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Myotubularin related protein 3

MTMR3, MTMR9, MTMR8, myotubularin-related protein 9, KIAA0371, FYVE-DSP1
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, MTM1, Inactive, MTMR6, CAN
Papers on MTMR3
The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity.
Noda et al., Ōsaka, Japan. In Febs Lett, Jan 2016
We previously reported that overexpression of phosphatase-deficient MTMR3, a member of the myotubularin phosphatidylinositol (PI) 3-phosphatase family, leads to induction of autophagy.
Chromosomal Instability and Phosphoinositide Pathway Gene Signatures in Glioblastoma Multiforme.
Waugh, London, United Kingdom. In Mol Neurobiol, Jan 2016
Of particular note were highly penetrant copy number losses for a group of X-linked phosphoinositide phosphatase genes OCRL, MTM1 and MTMR8; copy number amplifications for the chromosome 19 genes PIP5K1C, AKT2 and PIK3R2, and also for the phospholipase C genes PLCB1, PLCB4 and PLCG1 on chromosome 20.
Differential expression of genes involved in Bengal macrothrombocytopenia (BMTCP).
Shetty et al., Mumbai, India. In Blood Cells Mol Dis, Dec 2015
Four genes i.e. myotubularin related protein 9 (MTMR9), iron responsive element binding protein 2 (IREB2), alpha tubulin(TUBA) and tyrosine kinase ligand (TKL) were found to be differentially expressed in patient platelets as compared to that of normal healthy controls which was further confirmed by quantitative RT PCR analysis.
MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.
Abraham et al., New Haven, United States. In Proc Natl Acad Sci U S A, Sep 2015
We identified a previously undefined role for myotubularin-related protein 3 (MTMR3) in amplifying PRR-induced cytokine secretion in human macrophages and defined MTMR3-initiated mechanisms contributing to this amplification.
Structure of the catalytic phosphatase domain of MTMR8: implications for dimerization, membrane association and reversible oxidation.
Heo et al., Seoul, South Korea. In Acta Crystallogr D Biol Crystallogr, Jul 2015
Here, the crystal structure of the phosphatase domain of MTMR8 is reported.
The role of miR-100 in regulating apoptosis of breast cancer cells.
Zhang et al., Hangzhou, China. In Sci Rep, 2014
Antagonism of miR-100 in SK-BR-3 cells increased the expression of MTMR3, a target gene of miR-100, which resulted in the activation of p27 and eventually led to G2/M cell-cycle arrest and apoptosis.
A genetic variant in the seed region of miR-4513 shows pleiotropic effects on lipid and glucose homeostasis, blood pressure, and coronary artery disease.
Dehghan et al., Rotterdam, Netherlands. In Hum Mutat, 2014
We sought to identify miR-4513 target genes that may mediate these associations and revealed five genes (PCSK1, BNC2, MTMR3, ANK3, and GOSR2) through which these effects might be taking place.
Brief Report: identification of MTMR3 as a novel susceptibility gene for lupus nephritis in northern Han Chinese by shared-gene analysis with IgA nephropathy.
Zhang et al., Beijing, China. In Arthritis Rheumatol, 2014
RESULTS: In addition to associations with HLA gene polymorphisms, genetic variants of MTMR3 in 22q12 showed associations with lupus nephritis (for rs9983A, OR 1.61 [95% CI 1.19-2.19],
The MTMR9 rs2293855 polymorphism is associated with glucose tolerance, insulin secretion, insulin sensitivity and increased risk of prediabetes.
Tong et al., Chengdu, China. In Gene, 2014
BACKGROUND: Polymorphism of rs2293855 in gene MTMR9 has been associated with obesity and metabolic syndrome.
PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.
Wesche et al., Glasgow, United Kingdom. In Biochem J, 2014
Previously, we have shown that the phosphoinositide metabolizing enzymes PIKfyve (phosphoinositide 5-kinase, FYVE finger containing) and MTMR3 (myotubularin-related protein 3), together with their lipid product PtdIns5P, are important for migration of normal human fibroblasts.
Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.
Arai et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, 2014
By making use of information in the Caenorhabditis elegans mutants defective in fluid-phase endocytosis, we found that mammalian phosphoinositide phosphatase MTMR6 that dephosphorylates PI(3)P to PI, and its binding partner MTMR9, are required for macropinocytosis.
Myotubularin-related phosphatase 3 promotes growth of colorectal cancer cells.
Chai et al., Hangzhou, China. In Scientificworldjournal, 2013
In the present study, we aimed to investigate the role of myotubularin-related phosphatase 3 (MTMR3) in CRC cell growth via lentivirus-mediated small interfering RNA (siRNA) transduction in human colon cancer cell lines HCT116 and SW1116.
Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population.
Sekine et al., Kyoto, Japan. In J Hum Genet, 2011
Our data suggest that genetic variations in the FTO, SCG3 and MTMR9 genes independently influence the risk of metabolic syndrome.
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese.
Shen et al., Nanjing, China. In Nat Genet, 2011
P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively).
Genetics of childhood-onset inflammatory bowel disease.
Russell et al., Edinburgh, United Kingdom. In Inflamm Bowel Dis, 2011
The newly identified loci and expression data suggest mutations in genes encoding IL-27, which is involved in Th17 effector cell physiology; MTMR3, which we demonstrate is an essential component of autophagy; and CAPN10, which is necessary in regulating endoplasmic reticulum stress.
The role of PI3P phosphatases in the regulation of autophagy.
Deretic et al., Albuquerque, United States. In Febs Lett, 2010
Two recent studies indicate that PI3P metabolism involved in autophagy initiation is further regulated by the PI3P phosphatases Jumpy and MTMR3.
Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy.
Noda et al., Suita, Japan. In Traffic, 2010
Autophagosome formation was triggered by the overexpression of a dominant-negative inactive mutant of Myotubularin-related phosphatase 3 (MTMR3).
Mtmr8 is essential for vasculature development in zebrafish embryos.
Gui et al., Wuhan, China. In Bmc Dev Biol, 2009
These data indicate that Mtmr8 is essential for vasculature development in zebrafish embryos, and may play a role in arterial specification through repressing PI3K activity.
MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis.
Majerus et al., Saint Louis, United States. In J Biol Chem, 2009
MTMR9 greatly enhances the functions of MTMR6
Cooperation of Mtmr8 with PI3K regulates actin filament modeling and muscle development in zebrafish.
Gui et al., Wuhan, China. In Plos One, 2008
a conserved functional cooperation of Mtmr8 with PI3K regulates actin filament modeling and muscle development
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