MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective.
Buffalo, United States. In Annu Rev Pharmacol Toxicol, Feb 2016
Melatonin activates two high-affinity G protein-coupled receptors, termed MT1 and MT2, to exert beneficial actions in sleep and circadian abnormality, mood disorders, learning and memory, neuroprotection, drug abuse, and cancer.
Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling.
Atlanta, United States. In Invest Ophthalmol Vis Sci, Feb 2016
PURPOSE: Previous studies have demonstrated that melatonin has an important role in the modulation of photoreceptor viability during aging and may be involved in the pathogenesis of age-related macular degeneration.This hormone exerts its influence by binding to G-protein coupled receptors named melatonin receptor 1 (MT1) and 2 (MT2).
[Melatonin receptor agonist].
In Nihon Rinsho, Jun 2015
The melatonin MT1 and MT2 receptors located in the suprachiasmatic nucleus in the hypothalamus play a pivotal role in the sleep-wake regulation.
MMP-14 in skeletal muscle repair.
Pietermaritzburg, South Africa. In J Muscle Res Cell Motil, Jun 2015
MMP-14 (also known as MT1-MMP) is a membrane-bound collagenase and member of the Matrix Metalloprotease (MMP) family known to target a broad range of extracellular matrix (ECM) proteins.