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Matrix metallopeptidase 24

MT5-MMP, MMP-24, MMP-25
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MMP-28, MMP-2, MT1-MMP, MT3-MMP, MMP-9
Papers on MT5-MMP
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.
Rivera et al., Marseille, France. In Cell Mol Life Sci, Jan 2016
Membrane-type 5-matrix metalloproteinase (MT5-MMP) is a proteinase mainly expressed in the nervous system with emerging roles in brain pathophysiology.
DNA hypermethylation of extracellular matrix-related genes in human periodontal fibroblasts induced by stimulation for a prolonged period with lipopolysaccharide derived from Porphyromonas gingivalis.
Abiko et al., Tōbetsu, Japan. In J Periodontal Res, Dec 2015
Among these genes, hypermethylation of nine ECM-related genes, FANK1, COL4A1-A2, 12A1 and 15A1, LAMA5 and B1, MMP25, POMT1 and EMILIN3, induced a significantly downregulated expression of their mRNA.
η-Secretase processing of APP inhibits neuronal activity in the hippocampus.
Haass et al., München, Germany. In Nature, Nov 2015
CTF-η generation is mediated in part by membrane-bound matrix metalloproteinases such as MT5-MMP, referred to as η-secretase activity.
Expression and clinical significance of matrix metalloproteinase-17 and -25 in gastric cancer.
Luo et al., Wuhan, China. In Oncol Lett, Feb 2015
UNASSIGNED: The aim of the present study was to investigate the expression and clinicopathological features of matrix metalloproteinase 17 (MMP17; also known as MT4-MMP) and MMP25 (also known as MT6-MMP) in gastric cancer.
Association Study of GWAS-Derived Loci with Height in Brazilian Children: Importance of MAP3K3, MMP24 and IGF1R Polymorphisms for Height Variation.
Lima Jorge et al., Fortaleza, Brazil. In Horm Res Paediatr, 2014
BACKGROUND/AIM: The single nucleotide polymorphisms (SNPs) rs2282978 (CDK6), rs2425019 (MMP24), rs8081612 (MAP3K3), rs2871865 (IGF1R) and rs3782415 (SOCS2) were among the SNPs most strongly associated with height in a meta-analysis of 47 genome-wide association studies (GWAS) involving 114,223 adults from six ethnic groups.
Proteinases and plaque rupture: unblocking the road to translation.
Newby, Bristol, United Kingdom. In Curr Opin Lipidol, 2014
Novel targets, including MMP-8, MMP-10, MMP-14, MMP-19, MMP-25 and MMP-28, are also being considered.
Dysregulated expression of matrix metalloproteinases and their inhibitors may participate in the pathogenesis of pre-eclampsia and fetal growth restriction.
Yu et al., Guangzhou, China. In Early Hum Dev, 2014
We evaluated the expressions of MMP-2, -8, -9, -11, -19, -15 (MT2-MMP), -16 (MT3-MMP), and -24 (MT5-MMP), as well as TIMP-1 and -3, by applying Western blot and immunohistochemistry methods.
Ovarian membrane-type matrix metalloproteinases: induction of MMP14 and MMP16 during the periovulatory period in the rat, macaque, and human.
Curry et al., Göteborg, Sweden. In Biol Reprod, 2014
Among the six known MT-MMPs, mRNA expression of Mmp14, Mmp16, and Mmp25 was increased after human chorionic gonadotropin (hCG) administration in rats.
Neural stem cell quiescence comes to an un-sticky end.
Ffrench-Constant et al., Edinburgh, United Kingdom. In Nat Cell Biol, 2014
N-cadherin-mediated anchorage of neural stem cells within the adult neural niche maintains stem cell quiescence, and its release by the metalloproteinase MT5-MMP promotes neural stem cell activation.
MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin.
Fariñas et al., Madrid, Spain. In Nat Cell Biol, 2014
We further identify MT5-MMP as a membrane-type metalloproteinase responsible for the shedding of the N-cadherin ectodomain in this niche.
Lack of clinical manifestations in asymptomatic dengue infection is attributed to broad down-regulation and selective up-regulation of host defence response genes.
Devi Sekaran et al., Kuala Lumpur, Malaysia. In Plos One, 2013
Selected down-regulated genes include: TNF α (TNF), IL8, C1S, factor B (CFB), IL2, IL3, IL4, IL5, IL8, IL9, IL10 and IL13, CD80, CD28, and IL18, MMP8, MMP10, MMP12, MMP15, MMP16, and MMP24.
Expression of the matrix metalloproteases 2, 14, 24, and 25 and tissue inhibitor 3 as potential molecular markers in advanced human gastric cancer.
Remes-Troche et al., Veracruz, Mexico. In Dis Markers, 2013
RESULTS: We found a high expression of MMP1, MMP2, MMP14, TIMP1, and TIMP3; moderate one of MMP9 and MMP25, and low one of MMP13 and MMP24 in both tissues.
Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation.
López-Otín et al., Oviedo, Spain. In Proc Natl Acad Sci U S A, 2009
Findings demonstrate an essential role of MT5-MMP in the development of dermal neuro-immune synapses and suggest that this metalloproteinase may be a target for pain control.
[Inhibitory effects of RNA interference on MMP-24 expression and invasiveness of ovarian cancer SKOV(3) cells].
Li et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2009
MMP-24 gene silencing by RNAi can suppress the invasiveness of ovarian cancer SKOV(3) cells in vitro.
MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer.
Fridman et al., Detroit, United States. In Cancer Metastasis Rev, 2008
Two members of the MT-MMP subfamily, MMP-17 (MT4-MMP) and MMP-25 (MT6-MMP), are anchored to the plasma membrane via a glycosyl-phosphatidyl inositol (GPI) anchor, which confers these enzymes a unique set of regulatory and functional mechanisms that separates them from the rest of the MMP family.
Identification of a novel human MT5-MMP transcript variant in multipotent NT2 cells.
Fillmore et al., Richmond, United States. In Febs Lett, 2008
These results suggest more than one human MT5-MMP transcript may exist in the central nervous system.
The role of stratifin in fibroblast-keratinocyte interaction.
Ghahary et al., Vancouver, Canada. In Mol Cell Biochem, 2007
Other MMP family members such as stromelysin-1 (MMP-3), stromelysin-2 (MMP-10), neutrophil collagenase (MMP-8), and membrane-type MMP-24 (MT5-MMP) are also up-regulated by stratifin.
Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis.
Kaufmann et al., Frankfurt am Main, Germany. In Gynecol Endocrinol, 2007
MT5-MMP is expressed in normal human endometrium and there is enhanced exprestion in endometrium from patients with entometriosis with strongest signal in epithelial cells.
Membrane localization of membrane type 5 matrix metalloproteinase by AMPA receptor binding protein and cleavage of cadherins.
Ziff et al., New York City, United States. In J Neurosci, 2006
These results suggest that ABP directs MT5-MMP proteolytic activity to growth cones and synaptic sites in neurons, where it may regulate axon pathfinding or synapse remodeling through proteolysis of cadherins or other ECM or cell adhesion molecules.
The role of matrix metalloproteinases in the morphogenesis of the cerebellar cortex.
Luo, Morgantown, United States. In Cerebellum, 2004
MMP-2, -3, -9, membrane type 5-MMP (MT5-MMP), TIMP-1, -2 and -3 are expressed in the developing cerebellum.
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