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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2014.

Mechanistic target of rapamycin

mTOR, FRAP
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: Akt, PI3K, V1a, CAN, mTORC1
Papers using mTOR antibodies
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth
Supplier
Lisanti Michael P. et al., In Cell Cycle, 2010
... anti-phospho-AMPK (#2531, Cell Signaling), anti-AMPK (#2532, Cell Signaling), anti-LKB (#sc-32245 (Ley 37D/G6); Santa Cruz Biotech), anti-mTOR (#2983; Cell Signaling), anti-phospho-mTOR (#2971; Cell Signaling) ...
Bioengineering approaches to study multidrug resistance in tumor cells
Supplier
Munshi Hidayatullah G., In PLoS ONE, 2010
... , a PI3K and mTOR inhibitor was purchased from Cayman Chemical (Ann Arbor, MI).
ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice.
Supplier
Beaudoin Claude, In PLoS ONE, 2009
... phosphorylated Akt (Ser473), phosphorylated mTOR (Ser2448), phosphorylated IR-β (Tyr1345) and β-actin, as well as the mTOR inhibitor, rapamycin, were all obtained from Cell Signaling Technology (Danvers, MA) ...
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death
Supplier
Rocchi S et al., In Cell Death & Disease, 2008
... , mTOR, S6 ribosomal antibodies were from Cell Signaling (Berverly, MA, USA) ...
Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway
Supplier
Das Gobardhan, In PLoS ONE, 2008
... (sc- 7159) and β-actin (sc-130657) were purchased from Santa Cruz Biotechnology Inc., California, USA and mTOR (#2983) was procured from Cell Signaling Technology Inc., Danvers, MA, ...
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Papers on mTOR
Autologous bone marrow derived mesenchymal stromal cell therapy in combination with everolimus to preserve renal structure and function in renal transplant recipients.
New
de Fijter et al., In J Transl Med, 10 Jan 2015
In experimental animal studies the combination of mammalian target of rapamycin (mTOR) inhibitor and MSCs was shown to attenuate allo immune responses and to promote allograft tolerance.
4-Acetylantroquinonol B suppresses tumor growth and metastasis of hepatoma cells via blockade of translation-dependent signaling pathway and VEGF production.
New
Chung et al., In J Agric Food Chem, 10 Jan 2015
4AAQB efficiently inhibited the phosphorylation of mTOR and its upstream kinases and the downstream effectors, and decreased the production of VEGF and activity of Rho GTPases in HuH-7 cells.
The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer.
New
Miller et al., United States. In Breast Cancer Res Treat, 10 Jan 2015
UNLABELLED: Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway has been implicated in anti-estrogen resistance in breast cancer.
Subcellular Distribution and Activity of Mechanistic Target of Rapamycin in Aged Retinal Pigment Epithelium.
New
Chen et al., Galveston, United States. In Invest Ophthalmol Vis Sci, 09 Jan 2015
UNLABELLED: Purpose: Inhibiting mechanistic target of rapamycin (mTOR) by pharmacological or genetic approaches can extend lifespan in mammals.
Targeting ABL1-Mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer.
New
Impact
Linehan et al., Bethesda, United States. In Cancer Cell, 08 Jan 2015
ABL1 upregulates aerobic glycolysis via the mTOR/HIF1α pathway and neutralizes fumarate-induced proteotoxic stress by promoting nuclear localization of the antioxidant response transcription factor NRF2.
Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.
New
Impact
Lane et al., Boston, United States. In Nat Med, 08 Jan 2015
In vivo treatment with the dual PI3K-mTOR inhibitor BEZ235 suppressed GNB1-induced signaling and markedly increased survival.
Multicenter Phase II Trial of Temsirolimus and Bevacizumab in Pancreatic Neuroendocrine Tumors.
New
Impact
Erlichman et al., Rochester, United States. In J Clin Oncol, 08 Jan 2015
Recent placebo-controlled phase III trials of the mammalian target of rapamycin (mTOR) inhibitor everolimus and the vascular endothelial growth factor (VEGF)/platelet-derived growth factor receptor inhibitor sunitinib have noted improved progression-free survival (PFS).
PIKKs - the solenoid nest where partners and kinases meet.
Review
New
Williams et al., Cambridge, United Kingdom. In Curr Opin Struct Biol, 02 Jan 2015
UNLABELLED: The recent structure of a truncated mTOR in a complex with mLST8 has provided a basic framework for understanding all of the phosphoinositide 3-kinase (PI3K)-related kinases (PIKKs): mTOR, ATM, ATR, SMG-1, TRRAP and DNA-PK.
Translational control by oncogenic signaling pathways.
Review
New
Roux et al., Montréal, Canada. In Biochim Biophys Acta, 01 Jan 2015
In addition to having respective translational targets, these pathways also impinge on the mechanistic/mammalian target of rapamycin (mTOR), which acts as a critical signaling node linking nutrient sensing to the coordinated regulation of cellular metabolism.
Epidemiology, biology, and treatment of triple-negative breast cancer in women of African ancestry.
Review
New
Impact
Brown et al., Houston, United States. In Lancet Oncol, 31 Dec 2014
Discovery of the molecular signalling molecules that define TNBC heterogeneity has led to the development of targeted agents such as inhibitors of poly (ADP-ribose) polymerase-1 and mTOR and immunomodulatory drugs that are in the early stages of clinical testing.
Ketamine and other potential glutamate antidepressants.
Review
New
Deakin et al., Manchester, United Kingdom. In Psychiatry Res, 13 Dec 2014
However these are also reported effects on 5-HT, dopamine and intracellular effects on the mammalian target of rapamycin (mTOR) pathway.
The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8(+) T Cells during Chronic Infection.
New
Impact
Kaech et al., New Haven, United States. In Immunity, 13 Dec 2014
UNLABELLED: Protein kinase B (also known as AKT) and the mechanistic target of rapamycin (mTOR) are central regulators of T cell differentiation, proliferation, metabolism, and survival.
Targeted therapy: A new hope for thyroid carcinomas.
Review
New
Caponigro et al., Napoli, Italy. In Crit Rev Oncol Hematol, 01 Dec 2014
Also mTOR disruptions and VEGFR pathway disruption are common features in all advanced thyroid cancers.
[Subependymal Giant Cell Astrocytoma Associated with Tuberous Sclerosis Complex -  Pharmacological Treatment using mTOR Inhibitors.]
New
Zitterbart, In Klin Onkol, Dec 2013
Blocking of the dysregulated pathway with mTOR inhibitors has the potential to reduce the volume of this low grade brain tumor.
The involvement of miR-100 in bladder urothelial carcinogenesis changing the expression levels of mRNA and proteins of genes related to cell proliferation, survival, apoptosis and chromosomal stability.
New
Leite et al., São Paulo, Brazil. In Cancer Cell Int, Dec 2013
After transfection mRNA and protein levels of its supposed target genes THAP2, BAZ2A, mTOR, SMARCA5 and FGFR3 were analyzed by quantitative real time polymerase chain reaction (qRT-PCR) and western blotting.
The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice.
GeneRIF
Fu et al., Tianjin, China. In Biochim Biophys Acta, 2012
Our results provide new insights into the mechanism by which AMPK/mTOR/S6K1 signaling axis mediates the physiological process of exercise-induced insulin sensitization.
Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells.
GeneRIF
Alwine et al., Philadelphia, United States. In Genes Dev, 2012
mTORC1 activation requires dynein-dependent transport to a position in the cell where it can be activated
Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice.
GeneRIF
Pearce et al., United States. In J Immunol, 2012
mTOR is a molecular target for augmenting dendritic cell survival and activation, a novel approach for enhancing the efficacy of therapeutic autologous DC vaccination.
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons.
GeneRIF
Jan et al., San Francisco, United States. In Neuron, 2012
Our study reveals that an increase in mTOR signaling in hypothalamic pro-opiomelanocortin neurons contributes to age-dependent obesity
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor.
GeneRIF
Mohr et al., New York City, United States. In Genes Dev, 2012
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor.
More papers using mTOR antibodies
Cytoprotective effect of polypeptide from Chlamys farreri on neuroblastoma (SH-SY5Y) cells following HO exposure involves scavenging ROS and inhibition JNK phosphorylation.
Supplier
Sozzani Silvano, In PLoS ONE, 2008
... monoclonal antibodies to HIF-1α, mTOR and β-actin as well as rabbit polyclonal antibody against phospho-S2448 mTOR were from Abcam (Cambridge, UK) ...
TSC2 deficiency increases PTEN via HIF1alpha
Supplier
Tsilibary Effie C., In PLoS ONE, 2008
... (Ser-65) 4EBP-1, phospho-GSK3β, GSK3β, phospho-tuberin (Thr 1462), tuberin, phospho-PRAS40 (Thr 246), PRAS40, phospho-mTOR (Ser-2448) and mTOR antibodies were purchased from Cell Signaling, Boston, MA ...
Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes.
Supplier
Jin Dong-Yan, In PLoS ONE, 2007
... (Y416) rabbit polyclonal, anti-pAkt HM (S473), anti-pAkt A-loop (T308), anti-Akt rabbit polyclonal, anti-Rictor rabbit polyclonal, anti-mTOR rabbit polyclonal and anti-pPDK1 (S241) rabbit polyclonal antibodies were from Cell Signaling Technology (Beverly, MA, USA) ...
Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo
Supplier
Bruni Paola et al., In Biochimie, 2006
... Phospho-ERK1/2, pan ERK1/2, phosphorylated mTOR (Ser 2448) antibodies were from Cell Signaling Technology, Inc ...
Generation of a conditional disruption of the Tsc2 gene
Supplier
Sahin Mustafa et al., In Nature neuroscience, 2006
... phospho-TSC2 (T1462), Rheb, phospho-S6K1 (T389), total S6K1, phospho-S6 (S235/236), total S6, phospho-Akt (S473), phospho-4E-BP1 (T37/46), phospho-mTOR (S2481) (Cell Signaling), TSC2, EphA4, ephrin-A2, ephrin-A5, ...
Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN.
Supplier
Pal Soumitro, In PLoS ONE, 2005
... (Ser-473 and Thr-308), phospho-S6 kinase (Thr-389), phospho-tuberin (Thr-1462), phospho-mTOR (Ser-2448), phospho-p65 (Ser-536), Akt, S6 kinase, mTOR and tuberin were purchased from Cell Signaling, Boston, MA ...
Cellular targets of gefitinib.
Supplier
Zhang Lin, In PLoS ONE, 2004
... (LC3) (Cell Signaling Technology, #2775), ATG5 (Cell Signaling Technology, #2630), ATG7 (Cell Signaling Technology, #2631), phospho-mTOR (S2448) (Cell Signaling Technology, #2971), total mTOR ...
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Supplier
Navarro Alfons, In PLoS ONE, 2003
... Anti-cleaved PARP, anti-phospho-p53 at Ser15, anti-p53, anti-phospho-AMPK at Thr172, anti-mTOR, and anti-phospho-mTOR at Ser2448 antibodies were obtained from Cell Signaling (Danvers, MA, USA) ...
TNF-alpha–accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism.
Supplier
Cookson Mark, In PLoS ONE, 2001
... IPs were performed with 6 µg of mTOR (Santa Cruz), Rictor or Raptor (Bethyl), or control goat (Santa ...
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