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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Mechanistic target of rapamycin

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: Akt, PI3K, V1a, CAN, p70S6K
Papers using mTOR antibodies
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth
Lisanti Michael P. et al., In Cell Cycle, 2010
... anti-phospho-AMPK (#2531, Cell Signaling), anti-AMPK (#2532, Cell Signaling), anti-LKB (#sc-32245 (Ley 37D/G6); Santa Cruz Biotech), anti-mTOR (#2983; Cell Signaling), anti-phospho-mTOR (#2971; Cell Signaling) ...
Bioengineering approaches to study multidrug resistance in tumor cells
Munshi Hidayatullah G., In PLoS ONE, 2010
... , a PI3K and mTOR inhibitor was purchased from Cayman Chemical (Ann Arbor, MI).
ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice.
Beaudoin Claude, In PLoS ONE, 2009
... phosphorylated Akt (Ser473), phosphorylated mTOR (Ser2448), phosphorylated IR-β (Tyr1345) and β-actin, as well as the mTOR inhibitor, rapamycin, were all obtained from Cell Signaling Technology (Danvers, MA) ...
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death
Rocchi S et al., In Cell Death & Disease, 2008
... , mTOR, S6 ribosomal antibodies were from Cell Signaling (Berverly, MA, USA) ...
Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway
Das Gobardhan, In PLoS ONE, 2008
... (sc- 7159) and β-actin (sc-130657) were purchased from Santa Cruz Biotechnology Inc., California, USA and mTOR (#2983) was procured from Cell Signaling Technology Inc., Danvers, MA, ...
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Papers on mTOR
Combination of mTOR Inhibitors Augments Potency while Activating PI3K Signaling in Pituitary Tumors.
Shimon et al., Petah Tikva, Israel. In Neuroendocrinology, 13 Dec 2015
BACKGROUND/AIMS: Despite the success in treating some cancers, the efficacy of the mTOR inhibitors, rapalogs, as anti-cancer therapeutics, has been limited.
Effects of Fluoride on the Expression of Beclin1 and mTOR in Ameloblasts.
Liu et al., In Cells Tissues Organs, 13 Dec 2015
This study examined the effect of sodium fluoride (NaF) on the expression of Beclin1 and mTOR to elucidate the development mechanisms of dental fluorosis.
Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle.
Yen et al., Singapore, Singapore. In Endocrinology, 12 Dec 2015
TH induction of autophagy involved reactive oxygen species (ROS) stimulation of AMPK-mTOR-Ulk1 signaling.
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis.
Erez et al., Israel. In Nature, 11 Dec 2015
Building on these results, we demonstrate that ASS1 deficiency in cancer increases cytosolic aspartate levels, which increases CAD activation by upregulating its substrate availability and by increasing its phosphorylation by S6K1 through the mammalian target of rapamycin (mTOR) pathway.
The cytotoxic T cell proteome and its shaping by the kinase mTOR.
Cantrell et al., Cambridge, United Kingdom. In Nat Immunol, 09 Dec 2015
UNASSIGNED: We used high-resolution mass spectrometry to map the cytotoxic T lymphocyte (CTL) proteome and the effect of the metabolic checkpoint kinase mTORC1 on CTLs.
Potential therapeutic effects of mTOR inhibition in atherosclerosis.
Martinet et al., Antwerp, Belgium. In Br J Clin Pharmacol, 09 Dec 2015
Recently, the mechanistic target of rapamycin (mTOR) has been identified as a preeminent actor in the development of atherosclerosis.
Neuroendocrine differentiation: The mysterious fellow of colorectal cancer.
Poetsch et al., Kristiansand, Norway. In World J Gastroenterol, 07 Dec 2015
This review elucidates, whether new insights into the origin of neuroendocrine differentiation in the intestinal epithelium, its regulation by mTOR pathway components and its possible link to the intestinal stem cell compartment could determine a role of neuroendocrine cells as prognostic marker and putative therapeutic target in sporadic colorectal cancer.
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.
Kennedy et al., Novato, United States. In Cell Metab, 03 Dec 2015
Dietary restriction (DR) and inhibition of mechanistic Target of Rapamycin (mTOR) exclude Los1 from the nucleus in a Rad53-dependent manner.
An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development.
Gleeson et al., New York City, United States. In Nat Med, 02 Dec 2015
Postzygotic somatic mutations activating the phosphatidylinositol-4,5-bisphosphate-3-kinase (PI3K)-protein kinase B (AKT)-mammalian target of rapamycin (mTOR) pathway are found in a wide range of brain diseases, including FMCDs.
Transcriptional regulation of hepatic lipogenesis.
Sul et al., Berkeley, United States. In Nat Rev Mol Cell Biol, 22 Nov 2015
After feeding, high blood glucose and insulin levels activate lipogenic genes through several pathways, including the DNA-dependent protein kinase (DNA-PK), atypical protein kinase C (aPKC) and AKT-mTOR pathways.
Metabolic regulation of natural killer cells.
Finlay, Dublin, Ireland. In Biochem Soc Trans, Sep 2015
The mammalian target of rapamcyin (mTOR) complex 1 (mTORC1) has been identified as a key metabolic regulator that promotes glycolytic metabolism in multiple immune cell subsets.
CD8+ T-cell senescence: no role for mTOR.
Henson, London, United Kingdom. In Biochem Soc Trans, Sep 2015
Evidence implicates mammalian target of rapamycin (mTOR) to be a key modulator of aging and the use of mTOR inhibitors has been shown to ameliorate much age-related pathology; however, recent data suggest that senescent CD8(+) T-cells function independently of mTOR.
Targeted Therapies Overcoming Endocrine Resistance in Hormone Receptor-Positive Breast Cancer.
Schmidt et al., Mainz, Germany. In Breast Care (basel), Jul 2015
The focus of the current review is on the intracellular PI3K/AKT/mTOR signalling pathway and cyclin-dependant kinases (CDKs) in oestrogen receptor (ER)-positive breast cancer.
Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor.
Gambacurta et al., Roma, Italy. In Cell Death Dis, Dec 2014
We demonstrate that 'in vitro' neuroblastoma cancer cells (chosen as experimental model) are able to differentiate directly into osteoblastic (by rapamycin, an mTOR inhibitor) and hepatic lineage without an intermediate 'stem' cell step.
Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration.
Li et al., Beijing, China. In Cell Death Dis, Dec 2014
Whereas rapamycin augmented the A2E-mediated autophagy, attenuated protein expression of inflammation-associated and angiogenic factors, and blocked the Akt/mTOR pathway.
The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice.
Fu et al., Tianjin, China. In Biochim Biophys Acta, 2012
Our results provide new insights into the mechanism by which AMPK/mTOR/S6K1 signaling axis mediates the physiological process of exercise-induced insulin sensitization.
Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells.
Alwine et al., Philadelphia, United States. In Genes Dev, 2012
mTORC1 activation requires dynein-dependent transport to a position in the cell where it can be activated
Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice.
Pearce et al., United States. In J Immunol, 2012
mTOR is a molecular target for augmenting dendritic cell survival and activation, a novel approach for enhancing the efficacy of therapeutic autologous DC vaccination.
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons.
Jan et al., San Francisco, United States. In Neuron, 2012
Our study reveals that an increase in mTOR signaling in hypothalamic pro-opiomelanocortin neurons contributes to age-dependent obesity
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor.
Mohr et al., New York City, United States. In Genes Dev, 2012
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor.
More papers using mTOR antibodies
Cytoprotective effect of polypeptide from Chlamys farreri on neuroblastoma (SH-SY5Y) cells following HO exposure involves scavenging ROS and inhibition JNK phosphorylation.
Sozzani Silvano, In PLoS ONE, 2008
... monoclonal antibodies to HIF-1α, mTOR and β-actin as well as rabbit polyclonal antibody against phospho-S2448 mTOR were from Abcam (Cambridge, UK) ...
TSC2 deficiency increases PTEN via HIF1alpha
Tsilibary Effie C., In PLoS ONE, 2008
... (Ser-65) 4EBP-1, phospho-GSK3β, GSK3β, phospho-tuberin (Thr 1462), tuberin, phospho-PRAS40 (Thr 246), PRAS40, phospho-mTOR (Ser-2448) and mTOR antibodies were purchased from Cell Signaling, Boston, MA ...
Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes.
Jin Dong-Yan, In PLoS ONE, 2007
... (Y416) rabbit polyclonal, anti-pAkt HM (S473), anti-pAkt A-loop (T308), anti-Akt rabbit polyclonal, anti-Rictor rabbit polyclonal, anti-mTOR rabbit polyclonal and anti-pPDK1 (S241) rabbit polyclonal antibodies were from Cell Signaling Technology (Beverly, MA, USA) ...
Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo
Bruni Paola et al., In Biochimie, 2006
... Phospho-ERK1/2, pan ERK1/2, phosphorylated mTOR (Ser 2448) antibodies were from Cell Signaling Technology, Inc ...
Generation of a conditional disruption of the Tsc2 gene
Sahin Mustafa et al., In Nature neuroscience, 2006
... phospho-TSC2 (T1462), Rheb, phospho-S6K1 (T389), total S6K1, phospho-S6 (S235/236), total S6, phospho-Akt (S473), phospho-4E-BP1 (T37/46), phospho-mTOR (S2481) (Cell Signaling), TSC2, EphA4, ephrin-A2, ephrin-A5, ...
Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN.
Pal Soumitro, In PLoS ONE, 2005
... (Ser-473 and Thr-308), phospho-S6 kinase (Thr-389), phospho-tuberin (Thr-1462), phospho-mTOR (Ser-2448), phospho-p65 (Ser-536), Akt, S6 kinase, mTOR and tuberin were purchased from Cell Signaling, Boston, MA ...
Cellular targets of gefitinib.
Zhang Lin, In PLoS ONE, 2004
... (LC3) (Cell Signaling Technology, #2775), ATG5 (Cell Signaling Technology, #2630), ATG7 (Cell Signaling Technology, #2631), phospho-mTOR (S2448) (Cell Signaling Technology, #2971), total mTOR ...
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Navarro Alfons, In PLoS ONE, 2003
... Anti-cleaved PARP, anti-phospho-p53 at Ser15, anti-p53, anti-phospho-AMPK at Thr172, anti-mTOR, and anti-phospho-mTOR at Ser2448 antibodies were obtained from Cell Signaling (Danvers, MA, USA) ...
TNF-alpha–accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism.
Cookson Mark, In PLoS ONE, 2001
... IPs were performed with 6 µg of mTOR (Santa Cruz), Rictor or Raptor (Bethyl), or control goat (Santa ...
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