GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Metastasis associated 1 family, member 3
MTA3
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Top mentioned proteins:
MTA1, SNAIL, E-cadherin, PID, Histone
Papers on
MTA3
Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3.
New
Yokohama, Japan. In Proc Natl Acad Sci U S A, Nov 2015
This was a result of the failure of Bcl6 K379Q to recruit metastasis-associated protein 3 (MTA3).
[Regulation Mechanism of MTA3 in the Apoptosis of NSCLC Cells].
New
Xuzhou, China. In Zhongguo Fei Ai Za Zhi, Nov 2015
Abstract available from the publisher.
Expression of metastasis-associated protein 3 in human brain glioma related to tumor prognosis.
New
Qingdao, China. In Neurol Sci, Oct 2015
Recently, the newly identified MTA3 has been shown to play conflicting roles in human malignancies, while the expression pattern and potential clinical significance of MTA3 in human glioma have not been addressed yet.
MTA3 regulates differentiation of human cytotrophoblast stem cells.
New
San Diego, United States. In Placenta, Sep 2015
Metastasis associated protein-3 (MTA3) is a transcriptional co-repressor known to regulate cell migration.
Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.
New
Impact
Beijing, China. In Cancer Cell, Jul 2015
Here, we report that GATA3 nucleates a transcription repression program composed of G9A and MTA3-, but not MTA1- or MTA2-, constituted NuRD complex.
Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomics.
Review
New
Nijmegen, Netherlands. In Febs J, May 2015
STRUCTURED DIGITAL ABSTRACT: MBD3 physically interacts with ZNF512B, HDAC1, ZMYND8, GATAD2B, SALL4, GATAD2A, ZNF592, MTA3, ZNF687, CDK2AP1, CHD3, ZNF532, HDAC2, MTA2, CHD4, MTA1, KPNA2, CHD5, RBBP4 and RBBP7 by pull down (View interaction) CDK2AP1 physically interacts with MBD3, MTA3, HDAC2, GATAD2A, CHD4, CDK2AP1, MTA2, HDAC1, MTA1, CHD3, GATAD2B, MBD2, RBBP4 and RBBP7 by pull down (View interaction) MBD3 physically interacts with MTA2, MTA3, RBBP4, RBBP7, HDAC2, HDAC1, CHD4, CHD3 and MTA1 by cross-linking study (View interaction).
Function and regulation of MTA1 and MTA3 in malignancies of the female reproductive system.
Review
München, Germany. In Cancer Metastasis Rev, 2014
This review focuses on the current knowledge about the function and regulation of MTA1 and MTA3 proteins in gynecological cancer, including ovarian, endometrial, and cervical tumors.
Subcellular localization of MTA proteins in normal and cancer cells.
Review
Beijing, China. In Cancer Metastasis Rev, 2014
MTA1, MTA2, and MTA3 are the main members of the MTA family.
MTA1 and MTA3 Regulate HIF1a Expression in Hypoxia-Treated Human Trophoblast Cell Line HTR8/Svneo.
United States. In Med J Obstet Gynecol, 2014
Metastasis Associated Protein 1 and 3 (MTA1 and MTA3) are components of the Nucleosome Remodeling and Deacetylase (NuRD) complex, a chromatin remodeling complex, and are highly expressed in term placental trophoblasts.
Metastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cells.
GeneRIF
United States. In Biol Reprod, 2012
Metastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cells.
The metastasis-associated gene MTA3 is downregulated in advanced endometrioid adenocarcinomas.
GeneRIF
München, Germany. In Histol Histopathol, 2010
MTA3 is not a useful marker to assess and identify high-risk patients with endometrial adenocarcinomas
The metastasis-associated genes MTA1 and MTA3 are abundantly expressed in human placenta and chorionic carcinoma cells.
GeneRIF
München, Germany. In Histochem Cell Biol, 2009
the high expression level of MTA proteins in human chorionic cells might facilitate trophoblast cell migration and neoangiogenesis
The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications.
Review
Fukuoka, Japan. In Clin Exp Metastasis, 2008
Another member of this family, MTA3, is induced by estrogen and represses the expression of the transcriptional repressor Snail, a master regulator of "epithelial to mesenchymal transitions", resulting in the expression of the cell adhesion molecule E-cadherin and maintenance of a differentiated, normal epithelial phenotype in breast cells.
The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex.
GeneRIF
Chicago, United States. In J Mol Cell Cardiol, 2008
These results demonstrate the importance of FOG-2/MTA/RbAp interactions for FOG-2-mediated transcriptional repression and further define the molecular interactions between the FOG repression motif and the NuRD complex.
MTA family of coregulators in nuclear receptor biology and pathology.
Review
Houston, United States. In Nucl Recept Signal, 2006
Recent findings that repression of estrogen receptor transactivation functions by MTA1, MTA1s, and MTA2 and regulation of MTA3 by estrogen signaling have indicated the significance of these proteins in NR signaling.
Metastatic tumor antigen 3 is a direct corepressor of the Wnt4 pathway.
GeneRIF
Houston, United States. In Genes Dev, 2006
These findings identify MTA3 as an upstream physiologic repressor of Wnt4 in mammary epithelial cells.
MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.
Impact
GeneRIF
Atlanta, United States. In Cell, 2004
a cell type-specific subunit of the corepressor complex Mi-2/NuRD,a cofactor for BCL-6-dependent B cell fate determination.
Another tie that binds the MTA family to breast cancer.
Review
Impact
Houston, United States. In Cell, 2003
In this issue of Cell, demonstrate that MTA3 is an estrogen-dependent component of the NuRD complex and identify the Snail gene as its direct target.
MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer.
Impact
GeneRIF
Atlanta, United States. In Cell, 2003
The absence of MTA3 leads to aberrant expression of Snail, a master regulator of epithelial to mesenchymal transitions. This results in loss of expression of E-cadherin, causing changes in epithelial architecture and invasive growth.
Connecting estrogen receptor function, transcriptional repression, and E-cadherin expression in breast cancer.
Review
Impact
Ann Arbor, United States. In Cancer Cell, 2003
A recent paper in Cell (Fujita et al., 2003) demonstrates that MTA3, a novel component of the Mi-2/NuRD transcriptional repression complex, is an estrogen receptor-regulated inhibitor of the Snail zinc finger transcription factor in breast cancer.
