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Matrix metallopeptidase 16

MT3-MMP, Matrix Metalloproteinase 16, MMP-16
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: MT1-MMP, MT1, MMP-2, MT2-MMP, MMP-9
Papers using MT3-MMP antibodies
Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain.
Supplier
Zhou Zhongjun, In PLoS ONE, 1999
... Rabbit polyclonal antibodies against MT3-MMP hinge domain were from Abcam (ab38968), or kindly provided ...
Papers on MT3-MMP
miR-146b-5p promotes invasion and metastasis contributing to chemoresistance in osteosarcoma by targeting zinc and ring finger 3.
New
Zhou et al., Shanghai, China. In Oncol Rep, Jan 2016
Results of western blot assay indicated that miR-146b-5p increased MMP-16 protein expression and showed a decrease of ZNRF3 protein.
Association of age-of-onset groups with GWAS significant schizophrenia and bipolar disorder loci in Romanian bipolar I patients.
New
Becker et al., Bucureşti, Romania. In Psychiatry Res, Jan 2016
The AO-analysis implicated the EGFR gene, as well as loci in other genes, in the AO variation of BP-type-I and revealed for the first time the link between BP-type-I and risk variants considered specific to schizophrenia (polymorphisms in MMP16/RIPK2 and CNNM2 genes).
Catalpol suppresses proliferation and facilitates apoptosis of MCF-7 breast cancer cells through upregulating microRNA-146a and downregulating matrix metalloproteinase-16 expression.
New
Meng et al., Yantai, China. In Mol Med Report, Nov 2015
Matrix metalloproteinase-16 (MMP-16) is an enhancer of the invasion of breast cancer cells.
Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma.
New
Zhu et al., Shanghai, China. In Cancer Res, Sep 2015
miR-150 repressed HCC cell invasion by inhibiting ZEB1 and the matrix metalloproteinases MMP14 and MMP16.
Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming.
New
Avadhani et al., Philadelphia, United States. In Oncogene, Aug 2015
Propagation of this signaling includes activation of PI3-kinase, IGF1R and Akt, Ca2(+)-sensitive transcription factors and also TGFβ1, MMP16 and periostin, which are involved in oncogenic progression.
Promoter hypermethylation of membrane type 3 matrix metalloproteinase is associated with cell migration in colorectal adenocarcinoma.
New
Park et al., Seoul, South Korea. In Cancer Genet, May 2015
The gene MT3-MMP (also known as MMP16) encodes the membrane type 3 matrix metalloproteinase, which is a member of the matrix metalloproteinase (MMP) gene family.
[Virtual screening and molecular simulations of antisense peptides targeting MT1-MMP].
New
Mao et al., In Sheng Wu Gong Cheng Xue Bao, Feb 2015
Analysis of the affinities of these five antisense peptides to other MMPs (MMP1-3, MMP7-13, MMP14 HPX, MMP16) revealed that the peptide FVTFPYIR was more specific to MT1-MMP.
Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation.
Han et al., Seoul, South Korea. In Cell Death Dis, 2014
Subsequently, AA stimulated phosphorylation of p38 MAPK and transcription factor Sp1, and induced membrane type 3-matrix metalloproteinase (MT3-MMP)-dependent fibronectin degradation in promoting hUCB-MSCs motility.
Genetic and Immunohistochemical Expression of Integrins ITGAV, ITGA6, and ITGA3 As Prognostic Factor for Colorectal Cancer: Models for Global and Disease-Free Survival.
Matos et al., São Paulo, Brazil. In Plos One, 2014
RESULTS: In the univariate analyses, significant differences in GS in relation to the expression profiles of ITGAV (p = 0.001), ITGA3 (p = 0.002), ITGA6 (p = 0.001), SPARC (p = 0.036), MMP9 (p = 0.034), and MMP16 (p = 0.038) were observed.
MicroRNA-145 Suppresses Osteosarcoma Metastasis via Targeting MMP16.
Li et al., In Cell Physiol Biochem, 2014
RESULTS: Further, we identified three genes, MMP16, ADAM17 and metadherin, as possible targets of miR-145.
miR-132 can inhibit glioma cells invasion and migration by target MMP16 in vitro.
Zhou et al., Suzhou, China. In Onco Targets Ther, 2014
Based on the prediction of the target genes of miR-132, we hypothesized that there is a significant association between miR-132 and matrix metalloproteinase (MMP) 16 (MT3-MMP), a protein of the MMP family.
Association of genetic loci for migraine susceptibility in the she people of China.
Huang et al., Ningde, China. In J Headache Pain, 2014
rs4379368 is in the succinic HMG coenzyme A transferase (C7orf10) gene; rs10504861 is near the matrix metallopeptidase 16 (MMP16) gene; rs10915437 is near the adherens junctions associated protein 1 (AJAP1) gene; rs12134493 is upstream of the tetraspanin 2 (TSPAN2) gene; and rs13208321 is within the four and a half LIM domains protein 5 (FHL5) gene.
Effects of hydrogen sulfide on myocardial fibrosis in diabetic rats: Changes in matrix metalloproteinases parameters.
Yang et al., Hengyang, China. In Biomed Mater Eng, 2014
Eight weeks later, Van Gieson staining was used to observe pathological changes, and basic hydrolysis methods were adopted to measure hydroxyproline content, while Western Blot was used to determine the expression of MMP2, MMP7, MMP11, MMP13, MMP16, TIMP1 and TGFβ1.The results showed that significant myocardial fibrosis, decreased TIMP1 and MMP2 expression and increased MMP7, MMP11, MMP13, MMP16 expressions occurred in diabetic group, but all these changes were significantly reversed in diabetic rats after NaHS treatment.
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
Impact
International Headache Genetics Consortium et al., Cambridge, United Kingdom. In Nat Genet, 2013
Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21.
Matrix metalloprotease 16 expression is downregulated by microRNA-146a in spontaneously differentiating Caco-2 cells.
GeneRIF
Banerjee et al., Ankara, Turkey. In Dev Growth Differ, 2012
Data show that MMP16 is regulated by miR-146a in spontaneously differentiated Caco-2 cells.
Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage.
GeneRIF
Fournier et al., Montréal, Canada. In J Biol Chem, 2011
Neuronal knockdown of MT3-MMP resulted in the accumulation of NgR1 at the cell surface and reduced the accumulation of the NgR1 cleavage fragment in medium conditioned by cortical neurons
Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion.
GeneRIF
Lehti et al., Helsinki, Finland. In Plos One, 2010
MT3-MMP is a matrix-dependent modifier of the invasive tumor cell functions during melanoma progression
microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs.
GeneRIF
Lin et al., Hong Kong, Hong Kong. In Brain Res, 2009
miR-146b is involved in glioma cell migration and invasion by targeting MMP16; implicating miR-146b as a metastasis-inhibiting miRNA in glioma
Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.
GeneRIF
Delacourt et al., Créteil, France. In Plos One, 2007
MMP16 polymorphisms appear to influence not only the pulmonary expression and function of MMP16 but also the risk of bronchopulmonary dysplasia
Membrane-type matrix metalloproteinases (MT-MMPs) in cell invasion.
Review
Seiki et al., Kanazawa, Japan. In Thromb Haemost, 1997
Following the first-discovery of MT1-MMP, two other MT-MMPs which can activate progelatinase A were identified (MT2- and MT3-MMP, respectively).
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