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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Matrix metallopeptidase 17

MT4-MMP, MMP-17, Membrane-type 4 matrix metalloproteinase
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MT1-MMP, MT1, MT3-MMP, MT2-MMP, MMP-2
Papers on MT4-MMP
Dynamics of Internalization and Recycling of the Pro-Metastatic Membrane Type 4-Matrix Metalloproteinase (MT4-MMP) in Breast Cancer Cells.
New
Sounni et al., Liège, Belgium. In Febs J, Jan 2016
UNASSIGNED: MT4-MMP (MMP17) is a glycosylphosphatidyl inositol (GPI)-anchored membrane-type MMP expressed on the cell surface of human breast cancer cells.
Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice.
New
Arroyo et al., Madrid, Spain. In Circ Res, Aug 2015
OBJECTIVE: To determine the role of the protease MMP17/MT4-MMP in the arterial wall and its possible relevance in human aortic pathology.
Histone Methyltransferase hSETD1A Is a Novel Regulator of Metastasis in Breast Cancer.
New
Huang et al., Gainesville, United States. In Mol Cancer Res, Mar 2015
Furthermore, a group of matrix metalloproteinases (including MMP2, MMP9, MMP12, MMP13, and MMP17) were identified which were downregulated upon depletion of hSETD1A and demonstrated a decrease in H3K4me3 at their proximal promoters based on chromatin immunoprecipitation analysis.
Expression and clinical significance of matrix metalloproteinase-17 and -25 in gastric cancer.
New
Luo et al., Wuhan, China. In Oncol Lett, Feb 2015
UNASSIGNED: The aim of the present study was to investigate the expression and clinicopathological features of matrix metalloproteinase 17 (MMP17; also known as MT4-MMP) and MMP25 (also known as MT6-MMP) in gastric cancer.
EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP.
Sounni et al., Liège, Belgium. In Cancer Res, 2015
MT4-MMP (MMP-17) is a glycosylphosphatidyl inositol-anchored matrix metalloprotease expressed on the surface of cancer cells that promotes tumor growth and metastasis.
Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer.
Yasui et al., Hiroshima, Japan. In Oncol Rep, 2014
The invasiveness of ZDHHC14-knockdown HSC-44PE and 44As3 gastric cancer cells was decreased in comparison with that of the negative control siRNA-transfected cells, together with downregulation of MMP-17 mRNA.
Effects of thymoquinone on STZ-induced diabetic nephropathy: an immunohistochemical study.
Omran, Asyūţ, Egypt. In Ultrastruct Pathol, 2014
RESULTS: Diabetic rats exhibited morphological changes in both renal glomeruli and tubules with immunohistochemical expression of the mesenchymal markers Fsp1, desmin, and MMP-17 and disappearance of the epithelial marker ZO-1 largely in the glomeruli of diabetic kidneys.
Restoration of caveolin-1 expression suppresses growth, membrane-type-4 metalloproteinase expression and metastasis-associated activities in colon cancer cells.
Schwartz et al., Jerusalem, Israel. In Mol Carcinog, 2013
Expression of cav-1, flotillin-1, and MT4-MMP in lysates and lipid rafts of LS174T and HM-7 colon cancer cells was determined.
Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines.
Irmak-Yazicioglu et al., İstanbul, Turkey. In Chin J Cancer Res, 2013
We aimed to analyze the effect of the accumulation of oxidative stress in the gastric cancer MKN-45 and 23132/87 cells following hydrogen peroxide (H2O2) exposure on the expression patterns of MMP-1, MMP-3, MMP-7, MMP-9, MMP-10, MMP-11, MMP-12, MMP-14, MMP-15, MMP-17, MMP-23, MMP-28, and β-catenin genes.
Spatial and temporal analysis of nociception-related spinal cord matrix metalloproteinase expression in a murine neuropathic pain model.
Day et al., Taiwan. In J Chin Med Assoc, 2013
The expression of several nociception-related MMPs (MMP-2, MMP-9, MMP-12, MMP-17, and MMP-24) in the spinal cord was detected by immunohistochemical analysis, Western blotting, and real-time polymerase chain reaction.
MT-MMPs in pre-eclamptic placenta: relationship to soluble endoglin production.
Tong et al., Melbourne, Australia. In Placenta, 2013
RESULTS: Immunolocalisation studies revealed MMP-16, -24 and -25 were localized to the syncytiotrophoblast, the same site as endoglin, whilst MMP-17 was predominantly localized to fetal vessels and underlying stroma.
The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic promoting effects.
GeneRIF
Noel et al., Liège, Belgium. In Int J Cancer, 2012
It identifies MT4-MMP as a key intrinsic tumor cell determinant that contributes to the elaboration of a permissive microenvironment for metastatic dissemination.
Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms.
Eriksson et al., Stockholm, Sweden. In J Thorac Cardiovasc Surg, 2012
RESULTS: We detected messenger RNA expression for gelatinases (MMP2 and MMP9), stromelysin 3 (MMP11), all membrane bound MMPs (MMP14, MMP15, MMP16, MMP17, MMP24, MMP25), MMP19, MMP21, and MMP28 in ascending aorta.
Characterization of the dimerization interface of membrane type 4 (MT4)-matrix metalloproteinase.
GeneRIF
Fridman et al., Detroit, United States. In J Biol Chem, 2011
The data presented here provide a new insight into the characteristics of MT4-MMP and highlight the common and distinct properties of the glycosylphosphatidylinositol-anchored membrane type-matrix metalloproteinases.
Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice.
GeneRIF
Zent et al., Nashville, United States. In Plos One, 2010
function and expression of MT4-MMP
Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis.
GeneRIF
Yang et al., Taipei, Taiwan. In Neoplasia, 2009
Studies suggest a model of hypoxia induced metastasis through expression of HIF-1alpha, and SLUG regulation of MT4-MMP transcription.
Membrane-type 4 matrix metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumour vascular architecture.
GeneRIF
Noel et al., Liège, Belgium. In J Cell Mol Med, 2009
MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation
MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer.
Review
Fridman et al., Detroit, United States. In Cancer Metastasis Rev, 2008
Two members of the MT-MMP subfamily, MMP-17 (MT4-MMP) and MMP-25 (MT6-MMP), are anchored to the plasma membrane via a glycosyl-phosphatidyl inositol (GPI) anchor, which confers these enzymes a unique set of regulatory and functional mechanisms that separates them from the rest of the MMP family.
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