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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 16 Apr 2015.

Mechanistic target of rapamycin

mTOR, FRAP
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: Akt, PI3K, CAN, V1a, HAD
Papers using mTOR antibodies
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth
Supplier
Lisanti Michael P. et al., In Cell Cycle, 2010
... anti-phospho-AMPK (#2531, Cell Signaling), anti-AMPK (#2532, Cell Signaling), anti-LKB (#sc-32245 (Ley 37D/G6); Santa Cruz Biotech), anti-mTOR (#2983; Cell Signaling), anti-phospho-mTOR (#2971; Cell Signaling) ...
Bioengineering approaches to study multidrug resistance in tumor cells
Supplier
Munshi Hidayatullah G., In PLoS ONE, 2010
... , a PI3K and mTOR inhibitor was purchased from Cayman Chemical (Ann Arbor, MI).
ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice.
Supplier
Beaudoin Claude, In PLoS ONE, 2009
... phosphorylated Akt (Ser473), phosphorylated mTOR (Ser2448), phosphorylated IR-β (Tyr1345) and β-actin, as well as the mTOR inhibitor, rapamycin, were all obtained from Cell Signaling Technology (Danvers, MA) ...
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death
Supplier
Rocchi S et al., In Cell Death & Disease, 2008
... , mTOR, S6 ribosomal antibodies were from Cell Signaling (Berverly, MA, USA) ...
Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway
Supplier
Das Gobardhan, In PLoS ONE, 2008
... (sc- 7159) and β-actin (sc-130657) were purchased from Santa Cruz Biotechnology Inc., California, USA and mTOR (#2983) was procured from Cell Signaling Technology Inc., Danvers, MA, ...
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Papers on mTOR
Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against osteosarcoma.
New
Zhang et al., Jiangyin, China. In Cancer Biol Ther, 14 May 2015
UNASSIGNED: Recent studies have identified that constitutively active phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling is an important feature of osteosarcoma, where it promotes cell proliferation, survival, and chemo-resistance.
AXL Mediates Resistance to PI3Kα Inhibition by Activating the EGFR/PKC/mTOR Axis in Head and Neck and Esophageal Squamous Cell Carcinomas.
New
Impact
Baselga et al., New York City, United States. In Cancer Cell, 13 May 2015
Studying models of therapeutic resistance, we have observed that SCC cells that become refractory to PI3Kα inhibition maintain PI3K-independent activation of the mammalian target of rapamycin (mTOR).
Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy.
New
Zhao et al., Jinan, China. In Biochim Biophys Acta, 11 May 2015
Subsequent studies revealed that SPC downregulated the phosphorylation of p70S6K and 4EBP1 (two substrates of mTOR) but enhanced that of JNK when inducing autophagy.
Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy.
New
Impact
Lee et al., Taejŏn, South Korea. In Nat Med, 30 Apr 2015
Here, we used deep whole-exome sequencing (read depth, 412-668×) validated by site-specific amplicon sequencing (100-347,499×) in paired brain-blood DNA from four subjects with FCDII and uncovered a de novo brain somatic mutation, mechanistic target of rapamycin (MTOR) c.7280T>C (p.Leu2427Pro) in two subjects.
Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway in non-small cell lung cancer.
Review
New
Yip, Australia. In Transl Lung Cancer Res, 30 Apr 2015
The PI3K-Akt-mTOR pathway is commonly deregulated in human malignancy including NSCLC.
Targeted therapies for advanced Ewing sarcoma family of tumors.
Review
New
Janku et al., Houston, United States. In Cancer Treat Rev, 27 Apr 2015
In this review, we focus on early clinical and translational research that identified multiple molecular targets, including IGF-1R; mTOR; tyrosine kinase inhibitors; EWS-FLI1-related targets, and others.
Therapy-induced tumour secretomes promote resistance and tumour progression.
New
Impact
Massagué et al., New York City, United States. In Nature, 25 Apr 2015
Dual inhibition of RAF and the PI(3)K/AKT/mTOR intracellular signalling pathways blunted the outgrowth of the drug-resistant cell population in BRAF mutant human melanoma, suggesting this combination therapy as a strategy against tumour relapse.
CD5 Instructs Extrathymic Regulatory T Cell Development in Response to Self and Tolerizing Antigens.
New
Impact
Hawiger et al., Saint Louis, United States. In Immunity, 17 Apr 2015
Our findings further revealed that CD5 promoted Treg cell induction by blocking mechanistic target of rapamycin (mTOR) activation.
Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies.
New
Impact
Ronai et al., Los Angeles, United States. In Cancer Cell, 09 Apr 2015
This decreases Gln uptake, levels of TCA cycle components, mTOR signaling, and proliferation while increasing autophagy and cell death.
Germline and somatic mutations in meningiomas.
Review
New
Smith, Manchester, United Kingdom. In Cancer Genet, 19 Mar 2015
The recent identification of somatic mutations in components of the SHH-GLI1 and AKT1-MTOR signaling pathways indicates the potential for cross talk of these pathways in the development of meningiomas.
mTOR Signaling in Epilepsy: Insights from Malformations of Cortical Development.
Review
New
Crino, Philadelphia, United States. In Cold Spring Harb Perspect Med, Dec 2014
UNASSIGNED: Over the past decade enhanced activation of the mammalian target of rapamycin (mTOR)-signaling cascade has been identified in focal malformations of cortical development (MCD) subtypes, which have been collectively referred to as "mTORopathies."
Increased Expression of GOLPH3 is Associated with the Proliferation of Prostate Cancer.
New
Wang et al., Linyi, China. In J Cancer, Dec 2014
Western blots were also employed to assess AKT-mTOR and cell cycle-related proteins.
The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies.
New
Kim et al., Taejŏn, South Korea. In Front Pharmacol, Dec 2014
CX-4945 exerts anti-proliferative effects in hematological tumors by downregulating CK2 expression and suppressing activation of CK2-mediated PI3K/Akt/mTOR signaling pathways.
The role of mTOR signaling pathway in premalignant and malignant cervical lesions.
New
Creatsas et al., In Eur J Gynaecol Oncol, Dec 2014
PURPOSE OF THE STUDY: Aberrant activation of the Akt/mTOR/pS6 signaling pathway has been identified in various types of cancer and is under investigation in cervical cancer.
Oedema, solid organ transplantation and mammalian target of rapamycin inhibitor/proliferation signal inhibitors (mTOR-I/PSIs).
Review
New
Izzedine et al., Paris, France. In Clin Kidney J, Apr 2014
Mammalian target of rapamycin inhibitor (mTOR-I)/proliferation signal inhibitors (PSI) including sirolimus and everolimus represent a new class of drugs increasingly used in solid-organ transplantation as alternatives to calcineurin inhibitors for patients with renal dysfunction, transplant coronary arterial vasculopathy or malignancy.
The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice.
GeneRIF
Fu et al., Tianjin, China. In Biochim Biophys Acta, 2012
Our results provide new insights into the mechanism by which AMPK/mTOR/S6K1 signaling axis mediates the physiological process of exercise-induced insulin sensitization.
Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells.
GeneRIF
Alwine et al., Philadelphia, United States. In Genes Dev, 2012
mTORC1 activation requires dynein-dependent transport to a position in the cell where it can be activated
Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice.
GeneRIF
Pearce et al., United States. In J Immunol, 2012
mTOR is a molecular target for augmenting dendritic cell survival and activation, a novel approach for enhancing the efficacy of therapeutic autologous DC vaccination.
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons.
GeneRIF
Jan et al., San Francisco, United States. In Neuron, 2012
Our study reveals that an increase in mTOR signaling in hypothalamic pro-opiomelanocortin neurons contributes to age-dependent obesity
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor.
GeneRIF
Mohr et al., New York City, United States. In Genes Dev, 2012
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor.
More papers using mTOR antibodies
Cytoprotective effect of polypeptide from Chlamys farreri on neuroblastoma (SH-SY5Y) cells following HO exposure involves scavenging ROS and inhibition JNK phosphorylation.
Supplier
Sozzani Silvano, In PLoS ONE, 2008
... monoclonal antibodies to HIF-1α, mTOR and β-actin as well as rabbit polyclonal antibody against phospho-S2448 mTOR were from Abcam (Cambridge, UK) ...
TSC2 deficiency increases PTEN via HIF1alpha
Supplier
Tsilibary Effie C., In PLoS ONE, 2008
... (Ser-65) 4EBP-1, phospho-GSK3β, GSK3β, phospho-tuberin (Thr 1462), tuberin, phospho-PRAS40 (Thr 246), PRAS40, phospho-mTOR (Ser-2448) and mTOR antibodies were purchased from Cell Signaling, Boston, MA ...
Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes.
Supplier
Jin Dong-Yan, In PLoS ONE, 2007
... (Y416) rabbit polyclonal, anti-pAkt HM (S473), anti-pAkt A-loop (T308), anti-Akt rabbit polyclonal, anti-Rictor rabbit polyclonal, anti-mTOR rabbit polyclonal and anti-pPDK1 (S241) rabbit polyclonal antibodies were from Cell Signaling Technology (Beverly, MA, USA) ...
Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo
Supplier
Bruni Paola et al., In Biochimie, 2006
... Phospho-ERK1/2, pan ERK1/2, phosphorylated mTOR (Ser 2448) antibodies were from Cell Signaling Technology, Inc ...
Generation of a conditional disruption of the Tsc2 gene
Supplier
Sahin Mustafa et al., In Nature neuroscience, 2006
... phospho-TSC2 (T1462), Rheb, phospho-S6K1 (T389), total S6K1, phospho-S6 (S235/236), total S6, phospho-Akt (S473), phospho-4E-BP1 (T37/46), phospho-mTOR (S2481) (Cell Signaling), TSC2, EphA4, ephrin-A2, ephrin-A5, ...
Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN.
Supplier
Pal Soumitro, In PLoS ONE, 2005
... (Ser-473 and Thr-308), phospho-S6 kinase (Thr-389), phospho-tuberin (Thr-1462), phospho-mTOR (Ser-2448), phospho-p65 (Ser-536), Akt, S6 kinase, mTOR and tuberin were purchased from Cell Signaling, Boston, MA ...
Cellular targets of gefitinib.
Supplier
Zhang Lin, In PLoS ONE, 2004
... (LC3) (Cell Signaling Technology, #2775), ATG5 (Cell Signaling Technology, #2630), ATG7 (Cell Signaling Technology, #2631), phospho-mTOR (S2448) (Cell Signaling Technology, #2971), total mTOR ...
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Supplier
Navarro Alfons, In PLoS ONE, 2003
... Anti-cleaved PARP, anti-phospho-p53 at Ser15, anti-p53, anti-phospho-AMPK at Thr172, anti-mTOR, and anti-phospho-mTOR at Ser2448 antibodies were obtained from Cell Signaling (Danvers, MA, USA) ...
TNF-alpha–accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism.
Supplier
Cookson Mark, In PLoS ONE, 2001
... IPs were performed with 6 µg of mTOR (Santa Cruz), Rictor or Raptor (Bethyl), or control goat (Santa ...
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