR (#2971; Cell Signaling) ...
Bioengineering approaches to study multidrug resistance in tumor cells
Supplier
Munshi Hidayatullah G., In PLoS ONE, 2010
... , a PI3K and mTOR inhibitor was purchased from Cayman Chemical (Ann Arbor, MI).
ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice.
Supplier
Beaudoin Claude, In PLoS ONE, 2009
... phosphorylated Akt (Ser473), phosphorylated mTOR (Ser2448), phosphorylated IR-β (Tyr1345) and β-actin, as well as the mTOR inhibitor, rapamycin, were all obtained from Cell Signaling Technology (Danvers, MA) ...
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death
Supplier
Rocchi S et al., In Cell Death & Disease, 2008
... , mTOR, S6 ribosomal antibodies were from Cell Signaling (Berverly, MA, USA) ...
Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway
Supplier
Das Gobardhan, In PLoS ONE, 2008
... (sc- 7159) and β-actin (sc-130657) were purchased from Santa Cruz Biotechnology Inc., California, USA and mTOR (#2983) was procured from Cell Signaling Technology Inc., Danvers, MA, ...
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Papers on mTOR
mTOR in Brain Physiology and Pathologies.
Review
New
Impact
Marin et al., Montpellier, France. In Physiol Rev, 31 Oct 2015
TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an effort to understand the mechanisms of action of the immunosuppressant drug rapamycin extracted from a bacterium of the Easter Island (Rapa Nui) soil.
Selective phosphorylation during early macrophage differentiation.
New
Ravasi et al., Saudi Arabia. In Proteomics, 26 Sep 2015
Some key involved regulators of these pathways are mTOR, MYB, STAT1 and CTNNB.
Metformin inhibits proliferation and proinflammatory cytokines of human keratinocytes in vitro via mTOR-signaling pathway.
New
Sun et al., Jinan, China. In Pharm Biol, 25 Sep 2015
Western blot was used to investigate the expression of the mammalian target of rapamycin (mTOR) and its downstream effectors p70 ribosomal S6 kinase (p70S6K).
Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma.
New
Mandal et al., Kharagpur, India. In Eur J Pharmacol, 22 Sep 2015
However, earlier reports reveal that PI3K/Akt/ mTOR inhibitors promote autophagy at the early stage as a survival mechanism that might affect its apoptotic potential.
BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory.
New
Impact
Sun et al., New York City, United States. In Immunity, 18 Sep 2015
Inhibition of mechanistic target of rapamycin (mTOR) or activation of AMP-activated protein kinase (AMPK) during the contraction-to-memory phase transition of the antiviral response increased autophagic activity and enhanced memory NK cell numbers through an Atg3-dependent mechanism.
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.
New
Impact
Gil et al., London, United Kingdom. In Nat Cell Biol, 17 Sep 2015
In a drug screen to find new SASP regulators, we uncovered the mTOR inhibitor rapamycin as a potent SASP suppressor.
Role of autophagy in cisplatin-induced ototoxicity.
New
Cho et al., Kwangju, South Korea. In Int J Pediatr Otorhinolaryngol, 15 Sep 2015
Markers of two autophagy-related pathways, mTOR and class III PI3K, were also investigated.
Neoplastic disease after liver transplantation: Focus on de novo neoplasms.
Review
New
Rodriguez-Castro et al., Padova, Italy. In World J Gastroenterol, 07 Sep 2015
Promising results in the prevention of hepatocellular carcinoma (HCC) recurrence have been reported with the use of mTOR inhibitors including everolimus and sirolimus and the ongoing open-label prospective randomized controlled SILVER.
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
New
Impact
Campisi et al., Novato, United States. In Nat Cell Biol, 31 Aug 2015
MTOR inhibition suppressed the secretion of inflammatory cytokines by senescent cells.
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.
New
Impact
Huang et al., Los Angeles, United States. In Cell Metab, 14 Aug 2015
We show that, like α-KG, both (R)-2HG and (S)-2HG bind and inhibit ATP synthase and inhibit mTOR signaling.
Blockade of the acute activation of mTOR complex 1 decreases hypertrophy development in rats with severe aortic valve regurgitation.
New
Arsenault et al., Québec, Canada. In Springerplus, Dec 2014
Increased protein turnover is a major event during development of LVH and the mechanistic target of rapamycin (mTOR) is a key molecule for its control.
Cutaneous Squamous Cell Carcinomas in Organ Transplant Recipients.
Review
New
Tyring et al., Houston, United States. In J Clin Med, Dec 2014
Compared to other immunosuppressives, mTOR inhibitors and mycophenolate mofetil have been associated with a decreased risk of developing post-transplant non-melanoma skin cancers.
PI3K/Akt/mTOR signaling pathway in cancer stem cells: from basic research to clinical application.
Review
New
Xu et al., Jinzhou, China. In Am J Cancer Res, Dec 2014
The PI3K/Akt/mTOR signaling pathway can be considered as a master regulator for cancer.
TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation.
Review
New
Asaduzzaman et al., Dhaka, Bangladesh. In Bone Res, Dec 2014
Additive, positive, negative, or synergistic effects are observed when TGF-β/BMP interacts with the pathways of MAPK, Wnt, Hedgehog (Hh), Notch, Akt/mTOR, and miRNA to regulate the effects of BMP-induced signaling in bone dynamics.
Gene expression profiling by mRNA array reveals different pattern in Chinese glioblastoma patients between Uygur and Han populations.
New
Li et al., Ürümqi, China. In Int J Clin Exp Med, Dec 2014
The KEGG pathway enrichment analysis showed that the differentially expressed genes were covered by 28 signaling pathways associated with tumorigenesis, including metabolic pathways, tumor suppressor pathways, MAP kinase signaling pathways, TGF-β signaling pathway, neurotrophin signaling pathways, and mTOR signaling pathway.
The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice.
GeneRIF
Fu et al., Tianjin, China. In Biochim Biophys Acta, 2012
Our results provide new insights into the mechanism by which AMPK/mTOR/S6K1 signaling axis mediates the physiological process of exercise-induced insulin sensitization.
Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells.
GeneRIF
Alwine et al., Philadelphia, United States. In Genes Dev, 2012
mTORC1 activation requires dynein-dependent transport to a position in the cell where it can be activated
Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice.
GeneRIF
Pearce et al., United States. In J Immunol, 2012
mTOR is a molecular target for augmenting dendritic cell survival and activation, a novel approach for enhancing the efficacy of therapeutic autologous DC vaccination.
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons.
GeneRIF
Jan et al., San Francisco, United States. In Neuron, 2012
Our study reveals that an increase in mTOR signaling in hypothalamic pro-opiomelanocortin neurons contributes to age-dependent obesity
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor.
GeneRIF
Mohr et al., New York City, United States. In Genes Dev, 2012
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor.
More papers using mTOR antibodies
Cytoprotective effect of polypeptide from Chlamys farreri on neuroblastoma (SH-SY5Y) cells following HO exposure involves scavenging ROS and inhibition JNK phosphorylation.
Supplier
Sozzani Silvano, In PLoS ONE, 2008
... monoclonal antibodies to HIF-1α, mTOR and β-actin as well as rabbit polyclonal antibody against phospho-S2448 mTOR were from Abcam (Cambridge, UK) ...
TSC2 deficiency increases PTEN via HIF1alpha
Supplier
Tsilibary Effie C., In PLoS ONE, 2008
... (Ser-65) 4EBP-1, phospho-GSK3β, GSK3β, phospho-tuberin (Thr 1462), tuberin, phospho-PRAS40 (Thr 246), PRAS40, phospho-mTOR (Ser-2448) and mTOR antibodies were purchased from Cell Signaling, Boston, MA ...
Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes.
Supplier
Jin Dong-Yan, In PLoS ONE, 2007
... (Y416) rabbit polyclonal, anti-pAkt HM (S473), anti-pAkt A-loop (T308), anti-Akt rabbit polyclonal, anti-Rictor rabbit polyclonal, anti-mTOR rabbit polyclonal and anti-pPDK1 (S241) rabbit polyclonal antibodies were from Cell Signaling Technology (Beverly, MA, USA) ...
Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo
Supplier
Bruni Paola et al., In Biochimie, 2006
... Phospho-ERK1/2, pan ERK1/2, phosphorylated mTOR (Ser 2448) antibodies were from Cell Signaling Technology, Inc ...
Generation of a conditional disruption of the Tsc2 gene
Supplier
Sahin Mustafa et al., In Nature neuroscience, 2006
... phospho-TSC2 (T1462), Rheb, phospho-S6K1 (T389), total S6K1, phospho-S6 (S235/236), total S6, phospho-Akt (S473), phospho-4E-BP1 (T37/46), phospho-mTOR (S2481) (Cell Signaling), TSC2, EphA4, ephrin-A2, ephrin-A5, ...
Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN.
Supplier
Pal Soumitro, In PLoS ONE, 2005
... (Ser-473 and Thr-308), phospho-S6 kinase (Thr-389), phospho-tuberin (Thr-1462), phospho-mTOR (Ser-2448), phospho-p65 (Ser-536), Akt, S6 kinase, mTOR and tuberin were purchased from Cell Signaling, Boston, MA ...
Cellular targets of gefitinib.
Supplier
Zhang Lin, In PLoS ONE, 2004
... (LC3) (Cell Signaling Technology, #2775), ATG5 (Cell Signaling Technology, #2630), ATG7 (Cell Signaling Technology, #2631), phospho-mTOR (S2448) (Cell Signaling Technology, #2971), total mTOR ...
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Supplier
Navarro Alfons, In PLoS ONE, 2003
... Anti-cleaved PARP, anti-phospho-p53 at Ser15, anti-p53, anti-phospho-AMPK at Thr172, anti-mTOR, and anti-phospho-mTOR at Ser2448 antibodies were obtained from Cell Signaling (Danvers, MA, USA) ...
TNF-alpha–accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism.
Supplier
Cookson Mark, In PLoS ONE, 2001
... IPs were performed with 6 µg of mTOR (Santa Cruz), Rictor or Raptor (Bethyl), or control goat (Santa ...
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