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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog

MT1, mannosyltransferase
The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: MT1-MMP, CAN, V1a, MMP-2, HAD
Papers using MT1 antibodies
The ham-5, rcm-1 and rco-1 genes regulate hyphal fusion in Neurospora crassa
Supplier
Free Stephen J. et al., In Microbiology, 1995
... Mannosyltransferase is required for cell wall biosynthesis, morphology and control of ...
Papers on MT1
Multiple essential MT1-MMP functions in tooth root formation, dentinogenesis, and tooth eruption.
New
Foster et al., Beijing, China. In Matrix Biol, Feb 2016
UNASSIGNED: Membrane-type matrix metalloproteinase 1 (MT1-MMP) is a transmembrane zinc-endopeptidase that breaks down extracellular matrix components, including several collagens, during tissue development and physiological remodeling.
Synthesis of 2-arylfuro[3,2-b]pyridines: Effect of the C2-aryl group on melatoninergic activity.
New
Guillaumet et al., Orléans, France. In Eur J Med Chem, Feb 2016
Introduction of 1-naphthyl substituent gave the best result in terms of selectivity with a MT1/MT2 ratio of about 150 (MT1 Ki = 198 nM, MT2 Ki = 1.3 nM).
Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats.
New
Lazarov et al., Sofia, Bulgaria. In Behav Brain Res, Feb 2016
The aim of the present study was to determine whether the antidepressant drug agomelatine, a MT1/MT2 melatoninergic receptor agonist/5-HT2C receptor antagonist is able to prevent some of the behavioral, biochemical and cellular abnormalities induced by pinealectomy.
MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective.
New
Impact
Dubocovich et al., Buffalo, United States. In Annu Rev Pharmacol Toxicol, Feb 2016
Melatonin activates two high-affinity G protein-coupled receptors, termed MT1 and MT2, to exert beneficial actions in sleep and circadian abnormality, mood disorders, learning and memory, neuroprotection, drug abuse, and cancer.
Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling.
New
Tosini et al., Atlanta, United States. In Invest Ophthalmol Vis Sci, Feb 2016
PURPOSE: Previous studies have demonstrated that melatonin has an important role in the modulation of photoreceptor viability during aging and may be involved in the pathogenesis of age-related macular degeneration.This hormone exerts its influence by binding to G-protein coupled receptors named melatonin receptor 1 (MT1) and 2 (MT2).
Synergistic effect of blocking cancer cell invasion revealed by computer simulations.
New
Ichikawa, Tokyo, Japan. In Math Biosci Eng, Jan 2016
Membranous metalloproteinase MT1-MMP and soluble metalloproteinase MMP-2 are thought to play an important role in the degradation of ECM.
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drug abuse.
Review
New
Vigo et al., Buenos Aires, Argentina. In Pharmacol Res, Nov 2015
This action is attributed to MT1 and MT2 melatoninergic receptors localized in the SCN, as well as in other brain areas.
The role of melatonin in diabetes: therapeutic implications.
Review
New
Tiwari et al., Bhopāl, India. In Arch Endocrinol Metab, Oct 2015
The effects of melatonin on insulin secretion are mediated through the melatonin receptors (MT1 and MT2).
[Melatonin receptor agonist].
Review
New
Uchiyama, In Nihon Rinsho, Jun 2015
The melatonin MT1 and MT2 receptors located in the suprachiasmatic nucleus in the hypothalamus play a pivotal role in the sleep-wake regulation.
MMP-14 in skeletal muscle repair.
Review
New
Niesler et al., Pietermaritzburg, South Africa. In J Muscle Res Cell Motil, Jun 2015
MMP-14 (also known as MT1-MMP) is a membrane-bound collagenase and member of the Matrix Metalloprotease (MMP) family known to target a broad range of extracellular matrix (ECM) proteins.
Profile of agomelatine and its potential in the treatment of generalized anxiety disorder.
Review
Nardi et al., Rio de Janeiro, Brazil. In Neuropsychiatr Dis Treat, 2014
Therefore, the aim of this review was to report the clinical profile of agomelatine, a selective melatonergic MT1/MT2 receptor agonist with serotonin 5-HT2c receptor antagonist activities, as a potential pharmacological option in the treatment of GAD.
Description of the constitutive activity of cloned human melatonin receptors hMT(1) and hMT(2) and discovery of inverse agonists.
GeneRIF
Nosjean et al., France. In J Pineal Res, 2012
Description of the constitutive activity of cloned human melatonin receptors hMT(1) and hMT(2) and discovery of inverse agonists.
Melatonin pathway genes and breast cancer risk among Chinese women.
GeneRIF
Zheng et al., Nashville, United States. In Breast Cancer Res Treat, 2012
Results suggest that common genetic variation in the MTNR1a and 1b genes may contribute to breast cancer susceptibility, and that associations may vary by menopausal status.
A member of the mitogen-activated protein 3-kinase family is involved in the regulation of plant vacuolar glucose uptake.
GeneRIF
Neuhaus et al., Kaiserslautern, Germany. In Plant J, 2011
VIK-dependent phosphorylation stimulates TMT1 transport activity.
The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.
GeneRIF
Friedlander et al., Boston, United States. In J Neurosci, 2011
This study delineated a pathologic process whereby mutant htt-induced loss of the mitochondrial MT1 receptor enhances neuronal vulnerability and potentially accelerates the neurodegenerative process.
Decreased expression of the melatonin receptor 1 in human colorectal adenocarcinomas.
GeneRIF
Ekmekcioglu et al., Vienna, Austria. In J Biol Regul Homeost Agents, 2011
the decreased expression of MT1 in human colorectal cancer could point to a role of melatonin in this disease.
Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling.
Impact
Lapidot et al., Israel. In Nat Immunol, 2007
Treatment with neurotransmitters increased the motility, proliferation and colony formation of human progenitor cells, correlating with increased polarity, expression of the metalloproteinase MT1-MMP and activity of the metalloproteinase MMP-2.
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion.
Impact
Friedl et al., Würzburg, Germany. In Nat Cell Biol, 2007
Invasive cell migration through tissue barriers requires pericellular remodelling of extracellular matrix (ECM) executed by cell-surface proteases, particularly membrane-type-1 matrix metalloproteinase (MT1-MMP/MMP-14).
Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency.
Impact
Karadimitris et al., London, United Kingdom. In Nat Med, 2006
In two unrelated kindreds, a point mutation (c --> g) at position -270 from the start codon of PIGM, a mannosyltransferase-encoding gene, disrupts binding of the transcription factor Sp1 to its cognate promoter motif.
A pericellular collagenase directs the 3-dimensional development of white adipose tissue.
Impact
Weiss et al., Ann Arbor, United States. In Cell, 2006
Herein, we demonstrate that the membrane-anchored metalloproteinase, MT1-MMP, coordinates adipocyte differentiation in vivo.
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