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Mitochondrial transcription termination factor

mTERF, mitochondrial transcription termination factor, mitochondrial transcription termination factor mTERF
This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, CAN, ACID, TFAM, HAD
Papers on mTERF
The roles of mitochondrial transcription termination factors (MTERFs) in plants.
Review
New
Quesada, Elx, Spain. In Physiol Plant, Feb 2016
The mitochondrial transcription termination factor (MTERF) family could be a good example of this.
A human transcription factor in search mode.
New
Simmerling et al., Stony Brook, United States. In Nucleic Acids Res, Feb 2016
Here, we investigate the conformational switch of the human mitochondrial transcription termination factor MTERF1, which has a modular, superhelical topology complementary to DNA.
Functional relationship between mTERF4 and GUN1 in retrograde signaling.
New
Leister et al., Martinsried, Germany. In J Exp Bot, Jan 2016
The coe1 mutant has a single-base mutation in the gene for mitochondrial transcription termination factor 4 (mTERF4)/BSM/RUG2, which plays a role in regulating the processing of certain plastid transcripts.
A Member of the Arabidopsis Mitochondrial Transcription Termination Factor Family Is Required for Maturation of Chloroplast Transfer RNAIle(GAU).
New
Kleine et al., Berlin, Germany. In Plant Physiol, Sep 2015
Members of the so-called mitochondrial transcription termination factor (mTERF) family are found in metazoans and plants and regulate organellar gene expression at different levels.
Emerging functions of mammalian and plant mTERFs.
Review
New
Leister et al., Martinsried, Germany. In Biochim Biophys Acta, Sep 2015
In mammals, members of the mitochondrial transcription termination factor (mTERF) family play important roles in OGE.
MTERF4 regulates the mitochondrial dysfunction induced by MPP(+) in SH-SY5Y cells.
New
Zuo et al., Shanghai, China. In Biochem Biophys Res Commun, Sep 2015
Mitochondrial transcription termination factor 4, MTERF4, a member of the MTERF family, has been implicated in the regulation of mitochondrial translation by targeting NSUN4 to the large mitochondrial ribosome.
Mitochondria, Chloroplasts in Animal and Plant Cells: Significance of Conformational Matching.
Review
Kream et al., United States. In Med Sci Monit, 2014
Furthermore, the dual regulatory targeting of mitochondrial and chloroplast gene expression by mitochondrial transcription termination factor (MTERF) proteins to promote optimal energy production and oxygen consumption further advances these evolutionary contentions.
Gene expression profile in breast cancer comprising predictive markers for metastatic risk.
Santiyanont et al., Bangkok, Thailand. In Genet Mol Res, 2014
The multiplex gene expression profile indicated significantly downregulated levels of G protein-coupled receptor kinase interacting ArfGAP 2 (GIT2) and mitochondrial transcription termination factor (MTERF) genes in a lymph node-positive group of patients, with P values of 0.004 and 0.038, respectively.
Nucleic acid recognition by tandem helical repeats.
Review
Eichman et al., Nashville, United States. In Curr Opin Struct Biol, 2012
Unlike DNA sequence recognition motifs that rely mainly on major groove read-out, MTERF and ALK motifs locate target sequences and aberrant nucleotides within DNA by resculpting the double-helix through extensive backbone contacts.
Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk.
GeneRIF
Sellers et al., Tampa, United States. In Cancer Epidemiol Biomarkers Prev, 2011
Single nucleotide polymorphism in MTERF gene is associated with epithelial ovarian cancer.
MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome.
Impact
Larsson et al., Stockholm, Sweden. In Cell Metab, 2011
The MTERF protein family plays a key role in this process, and its members have been implicated in regulation of transcription initiation and site-specific transcription termination.
hMTERF4 knockdown in HeLa cells results in sub-G1 cell accumulation and cell death.
GeneRIF
Tan et al., Kunming, China. In Acta Biochim Biophys Sin (shanghai), 2011
data suggested that hMTERF4 is an essential factor for cell proliferation, which is probably modulated by mitochondrial transcription to promote cell proliferation
Mitochondrial transcription: how does it end?
GeneRIF
Garcia-Diaz et al., Stony Brook, United States. In Transcription, 2011
Studies indicate that the structure of the mitochondrial transcription termination factor (MTERF1) provides insight into the mechanism of binding, recognition of the termination sequence and the conformational changes involved in mediating termination.
MTERF1 gives mtDNA an unusual twist.
Impact
Larsson et al., Göteborg, Sweden. In Cell Metab, 2010
Recent work in Cell (Yakubovskaya et al., 2010) reports a novel DNA-binding fold in mitochondrial transcription termination factor 1 (MTERF1), which causes unwinding and base eversion at its target mtDNA sequence.
Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription.
Impact
GeneRIF
Garcia-Diaz et al., Stony Brook, United States. In Cell, 2010
The structure indicates that upon sequence recognition MTERF1 unwinds the DNA molecule, promoting eversion of three nucleotides.
Effects on mitochondrial transcription of manipulating mTERF protein levels in cultured human HEK293 cells.
GeneRIF
Jacobs et al., Tampere, Finland. In Bmc Mol Biol, 2009
Data show that mTERF protein levels materially affect the amount of readthrough transcription on the antisense strand of mtDNA, whilst the effects on sense-strand transcripts are complex, and suggest the influence of compensatory mechanisms.
mTERF2 regulates oxidative phosphorylation by modulating mtDNA transcription.
Impact
Moraes et al., Miami, United States. In Cell Metab, 2009
Here, we characterized mTERF2, a mitochondria-localized homolog of the mitochondrial transcription termination factor mTERF1.
The MTERF family proteins: mitochondrial transcription regulators and beyond.
Review
Cantatore et al., Bari, Italy. In Biochim Biophys Acta, 2009
The MTERF family is a wide protein family, identified in Metazoa and plants, which consists of 4 subfamilies named MTERF1-4.
Transcriptional paradigms in mammalian mitochondrial biogenesis and function.
Review
Impact
Scarpulla, Chicago, United States. In Physiol Rev, 2008
Transcription of mtDNA requires a small number of nucleus-encoded proteins including a single RNA polymerase (POLRMT), auxiliary factors necessary for promoter recognition (TFB1M, TFB2M) and activation (Tfam), and a termination factor (mTERF).
Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesis.
Impact
Attardi et al., Pasadena, United States. In Cell, 2006
The human mitochondrial transcription termination factor mTERF plays a central role in the control of heavy-strand rDNA transcription by promoting initiation, besides termination, of this transcription.
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